-
1
-
-
36448994709
-
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
-
Ajami, B., Bennett, J.L., Krieger, C., Tetzlaff, W. Rossi, F.M. (2007) Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat. Neurosci., 10, 1538 1543.
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 1538-1543
-
-
Ajami, B.1
Bennett, J.L.2
Krieger, C.3
Tetzlaff, W.4
Rossi, F.M.5
-
2
-
-
0034099564
-
Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase
-
Alexander, G.M., Deitch, J.S., Seeburger, J.L., Del Valle, L. Heiman-Patterson, T.D. (2000) Elevated cortical extracellular fluid glutamate in transgenic mice expressing human mutant (G93A) Cu/Zn superoxide dismutase. J. Neurochem., 74, 1666 1673.
-
(2000)
J. Neurochem.
, vol.74
, pp. 1666-1673
-
-
Alexander, G.M.1
Deitch, J.S.2
Seeburger, J.L.3
Del Valle, L.4
Heiman-Patterson, T.D.5
-
3
-
-
7444237149
-
Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS
-
Alexander, G.M., Erwin, K.L., Byers, N., Deitch, J.S., Augelli, B.J., Blankenhorn, E.P. Heiman-Patterson, T.D. (2004) Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS. Brain Res. Mol. Brain Res., 130, 7 15.
-
(2004)
Brain Res. Mol. Brain Res.
, vol.130
, pp. 7-15
-
-
Alexander, G.M.1
Erwin, K.L.2
Byers, N.3
Deitch, J.S.4
Augelli, B.J.5
Blankenhorn, E.P.6
Heiman-Patterson, T.D.7
-
4
-
-
0027946813
-
The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
-
Alexianu, M.E., Ho, B.K., Mohamed, A.H., La Bella, V., Smith, R.G. Appel, S.H. (1994) The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis. Ann. Neurol., 36, 846 858.
-
(1994)
Ann. Neurol.
, vol.36
, pp. 846-858
-
-
Alexianu, M.E.1
Ho, B.K.2
Mohamed, A.H.3
La Bella, V.4
Smith, R.G.5
Appel, S.H.6
-
5
-
-
0029010496
-
Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase
-
Andersen, P.M., Nilsson, P., Ala-Hurula, V., Keranen, M.L., Tarvainen, I., Haltia, T., Nilsson, L., Binzer, M., Forsgren, L. Marklund, S.L. (1995) Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in CuZn-superoxide dismutase. Nat. Genet., 10, 61 66.
-
(1995)
Nat. Genet.
, vol.10
, pp. 61-66
-
-
Andersen, P.M.1
Nilsson, P.2
Ala-Hurula, V.3
Keranen, M.L.4
Tarvainen, I.5
Haltia, T.6
Nilsson, L.7
Binzer, M.8
Forsgren, L.9
Marklund, S.L.10
-
6
-
-
0035097484
-
Familial dysautonomia is caused by mutations of the IKAP gene
-
Anderson, S.L., Coli, R., Daly, I.W., Kichula, E.A., Rork, M.J., Volpi, S.A., Ekstein, J. Rubin, B.Y. (2001) Familial dysautonomia is caused by mutations of the IKAP gene. Am. J. Hum. Genet., 68, 753 758.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 753-758
-
-
Anderson, S.L.1
Coli, R.2
Daly, I.W.3
Kichula, E.A.4
Rork, M.J.5
Volpi, S.A.6
Ekstein, J.7
Rubin, B.Y.8
-
7
-
-
0031784348
-
Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis
-
Andrus, P.K., Fleck, T.J., Gurney, M.E. Hall, E.D. (1998) Protein oxidative damage in a transgenic mouse model of familial amyotrophic lateral sclerosis. J. Neurochem., 71, 2041 2048.
-
(1998)
J. Neurochem.
, vol.71
, pp. 2041-2048
-
-
Andrus, P.K.1
Fleck, T.J.2
Gurney, M.E.3
Hall, E.D.4
-
8
-
-
0033352861
-
Drosophila UNC-13 is essential for synaptic transmission
-
Aravamudan, B., Fergestad, T., Davis, W.S., Rodesch, C.K. Broadie, K. (1999) Drosophila UNC-13 is essential for synaptic transmission. Nat. Neurosci., 2, 965 971.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 965-971
-
-
Aravamudan, B.1
Fergestad, T.2
Davis, W.S.3
Rodesch, C.K.4
Broadie, K.5
-
9
-
-
62449225007
-
Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis
-
Awano, T., Johnson, G.S., Wade, C.M., Katz, M.L., Johnson, G.C., Taylor, J.F., Perloski, M., Biagi, T., Baranowska, I., Long, S., March, P.A., Olby, N.J., Shelton, G.D., Khan, S., O'Brien, D.P., Lindblad-Toh, K. Coates, J.R. (2009) Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 106, 2794 2799.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 2794-2799
-
-
Awano, T.1
Johnson, G.S.2
Wade, C.M.3
Katz, M.L.4
Johnson, G.C.5
Taylor, J.F.6
Perloski, M.7
Biagi, T.8
Baranowska, I.9
Long, S.10
March, P.A.11
Olby, N.J.12
Shelton, G.D.13
Khan, S.14
O'Brien, D.P.15
Lindblad-Toh, K.16
Coates, J.R.17
-
10
-
-
2642526164
-
VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model
-
Azzouz, M., Ralph, G.S., Storkebaum, E., Walmsley, L.E., Mitrophanous, K.A., Kingsman, S.M., Carmeliet, P. Mazarakis, N.D. (2004) VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature, 429, 413 417.
-
(2004)
Nature
, vol.429
, pp. 413-417
-
-
Azzouz, M.1
Ralph, G.S.2
Storkebaum, E.3
Walmsley, L.E.4
Mitrophanous, K.A.5
Kingsman, S.M.6
Carmeliet, P.7
Mazarakis, N.D.8
-
11
-
-
0041624017
-
Biomagnification of cycad neurotoxins in flying foxes: Implications for ALS-PDC in Guam
-
Banack, S.A. Cox, P.A. (2003) Biomagnification of cycad neurotoxins in flying foxes: implications for ALS-PDC in Guam. Neurology, 61, 387 389.
-
(2003)
Neurology
, vol.61
, pp. 387-389
-
-
Banack, S.A.1
Cox, P.A.2
-
12
-
-
75149155060
-
Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target
-
Barber, S.C. Shaw, P.J. (2010) Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic. Biol. Med., 48, 629 641.
-
(2010)
Free Radic. Biol. Med.
, vol.48
, pp. 629-641
-
-
Barber, S.C.1
Shaw, P.J.2
-
13
-
-
74949135753
-
Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis
-
Barmada, S.J., Skibinski, G., Korb, E., Rao, E.J., Wu, J.Y. Finkbeiner, S. (2010) Cytoplasmic mislocalization of TDP-43 is toxic to neurons and enhanced by a mutation associated with familial amyotrophic lateral sclerosis. J. Neurosci., 30, 639 649.
-
(2010)
J. Neurosci.
, vol.30
, pp. 639-649
-
-
Barmada, S.J.1
Skibinski, G.2
Korb, E.3
Rao, E.J.4
Wu, J.Y.5
Finkbeiner, S.6
-
14
-
-
0034763566
-
Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis
-
Beers, D.R., Ho, B.K., Siklos, L., Alexianu, M.E., Mosier, D.R., Mohamed, A.H., Otsuka, Y., Kozovska, M.E., McAlhany, R.E., Smith, R.G. Appel, S.H. (2001) Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis. J. Neurochem., 79, 499 509.
