Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 14, 2008, Pages 5477-5482

  Wang, ZhiChao ^a   Choi, Myoung Kwon ^a   Ban, Tatsuma ^a   Yanai, Hideyuki ^a   Negishi, Hideo ^a   Lu, Yan ^a   Tamura, Tomohiko ^a   Takaoka, Akinori ^a,c   Nishikura, Kazuko ^b   Taniguchi, Tadatsugu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b WISTAR INSTITUTE   (United States)

^c HOKKAIDO UNIVERSITY   (Japan)

Author keywords

ADAR1; E3L; IFN regulatory factor; Interferon

Indexed keywords

DNA DEPENDENT ACTIVATOR OF INTERFERON REGULATORY FACTOR; REGULATOR PROTEIN;

ARTICLE; CONTROLLED STUDY; DIMERIZATION; DNA BINDING; EMBRYO; GENE ACTIVATION; GENE INTERACTION; HUMAN; HUMAN CELL; IMMUNOREGULATION; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE DEAMINASE; ANIMALS; BINDING SITES; CELL LINE; CYTOSOL; DIMERIZATION; DNA; DNA-BINDING PROTEINS; GLYCOPROTEINS; HUMANS; IMMUNITY, NATURAL; INTERFERON TYPE I; MICE;

EID: 44449157593     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0801295105     Document Type: Article

References (31)

1. Tokunaga T, Yamamoto T, Yamamoto S (1999) How BCG led to the discovery of immunostimulatory DNA. Jpn J Infect Dis 52:1-11.
2. Ishii KJ, et al. (2006) A Toll-like receptor-independent antiviral response induced by double-stranded B-form DNA. Nat Immunol 7:40-48.
3. Stetson DB, Medzhitov R (2006) Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 24:93-103.
4. Yoshida H, Okabe Y, Kawane K, Fukuyama H, Nagata S (2005) Lethal anemia caused by interferon-β produced in mouse embryos carrying undigested DNA. Nat Immunol 6:49-56.
5. Napirei M, et al. (2000) Features of systemic lupus erythematosus in Dnase1-deficient mice. Nat Genet 25:177-181.
6. Takeda K, Kaisho T, Akira S (2003) Toll-like receptors. Annu Rev Immunol 21:335-376.
7. Janeway CA, Jr, Medzhitov R (2002) Innate immune recognition. Annu Rev Immunol 20:197-216.
8. Yoneyama M, et al. (2005) Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity. J Immunol 175:2851-2858.
9. Pichlmair A, et al. (2006) RIG-I-mediated antiviral responses to single-stranded RNA bearing 5′-phosphates. Science 314:997-1001.
10. Kato H, et al. (2006) Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature 441:101-105.
11. Hornung V, et al. (2006) 5′-Triphosphate RNA is the ligand for RIG-I Science 314:994-997.
12. Venkataraman T, et al. (2007) Loss of DExD/H box RNA helicase LGP2 manifests disparate antiviral responses. J Immunol 178:6444-6455.
13. Fu Y, et al. (1999) Cloning of DLM-1, a novel gene that is up-regulated in activated macrophages, using RNA differential display. Gene 240:157-163.
14. Takaoka A, et al. (2007) DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-505.
15. Schwartz T, Behlke J, Lowenhaupt K, Heinemann U, Rich A (2001) Structure of the DLM-1-Z-DNA complex reveals a conserved family of Z-DNA-binding proteins. Nat Struct Biol 8:761-765.
16. Ha SC, et al. (2006) Biochemical characterization and preliminary X-ray crystallographic study of the domains of human ZBP1 bound to left-handed Z-DNA. Biochim Biophys Acta 1764:320-323.
17. Wang Q, et al. (2004) Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem 279:4952-4961.
18. Langland JO, et al. (2006) Suppression of proinflammatory signal transduction and gene expression by the dual nucleic acid binding domains of the vaccinia virus E3L proteins. J Virol 80:10083-10095.
19. Rich A, Zhang S (2003) Z-DNA: The long road to biological function. Nat Rev Genet 4:566-572.
20. Malathi K, Dong B, Gale MJ, H, Silverman RH (2070) Small self-RNA generated by RNase L amplifies antiviral innate immunity. Nature 448:816-819.
21. Amara JF, et al. (1997) A versatile synthetic dimerizer for the regulation of protein-protein interactions. Proc Natl Acad Sci USA 94:10618-10623.
22. Iakoucheva LM, et al. (2004) The importance of intrinsic disorder for protein phosphorylation. Nucleic Acids Res 32:1037-1049.
23. Diella F, Gould CM, Chica C, Via A, Gibson TJ (2008) Phospho.ELM: A database of phosphorylation sites. Nucleic Acids Res 36:D240-D244.
24. McWhirter SM, et al. (2004) IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci USA 101:233-238.
25. Thompson AJ, Locarnini SA (2007) Toll-like receptors, RIG-I-like RNA helicases and the antiviral innate immune response. Immunol Cell Biol 85:435-445.
26. Melcher T, et al. (1996) A mammalian RNA editing enzyme. Nature 379:460-464.
27. Kim U, Wang Y, Sanford T, Zeng Y, Nishikura K (1994) Molecular cloning of cDNA for double-stranded RNA adenosine deaminase, a candidate enzyme for nuclear RNA editing. (1994) Proc Natl Acad Sci USA 91; 11457-11461.
28. Chen CX, et al. (2000) A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains. RNA 6:755-767.
29. Nishikura K (2006) Editor meets silencer: Crosstalk between RNA editing and RNA interference. Nat Rev Mol Cell Biol 7:919-931.
30. Patterson JB, Samuel CE (1995) Expression and regulation by interferon of a double-stranded-RNA-specific adenosine deaminase from human cells: Evidence for two forms of the deaminase. Mol Cell Biol 15:5376-5388.
31. Ishii KJ, et al. (2008) TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature 451:725-729.