Interferon-α-inducible proteins are novel autoantigens in murine lupus

Arthritis and Rheumatism

Volumn 50, Issue 10, 2004, Pages 3239-3249

  Hueber, Wolfgang ^a   Zeng, Defu ^a   Strober, Samuel ^a   Utz, Paul J ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; AUTOANTIGEN; CD1 ANTIGEN; HEAT SHOCK PROTEIN 70; INTERFERON ALPHA INDUCIBLE PROTEIN; PHOSPHOAMINO ACID; PROTEIN P50; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ARTICLE; AUTOIMMUNITY; B LYMPHOCYTE; BONE MARROW CELL; CELL LYSATE; CELL STRAIN 3T3; CONTROLLED STUDY; FIBROBLAST; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SERUM; SPLEEN CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; BLOTTING, WESTERN; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR BETA; IMMUNOPRECIPITATION; INTERFERON-ALPHA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MICE, INBRED C57BL; PHOSPHOPROTEINS; TRANSGENES;

EID: 5644255667     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.20508     Document Type: Article

References (38)

1. Reeves WH, Satoh M, Wang J, Chou CH, Ajmani A. Systemic lupus erythematosus: antibodies to DNA, DNA-binding proteins, and histones. Rheum Dis Clin North Am 1994;20:1-28.
2. Lefkowith JB, Kiehl M, Rubenstein J, Di Valerio R, Bernstein K, Kahl L, et al. Heterogeneity and clinical significance of glomerular-binding antibodies in systemic lupus erythematosus. J Clin Invest 1996;98:1373-80.
3. Beckman EM, Porcelli SA, Morita CT, Behar SM, Furlong ST, Brenner MB. Recognition of a lipid antigen by CD1-restricted αβ+T cells. Nature 1994;372:691-4.
4. Castano AR, Tangri S, Miller J, Holcombe HR, Jackson MR, Huse WD, et al. Peptide binding and presentation by mouse CD1. Science 1995;269:223-6.
5. Lee DJ, Abeyratne A, Carson DA, Corr M. Induction of an antigen-specific, CD1-restricted cytotoxic T lymphocyte response in vivo. J Exp Med 1998;187:433-8.
6. Wilson MT, Singh AK, Van Kaer L. Immunotherapy with ligands of natural killer T cells. Trends Mol Med 2002;8:225-31.
7. Zeng D, Lee MK, Tung J, Brendolan A, Strober S. Cutting edge: a role for CD1 in the pathogenesis of lupus in NZB/NZW mice. J Immunol 2000;164:5000-4.
8. Zeng D, Dick M, Cheng L, Amano M, Dejbakhsh-Jones S, Huie P, et al. Subsets of transgenic T cells that recognize CD1 induce or prevent murine lupus: role of cytokines. J Exp Med 1998;187:525-36.
9. Rozzo SJ, Allard JD, Choubey D, Vyse TJ, Izui S, Peltz G, et al. Evidence for an interferon-inducible gene, Ifi202, in the susceptibility to systemic lupus. Immunity 2001;15:435-43.
10. Bennett L, Palucka AK, Arce E, Cantrell V, Borvak J, Banchereau J, et al. Interferon and granulopoiesis signatures in systemic lupus erythematosus blood. J Exp Med 2003;197:711-23.
11. Blanco P, Palucka AK, Gill M, Pascual V, Banchereau J. Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus. Science 2001;294:1540-3.
12. Ronnblom L, Alm GV. A pivotal role for the natural interferon α-producing cells (plasmacytoid dendritic cells) in the pathogenesis of lupus. J Exp Med 2001;194:59-64.
13. Santiago-Raber ML, Baccala R, Haraldsson KM, Choubey D, Stewart TA, Kono DH, et al. Type-I interferon receptor deficiency reduces lupus-like disease in NZB mice. J Exp Med 2003;197:777-88.
14. Johnstone RW, Trapani JA. Transcription and growth regulation of the HIN-200 family of proteins. Mol Cell Biol 1999;19:5833-8.
15. Seelig HP, Ehrfeld H, Renz M. Interferon-γ-inducible protein p16: a new target of antinuclear antibodies in patients with systemic lupus erythematosus. Arthritis Rheum 1994;37:1672-83.
16. Cheng L, Dejbakhsh-Jones S, Liblau R, Zeng D, Strober S. Different patterns of TCR transgenic expression in single-positive and double-negative cells: evidence for separate pathways of T cell maturation. J Immunol 1996;156:3592-601.
