-
1
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., O. Takeuchi, T. Kawai, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740.
-
(2000)
Nature
, vol.408
, pp. 740
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Sato, S.4
Sanjo, H.5
Matsumoto, M.6
Hoshino, K.7
Wagner, H.8
Takeda, K.9
Akira, S.10
-
2
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition
-
Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and O. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98:9237.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, O.B.8
-
3
-
-
0035477969
-
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
-
Takeshita, F., C. A. Leifer, I. Gursel, K. Ishii, S. Takeshita, M. Gursel, and D. M. Klinman. 2001. Cutting edge: role of Toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167:3555.
-
(2001)
J. Immunol.
, vol.167
, pp. 3555
-
-
Takeshita, F.1
Leifer, C.A.2
Gursel, I.3
Ishii, K.4
Takeshita, S.5
Gursel, M.6
Klinman, D.M.7
-
4
-
-
0042346153
-
Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation
-
Gursel, I., M. Gursel, H. Yamada, K. J. Ishii, F. Takeshita, and D. M. Klinman. 2003. Repetitive elements in mammalian telomeres suppress bacterial DNA-induced immune activation. J. Immunol. 171:1393.
-
(2003)
J. Immunol.
, vol.171
, pp. 1393
-
-
Gursel, I.1
Gursel, M.2
Yamada, H.3
Ishii, K.J.4
Takeshita, F.5
Klinman, D.M.6
-
5
-
-
2342491490
-
Suppressive oligodeoxynucleotides protect against the development of collagen-induced arthritis in mice
-
Dong, I., S. Ito, K. J. Ishii, and D. M. Klinman. 2004. Suppressive oligodeoxynucleotides protect against the development of collagen-induced arthritis in mice. Arthritis Rheum. 50:1686.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1686
-
-
Dong, I.1
Ito, S.2
Ishii, K.J.3
Klinman, D.M.4
-
6
-
-
0036674998
-
Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides
-
Zeuner, R. A., K. J. Ishii, M. J. Lizak, I. Gursel, H. Yamada, D. M. Klinman, and D. Verthelyi. 2002. Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum. 46:2219.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2219
-
-
Zeuner, R.A.1
Ishii, K.J.2
Lizak, M.J.3
Gursel, I.4
Yamada, H.5
Klinman, D.M.6
Verthelyi, D.7
-
7
-
-
0037637548
-
Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis
-
Zeuner, R. A., D. Verthelyi, M. Gursel, K. J. Ishii, and D. M. Klinman. 2003. Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis. Arthritis Rheum. 48:1701.
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 1701
-
-
Zeuner, R.A.1
Verthelyi, D.2
Gursel, M.3
Ishii, K.J.4
Klinman, D.M.5
-
8
-
-
0142210343
-
An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems
-
Ho, P. P., P. Fontoura, P. J. Ruiz, L. Steinman, and H. Garren. 2003. An immunomodulatory GpG oligonucleotide for the treatment of autoimmunity via the innate and adaptive immune systems. J. Immunol. 171:4920.
-
(2003)
J. Immunol.
, vol.171
, pp. 4920
-
-
Ho, P.P.1
Fontoura, P.2
Ruiz, P.J.3
Steinman, L.4
Garren, H.5
-
10
-
-
0022640843
-
Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins
-
Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Gíedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clones. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
-
(1986)
J. Immunol.
, vol.136
, pp. 2348
-
-
Mosmann, T.R.1
Cherwinski, H.2
Bond, M.W.3
Gíedlin, M.A.4
Coffman, R.L.5
-
11
-
-
0036366462
-
H2 cells: A historical perspective
-
H2 cells: a historical perspective. Nat. Rev. Immunol. 2:55.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 55
-
-
Liew, F.Y.1
-
12
-
-
0023232366
-
Two types of mouse helper T-cell clone
-
Mosmann, T. R., and R. L. Coffman. 1987. Two types of mouse helper T-cell clone. Immunol. Today 8:223.
-
(1987)
Immunol. Today
, vol.8
, pp. 223
-
-
Mosmann, T.R.1
Coffman, R.L.2
-
13
-
-
0025918159
-
+ T cells
-
+ T cells. Immunol. Rev. 123:209.
-
(1991)
Immunol. Rev.
