Viral 5′-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinctTLR-independent immune responses

European Journal of Immunology

Volumn 38, Issue 12, 2008, Pages 3487-3498

  Allam, Ramanjaneyulu ^a   Pawar, Rahul D ^a   Kulkarni, Onkar P ^a   Hornung, Veit ^b   Hartmann, Gunter ^b   Segerer, Stephan ^a   Akira, Shizuo ^c   Endres, Stefan ^a   Anders, Hans Joachin ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Autoimmunity; Innate immunity; Lupus; Lupus nephritis; TLR

Indexed keywords

ALPHA INTERFERON; AUTOANTIBODY; CD45 ANTIGEN; COMPLEMENT COMPONENT C3C; GAMMA INTERFERON; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; INTERFERON; INTERLEUKIN 12; INTERLEUKIN 6; MESSENGER RNA; MYELOID DIFFERENTIATION FACTOR 88; RHEUMATOID FACTOR; SYNDECAN 1; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VIRAL 5' TRIPHOSPHATE RNA; VIRUS DNA; VIRUS RNA; MYD88 PROTEIN, MOUSE; POLYPHOSPHATE; TRIPHOSPHORIC ACID;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY BLOOD LEVEL; ARTICLE; AUTOIMMUNITY; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CONTROLLED STUDY; CPG ISLAND; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE EXACERBATION; GENE EXPRESSION; HYPERGAMMAGLOBULINEMIA; IMMUNE RESPONSE; LUPUS ERYTHEMATOSUS NEPHRITIS; LYMPHOCYTE PROLIFERATION; MESANGIUM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SPLENOMEGALY; VIRUS IMMUNITY; ANIMAL; CELL CULTURE; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; LYMPHOCYTE; METABOLISM; MOUSE MUTANT; PATHOLOGY; SECRETION; SPLEEN;

ANIMALS; AUTOANTIBODIES; AUTOIMMUNITY; CELL PROLIFERATION; CELLS, CULTURED; CPG ISLANDS; FEMALE; GENE EXPRESSION REGULATION; HYPERGAMMAGLOBULINEMIA; IMMUNOGLOBULIN G; INTERLEUKIN-6; LUPUS NEPHRITIS; LYMPHOCYTES; MESANGIAL CELLS; MICE; MICE, KNOCKOUT; MYELOID DIFFERENTIATION FACTOR 88; POLYPHOSPHATES; RNA, MESSENGER; RNA, VIRAL; SPLEEN; TOLL-LIKE RECEPTORS;

EID: 59749101255     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.200838604     Document Type: Article

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