-
1
-
-
0026625208
-
Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity
-
Yamamoto, S., T. Yamamoto, T. Katoaka, E. Kuramoto, O. Yano, and T. Tokunaga. 1992. Unique palindromic sequences in synthetic oligonucleotides are required to induce IFN and augment IFN-mediated natural killer activity. J. Immunol. 148:4072.
-
(1992)
J. Immunol.
, vol.148
, pp. 4072
-
-
Yamamoto, S.1
Yamamoto, T.2
Katoaka, T.3
Kuramoto, E.4
Yano, O.5
Tokunaga, T.6
-
2
-
-
0029984358
-
CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ
-
Klinman, D. M., A. Yi, S. L. Beaucage, J. Conover, and A. M. Krieg. 1996. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ. Proc. Natl. Acad. Sci. USA 93:2879.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 2879
-
-
Klinman, D.M.1
Yi, A.2
Beaucage, S.L.3
Conover, J.4
Krieg, A.M.5
-
3
-
-
0031867535
-
Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
-
Sparwasser, T., E. Koch, R. M. Vabulas, K. Heeg, G. B. Lipford, J. W. Ellwart, and H. Wager. 1998. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur. J. Immunol. 28:2045.
-
(1998)
Eur. J. Immunol.
, vol.28
, pp. 2045
-
-
Sparwasser, T.1
Koch, E.2
Vabulas, R.M.3
Heeg, K.4
Lipford, G.B.5
Ellwart, J.W.6
Wager, H.7
-
4
-
-
0033980073
-
The role of CpG motifs in innate immunity
-
Krieg, A. M. 2000. The role of CpG motifs in innate immunity. Curr. Opin. Immunol. 12:35.
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 35
-
-
Krieg, A.M.1
-
5
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
Hemmi, H., O. Takeuchi, T. Kawai, S. Sato, H. Sanjo, M. Matsumoto, K. Hoshino, H. Wagner, K. Takeda, and S. Akira. 2000. A Toll-like receptor recognizes bacterial DNA. Nature 408:740.
-
(2000)
Nature
, vol.408
, pp. 740
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Sato, S.4
Sanjo, H.5
Matsumoto, M.6
Hoshino, K.7
Wagner, H.8
Takeda, K.9
Akira, S.10
-
6
-
-
0035979192
-
Human TLR9 confers responsiveness to bacterial DNA via species specific CpG motif recognition
-
Bauer, S., C. J. Kirschning, H. Hacker, V. Redecke, S. Hausmann, S. Akira, H. Wagner, and G. B. Lipford. 2001. Human TLR9 confers responsiveness to bacterial DNA via species specific CpG motif recognition. Proc. Natl. Acad. Sci. USA 98:9237.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9237
-
-
Bauer, S.1
Kirschning, C.J.2
Hacker, H.3
Redecke, V.4
Hausmann, S.5
Akira, S.6
Wagner, H.7
Lipford, G.B.8
-
7
-
-
0035477969
-
Cutting edge: Role of Toll-like receptor 9 in CpG DNA-induced activation of human cells
-
Takeshita, F., C. A. Leifer, I. Gursel, K. Ishii, S. Takeshita, M. Gursel, and D. M. Klinman. 2001. Cutting edge: role of toll-like receptor 9 in CpG DNA-induced activation of human cells. J. Immunol. 167:3555.
-
(2001)
J. Immunol.
, vol.167
, pp. 3555
-
-
Takeshita, F.1
Leifer, C.A.2
Gursel, I.3
Ishii, K.4
Takeshita, S.5
Gursel, M.6
Klinman, D.M.7
-
8
-
-
0033179892
-
Immune recognition of foreign DNA: A cure for bioterrorism?
-
Klinman, D. M., D. Verthelyi, F. Takeshita, and K. J. Ishii. 1999. Immune recognition of foreign DNA: a cure for bioterrorism? Immunity 11:123.