-
(2001)
J. Neurochem.
, vol.79
, pp. 499-509
-
-
Beers, D.R.1
Ho, B.K.2
Siklos, L.3
Alexianu, M.E.4
Mosier, D.R.5
Mohamed, A.H.6
Otsuka, Y.7
Kozovska, M.E.8
McAlhany, R.E.9
Smith, R.G.10
Appel, S.H.11
-
15
-
-
33750478657
-
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
-
Beers, D.R., Henkel, J.S., Xiao, Q., Zhao, W., Wang, J., Yen, A.A., Siklos, L., McKercher, S.R. Appel, S.H. (2006) Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 103, 16021 16026.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 16021-16026
-
-
Beers, D.R.1
Henkel, J.S.2
Xiao, Q.3
Zhao, W.4
Wang, J.5
Yen, A.A.6
Siklos, L.7
McKercher, S.R.8
Appel, S.H.9
-
16
-
-
55749110043
-
CD4 + T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS
-
Beers, D.R., Henkel, J.S., Zhao, W., Wang, J. Appel, S.H. (2008) CD4 + T cells support glial neuroprotection, slow disease progression, and modify glial morphology in an animal model of inherited ALS. Proc. Natl Acad. Sci. USA, 105, 15558 15563.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 15558-15563
-
-
Beers, D.R.1
Henkel, J.S.2
Zhao, W.3
Wang, J.4
Appel, S.H.5
-
17
-
-
70350045802
-
Mutations in FUS cause FALS and SALS in French and French Canadian populations
-
Belzil, V.V., Valdmanis, P.N., Dion, P.A., Daoud, H., Kabashi, E., Noreau, A., Gauthier, J., Hince, P., Desjarlais, A., Bouchard, J.P., Lacomblez, L., Salachas, F., Pradat, P.F., Camu, W., Meininger, V., Dupre, N. Rouleau, G.A. (2009) Mutations in FUS cause FALS and SALS in French and French Canadian populations. Neurology, 73, 1176 1179.
-
(2009)
Neurology
, vol.73
, pp. 1176-1179
-
-
Belzil, V.V.1
Valdmanis, P.N.2
Dion, P.A.3
Daoud, H.4
Kabashi, E.5
Noreau, A.6
Gauthier, J.7
Hince, P.8
Desjarlais, A.9
Bouchard, J.P.10
Lacomblez, L.11
Salachas, F.12
Pradat, P.F.13
Camu, W.14
Meininger, V.15
Dupre, N.16
Rouleau, G.A.17
-
18
-
-
65649112431
-
TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration
-
Benajiba, L., Le Ber, I., Camuzat, A., Lacoste, M., Thomas-Anterion, C., Couratier, P., Legallic, S., Salachas, F., Hannequin, D., Decousus, M., Lacomblez, L., Guedj, E., Golfier, V., Camu, W., Dubois, B., Campion, D., Meininger, V. Brice, A. (2009) TARDBP mutations in motoneuron disease with frontotemporal lobar degeneration. Ann. Neurol., 65, 470 473.
-
(2009)
Ann. Neurol.
, vol.65
, pp. 470-473
-
-
Benajiba, L.1
Le Ber, I.2
Camuzat, A.3
Lacoste, M.4
Thomas-Anterion, C.5
Couratier, P.6
Legallic, S.7
Salachas, F.8
Hannequin, D.9
Decousus, M.10
Lacomblez, L.11
Guedj, E.12
Golfier, V.13
Camu, W.14
Dubois, B.15
Campion, D.16
Meininger, V.17
Brice, A.18
-
19
-
-
0028097839
-
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group
-
Bensimon, G., Lacomblez, L. Meininger, V. (1994) A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole Study Group. N. Engl. J. Med., 330, 585 591.
-
(1994)
N. Engl. J. Med.
, vol.330
, pp. 585-591
-
-
Bensimon, G.1
Lacomblez, L.2
Meininger, V.3
-
20
-
-
77952111070
-
FUS mutations in amyotrophic lateral sclerosis: Clinical, pathological, neurophysiological and genetic analysis
-
in press
-
Blair, I.P., Williams, K.L., Warraich, S.T., Durnall, J.C., Thoeng, A.D., Manavis, J., Blumbergs, P.C., Vucic, S., Kiernan, M.C. Nicholson, G.A. (2010) FUS mutations in amyotrophic lateral sclerosis: clinical, pathological, neurophysiological and genetic analysis. J. Neurol. Neurosurg. Psychiatry, in press.
-
(2010)
J. Neurol. Neurosurg. Psychiatry
-
-
Blair, I.P.1
Williams, K.L.2
Warraich, S.T.3
Durnall, J.C.4
Thoeng, A.D.5
Manavis, J.6
Blumbergs, P.C.7
Vucic, S.8
Kiernan, M.C.9
Nicholson, G.A.10
-
21
-
-
33749385489
-
Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases
-
Bogaert, E., Van Damme, P., Van Den Bosch, L. Robberecht, W. (2006) Vascular endothelial growth factor in amyotrophic lateral sclerosis and other neurodegenerative diseases. Muscle Nerve, 34, 391 405.
-
(2006)
Muscle Nerve
, vol.34
, pp. 391-405
-
-
Bogaert, E.1
Van Damme, P.2
Van Den Bosch, L.3
Robberecht, W.4
-
22
-
-
77953732352
-
VEGF protects motor neurons against excitotoxicity by upregulation of GluR2
-
in press
-
Bogaert, E., Van Damme, P., Poesen, K., Dhondt, J., Hersmus, N., Kiraly, D., Scheveneels, W., Robberecht, W. Van Den Bosch, L. (2010) VEGF protects motor neurons against excitotoxicity by upregulation of GluR2. Neurobiol. Aging, in press.
-
(2010)
Neurobiol. Aging
-
-
Bogaert, E.1
Van Damme, P.2
Poesen, K.3
Dhondt, J.4
Hersmus, N.5
Kiraly, D.6
Scheveneels, W.7
Robberecht, W.8
Van Den Bosch, L.9
-
23
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
Boillee, S., Yamanaka, K., Lobsiger, C.S., Copeland, N.G., Jenkins, N.A., Kassiotis, G., Kollias, G. Cleveland, D.W. (2006) Onset and progression in inherited ALS determined by motor neurons and microglia. Science, 312, 1389 1392.
-
(2006)
Science
, vol.312
, pp. 1389-1392
-
-
Boillee, S.1
Yamanaka, K.2
Lobsiger, C.S.3
Copeland, N.G.4
Jenkins, N.A.5
Kassiotis, G.6
Kollias, G.7
Cleveland, D.W.8
-
24
-
-
2942623743
-
HnRNP K: One protein multiple processes
-
Bomsztyk, K., Denisenko, O. Ostrowski, J. (2004) hnRNP K: one protein multiple processes. Bioessays, 26, 629 638.
-
(2004)
Bioessays
, vol.26
, pp. 629-638
-
-
Bomsztyk, K.1
Denisenko, O.2
Ostrowski, J.3
-
25
-
-
0027965073
-
Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity
-
Borchelt, D.R., Lee, M.K., Slunt, H.S., Guarnieri, M., Xu, Z.S., Wong, P.C., Brown, R.H. Jr., Price, D.L., Sisodia, S.S. Cleveland, D.W. (1994) Superoxide dismutase 1 with mutations linked to familial amyotrophic lateral sclerosis possesses significant activity. Proc. Natl Acad. Sci. USA, 91, 8292 8296.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 8292-8296
-
-
Borchelt, D.R.1
Lee, M.K.2
Slunt, H.S.3
Guarnieri, M.4
Xu, Z.S.5
Wong, P.C.6
Brown, Jr.R.H.7
Price, D.L.8
Sisodia, S.S.9
Cleveland, D.W.10
-
26
-
-
70350721803
-
Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease
-
Borroni, B., Bonvicini, C., Alberici, A., Buratti, E., Agosti, C., Archetti, S., Papetti, A., Stuani, C., Di Luca, M., Gennarelli, M. Padovani, A. (2009) Mutation within TARDBP leads to frontotemporal dementia without motor neuron disease. Hum. Mutat., 30, E974 E983.
-
(2009)
Hum. Mutat.