, vol.123
, pp. 209
-
-
Mosmann, T.R.1
Schumacher, J.H.2
Street, N.F.3
Budd, R.4
O'Garra, A.5
Fong, T.A.6
Bond, M.W.7
Moore, K.W.8
Sher, A.9
Florentino, D.F.10
-
15
-
-
0031180973
-
TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes
-
Bright, J. J., L. D. Kerr, and S. Sriram. 1997. TGF-β inhibits IL-2-induced tyrosine phosphorylation and activation of Jak-1 and Stat 5 in T lymphocytes. J. Immunol. 159:175.
-
(1997)
J. Immunol.
, vol.159
, pp. 175
-
-
Bright, J.J.1
Kerr, L.D.2
Sriram, S.3
-
16
-
-
0030967214
-
Establishment of an IL-12-responsive T cell clone: Its characterization and utilization in the quantitation of IL-12 activity
-
Maruo, S., H. J. Ahn, W. G. Yu, M. Tomura, M. Wysocka, N. Yamamoto, M. Kobayashi, T. Hamaoka, G. Trinchieri, and H. Fuijiwara. 1997. Establishment of an IL-12-responsive T cell clone: its characterization and utilization in the quantitation of IL-12 activity. J. Leukocyte Biol. 61:346.
-
(1997)
J. Leukocyte Biol.
, vol.61
, pp. 346
-
-
Maruo, S.1
Ahn, H.J.2
Yu, W.G.3
Tomura, M.4
Wysocka, M.5
Yamamoto, N.6
Kobayashi, M.7
Hamaoka, T.8
Trinchieri, G.9
Fuijiwara, H.10
-
17
-
-
0029984358
-
CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ
-
Klinman, D. M., A. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ. Proc. Natl. Acad. Sci. USA 93:2879.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2879
-
-
Klinman, D.M.1
Yi, A.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
18
-
-
0034090116
-
Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
-
Shirota, H., K. Sano, T. Kikuchi, G. Tamura, and K. Shirato. 2000. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J. Immunol. 164:5575.
-
(2000)
J. Immunol.
, vol.164
, pp. 5575
-
-
Shirota, H.1
Sano, K.2
Kikuchi, T.3
Tamura, G.4
Shirato, K.5
-
19
-
-
0035399836
-
Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells
-
Shirota, H., K. Sano, N. Hirasawa, T. Terui, K. Ohuchi, T. Hattori, K. Shirato, and G. Tamura. 2001. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-tagged antigen by dendritic cells. J. Immunol. 167:66.
-
(2001)
J. Immunol.
, vol.167
, pp. 66
-
-
Shirota, H.1
Sano, K.2
Hirasawa, N.3
Terui, T.4
Ohuchi, K.5
Hattori, T.6
Shirato, K.7
Tamura, G.8
-
20
-
-
0030586560
-
A direct role for IFN-γ in regulation of Th1 cell development
-
Bradley, L. M., D. K. Dalton, and M. Croft. 1996. A direct role for IFN-γ in regulation of Th1 cell development. J. Immunol. 157:1350.
-
(1996)
J. Immunol.
, vol.157
, pp. 1350
-
-
Bradley, L.M.1
Dalton, D.K.2
Croft, M.3
-
21
-
-
0032103969
-
Generation, persistence, and modulation of Th0 effector cells: Role of autocrine IL-4 and IFN-γ
-
Miner, K. T., and M. Croft. 1998. Generation, persistence, and modulation of Th0 effector cells: role of autocrine IL-4 and IFN-γ. J. Immunol. 160:5280.
-
(1998)
J. Immunol.
, vol.160
, pp. 5280
-
-
Miner, K.T.1
Croft, M.2
-
22
-
-
0027409793
-
Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells
-
Manetti, R., P. Parronchi, M. G. Giudizi, M. P. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1199
-
-
Manetti, R.1
Parronchi, P.2
Giudizi, M.G.3
Piccinni, M.P.4
Maggi, E.5
Trinchieri, G.6
Romagnani, S.7
-
23
-
-
0031569126
-
Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype
-
Nakamura, T., R. K. Lee, S. Y. Nam, E. R. Podack, K. Bottomly, and R. A. Flavell. 1997. Roles of IL-4 and IFN-γ in stabilizing the T helper cell type 1 and 2 phenotype. J. Immunol. 158:2648.
-
(1997)
J. Immunol.
, vol.158
, pp. 2648
-
-
Nakamura, T.1
Lee, R.K.2
Nam, S.Y.3
Podack, E.R.4
Bottomly, K.5
Flavell, R.A.6
-
24
-
-
0028349904
-
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
-
Shuai, K., C. M. Horvath, L. H. Huang, S. A. Qureshi, D. Cowburn, and J. E. Darnell, Jr. 1994. Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell 76:821.