-
(1999)
Immunity
, vol.11
, pp. 123
-
-
Klinman, D.M.1
Verthelyi, D.2
Takeshita, F.3
Ishii, K.J.4
-
9
-
-
0033558121
-
Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria
-
Elkins, K. L., T. R. Rhinehart-Jones, S. Stibitz, J. S. Conover, and D. M. Klinman. 1999. Bacterial DNA containing CpG motifs stimulates lymphocyte-dependent protection of mice against lethal infection with intracellular bacteria. J. Immunol. 162:2291.
-
(1999)
J. Immunol.
, vol.162
, pp. 2291
-
-
Elkins, K.L.1
Rhinehart-Jones, T.R.2
Stibitz, S.3
Conover, J.S.4
Klinman, D.M.5
-
10
-
-
0033536013
-
Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12 and IFNγ dependent mechanisms
-
Walker, P. S., T. Scharton-Kersten, A. M. Krieg, L. Love-Homan, E. D. Rowton, M. C. Udey, and J. C. Vogel. 1999. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leishmaniasis via IL-12 and IFNγ dependent mechanisms. Proc. Natl. Acad. Sci. USA 96:6970.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 6970
-
-
Walker, P.S.1
Scharton-Kersten, T.2
Krieg, A.M.3
Love-Homan, L.4
Rowton, E.D.5
Udey, M.C.6
Vogel, J.C.7
-
11
-
-
0024520930
-
Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA
-
Gilkeson, G. S., J. P. Grudier, D. G. Karounos, and D. S. Pisetsky. 1989. Induction of anti-double stranded DNA antibodies in normal mice by immunization with bacterial DNA. J. Immunol. 142:1482.
-
(1989)
J. Immunol.
, vol.142
, pp. 1482
-
-
Gilkeson, G.S.1
Grudier, J.P.2
Karounos, D.G.3
Pisetsky, D.S.4
-
12
-
-
0030897625
-
Bacterial DNA causes septic shock
-
Sparwasser, T., T. Meithke, G. Lipford, K. Borschert, H. Hicker, K. Heeg, and H. Wagner. 1997. Bacterial DNA causes septic shock. Nature 386:336.
-
(1997)
Nature
, vol.386
, pp. 336
-
-
Sparwasser, T.1
Meithke, T.2
Lipford, G.3
Borschert, K.4
Hicker, H.5
Heeg, K.6
Wagner, H.7
-
13
-
-
0030844985
-
Immunostimulatory DNA: A clear and present danger?
-
Pisetsky, D. S. 1997. Immunostimulatory DNA: a clear and present danger? Nat. Med. 3:829.
-
(1997)
Nat. Med.
, vol.3
, pp. 829
-
-
Pisetsky, D.S.1
-
14
-
-
0029934754
-
Bacterial DNA induces NK cells to produce IFN in vivo and increases the toxicity of lipopolysaccharides
-
Cowdery, J. S., J. H. Chace, A.-K. Yi, and A. M. Krieg. 1996. Bacterial DNA induces NK cells to produce IFN in vivo and increases the toxicity of lipopolysaccharides. J. Immunol. 156:4570.
-
(1996)
J. Immunol.
, vol.156
, pp. 4570
-
-
Cowdery, J.S.1
Chace, J.H.2
Yi, A.-K.3
Krieg, A.M.4
-
15
-
-
0034043957
-
CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
-
Segal, B. M., J. T. Chang, and E. M. Shevach. 2000. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J. Immunol. 164:5683.
-
(2000)
J. Immunol.
, vol.164
, pp. 5683
-
-
Segal, B.M.1
Chang, J.T.2
Shevach, E.M.3
-
16
-
-
0033038486
-
Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
-
Deng, G. M., I. M. Nilsson, M. Verdrengh, L. V. Collins, and A. Tarkowski. 1999. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat. Med. 5:702.
-
(1999)
Nat. Med.
, vol.5
, pp. 702
-
-
Deng, G.M.1
Nilsson, I.M.2
Verdrengh, M.3
Collins, L.V.4
Tarkowski, A.5
-
17
-
-
0028931102
-
CpG motifs in bacterial DNA trigger direct B-cell activation
-
Krieg, A. M., A. Yi, S. Matson, T. J. Waldschmidt, G. A. Bishop, R. Teasdale, G. A. Koretzky, and D. M. Klinman. 1995. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature 374:546.