, vol.30
-
-
Borroni, B.1
Bonvicini, C.2
Alberici, A.3
Buratti, E.4
Agosti, C.5
Archetti, S.6
Papetti, A.7
Stuani, C.8
Di Luca, M.9
Gennarelli, M.10
Padovani, A.11
-
27
-
-
57649174592
-
TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing
-
Bose, J.K., Wang, I.F., Hung, L., Tarn, W.Y. Shen, C.K. (2008) TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing. J. Biol. Chem., 283, 28852 28859.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 28852-28859
-
-
Bose, J.K.1
Wang, I.F.2
Hung, L.3
Tarn, W.Y.4
Shen, C.K.5
-
28
-
-
33744909882
-
Caspase-3 cleaves and inactivates the glutamate transporter EAAT2
-
Boston-Howes, W., Gibb, S.L., Williams, E.O., Pasinelli, P., Brown, R.H. Jr. Trotti, D. (2006) Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. J. Biol. Chem., 281, 14076 14084.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14076-14084
-
-
Boston-Howes, W.1
Gibb, S.L.2
Williams, E.O.3
Pasinelli, P.4
Brown, Jr.R.H.5
Trotti, D.6
-
29
-
-
33644913172
-
Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis
-
Brockington, A., Wharton, S.B., Fernando, M., Gelsthorpe, C.H., Baxter, L., Ince, P.G., Lewis, C.E. Shaw, P.J. (2006) Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 65, 26 36.
-
(2006)
J. Neuropathol. Exp. Neurol.
, vol.65
, pp. 26-36
-
-
Brockington, A.1
Wharton, S.B.2
Fernando, M.3
Gelsthorpe, C.H.4
Baxter, L.5
Ince, P.G.6
Lewis, C.E.7
Shaw, P.J.8
-
30
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
Bruijn, L.I., Becher, M.W., Lee, M.K., Anderson, K.L., Jenkins, N.A., Copeland, N.G., Sisodia, S.S., Rothstein, J.D., Borchelt, D.R., Price, D.L. Cleveland, D.W. (1997) ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron, 18, 327 338.
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
31
-
-
0032544674
-
Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1
-
Bruijn, L.I., Houseweart, M.K., Kato, S., Anderson, K.L., Anderson, S.D., Ohama, E., Reaume, A.G., Scott, R.W. Cleveland, D.W. (1998) Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1. Science, 281, 1851 1854.
-
(1998)
Science
, vol.281
, pp. 1851-1854
-
-
Bruijn, L.I.1
Houseweart, M.K.2
Kato, S.3
Anderson, K.L.4
Anderson, S.D.5
Ohama, E.6
Reaume, A.G.7
Scott, R.W.8
Cleveland, D.W.9
-
32
-
-
69549114542
-
The molecular links between TDP-43 dysfunction and neurodegeneration
-
Buratti, E. Baralle, F.E. (2009) The molecular links between TDP-43 dysfunction and neurodegeneration. Adv. Genet., 66, 1 34.
-
(2009)
Adv. Genet.
, vol.66
, pp. 1-34
-
-
Buratti, E.1
Baralle, F.E.2
-
33
-
-
0035794665
-
Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping
-
Buratti, E., Dork, T., Zuccato, E., Pagani, F., Romano, M. Baralle, F.E. (2001) Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J., 20, 1774 1784.
-
(2001)
EMBO J.
, vol.20
, pp. 1774-1784
-
-
Buratti, E.1
Dork, T.2
Zuccato, E.3
Pagani, F.4
Romano, M.5
Baralle, F.E.6
-
34
-
-
67651083390
-
Spinal muscular atrophy: Why do low levels of survival motor neuron protein make motor neurons sick?
-
Burghes, A.H. Beattie, C.E. (2009) Spinal muscular atrophy: why do low levels of survival motor neuron protein make motor neurons sick? Nat Rev Neurosci, 10, 597 609.
-
(2009)
Nat Rev Neurosci
, vol.10
, pp. 597-609
-
-
Burghes, A.H.1
Beattie, C.E.2
-
35
-
-
0034802145
-
RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis
-
Canton, T., Bohme, G.A., Boireau, A., Bordier, F., Mignani, S., Jimonet, P., Jahn, G., Alavijeh, M., Stygall, J., Roberts, S., Brealey, C., Vuilhorgne, M., Debono, M.W., Le Guern, S., Laville, M., Briet, D., Roux, M., Stutzmann, J.M. Pratt, J. (2001) RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4- isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis. J. Pharmacol. Exp. Ther., 299, 314 322.
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 314-322
-
-
Canton, T.1
Bohme, G.A.2
Boireau, A.3
Bordier, F.4
Mignani, S.5
Jimonet, P.6
Jahn, G.7
Alavijeh, M.8
Stygall, J.9
Roberts, S.10
Brealey, C.11
Vuilhorgne, M.12
Debono, M.W.13
Le Guern, S.14
Laville, M.15
Briet, D.16
Roux, M.17
Stutzmann, J.M.18
Pratt, J.19
-
36
-
-
0030015076
-
Motor neurons are selectively vulnerable to AMPA/kainate receptor- mediated injury in vitro
-
Carriedo, S.G., Yin, H.Z. Weiss, J.H. (1996) Motor neurons are selectively vulnerable to AMPA/kainate receptor- mediated injury in vitro. J. Neurosci., 16, 4069 4079.
-
(1996)
J. Neurosci.
, vol.16
, pp. 4069-4079
-
-
Carriedo, S.G.1
Yin, H.Z.2
Weiss, J.H.3
-
38
-
-
57649232173
-
Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis
-
Cheroni, C., Marino, M., Tortarolo, M., Veglianese, P., De Biasi, S., Fontana, E., Zuccarello, L.V., Maynard, C.J., Dantuma, N.P. Bendotti, C. (2009) Functional alterations of the ubiquitin-proteasome system in motor neurons of a mouse model of familial amyotrophic lateral sclerosis. Hum. Mol. Genet., 18, 82 96.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 82-96
-
-
Cheroni, C.1
Marino, M.2
Tortarolo, M.3
Veglianese, P.4
De Biasi, S.5
Fontana, E.6
Zuccarello, L.V.7
Maynard, C.J.8
Dantuma, N.P.9
Bendotti, C.10
-
39
-
-
70249131804
-
ALS in Italian professional soccer players: The risk is still present and could be soccer-specific
-
Chio, A., Calvo, A., Dossena, M., Ghiglione, P., Mutani, R. Mora, G. (2009a) ALS in Italian professional soccer players: the risk is still present and could be soccer-specific. Amyotroph Lateral Scler, 10, 205 209.
-
(2009)
Amyotroph Lateral Scler
, vol.10
, pp. 205-209
-
-
Chio, A.1
Calvo, A.2
Dossena, M.3
Ghiglione, P.4
Mutani, R.5
Mora, G.6
-
40
-
-
67349155310
-
Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation
-
Chio, A., Restagno, G., Brunetti, M., Ossola, I., Calvo, A., Mora, G., Sabatelli, M., Monsurro, M.R., Battistini, S., Mandrioli, J., Salvi, F., Spataro, R., Schymick, J., Traynor, B.J. La Bella, V. (2009b) Two Italian kindreds with familial amyotrophic lateral sclerosis due to FUS mutation. Neurobiol. Aging, 30, 1272 1275.