17. Utz PJ, Hottelet M, van Venrooij W, Anderson P. Association of phosphorylated SR proteins and the U1-small nuclear ribonuclear protein autoantigen complex accompanies apoptotic cell death. J Exp Med 1998;187:547-60.
18. Coligan J, Kruisbeek A, Margulies D, Shevach E, Strober W. Two dimensional phosphopeptide mapping. Curr Protocols Immunol 1994;3:11.2.1-8.
19. Hueber W, Zeng D, Sharpe O, Robinson WH, Strober S, Utz PJ. Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-trangenic lupus mice. Eur J Immunol 2004;34:1654-62.
20. Faulds G, Conroy S, Madaio M, Isenberg D, Latchman D. Increased levels of antibodies to heat shock proteins with increasing age in Mrl/Mp-lpr/lpr mice. Br J Rheumatol 1995;34:610-5.
21. Minota S, Cameron B, Welch WJ, Winfield JB. Autoantibodies to the constitutive 73-kD member of the hsp70 family of heat shock proteins in systemic lupus erythematosus. J Exp Med 1988;168:1475-80.
22. Mairesse N, Kahn MF, Appelboom T. Antibodies to the constitutive 73kD heat shock protein: a new marker of mixed connective tissue disease? Am J Med 1993;95:595-600.
23. Hayem G, De Brandt M, Palazzo E, Roux S, Combe B, Eliaou JF, et al. Anti-heat shock protein 70kDa and 90kDa antibodies in serum of patients with rheumatoid arthritis. Ann Rheum Dis 1999;58:291-6.
24. Choubey D, Lengyel P. Interferon action: cytoplasmic and nuclear localization of the interferon-inducible 52-kD protein that is encoded by the Ifi202 gene from the gene 200 cluster. J Interferon Res 1993;13:43-52.
25. Wang H, Chatterjee G, Meyer JJ, Liu CJ, Manjunath NA, Bray-Ward P, et al. Characteristics of three homologous 202 genes (Ifi202a, Ifi202b, and Ifi202c) from the murine interferon-activatable gene 200 cluster. Genomics 1999;15:281-94.
26. Wang H, Liu CJ, Lu Y, Chatterjee G, Ma XY, Eisenman RN, et al. The interferon- and differentiation-inducible p202a protein inhibits the transcriptional activity of c-myc by blocking its association with max. J Biol Chem 2000;275:27377-85.
27. Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, et al. Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 2003;100:2610-5.
28. Casciola-Rosen LA, Andrade F, Rosen A. Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes. J Exp Med 1994;179:1317-30.
29. Leslie D, Lipsky P, Notkins AL. Autoantibodies as predictors of disease. J Clin Invest 2001;108:1417-22.
30. Ronnblom L, Alm GV. An etiopathogenic role for the type I IFN system in SLE. Trends Immunol 2001;22:427-31.
31. Hooks JJ, Moutsopoulos HM, Geis SA, Stahl NI, Decker JL, Notkins AL. Immune interferon in the circulation of patients with autoimmune disease. N Engl J Med 1979;301:5-8.
32. Ioannou Y, Isenberg DA. Current evidence for the induction of autoimmune rheumatic manifestations by cytokine therapy. Arthritis Rheum 2000;43:1431-42.
33. 1 mice. Arthritis Rheum 2002;46:2235-44.
34. Lee CG, Eki T, Okumura K, da Costa Soares V, Hurwitz J. Molecular analysis of the cDNA and genomic DNA encoding mouse RNA helicase. Genomics 1998;47:365-71.
35. Braun D, Geraldes P, Demengeot J. Type I interferon controls the onset and severity of autoimmune manifestations in lpr mice. J Autoimmun 2003;20:15-25.
36. Kinoshita G, Purcell AW, Keech CL, Farris AD, McCluskey J, Gordon TP. Molecular chaperones are targets of autoimmunity in Ro(SS-A) immune mice. Clin Exp Immunol 1999;115:268-74.
37. Tishler M, Shoenfeld Y. Anti-heat shock protein antibodies in rheumatic and autoimmune disease. Semin Arthritis Rheum 1996;26:558-63.
38. Sieling PA, Porcelli SA, Duong BT, Spada F, Bloom BR, Diamond B, et al. Human double-negative T cells in systemic lupus erythematosus provide help for IgG and are restricted by CD1c. J Immunol 2000;165:5338-44.