Late endosome/lysosome-localized Rab7b suppresses TLR9-initiated proinflammatory cytokine and type I IFN production in macrophages

Journal of Immunology

Volumn 183, Issue 3, 2009, Pages 1751-1758

  Yao, Ming ^a,b   Liu, Xingguang ^b   Li, Dong ^a   Chen, Taoyong ^b   Cai, Zhen ^a   Cao, Xuetao ^a,b  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON; INTERLEUKIN 6; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE; RAB PROTEIN; RAB7B PROTEIN; SYNAPTOPHYSIN; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; RAB7 PROTEIN; TLR9 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; ENDOSOME; ENZYME ACTIVATION; HUMAN; HUMAN CELL; LYSOSOME; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; IMMUNOLOGY; INFLAMMATION; METABOLISM; PHYSIOLOGY; PROTEIN STABILITY;

ANIMALS; CELL LINE; CYTOKINES; DOWN-REGULATION; ENDOSOMES; HUMANS; INFLAMMATION; INTERFERON TYPE I; LYSOSOMES; MACROPHAGES; MICE; MICE, INBRED C57BL; PROTEIN STABILITY; RAB GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 68149132205     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900249     Document Type: Article

References (37)

1. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
2. Kawai, T., and S. Akira. 2007. TLR signaling. Semin. Immunol. 19: 24-32.
3. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4: 499-511.
4. Fitzgerald, K. A., and Z. J. Chen. 2006. Sorting out Toll signals. Cell 125: 834-836.
5. Lee, M. S., and Y. J. Kim. 2007. Signaling pathways downstream of patternrecognition receptors and their cross talk. Annu. Rev. Biochem. 76: 447-480.
6. O'Neill, L. A., and A. G. Bowie. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7: 353-364.
7. Marshak-Rothstein, A., and I. R. Rifkin. 2007. Immunologically active autoantigens: the role of Toll-like receptors in the development of chronic inflammatory disease. Annu. Rev. Immunol. 25: 419-441.
8. Baccala, R., K. Hoebe, D. H. Kono, B. Beutler, and A. N. Theofilopoulos. 2007. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 13: 543-551.
9. Adib-Conquy, M., C. Adrie, C. Fitting, O. Gattolliat, R. Beyaert, and J. M. Cavaillon. 2006. Up-regulation of MyD88s and SIGIRR, molecules inhibiting Toll-like receptor signaling, in monocytes from septic patients. Crit. Care Med. 34: 2377-2385.
10. Liew, F. Y., D. Xu, E. K. Brint, and L. A. O'Neill. 2005. Negative regulation of Toll-like receptor-mediated immune responses. Nat. Rev. Immunol. 5: 446-458.
11. Kinjyo, I., T. Hanada, K. Inagaki-Ohara, H. Mori, D. Aki, M. Ohishi, H. Yoshida, M. Kubo, and A. Yoshimura. 2002. SOCS1/JAB is a negative regulator of LPSinduced macrophage activation. Immunity 17: 583-591.
12. Dalpke, A., K. Heeg, H. Bartz, and A. Baetz. 2008. Regulation of innate immunity by suppressor of cytokine signaling (SOCS) proteins. Immunobiology 213: 225-235.
13. Chuang, T. H., and R. J. Ulevitch. 2004. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5: 495-502.
14. Wu, P., J. Wu, S. Liu, X. Han, J. Lu, Y. Shi, J. Wang, L. Lu, and X. Cao. 2008. TLR9/TLR7-triggered down-regulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients. Clin. Immunol. 129: 40-48.
15. Pfeffer, S., and D. Aivazian. 2004. Targeting Rab GTPases to distinct membrane compartments. Nat. Rev. Mol. Cell Biol. 5: 886-896.
16. Seachrist, J. L., and S. S. Ferguson. 2003. Regulation of G protein-coupled receptor endocytosis and trafficking by Rab GTPases. Life Sci. 4: 225-235.
17. Markgraf, D. F., K. Peplowska, and C. Ungermann. 2007. Rab cascades and tethering factors in the endomembrane system. FEBS Lett. 581: 2125-2130.