-
(2009)
Neurobiol. Aging
, vol.30
, pp. 1272-1275
-
-
Chio, A.1
Restagno, G.2
Brunetti, M.3
Ossola, I.4
Calvo, A.5
Mora, G.6
Sabatelli, M.7
Monsurro, M.R.8
Battistini, S.9
Mandrioli, J.10
Salvi, F.11
Spataro, R.12
Schymick, J.13
Traynor, B.J.14
La Bella, V.15
-
41
-
-
64549117768
-
A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis
-
Chio, A., Schymick, J.C., Restagno, G., Scholz, S.W., Lombardo, F., Lai, S.L., Mora, G., Fung, H.C., Britton, A., Arepalli, S., Gibbs, J.R., Nalls, M., Berger, S., Kwee, L.C., Oddone, E.Z., Ding, J., Crews, C., Rafferty, I., Washecka, N., Hernandez, D., Ferrucci, L., Bandinelli, S., Guralnik, J., Macciardi, F., Torri, F., Lupoli, S., Chanock, S.J., Thomas, G., Hunter, D.J., Gieger, C., Wichmann, H.E., Calvo, A., Mutani, R., Battistini, S., Giannini, F., Caponnetto, C., Mancardi, G.L., La Bella, V., Valentino, F., Monsurro, M.R., Tedeschi, G., Marinou, K., Sabatelli, M., Conte, A., Mandrioli, J., Sola, P., Salvi, F., Bartolomei, I., Siciliano, G., Carlesi, C., Orrell, R.W., Talbot, K., Simmons, Z., Connor, J., Pioro, E.P., Dunkley, T., Stephan, D.A., Kasperaviciute, D., Fisher, E.M., Jabonka, S., Sendtner, M., Beck, M., Bruijn, L., Rothstein, J., Schmidt, S., Singleton, A., Hardy, J. Traynor, B.J. (2009c) A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Hum. Mol. Genet., 18, 1524 1532.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1524-1532
-
-
Chio, A.1
Schymick, J.C.2
Restagno, G.3
Scholz, S.W.4
Lombardo, F.5
Lai, S.L.6
Mora, G.7
Fung, H.C.8
Britton, A.9
Arepalli, S.10
Gibbs, J.R.11
Nalls, M.12
Berger, S.13
Kwee, L.C.14
Oddone, E.Z.15
Ding, J.16
Crews, C.17
Rafferty, I.18
Washecka, N.19
Hernandez, D.20
Ferrucci, L.21
Bandinelli, S.22
Guralnik, J.23
MacCiardi, F.24
Torri, F.25
Lupoli, S.26
Chanock, S.J.27
Thomas, G.28
Hunter, D.J.29
Gieger, C.30
Wichmann, H.E.31
Calvo, A.32
Mutani, R.33
Battistini, S.34
Giannini, F.35
Caponnetto, C.36
Mancardi, G.L.37
La Bella, V.38
Valentino, F.39
Monsurro, M.R.40
Tedeschi, G.41
Marinou, K.42
Sabatelli, M.43
Conte, A.44
Mandrioli, J.45
Sola, P.46
Salvi, F.47
Bartolomei, I.48
Siciliano, G.49
Carlesi, C.50
Orrell, R.W.51
Talbot, K.52
Simmons, Z.53
Connor, J.54
Pioro, E.P.55
Dunkley, T.56
Stephan, D.A.57
Kasperaviciute, D.58
Fisher, E.M.59
Jabonka, S.60
Sendtner, M.61
Beck, M.62
Bruijn, L.63
Rothstein, J.64
Schmidt, S.65
Singleton, A.66
Hardy, J.67
Traynor, B.J.68
more..
-
42
-
-
56649100689
-
T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS
-
Chiu, I.M., Chen, A., Zheng, Y., Kosaras, B., Tsiftsoglou, S.A., Vartanian, T.K., Brown, R.H. Jr. Carroll, M.C. (2008) T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc. Natl Acad. Sci. USA, 105, 17913 17918.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 17913-17918
-
-
Chiu, I.M.1
Chen, A.2
Zheng, Y.3
Kosaras, B.4
Tsiftsoglou, S.A.5
Vartanian, T.K.6
Brown, Jr.R.H.7
Carroll, M.C.8
-
43
-
-
58049192812
-
Deleterious variants of FIG 4, a phosphoinositide phosphatase, in patients with ALS
-
Chow, C.Y., Landers, J.E., Bergren, S.K., Sapp, P.C., Grant, A.E., Jones, J.M., Everett, L., Lenk, G.M., McKenna-Yasek, D.M., Weisman, L.S., Figlewicz, D., Brown, R.H. Meisler, M.H. (2009) Deleterious variants of FIG 4, a phosphoinositide phosphatase, in patients with ALS. Am. J. Hum. Genet., 84, 85 88.
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 85-88
-
-
Chow, C.Y.1
Landers, J.E.2
Bergren, S.K.3
Sapp, P.C.4
Grant, A.E.5
Jones, J.M.6
Everett, L.7
Lenk, G.M.8
McKenna-Yasek, D.M.9
Weisman, L.S.10
Figlewicz, D.11
Brown, R.H.12
Meisler, M.H.13
-
44
-
-
34047131622
-
2+ determine motoneuron vulnerability in rat spinal cord in vivo
-
2+ determine motoneuron vulnerability in rat spinal cord in vivo. Neuropharmacology, 52, 1219 1228.
-
(2007)
Neuropharmacology
, vol.52
, pp. 1219-1228
-
-
Corona, J.C.1
Tapia, R.2
-
45
-
-
77949760219
-
Mutations of FUS gene in sporadic amyotrophic lateral sclerosis
-
Corrado, L., Del Bo, R., Castellotti, B., Ratti, A., Cereda, C., Penco, S., Soraru, G., Carlomagno, Y., Ghezzi, S., Pensato, V., Colombrita, C., Gagliardi, S., Cozzi, L., Orsetti, V., Mancuso, M., Siciliano, G., Mazzini, L., Comi, G.P., Gellera, C., Ceroni, M., D'Alfonso, S. Silani, V. (2010) Mutations of FUS gene in sporadic amyotrophic lateral sclerosis. J. Med. Genet., 47, 190 194.
-
(2010)
J. Med. Genet.
, vol.47
, pp. 190-194
-
-
Corrado, L.1
Del Bo, R.2
Castellotti, B.3
Ratti, A.4
Cereda, C.5
Penco, S.6
Soraru, G.7
Carlomagno, Y.8
Ghezzi, S.9
Pensato, V.10
Colombrita, C.11
Gagliardi, S.12
Cozzi, L.13
Orsetti, V.14
Mancuso, M.15
Siciliano, G.16
Mazzini, L.17
Comi, G.P.18
Gellera, C.19
Ceroni, M.20
D'Alfonso, S.21
Silani, V.22
more..
-
46
-
-
0345255588
-
Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam
-
Cox, P.A., Banack, S.A. Murch, S.J. (2003) Biomagnification of cyanobacterial neurotoxins and neurodegenerative disease among the Chamorro people of Guam. Proc. Natl Acad. Sci. USA, 100, 13380 13383.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 13380-13383
-
-
Cox, P.A.1
Banack, S.A.2
Murch, S.J.3
-
47
-
-
59349089711
-
Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin
-
Creppe, C., Malinouskaya, L., Volvert, M.L., Gillard, M., Close, P., Malaise, O., Laguesse, S., Cornez, I., Rahmouni, S., Ormenese, S., Belachew, S., Malgrange, B., Chapelle, J.P., Siebenlist, U., Moonen, G., Chariot, A. Nguyen, L. (2009) Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin. Cell, 136, 551 564.
-
(2009)
Cell
, vol.136
, pp. 551-564
-
-
Creppe, C.1
Malinouskaya, L.2
Volvert, M.L.3
Gillard, M.4
Close, P.5
Malaise, O.6
Laguesse, S.7
Cornez, I.8
Rahmouni, S.9
Ormenese, S.10
Belachew, S.11
Malgrange, B.12
Chapelle, J.P.13
Siebenlist, U.14
Moonen, G.15
Chariot, A.16
Nguyen, L.17
-
48
-
-
39749119374
-
A genome-wide association study of sporadic ALS in a homogenous Irish population
-
Cronin, S., Berger, S., Ding, J., Schymick, J.C., Washecka, N., Hernandez, D.G., Greenway, M.J., Bradley, D.G., Traynor, B.J. Hardiman, O. (2008) A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum. Mol. Genet., 17, 768 774.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 768-774
-
-
Cronin, S.1
Berger, S.2
Ding, J.3
Schymick, J.C.4
Washecka, N.5
Hernandez, D.G.6
Greenway, M.J.7
Bradley, D.G.8
Traynor, B.J.9
Hardiman, O.10
-
49
-
-
0031814006
-
Limited corticospinal tract involvement in amyotrophic lateral sclerosis subjects with the A4V mutation in the copper/zinc superoxide dismutase gene
-
Cudkowicz, M.E., McKenna-Yasek, D., Chen, C., Hedley-Whyte, E.T. Brown, R.H. Jr. (1998) Limited corticospinal tract involvement in amyotrophic lateral sclerosis subjects with the A4V mutation in the copper/zinc superoxide dismutase gene. Ann. Neurol., 43, 703 710.
-
(1998)
Ann. Neurol.
, vol.43
, pp. 703-710
-
-
Cudkowicz, M.E.1
McKenna-Yasek, D.2
Chen, C.3
Hedley-Whyte, E.T.4
Brown, Jr.R.H.5
-
50
-
-
77950897685
-
The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS
-
Damme, P.V., Goris, A., Race, V., Hersmus, N., Dubois, B., Bosch, L.V., Matthijs, G. Robberecht, W. (2009) The occurrence of mutations in FUS in a Belgian cohort of patients with familial ALS. Eur J Neurol, 17, 754 756.