-
(1995)
Nature
, vol.374
, pp. 546
-
-
Krieg, A.M.1
Yi, A.2
Matson, S.3
Waldschmidt, T.J.4
Bishop, G.A.5
Teasdale, R.6
Koretzky, G.A.7
Klinman, D.M.8
-
18
-
-
0023472826
-
CpG-rich islands and the function of DNA methylation
-
Bird, A. P. 1987. CpG-rich islands and the function of DNA methylation. Trends Genet. 3:342.
-
(1987)
Trends Genet.
, vol.3
, pp. 342
-
-
Bird, A.P.1
-
20
-
-
0032125838
-
The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors
-
Wloch, M. K., S. Pasquini, H. C. Ertl, and D. S. Pisetsky. 1998. The influence of DNA sequence on the immunostimulatory properties of plasmid DNA vectors. Hum. Gene Ther. 9:1439.
-
(1998)
Hum. Gene Ther.
, vol.9
, pp. 1439
-
-
Wloch, M.K.1
Pasquini, S.2
Ertl, H.C.3
Pisetsky, D.S.4
-
21
-
-
0033843575
-
Inhibition of murine macrophage IL-12 production by natural and synthetic DNA
-
Pisetsky, D. S., and C. F. Reich. 2000. Inhibition of murine macrophage IL-12 production by natural and synthetic DNA. Clin. Immunol. 96:198.
-
(2000)
Clin. Immunol.
, vol.96
, pp. 198
-
-
Pisetsky, D.S.1
Reich, C.F.2
-
22
-
-
0034932263
-
Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs
-
Chen, Y., P. Lenert, R. Weeratna, M. McCluskie, T. Wu, H. L. Davis, and A. M. Krieg. 2001. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther. 8:1024.
-
(2001)
Gene Ther.
, vol.8
, pp. 1024
-
-
Chen, Y.1
Lenert, P.2
Weeratna, R.3
McCluskie, M.4
Wu, T.5
Davis, H.L.6
Krieg, A.M.7
-
23
-
-
0033529563
-
For better or worse? Telomerase inhibition and cancer
-
de Lange, T., and T. Jacks. 1999. For better or worse? Telomerase inhibition and cancer. Cell 98:273.
-
(1999)
Cell
, vol.98
, pp. 273
-
-
De Lange, T.1
Jacks, T.2
-
25
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco, M. A., H. W. Lee, M. P. Hande, E. Samper, P. M. Lansdorp, R. A. DePinho, and C. W. Greider. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25.
-
(1997)
Cell
, vol.91
, pp. 25
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
Greider, C.W.7
-
26
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph, K. L., S. Chang, H. W. Lee, M. Blasco, G. J. Gottlieb, C. Greider, and R. A. DePinho. 1999. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96:701.
-
(1999)
Cell
, vol.96
, pp. 701
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
Blasco, M.4
Gottlieb, G.J.5
Greider, C.6
DePinho, R.A.7
-
27
-
-
0029563009
-
Telomeres: Beginning to understand the end
-
Zakian, V. A. 1995. Telomeres: beginning to understand the end. Science 270:1601.
-
(1995)
Science
, vol.270
, pp. 1601
-
-
Zakian, V.A.1
-
28
-
-
0030662578
-
DNA vaccines: Safety and efficacy issues
-
Klinman, D. M., M. Takeno, M. Ichino, M. Gu, G. Yamshchikov, G. Mor, and J. Conover. 1997. DNA vaccines: safety and efficacy issues. Springer. Semin. Immunopathol. 19:245.
-
(1997)
Springer. Semin. Immunopathol.
, vol.19
, pp. 245
-
-
Klinman, D.M.1
Takeno, M.2
Ichino, M.3
Gu, M.4
Yamshchikov, G.5
Mor, G.6
Conover, J.7
-
29
-
-
0033989756
-
Positive and negative regulatory elements contribute to CpG ODN mediated regulation of human IL-6 gene expression
-
Takeshita, F., K. J. Ishii, A. Ueda, Y. Ishigatsubo, and D. M. Klinman. 2000. Positive and negative regulatory elements contribute to CpG ODN mediated regulation of human IL-6 gene expression. Eur. J. Immunol. 30:108.
