Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis

Arthritis and Rheumatism

Volumn 48, Issue 6, 2003, Pages 1701-1707

  Zeuner, Rainald A ^a,b   Verthelyi, Daniela ^a   Gursel, Mayda ^a   Ishii, Ken J ^a   Klinman, Dennis M ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; GLYCOPROTEIN P 15095; OLIGODEOXYNUCLEOTIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTHRITIS; ARTICLE; CONTROLLED STUDY; CPG ISLAND; DISEASE PREDISPOSITION; DISEASE RESISTANCE; FEMALE; HOST SUSCEPTIBILITY; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; ADOPTIVE TRANSFER; ANIMALS; ARTHRITIS, EXPERIMENTAL; ARTHRITIS, REACTIVE; CELL TRANSPLANTATION; CPG ISLANDS; DISEASE MODELS, ANIMAL; DISEASE SUSCEPTIBILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; HINDLIMB; INJECTIONS, INTRA-ARTICULAR; JOINTS; MICE; MICE, INBRED BALB C; OLIGONUCLEOTIDES; SPLEEN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0037637548     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11035     Document Type: Article

References (34)

1. Braun J, Kingsley G, van der Heijde D, Sieper J. On the difficulties of establishing a consensus on the definition of and diagnostic investigations for reactive arthritis: results and discussion of a questionnaire prepared for the 4th International Workshop on Reactive Arthritis, Berlin, Germany, July 3-6, 1999. J Rheumatol 2000;27:2185-92.
2. Sieper J, Braun J, Kingsley GH. Report on the Fourth International Workshop on Reactive Arthritis. Arthritis Rheum 2000;43:720-34.
3. Dworkin MS, Shoemaker PC, Goldoft MJ, Kobayashi JM. Reactive arthritis and Reiter's syndrome following an outbreak of gastroenteritis caused by Salmonella enteritidis. Clin Infect Dis 2001;33:1010-4.
4. Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intraarticularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 1999;5:702-5.
5. Zeuner RA, Ishii KJ, Lizak MJ, Gursel I, Yamada H, Klinman DM, et al. Reduction of CpG-induced arthritis by suppressive oligodeoxynucleotides. Arthritis Rheum 2002;46:2219-24.
6. Aderem A, Hume DA. How do you see CG? Cell 2000;103:993-6.
7. Klinman DM, Yi A, Beaucage SL, Conover J, Krieg AM. CpG motifs expressed by bacterial DNA rapidly induce lymphocytes to secrete IL-6, IL-12 and IFNγ. Proc Natl Acad Sci U S A 1996;93:2879-83.
8. Bauer M, Heeg K, Wagner H, Lipford GB. DNA activates human immune cells through a CpG sequence-dependent manner. Immunology 1999;97:699-705.
9. Sparwasser T, Koch E, Vabulas RM, Heeg K, Lipford GB, Ellwart JW, et al. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells. Eur J Immunol 1998;28:2045-54.
10. Krieg AM, Wu T, Weeratna R, Efler SM, Love-Homan L, Yang L, et al. Sequence motifs in adenoviral DNA block immune activation by stimulatory CpG motifs. Proc Natl Acad Sci U S A 1998;95:12631-6.
11. Chen Y, Lenert P, Weeratna R, McCluskie M, Wu T, Davis HL, et al. Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs. Gene Ther 2001;8:1024-32.
12. Stunz LL, Lenert P, Peckham D, Yi AK, Haxhinasto S, Chang M, et al. Inhibitory oligonucleotides specifically block effects of stimulatory CpG oligonucleotides in B cells. Eur J Immunol 2002;32:1212-22.
13. Yamada H, Gursel I, Takeshita F, Conover J, Ishii KJ, Gursel M, et al. Effect of suppressive DNA on CpG-induced immune activation. J Immunol 2002;169:5590-4.
14. Zhao H, Cheng SH, Yew NS. Requirements for effective inhibition of immunostimulatory CpG motifs by neutralizing motifs. Antisense Nucleic Acid Drug Dev 2000;10:381-9.