-
(2009)
Eur J Neurol
, vol.17
, pp. 754-756
-
-
Damme, P.V.1
Goris, A.2
Race, V.3
Hersmus, N.4
Dubois, B.5
Bosch, L.V.6
Matthijs, G.7
Robberecht, W.8
-
51
-
-
62149146109
-
Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis
-
Daoud, H., Valdmanis, P.N., Kabashi, E., Dion, P., Dupre, N., Camu, W., Meininger, V. Rouleau, G.A. (2009) Contribution of TARDBP mutations to sporadic amyotrophic lateral sclerosis. J. Med. Genet., 46, 112 114.
-
(2009)
J. Med. Genet.
, vol.46
, pp. 112-114
-
-
Daoud, H.1
Valdmanis, P.N.2
Kabashi, E.3
Dion, P.4
Dupre, N.5
Camu, W.6
Meininger, V.7
Rouleau, G.A.8
-
52
-
-
35548991459
-
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content
-
De Vos, K.J., Chapman, A.L., Tennant, M.E., Manser, C., Tudor, E.L., Lau, K.F., Brownlees, J., Ackerley, S., Shaw, P.J., McLoughlin, D.M., Shaw, C.E., Leigh, P.N., Miller, C.C. Grierson, A.J. (2007) Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria content. Hum. Mol. Genet., 16, 2720 2728.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 2720-2728
-
-
De Vos, K.J.1
Chapman, A.L.2
Tennant, M.E.3
Manser, C.4
Tudor, E.L.5
Lau, K.F.6
Brownlees, J.7
Ackerley, S.8
Shaw, P.J.9
McLoughlin, D.M.10
Shaw, C.E.11
Leigh, P.N.12
Miller, C.C.13
Grierson, A.J.14
-
53
-
-
48249102303
-
Role of axonal transport in neurodegenerative diseases
-
De Vos, K.J., Grierson, A.J., Ackerley, S. Miller, C.C. (2008) Role of axonal transport in neurodegenerative diseases. Annu. Rev. Neurosci., 31, 151 173.
-
(2008)
Annu. Rev. Neurosci.
, vol.31
, pp. 151-173
-
-
De Vos, K.J.1
Grierson, A.J.2
Ackerley, S.3
Miller, C.C.4
-
54
-
-
77951784437
-
De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis
-
Dejesus-Hernandez, M., Kocerha, J., Finch, N., Crook, R., Baker, M., Desaro, P., Johnston, A., Rutherford, N., Wojtas, A., Kennelly, K., Wszolek, Z.K., Graff-Radford, N., Boylan, K. Rademakers, R. (2010) De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis. Hum. Mutat., 31, E1377 E1389.
-
(2010)
Hum. Mutat.
, vol.31
-
-
Dejesus-Hernandez, M.1
Kocerha, J.2
Finch, N.3
Crook, R.4
Baker, M.5
Desaro, P.6
Johnston, A.7
Rutherford, N.8
Wojtas, A.9
Kennelly, K.10
Wszolek, Z.K.11
Graff-Radford, N.12
Boylan, K.13
Rademakers, R.14
-
55
-
-
2942627907
-
Low levels of the vascular endothelial growth factor in CSF from early ALS patients
-
Devos, D., Moreau, C., Lassalle, P., Perez, T., De Seze, J., Brunaud-Danel, V., Destee, A., Tonnel, A.B. Just, N. (2004) Low levels of the vascular endothelial growth factor in CSF from early ALS patients. Neurology, 62, 2127 2129.
-
(2004)
Neurology
, vol.62
, pp. 2127-2129
-
-
Devos, D.1
Moreau, C.2
Lassalle, P.3
Perez, T.4
De Seze, J.5
Brunaud-Danel, V.6
Destee, A.7
Tonnel, A.B.8
Just, N.9
-
56
-
-
34147131311
-
Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death
-
Dewil, M., dela Cruz, V.F., Van Den Bosch, L. Robberecht, W. (2007a) Inhibition of p38 mitogen activated protein kinase activation and mutant SOD1(G93A)-induced motor neuron death. Neurobiol Dis, 26, 332 341.
-
(2007)
Neurobiol Dis
, vol.26
, pp. 332-341
-
-
Dewil, M.1
Dela Cruz, V.F.2
Van Den Bosch, L.3
Robberecht, W.4
-
57
-
-
34548552816
-
Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis
-
Dewil, M., Lambrechts, D., Sciot, R., Shaw, P.J., Ince, P.G., Robberecht, W. Van den Bosch, L. (2007b) Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol., 33, 499 509.
-
(2007)
Neuropathol. Appl. Neurobiol.
, vol.33
, pp. 499-509
-
-
Dewil, M.1
Lambrechts, D.2
Sciot, R.3
Shaw, P.J.4
Ince, P.G.5
Robberecht, W.6
Van Den Bosch, L.7
-
58
-
-
13844253540
-
Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
-
Dobrowolny, G., Giacinti, C., Pelosi, L., Nicoletti, C., Winn, N., Barberi, L., Molinaro, M., Rosenthal, N. Musaro, A. (2005) Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model. J. Cell Biol., 168, 193 199.
-
(2005)
J. Cell Biol.
, vol.168
, pp. 193-199
-
-
Dobrowolny, G.1
Giacinti, C.2
Pelosi, L.3
Nicoletti, C.4
Winn, N.5
Barberi, L.6
Molinaro, M.7
Rosenthal, N.8
Musaro, A.9
-
59
-
-
44449177217
-
RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells
-
Doi, H., Okamura, K., Bauer, P.O., Furukawa, Y., Shimizu, H., Kurosawa, M., Machida, Y., Miyazaki, H., Mitsui, K., Kuroiwa, Y. Nukina, N. (2008) RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells. J. Biol. Chem., 283, 6489 6500.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 6489-6500
-
-
Doi, H.1
Okamura, K.2
Bauer, P.O.3
Furukawa, Y.4
Shimizu, H.5
Kurosawa, M.6
MacHida, Y.7
Miyazaki, H.8
Mitsui, K.9
Kuroiwa, Y.10
Nukina, N.11
-
60
-
-
73249135817
-
The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases
-
Doi, H., Koyano, S., Suzuki, Y., Nukina, N. Kuroiwa, Y. (2010) The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases. Neurosci. Res., 66, 131 133.
-
(2010)
Neurosci. Res.
, vol.66
, pp. 131-133
-
-
Doi, H.1
Koyano, S.2
Suzuki, Y.3
Nukina, N.4
Kuroiwa, Y.5
-
61
-
-
67650432367
-
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin
-
Dormann, D., Capell, A., Carlson, A.M., Shankaran, S.S., Rodde, R., Neumann, M., Kremmer, E., Matsuwaki, T., Yamanouchi, K., Nishihara, M. Haass, C. (2009) Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J. Neurochem., 110, 1082 1094.
-
(2009)
J. Neurochem.
, vol.110
, pp. 1082-1094
-
-
Dormann, D.1
Capell, A.2
Carlson, A.M.3
Shankaran, S.S.4
Rodde, R.5
Neumann, M.6
Kremmer, E.7
Matsuwaki, T.8
Yamanouchi, K.9
Nishihara, M.10
Haass, C.11
-
62
-
-
77952105503
-
C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany
-
in press
-
Drepper, C., Herrmann, T., Wessig, C., Beck, M. Sendtner, M. (2010) C-terminal FUS/TLS mutations in familial and sporadic ALS in Germany. Neurobiol. Aging, in press.