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 108
-
-
Takeshita, F.1
Ishii, K.J.2
Ueda, A.3
Ishigatsubo, Y.4
Klinman, D.M.5
-
30
-
-
0020638326
-
Differentiation between attached and ingested immune complexes by a fluorescence quenching cytofluorometric assay
-
Sahlin, S., J. Hed, and I. Rundquist. 1983. Differentiation between attached and ingested immune complexes by a fluorescence quenching cytofluorometric assay. J. Immunol. Methods 60:115.
-
(1983)
J. Immunol. Methods.
, vol.60
, pp. 115
-
-
Sahlin, S.1
Hed, J.2
Rundquist, I.3
-
31
-
-
0013462065
-
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes
-
Moyzis, R. K., J. M. Buckingham, L. S. Cram, M. Dani, L. L. Deaven, M. D. Jones, J. Meyne, R. L. Ratliff, and J. R. Wu. 1988. A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. USA 85:6622.
-
(1988)
Proc. Natl. Acad. Sci. USA
, vol.85
, pp. 6622
-
-
Moyzis, R.K.1
Buckingham, J.M.2
Cram, L.S.3
Dani, M.4
Deaven, L.L.5
Jones, M.D.6
Meyne, J.7
Ratliff, R.L.8
Wu, J.R.9
-
32
-
-
0034176194
-
G-quadruplex DNA: A potential target for anti-cancer drug design
-
Han, H., and H. L. Hurley. 2000. G-quadruplex DNA: a potential target for anti-cancer drug design. Trends Pharmacol. Sci. 21:136.
-
(2000)
Trends Pharmacol. Sci.
, vol.21
, pp. 136
-
-
Han, H.1
Hurley, H.L.2
-
33
-
-
0028158657
-
Tetraplex folding of telomere sequences and the inclusion of adenine bases
-
Murchie A. I., and D. M. Lilley. 1994. Tetraplex folding of telomere sequences and the inclusion of adenine bases. EMBO J. 13:993.
-
(1994)
EMBO J.
, vol.13
, pp. 993
-
-
Murchie, A.I.1
Lilley, D.M.2
-
34
-
-
0028824955
-
CpG DNA: A pathogenic factor in systemic lupus erythematosus?
-
Krieg, A. M. 1995. CpG DNA: a pathogenic factor in systemic lupus erythematosus? J. Clin. Immunol. 15:284.
-
(1995)
J. Clin. Immunol.
, vol.15
, pp. 284
-
-
Krieg, A.M.1
-
35
-
-
0025666735
-
Evidence for impaired T cell DNA methylation in SLE and RA
-
Richardson, B., L. Scheinbart, J. Strahler, L. Gross, S. Hanash, and M. Johnson. 1990. Evidence for impaired T cell DNA methylation in SLE and RA. Arthritis Rheum. 33:1665.
-
(1990)
Arthritis Rheum.
, vol.33
, pp. 1665
-
-
Richardson, B.1
Scheinbart, L.2
Strahler, J.3
Gross, L.4
Hanash, S.5
Johnson, M.6
-
36
-
-
0032168355
-
CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge
-
Krieg, A. M., L. L. Homan, A. K. Yi, and J. T. Harty. 1998. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J. Immunol. 161:2428.
-
(1998)
J. Immunol.
, vol.161
, pp. 2428
-
-
Krieg, A.M.1
Homan, L.L.2
Yi, A.K.3
Harty, J.T.4
-
37
-
-
0032521881
-
CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
-
Zimmermann, S., O. Egeter, S. Hausmann, G. B. Lipford, M. Rocken, H. Wagner, and K. Heeg. 1998. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis. J. Immunol. 160:3627.
