Identification of methylated CpG motifs as inhibitors of the immune stimulatory CpG motifs

Gene Therapy

Volumn 8, Issue 13, 2001, Pages 1024-1032

  Chen, Y ^a   Lenert, P ^a   Weeratna, R ^b   McCluskie, M ^b   Wu, T ^b   Davis, H L ^b,c   Krieg, A M ^a,c,d  

^a UNIVERSITY OF IOWA   (United States)

^b OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

^c PFIZER INC   (United States)

^d VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Bacterial DNA; CpG; Endotoxin; Gene therapy; Immune stimulation; Interferon

Indexed keywords

BACTERIAL DNA; DNA; ENDOTOXIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PLASMID DNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL NUCLEUS; CELL TRANSPORT; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; ESCHERICHIA COLI; FEMALE; GENE THERAPY; IMMUNOSTIMULATION; IN VIVO STUDY; INFLAMMATION; INTRACELLULAR TRANSPORT; MAMMAL; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ANIMALS; CATTLE; CELL CULTURE TECHNIQUES; CELL LINE; CPG ISLANDS; CYTOKINES; DNA; DNA METHYLATION; DNA, BACTERIAL; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; ESCHERICHIA COLI; FEMALE; GENE THERAPY; IMMUNOSUPPRESSION; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED BALB C; MICE, INBRED C3H; NF-KAPPA B; PLASMIDS; SPLEEN; THYMUS GLAND; TRANSCRIPTION FACTOR AP-1;

EID: 0034932263     PISSN: 09697128     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gt.3301482     Document Type: Article

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