-
(2010)
Neurobiol. Aging
-
-
Drepper, C.1
Herrmann, T.2
Wessig, C.3
Beck, M.4
Sendtner, M.5
-
63
-
-
34548083742
-
Whole-genome analysis of sporadic amyotrophic lateral sclerosis
-
Dunckley, T., Huentelman, M.J., Craig, D.W., Pearson, J.V., Szelinger, S., Joshipura, K., Halperin, R.F., Stamper, C., Jensen, K.R., Letizia, D., Hesterlee, S.E., Pestronk, A., Levine, T., Bertorini, T., Graves, M.C., Mozaffar, T., Jackson, C.E., Bosch, P., McVey, A., Dick, A., Barohn, R., Lomen-Hoerth, C., Rosenfeld, J., O'Connor D, T., Zhang, K., Crook, R., Ryberg, H., Hutton, M., Katz, J., Simpson, E.P., Mitsumoto, H., Bowser, R., Miller, R.G., Appel, S.H. Stephan, D.A. (2007) Whole-genome analysis of sporadic amyotrophic lateral sclerosis. N. Engl. J. Med., 357, 775 788. (Pubitemid 47295644)
-
(2007)
New England Journal of Medicine
, vol.357
, Issue.8
, pp. 775-788
-
-
Dunckley, T.1
Huentelman, M.J.2
Craig, D.W.3
Pearson, J.V.4
Szelinger, S.5
Joshipura, K.6
Halperin, R.F.7
Stamper, C.8
Jensen, K.R.9
Letizia, D.10
Hesterlee, S.E.11
Pestronk, A.12
Levine, T.13
Bertorini, T.14
Graves, M.C.15
Mozaffar, T.16
Jackson, C.E.17
Bosch, P.18
McVey, A.19
Dick, A.20
Barohn, R.21
Lomen-Hoerth, C.22
Rosenfeld, J.23
O'Connor, D.T.24
Zhang, K.25
Crook, R.26
Ryberg, H.27
Hutton, M.28
Katz, J.29
Simpson, E.P.30
Mitsumoto, H.31
Bowser, R.32
Miller, R.G.33
Appel, S.H.34
Stephan, D.A.35
more..
-
64
-
-
34548646702
-
ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: A genome-wide association study
-
van Es, M.A., Van Vught, P.W., Blauw, H.M., Franke, L., Saris, C.G., Andersen, P.M., Van Den Bosch, L., de Jong, S.W., van 't Slot, R., Birve, A., Lemmens, R., de Jong, V., Baas, F., Schelhaas, H.J., Sleegers, K., Van Broeckhoven, C., Wokke, J.H., Wijmenga, C., Robberecht, W., Veldink, J.H., Ophoff, R.A. van den Berg, L.H. (2007) ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurol, 6, 869 877.
-
(2007)
Lancet Neurol
, vol.6
, pp. 869-877
-
-
Van Es, M.A.1
Van Vught, P.W.2
Blauw, H.M.3
Franke, L.4
Saris, C.G.5
Andersen, P.M.6
Van Den Bosch, L.7
De Jong, S.W.8
Van 'T Slot, R.9
Birve, A.10
Lemmens, R.11
De Jong, V.12
Baas, F.13
Schelhaas, H.J.14
Sleegers, K.15
Van Broeckhoven, C.16
Wokke, J.H.17
Wijmenga, C.18
Robberecht, W.19
Veldink, J.H.20
Ophoff, R.A.21
Van Den Berg, L.H.22
more..
-
65
-
-
37549062995
-
Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis
-
van Es, M.A., van Vught, P.W., Blauw, H.M., Franke, L., Saris, C.G., Van den Bosch, L., de Jong, S.W., de Jong, V., Baas, F., van't Slot, R., Lemmens, R., Schelhaas, H.J., Birve, A., Sleegers, K., Van Broeckhoven, C., Schymick, J.C., Traynor, B.J., Wokke, J.H., Wijmenga, C., Robberecht, W., Andersen, P.M., Veldink, J.H., Ophoff, R.A. van den Berg, L.H. (2008) Genetic variation in DPP6 is associated with susceptibility to amyotrophic lateral sclerosis. Nat. Genet., 40, 29 31.
-
(2008)
Nat. Genet.
, vol.40
, pp. 29-31
-
-
Van Es, M.A.1
Van Vught, P.W.2
Blauw, H.M.3
Franke, L.4
Saris, C.G.5
Van Den Bosch, L.6
De Jong, S.W.7
De Jong, V.8
Baas, F.9
Van'T Slot, R.10
Lemmens, R.11
Schelhaas, H.J.12
Birve, A.13
Sleegers, K.14
Van Broeckhoven, C.15
Schymick, J.C.16
Traynor, B.J.17
Wokke, J.H.18
Wijmenga, C.19
Robberecht, W.20
Andersen, P.M.21
Veldink, J.H.22
Ophoff, R.A.23
Van Den Berg, L.H.24
more..
-
66
-
-
70349592269
-
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis
-
van Es, M.A., Veldink, J.H., Saris, C.G., Blauw, H.M., van Vught, P.W., Birve, A., Lemmens, R., Schelhaas, H.J., Groen, E.J., Huisman, M.H., van der Kooi, A.J., de Visser, M., Dahlberg, C., Estrada, K., Rivadeneira, F., Hofman, A., Zwarts, M.J., van Doormaal, P.T., Rujescu, D., Strengman, E., Giegling, I., Muglia, P., Tomik, B., Slowik, A., Uitterlinden, A.G., Hendrich, C., Waibel, S., Meyer, T., Ludolph, A.C., Glass, J.D., Purcell, S., Cichon, S., Nothen, M.M., Wichmann, H.E., Schreiber, S., Vermeulen, S.H., Kiemeney, L.A., Wokke, J.H., Cronin, S., McLaughlin, R.L., Hardiman, O., Fumoto, K., Pasterkamp, R.J., Meininger, V., Melki, J., Leigh, P.N., Shaw, C.E., Landers, J.E., Al-Chalabi, A., Brown, R.H. Jr., Robberecht, W., Andersen, P.M., Ophoff, R.A. van den Berg, L.H. (2009) Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis. Nat. Genet., 41, 1083 1087.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1083-1087
-
-
Van Es, M.A.1
Veldink, J.H.2
Saris, C.G.3
Blauw, H.M.4
Van Vught, P.W.5
Birve, A.6
Lemmens, R.7
Schelhaas, H.J.8
Groen, E.J.9
Huisman, M.H.10
Van Der Kooi, A.J.11
De Visser, M.12
Dahlberg, C.13
Estrada, K.14
Rivadeneira, F.15
Hofman, A.16
Zwarts, M.J.17
Van Doormaal, P.T.18
Rujescu, D.19
Strengman, E.20
Giegling, I.21
Muglia, P.22
Tomik, B.23
Slowik, A.24
Uitterlinden, A.G.25
Hendrich, C.26
Waibel, S.27
Meyer, T.28
Ludolph, A.C.29
Glass, J.D.30
Purcell, S.31
Cichon, S.32
Nothen, M.M.33
Wichmann, H.E.34
Schreiber, S.35
Vermeulen, S.H.36
Kiemeney, L.A.37
Wokke, J.H.38
Cronin, S.39
McLaughlin, R.L.40
Hardiman, O.41
Fumoto, K.42
Pasterkamp, R.J.43
Meininger, V.44
Melki, J.45
Leigh, P.N.46
Shaw, C.E.47
Landers, J.E.48
Al-Chalabi, A.49
Brown, Jr.R.H.50
Robberecht, W.51
Andersen, P.M.52
Ophoff, R.A.53
Van Den Berg, L.H.54
more..
-
67
-
-
34250177650
-
Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation
-
Ezzi, S.A., Urushitani, M. Julien, J.P. (2007) Wild-type superoxide dismutase acquires binding and toxic properties of ALS-linked mutant forms through oxidation. J. Neurochem., 102, 170 178.
-
(2007)
J. Neurochem.
, vol.102
, pp. 170-178
-
-
Ezzi, S.A.1
Urushitani, M.2
Julien, J.P.3
-
68
-
-
67349271683
-
Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior
-
Feiguin, F., Godena, V.K., Romano, G., D'Ambrogio, A., Klima, R. Baralle, F.E. (2009) Depletion of TDP-43 affects Drosophila motoneurons terminal synapsis and locomotive behavior. FEBS Lett., 583, 1586 1592.
-
(2009)
FEBS Lett.