15. Roman M, Martin-Orozco E, Goodman JS, Nguyen M, Sato Y, Ronaghy A, et al. Immunostimulatory DNA sequences function as T helper-1 promoting adjuvants. Nat Med 1997;3:849-54.
16. Takeshita S, Takeshita F, Haddad DE, Ishii KJ, Klinman DM. CpG oligodeoxynucleotides induce murine macrophages to up-regulate chemokine mRNA expression. Cell Immunol 2000;206:101-6.
17. Deng GM, Tarkowski A. The features of arthritis induced by CpG motifs in bacterial DNA. Arthritis Rheum 2000;43:356-64.
18. Krieg AM, Homan LL, Yi AK, Harty JT. CpG DNA induces sustained IL-12 expression in vivo and resistance to Listeria monocytogenes challenge. J Immunol 1998;161:2428-34.
19. Elkins KL, Rhinehart-Jones TR, Stibitz S, Conover JS, Klinman DM. Bacterial DNA containing CpG motifs stimulate lymphocyte-dependent protection of mice against lethal infection with intra-cellular bacteria. J Immunol 1999;162:2291-8.
20. Zimmermann S, Egeter O, Hausmann S, Lipford GB, Rocken M, Wagner H, et al. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine Leishmaniasis. J Immunol 1998;160:3627-30.
21. Gilkeson GS, Conover JS, Halpern M, Pisetsky DS, Feagin A, Klinman DM. Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. J Immunol 1998;161:3890-5.
22. Sparwasser T, Meithke T, Lipford G, Borschert K, Hacker H, Heeg K, et al. Bacterial DNA causes septic shock [letter]. Nature 1997;386:336-7.
23. Pisetsky DS. Immunostimulatory DNA: a clear and present danger? Nat Med 1997;3:829-31.
24. Segal BM, Klinman DM, Shevach EM. Microbial products induce autoimmune disease by an IL-12 dependent process. J Immunol 1997;158:5087-91.
25. Lenert P, Stunz L, Yi AK, Krieg AM, Ashman RF. CpG stimulation of primary mouse B cells is blocked by inhibitory oligodeoxyribonucleotides at a site proximal to NF-κB activation. Anti-sense Nucleic Acid Drug Dev 2001;11:247-56.
26. Toivanen A. Bacteria-triggered reactive arthritis: implications for antibacterial treatment. Drugs 2001;61:343-51.
27. Wilbrink B, van der Heijden IM, Schouls LM, van Embden JD, Hazes JM, Breedveld FC, et al. Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers. Arthritis Rheum 1998;41:535-43.
28. Klinman DM. Therapeutic applications of CpG-containing oligodeoxynucleotides. Antisense Nucleic Acid Drug Dev 1998;8:181-4.
29. Verthelyi D, Kenney RT, Seder RA, Gam AA, Friedag B, Klinman DM. CpG oligodeoxynucleotides as vaccine adjuvants in primates. J Immunol 2002;168:1659-63.
30. Ronaghy A, Prakken BJ, Takabayashi K, Firestein GS, Boyle D, Zvaifler NJ, et al. Immunostimulatory DNA sequences influence the course of adjuvant arthritis. J Immunol 2002;168:51-6.
31. Yi AK, Yoon JG, Hong SC, Redford TW, Krieg AM. LPS and CpG DNA synergize for TNFα production through activation of NF-κB. Int Immunol 2001;13:1391-404.
32. Shoda LK, Kegerreis KA, Suarez CE, Mwangi W, Knowles DP, Brown WC. Immunostimulatory CpG-modified plasmid DNA enhances IL-12, TNF-α, and NO production by bovine macrophages. J Leukoc Biol 2001;70:103-12.
33. Rosenbaum JT, Smith JR. Anti-TNF therapy for eye involvement in spondyloarthropathy. Clin Exp Rheumatol 2002;20 Suppl 28: S143-5.
34. Lamprecht P, Voswinkel J, Lilienthal T, Nolle B, Heller M, Gross WL, et al. Effectiveness of TNF-α blockade with infliximab in refractory Wegener's granulomatosis. Rheumatology (Oxford) 2002;41:1303-7.