-
(1998)
J. Immunol.
, vol.160
, pp. 3627
-
-
Zimmermann, S.1
Egeter, O.2
Hausmann, S.3
Lipford, G.B.4
Rocken, M.5
Wagner, H.6
Heeg, K.7
-
38
-
-
0032514616
-
Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs
-
Krieg, A. M., T. Wu, R. Weeratna, S. M. Efler, L. Love, L. Yang, A. Yi, D. Short, and H. L. Davis. 1998. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc. Natl. Acad. Sci. USA 95:12631.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 12631
-
-
Krieg, A.M.1
Wu, T.2
Weeratna, R.3
Efler, S.M.4
Love, L.5
Yang, L.6
Yi, A.7
Short, D.8
Davis, H.L.9
-
39
-
-
0037378005
-
The molecular basis of the lack of immunostimulatory activity of vertebrate DNA
-
Stacey, K. J., G. R. Young, F. Clark, D. P. Sester, T. L. Roberts, S. Naik, M. J. Sweet, and D. A. Hume. 2003. The molecular basis of the lack of immunostimulatory activity of vertebrate DNA. J. Immunol. 170:3614.
-
(2003)
J. Immunol.
, vol.170
, pp. 3614
-
-
Stacey, K.J.1
Young, G.R.2
Clark, F.3
Sester, D.P.4
Roberts, T.L.5
Naik, S.6
Sweet, M.J.7
Hume, D.A.8
-
40
-
-
0037111465
-
Effect of suppressive DNA on CpG-induced immune activation
-
Yamada, H., I. Gursel, F. Takeshita, J. Conover, K. J. Ishii, M. Gursel, S. Takeshita, and D. M. Klinman. 2002. Effect of suppressive DNA on CpG-induced immune activation. J. Immunol. 169:5590.
-
(2002)
J. Immunol.
, vol.169
, pp. 5590
-
-
Yamada, H.1
Gursel, I.2
Takeshita, F.3
Conover, J.4
Ishii, K.J.5
Gursel, M.6
Takeshita, S.7
Klinman, D.M.8
-
41
-
-
0034856551
-
CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation
-
Lenert, P., L. Stunz, A. K. Yi, A. M. Krieg, and R. F. Ashman. 2001. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation. Antisense Nucleic Acid Drug Dev. 11:247.
-
(2001)
Antisense Nucleic Acid Drug Dev.
, vol.11
, pp. 247
-
-
Lenert, P.1
Stunz, L.2
Yi, A.K.3
Krieg, A.M.4
Ashman, R.F.5
-
42
-
-
0033007567
-
Regulation of immune responses through inhibitory receptors
-
Long, E. O. 1999. Regulation of immune responses through inhibitory receptors. Annu. Rev. Immunol. 17:875.
-
(1999)
Annu. Rev. Immunol.
, vol.17
, pp. 875
-
-
Long, E.O.1
-
43
-
-
0034613151
-
Immune inhibitory receptors
-
Ravetch, J. V., and L. L. Lanier. 2000. Immune inhibitory receptors. Science 290:84.
-
(2000)
Science
, vol.290
, pp. 84
-
-
Ravetch, J.V.1
Lanier, L.L.2
-
44
-
-
0036674998
-
Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides
-
Zeuner R. A., K. J., Ishii, M. J. Lizak, I. Gursel, H. Yamada, D. M. Klinman, and D. Verthelyi. 2002. Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum. 46:2219.
-
(2002)
Arthritis Rheum.
, vol.46
, pp. 2219
-
-
Zeuner, R.A.1
Ishii, K.J.2
Lizak, M.J.3
Gursel, I.4
Yamada, H.5
Klinman, D.M.6
Verthelyi, D.7
-
45
-
-
0037173057
-
DNA containing CpG motifs induces angiogenesis
-
Zheng, M., D. M. Klinman, M. Gierynska, and B. T. Rouse. 2002. DNA containing CpG motifs induces angiogenesis. Proc. Natl. Acad. Sci. USA 99:8944.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 8944
-
-
Zheng, M.1
Klinman, D.M.2
Gierynska, M.3
Rouse, B.T.4
|