, vol.583
, pp. 1586-1592
-
-
Feiguin, F.1
Godena, V.K.2
Romano, G.3
D'Ambrogio, A.4
Klima, R.5
Baralle, F.E.6
-
69
-
-
0033364166
-
Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
-
Feldmeyer, D., Kask, K., Brusa, R., Kornau, H.C., Kolhekar, R., Rozov, A., Burnashev, N., Jensen, V., Hvalby, O., Sprengel, R. Seeburg, P.H. (1999) Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat. Neurosci., 2, 57 64.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 57-64
-
-
Feldmeyer, D.1
Kask, K.2
Brusa, R.3
Kornau, H.C.4
Kolhekar, R.5
Rozov, A.6
Burnashev, N.7
Jensen, V.8
Hvalby, O.9
Sprengel, R.10
Seeburg, P.H.11
-
70
-
-
70450162088
-
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2
-
Ferguson, C.J., Lenk, G.M. Meisler, M.H. (2009) Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2. Hum. Mol. Genet., 18, 4868 4878.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 4868-4878
-
-
Ferguson, C.J.1
Lenk, G.M.2
Meisler, M.H.3
-
71
-
-
0345742771
-
Amyotrophic lateral sclerosis is a distal axonopathy: Evidence in mice and man
-
Fischer, L.R., Culver, D.G., Tennant, P., Davis, A.A., Wang, M., Castellano-Sanchez, A., Khan, J., Polak, M.A. Glass, J.D. (2004) Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man. Exp. Neurol., 185, 232 240.
-
(2004)
Exp. Neurol.
, vol.185
, pp. 232-240
-
-
Fischer, L.R.1
Culver, D.G.2
Tennant, P.3
Davis, A.A.4
Wang, M.5
Castellano-Sanchez, A.6
Khan, J.7
Polak, M.A.8
Glass, J.D.9
-
72
-
-
15744378126
-
The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology
-
Fujii, R., Okabe, S., Urushido, T., Inoue, K., Yoshimura, A., Tachibana, T., Nishikawa, T., Hicks, G.G. Takumi, T. (2005) The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Curr. Biol., 15, 587 593.
-
(2005)
Curr. Biol.
, vol.15
, pp. 587-593
-
-
Fujii, R.1
Okabe, S.2
Urushido, T.3
Inoue, K.4
Yoshimura, A.5
Tachibana, T.6
Nishikawa, T.7
Hicks, G.G.8
Takumi, T.9
-
73
-
-
0035783937
-
Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice
-
Fukada, K., Nagano, S., Satoh, M., Tohyama, C., Nakanishi, T., Shimizu, A., Yanagihara, T. Sakoda, S. (2001) Stabilization of mutant Cu/Zn superoxide dismutase (SOD1) protein by coexpressed wild SOD1 protein accelerates the disease progression in familial amyotrophic lateral sclerosis mice. Eur. J. Neurosci., 14, 2032 2036.
-
(2001)
Eur. J. Neurosci.
, vol.14
, pp. 2032-2036
-
-
Fukada, K.1
Nagano, S.2
Satoh, M.3
Tohyama, C.4
Nakanishi, T.5
Shimizu, A.6
Yanagihara, T.7
Sakoda, S.8
-
74
-
-
34547839586
-
Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia
-
Gardiner, J., Barton, D., Marc, J. Overall, R. (2007) Potential role of tubulin acetylation and microtubule-based protein trafficking in familial dysautonomia. Traffic, 8, 1145 1149.
-
(2007)
Traffic
, vol.8
, pp. 1145-1149
-
-
Gardiner, J.1
Barton, D.2
Marc, J.3
Overall, R.4
-
75
-
-
60549117972
-
Clinical and pathological continuum of multisystem TDP-43 proteinopathies
-
Geser, F., Martinez-Lage, M., Robinson, J., Uryu, K., Neumann, M., Brandmeir, N.J., Xie, S.X., Kwong, L.K., Elman, L., McCluskey, L., Clark, C.M., Malunda, J., Miller, B.L., Zimmerman, E.A., Qian, J., Van Deerlin, V., Grossman, M., Lee, V.M. Trojanowski, J.Q. (2009) Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Arch. Neurol., 66, 180 189.
-
(2009)
Arch. Neurol.
, vol.66
, pp. 180-189
-
-
Geser, F.1
Martinez-Lage, M.2
Robinson, J.3
Uryu, K.4
Neumann, M.5
Brandmeir, N.J.6
Xie, S.X.7
Kwong, L.K.8
Elman, L.9
McCluskey, L.10
Clark, C.M.11
Malunda, J.12
Miller, B.L.13
Zimmerman, E.A.14
Qian, J.15
Van Deerlin, V.16
Grossman, M.17
Lee, V.M.18
Trojanowski, J.Q.19
-
76
-
-
77949897022
-
Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies
-
Geser, F., Lee, V.M. Trojanowski, J.Q. (2010) Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology, 30, 103 112.
-
(2010)
Neuropathology
, vol.30
, pp. 103-112
-
-
Geser, F.1
Lee, V.M.2
Trojanowski, J.Q.3
-
77
-
-
41949119043
-
TDP-43 A315T mutation in familial motor neuron disease
-
Gitcho, M.A., Baloh, R.H., Chakraverty, S., Mayo, K., Norton, J.B., Levitch, D., Hatanpaa, K.J., White, C.L. III., Bigio, E.H., Caselli, R., Baker, M., Al-Lozi, M.T., Morris, J.C., Pestronk, A., Rademakers, R., Goate, A.M. Cairns, N.J. (2008) TDP-43 A315T mutation in familial motor neuron disease. Ann. Neurol., 63, 535 538.
-
(2008)
Ann. Neurol.
, vol.63
, pp. 535-538
-
-
Gitcho, M.A.1
Baloh, R.H.2
Chakraverty, S.3
Mayo, K.4
Norton, J.B.5
Levitch, D.6
Hatanpaa, K.J.7
White III, C.L.8
Bigio, E.H.9
Caselli, R.10
Baker, M.11
Al-Lozi, M.T.12
Morris, J.C.13
Pestronk, A.14
Rademakers, R.15
Goate, A.M.16
Cairns, N.J.17
-
78
-
-
33748261830
-
Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS
-
Gould, T.W., Buss, R.R., Vinsant, S., Prevette, D., Sun, W., Knudson, C.M., Milligan, C.E. Oppenheim, R.W. (2006) Complete dissociation of motor neuron death from motor dysfunction by Bax deletion in a mouse model of ALS. J. Neurosci., 26, 8774 8786.
-
(2006)
J. Neurosci.
, vol.26
, pp. 8774-8786
-
-
Gould, T.W.1
Buss, R.R.2
Vinsant, S.3
Prevette, D.4
Sun, W.5
Knudson, C.M.6
Milligan, C.E.7
Oppenheim, R.W.8
-
79
-
-
55049120934
-
Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase
-
Gowing, G., Philips, T., Van Wijmeersch, B., Audet, J.N., Dewil, M., Van Den Bosch, L., Billiau, A.D., Robberecht, W. Julien, J.P. (2008) Ablation of proliferating microglia does not affect motor neuron degeneration in amyotrophic lateral sclerosis caused by mutant superoxide dismutase. J. Neurosci., 28, 10234 10244.
-
(2008)
J. Neurosci.
, vol.28
, pp. 10234-10244
-
-
Gowing, G.1
Philips, T.2
Van Wijmeersch, B.3
Audet, J.N.4
Dewil, M.5
Van Den Bosch, L.6
Billiau, A.D.7
Robberecht, W.8
Julien, J.P.9
-
80
-
-
0031009542
-
British motor neuron disease twin study
-
Graham, A.J., Macdonald, A.M. Hawkes, C.H. (1997) British motor neuron disease twin study. J. Neurol. Neurosurg. Psychiatry, 62, 562 569.
-
(1997)
J. Neurol. Neurosurg. Psychiatry
, vol.62
, pp. 562-569
-
-
Graham, A.J.1
MacDonald, A.M.2
Hawkes, C.H.3
-
81
-
-
33645422711
-
ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis
-
Greenway, M.J., Andersen, P.M., Russ, C., Ennis, S., Cashman, S., Donaghy, C., Patterson, V., Swingler, R., Kieran, D., Prehn, J., Morrison, K.E., Green, A., Acharya, K.R., Brown, R.H. Jr. Hardiman, O. (2006) ANG mutations segregate with familial and 'sporadic' amyotrophic lateral sclerosis. Nat. Genet., 38, 411 413.