-
(1994)
Cell
, vol.76
, pp. 821
-
-
Shuai, K.1
Horvath, C.M.2
Huang, L.H.3
Qureshi, S.A.4
Cowburn, D.5
Darnell Jr., J.E.6
-
25
-
-
0032514616
-
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
-
Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love, L. Yang, A. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12631
-
-
Krieg, A.M.1
Wu, T.2
Weeratna, R.3
Efler, S.M.4
Love, L.5
Yang, L.6
Yi, A.7
Short, D.8
Davis, H.L.9
-
26
-
-
0037111465
-
Effect of suppressive DNA on CpG-induced immune activation
-
Yamada, H., I. Gursel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman. 2002. Effect of suppressive DNA on CpG-induced immune activation. J. Immunol. 169:5590.
-
(2002)
J. Immunol.
, vol.169
, pp. 5590
-
-
Yamada, H.1
Gursel, I.2
Takeshita, F.3
Conover, J.4
Ishii, K.J.5
Gursel, M.6
Takeshita, S.7
Klinman, D.M.8
-
27
-
-
0034932263
-
Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
-
Chen, Y., P. Lenert, R. Weeratna, M. McCluskie, T. Wu, H. L. Davis, and A. M. Krieg. 2001. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther. 8:1024.
-
(2001)
Gene Ther.
, vol.8
, pp. 1024
-
-
Chen, Y.1
Lenert, P.2
Weeratna, R.3
McCluskie, M.4
Wu, T.5
Davis, H.L.6
Krieg, A.M.7
-
28
-
-
0034856551
-
CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation
-
Lenert, P., L. Stunz, A. K. Yi, A. M. Krieg, and R. F. Ashman. 2001. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation. Antisense Nucleic Acid Drug Dev. 11:247.
-
(2001)
Antisense Nucleic Acid Drug Dev.
, vol.11
, pp. 247
-
-
Lenert, P.1
Stunz, L.2
Yi, A.K.3
Krieg, A.M.4
Ashman, R.F.5
-
29
-
-
10744219675
-
TLR9 signals after translocating from the ER to CpG DNA in the lysosome
-
Latz, E., A. Schoenemeyer, A. Visintin, K. A. Fitzgerald, B. G. Monks, C. F. Knetter, E. Lien, N. J. Nilsen, T. Espevik, and D. T. Golenbock. 2004. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol. 5:190.
-
(2004)
Nat. Immunol.
, vol.5
, pp. 190
-
-
Latz, E.1
Schoenemeyer, A.2
Visintin, A.3
Fitzgerald, K.A.4
Monks, B.G.5
Knetter, C.F.6
Lien, E.7
Nilsen, N.J.8
Espevik, T.9
Golenbock, D.T.10
-
30
-
-
0033843575
-
Inhibition of murine macrophage IL-12 production by natural and synthetic DNA
-
Pisetsky D.S., R. C. F. 2000. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA. Clin. Immunol. 96:198.
-
(2000)
Clin. Immunol.
, vol.96
, pp. 198
-
-
Pisetsky, D.S.1
-
31
-
-
0036554331
-
Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides
-
Zhu, F. G., C. F. Reich, and D. S. Pisetsky. 2002. Inhibition of murine macrophage nitric oxide production by synthetic oligonucleotides. J. Leukocyte Biol. 71:686.
-
(2002)
J. Leukocyte Biol.
, vol.71
, pp. 686
-
-
Zhu, F.G.1
Reich, C.F.2
Pisetsky, D.S.3
-
32
-
-
0036913736
-
Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides
-
Zhu, F. G., C. F. Reich, and D. S. Pisetsky. 2002. Inhibition of murine dendritic cell activation by synthetic phosphorothioate oligodeoxynucleotides. J. Leukocyte Biol. 72:1154.
-
(2002)
J. Leukocyte Biol.
, vol.72
, pp. 1154
-
-
Zhu, F.G.1
Reich, C.F.2
Pisetsky, D.S.3
-
33
-
-
0036587573
-
Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides
-
Gursel, M., D. Verthelyi, I. Gursel, K. J. Ishii, and D. M. Klinman. 2002. Differential and competitive activation of human immune cells by distinct classes of CpG oligodeoxynucleotides. J. Leukocyte Biol. 71:813.