18. Snider, M. D. 2003. A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis. Mol. Cell 12: 796-797.
19. Cheng, K. W., J. P. Lahad, J. W. Gray, and G. B. Mills. 2005. Emerging role of RAB GTPases in cancer and human disease. Cancer Res. 65: 2516-2519.
20. Yang, M., T. Chen, C. Han, N. Li, T. Wan, and X. Cao. 2004. Rab7b, a novel lysosome-associated small GTPase, is involved in monocytic differentiation of human acute promyelocytic leukemia cells. Biochem. Biophys. Res. Commun. 318: 792-729.
21. Wang, Y., T. Chen, C. Han, D. He, H. Liu, H. An, Z. Cai, and X. Cao. 2007. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood 110: 962-971.
22. Latz, E., A. Schoenemeyer, and A. Visintin. 2004. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5: 190-198.
23. Xu, H., H. An, Y. Yu, M. Zhang, R. Qi, and X. Cao. 2003. Ras participates in CpG oligodeoxynucleotide signaling through association with Toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages. J. Biol. Chem. 278: 36334-36340.
24. Liu, X., M. Yao, N. Li, C. Wang, Y. Zheng, and X. Cao. 2008. CaMKII promotes TLR-triggered proinflammatory cytokine and type I interferon production by directly binding and activating TAK1 and IRF3 in macrophages. Blood 112: 4961-4970.
25. An, H., J. Hou, J. Zhou, W. Zhao, H. Xu, Y. Zheng, Y. Yu, S. Liu, and X. Cao. 2008. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat. Immunol. 9: 542-550.
26. Ivanov, S., A. M. Dragoi, X. Wang, C. Dallacosta, J. Louten, G. Musco, G. Sitia, G. S. Yap, Y. Wan, C. A. Biron, et al. 2007. A novel role for HMGB1 in TLR9-mediated inflammatory responses to CpG-DNA. Blood 110: 1970-1981.
27. Saitoh, S., and K. Miyake. 2009. Regulatory molecules required for nucleotidesensing Toll-like receptors. Immunol. Rev. 227: 32-43.
28. Gilliet, M., W. Cao, and Y. J. Liu. 2008. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8: 594-606.
29. Christensen, S. R., J. Shupe, K. Nicherson, M. Kashgarian, R. A. Flavell, and M. J. Shlomchik. 2006. Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 25: 397-399.
30. Means, T. K., E. Latz, F. Hayashi, M. R. Murali, D. T. Golenbock, and A. D. Luster. 2005. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115: 407-417.
31. Christensen, S. R., M. Kashgarian, L. Alexopoulou, R. A. Flavell, S. Akira, and M. J. Shlomchik. 2007. Toll-like receptor 9 controls anti-DNA autoantibody production in murine lupus. J. Exp. Med. 202: 321-331.
32. Wong, F. S., C. Hu, L. Zhang, W. Du, L. Alexopoulou, R. A. Flavell, and L. Wen. 2008. The role of Toll-like receptors 3 and 9 in the development of autoimmune diabetes in NOD mice. Ann. NY Acad. Sci. 1150: 146-148.
33. Chirstensen, S. R., and M. J. Shlomchik. 2007. Regulation of lupus-related autoantibody production and clinical disease by Toll-like receptors. Semin. Immunol. 19: 11-23.
34. Barrat, F. J., and R. L. Coffman. 2008. Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol. Rev. 223: 271-283.
35. Snider, M. D. 2003. A role for rab7 GTPase in growth factor-regulated cell nutrition and apoptosis. Mol. Cell 12: 796-797.
36. Kim, S. H., A. Visser, C. Cruijsen, A. W. van der Velden, and M. Boes. 2008. Recruitment of Rab27a to phagosomes controls microbial antigen cross-presentation by dendritic cells. Infect. Immun. 76: 5373-5380.
37. O'Neill, L. A. 2008. When signaling pathways collide: positive and negative regulation of Toll-like receptor signal transduction. Immunity 29: 12-20.