-
(2002)
J. Leukocyte Biol.
, vol.71
, pp. 813
-
-
Gursel, M.1
Verthelyi, D.2
Gursel, I.3
Ishii, K.J.4
Klinman, D.M.5
-
34
-
-
0037371208
-
Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner
-
Sano, K., H. Shirota, T. Terui, T. Hattori, and G. Tamura. 2003. Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner. J. Immunol. 170:2367.
-
(2003)
J. Immunol.
, vol.170
, pp. 2367
-
-
Sano, K.1
Shirota, H.2
Terui, T.3
Hattori, T.4
Tamura, G.5
-
35
-
-
0028832030
-
In vitro inhibition of murine IFN γ production by phosphorothioate deoxyguanosine oligomers
-
Halpern, M. D., and D. S. Pisetsky. 1995. In vitro inhibition of murine IFN γ production by phosphorothioate deoxyguanosine oligomers. Immunopharmacology 29:47.
-
(1995)
Immunopharmacology
, vol.29
, pp. 47
-
-
Halpern, M.D.1
Pisetsky, D.S.2
-
36
-
-
0022518046
-
An antigen receptor-driven, interleukjn 2-independent pathway for proliferation of murine cytolytic T lymphocyte clones
-
Moldwin, R. L., D. W. Lancki, K. C. Herold, and F. W. Fitch. 1986. An antigen receptor-driven, interleukjn 2-independent pathway for proliferation of murine cytolytic T lymphocyte clones. J. Exp. Med. 163:1566.
-
(1986)
J. Exp. Med.
, vol.163
, pp. 1566
-
-
Moldwin, R.L.1
Lancki, D.W.2
Herold, K.C.3
Fitch, F.W.4
-
37
-
-
0024467154
-
Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes
-
Kobayashi, M., L. Fitz, M. Ryan, R. M. Hewick, S. C. Clark, S. Chan, R. Loudon, F. Sherman, B. Perussia, and O. Trinchieri. 1989. Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J. Exp. Med. 170:827.
-
(1989)
J. Exp. Med.
, vol.170
, pp. 827
-
-
Kobayashi, M.1
Fitz, L.2
Ryan, M.3
Hewick, R.M.4
Clark, S.C.5
Chan, S.6
Loudon, R.7
Sherman, F.8
Perussia, B.9
Trinchieri, O.10
-
38
-
-
0035827347
-
Role of T-bet in commitment of TH1 cells before IL-12-dependent selection
-
Mullen, A. C., F. A. High, A. S. Hutchins, H. W. Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292:1907.
-
(2001)
Science
, vol.292
, pp. 1907
-
-
Mullen, A.C.1
High, F.A.2
Hutchins, A.S.3
Lee, H.W.4
Villarino, A.V.5
Livingston, D.M.6
Kung, A.L.7
Cereb, N.8
Yao, T.P.9
Yang, S.Y.10
Reiner, S.L.11
-
39
-
-
0034677646
-
A novel transcription factor, T-bet, directs Th1 lineage commitment
-
Szabo, S. J., S. T. Kim, G. L. Costa, X. Zhang, C. G. Fathman, and L. H. Glimcher. 2000. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100:655.
-
(2000)
Cell
, vol.100
, pp. 655
-
-
Szabo, S.J.1
Kim, S.T.2
Costa, G.L.3
Zhang, X.4
Fathman, C.G.5
Glimcher, L.H.6
-
40
-
-
0028943484
-
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4
-
Jacobson, N. G., S. J. Szabo, R. M. Weber-Nordt, Z. Zhong, R. D. Schreiber, J. E. Darnell, Jr., and K. M. Murphy. 1995. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med. 181:1755.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 1755
-
-
Jacobson, N.G.1
Szabo, S.J.2
Weber-Nordt, R.M.3
Zhong, Z.4
Schreiber, R.D.5
Darnell Jr., J.E.6
Murphy, K.M.7
-
41
-
-
0344984245
-
Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells
-
Jing, N., Y. Li, X. Xu, W. Sha, P. Li, L. Feng, and D. J. Tweardy. 2003. Targeting Stat3 with G-quartet oligodeoxynucleotides in human cancer cells. DNA Cell Biol. 22:685.
-
(2003)
DNA Cell Biol.
, vol.22
, pp. 685
-
-
Jing, N.1
Li, Y.2
Xu, X.3
Sha, W.4
Li, P.5
Feng, L.6
Tweardy, D.J.7
|