-
(2006)
Nat. Genet.
, vol.38
, pp. 411-413
-
-
Greenway, M.J.1
Andersen, P.M.2
Russ, C.3
Ennis, S.4
Cashman, S.5
Donaghy, C.6
Patterson, V.7
Swingler, R.8
Kieran, D.9
Prehn, J.10
Morrison, K.E.11
Green, A.12
Acharya, K.R.13
Brown, Jr.R.H.14
Hardiman, O.15
-
82
-
-
0033985186
-
Characterization of the AMPA-activated receptors present on motoneurons
-
Greig, A., Donevan, S.D., Mujtaba, T.J., Parks, T.N. Rao, M.S. (2000) Characterization of the AMPA-activated receptors present on motoneurons. J. Neurochem., 74, 179 191.
-
(2000)
J. Neurochem.
, vol.74
, pp. 179-191
-
-
Greig, A.1
Donevan, S.D.2
Mujtaba, T.J.3
Parks, T.N.4
Rao, M.S.5
-
83
-
-
76149146012
-
FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands
-
Groen, E.J., van Es, M.A., van Vught, P.W., Spliet, W.G., van Engelen-Lee, J., de Visser, M., Wokke, J.H., Schelhaas, H.J., Ophoff, R.A., Fumoto, K., Pasterkamp, R.J., Dooijes, D., Cuppen, E., Veldink, J.H. van den Berg, L.H. (2010) FUS mutations in familial amyotrophic lateral sclerosis in the Netherlands. Arch. Neurol., 67, 224 230.
-
(2010)
Arch. Neurol.
, vol.67
, pp. 224-230
-
-
Groen, E.J.1
Van Es, M.A.2
Van Vught, P.W.3
Spliet, W.G.4
Van Engelen-Lee, J.5
De Visser, M.6
Wokke, J.H.7
Schelhaas, H.J.8
Ophoff, R.A.9
Fumoto, K.10
Pasterkamp, R.J.11
Dooijes, D.12
Cuppen, E.13
Veldink, J.H.14
Van Den Berg, L.H.15
-
84
-
-
76049085112
-
Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis
-
Gros-Louis, F., Andersen, P.M., Dupre, N., Urushitani, M., Dion, P., Souchon, F., D'Amour, M., Camu, W., Meininger, V., Bouchard, J.P., Rouleau, G.A. Julien, J.P. (2009) Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 106, 21777 21782.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 21777-21782
-
-
Gros-Louis, F.1
Andersen, P.M.2
Dupre, N.3
Urushitani, M.4
Dion, P.5
Souchon, F.6
D'Amour, M.7
Camu, W.8
Meininger, V.9
Bouchard, J.P.10
Rouleau, G.A.11
Julien, J.P.12
-
85
-
-
77549088703
-
Calcium dysregulation in amyotrophic lateral sclerosis
-
Grosskreutz, J., Van Den Bosch, L. Keller, B.U. (2010) Calcium dysregulation in amyotrophic lateral sclerosis. Cell Calcium, 47, 165 174.
-
(2010)
Cell Calcium
, vol.47
, pp. 165-174
-
-
Grosskreutz, J.1
Van Den Bosch, L.2
Keller, B.U.3
-
86
-
-
0141618315
-
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
-
Guo, H., Lai, L., Butchbach, M.E., Stockinger, M.P., Shan, X., Bishop, G.A. Lin, C.L. (2003) Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice. Hum. Mol. Genet., 12, 2519 2532.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2519-2532
-
-
Guo, H.1
Lai, L.2
Butchbach, M.E.3
Stockinger, M.P.4
Shan, X.5
Bishop, G.A.6
Lin, C.L.7
-
87
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
Gurney, M.E., Pu, H., Chiu, A.Y., Dal Canto, M.C., Polchow, C.Y., Alexander, D.D., Caliendo, J., Hentati, A., Kwon, Y.W., Deng, H.X., Chen, W., Zhai, P., Sufit, R.L. Siddique, T. (1994) Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science, 264, 1772 1775. (Pubitemid 24227760)
-
(1994)
Science
, vol.264
, Issue.5166
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.-X.10
Chen, W.11
Zhai, P.12
Sufit, R.L.13
Siddique, T.14
-
88
-
-
0030596083
-
Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties
-
Hackl, W. Luhrmann, R. (1996) Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties. J. Mol. Biol., 264, 843 851.
-
(1996)
J. Mol. Biol.
, vol.264
, pp. 843-851
-
-
Hackl, W.1
Luhrmann, R.2
-
89
-
-
0032125587
-
Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
-
Hall, E.D., Oostveen, J.A. Gurney, M.E. (1998) Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia, 23, 249 256.
-
(1998)
Glia
, vol.23
, pp. 249-256
-
-
Hall, E.D.1
Oostveen, J.A.2
Gurney, M.E.3
-
90
-
-
39149121834
-
Tubulin modifications and their cellular functions
-
Hammond, J.W., Cai, D. Verhey, K.J. (2008) Tubulin modifications and their cellular functions. Curr. Opin. Cell Biol., 20, 71 76.
-
(2008)
Curr. Opin. Cell Biol.
, vol.20
, pp. 71-76
-
-
Hammond, J.W.1
Cai, D.2
Verhey, K.J.3
-
91
-
-
35448962057
-
MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity
-
Harraz, M.M., Park, A., Abbott, D., Zhou, W., Zhang, Y. Engelhardt, J.F. (2007) MKK6 phosphorylation regulates production of superoxide by enhancing Rac GTPase activity. Antioxid. Redox Signal., 9, 1803 1813.
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 1803-1813
-
-
Harraz, M.M.1
Park, A.2
Abbott, D.3
Zhou, W.4
Zhang, Y.5
Engelhardt, J.F.6
-
92
-
-
47949086625
-
Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Hasegawa, M., Arai, T., Nonaka, T., Kametani, F., Yoshida, M., Hashizume, Y., Beach, T.G., Buratti, E., Baralle, F., Morita, M., Nakano, I., Oda, T., Tsuchiya, K. Akiyama, H. (2008) Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Ann. Neurol., 64, 60 70.
-
(2008)
Ann. Neurol.
, vol.64
, pp. 60-70
-
-
Hasegawa, M.1
Arai, T.2
Nonaka, T.3
Kametani, F.4
Yoshida, M.5
Hashizume, Y.6
Beach, T.G.7
Buratti, E.8
Baralle, F.9
Morita, M.10
Nakano, I.11
Oda, T.12
Tsuchiya, K.13
Akiyama, H.14
-
93
-
-
0037038109
-
Quantitative assessment of AMPA receptor mRNA in human spinal motor neurons isolated by laser capture microdissection
-
Heath, P.R., Tomkins, J., Ince, P.G. Shaw, P.J. (2002) Quantitative assessment of AMPA receptor mRNA in human spinal motor neurons isolated by laser capture microdissection. NeuroReport, 13, 1753 1757.
-
(2002)
NeuroReport
, vol.13
, pp. 1753-1757
-
-
Heath, P.R.1
Tomkins, J.2
Ince, P.G.3
Shaw, P.J.4
-
94
-
-
0033968408
-
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death
-
Hicks, G.G., Singh, N., Nashabi, A., Mai, S., Bozek, G., Klewes, L., Arapovic, D., White, E.K., Koury, M.J., Oltz, E.M., Van Kaer, L. Ruley, H.E. (2000) Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death. Nat. Genet., 24, 175 179.
-
(2000)
Nat. Genet.
, vol.24
, pp. 175-179
-
-
Hicks, G.G.1
Singh, N.2
Nashabi, A.3
Mai, S.4
Bozek, G.5
Klewes, L.6
Arapovic, D.7
White, E.K.8
Koury, M.J.9
Oltz, E.M.10
Van Kaer, L.11
Ruley, H.E.12
-
95
-
-
46849098989
-
Amyotrophic lateral sclerosis among 1991 Gulf War veterans: Evidence for a time-limited outbreak
-
Horner, R.D., Grambow, S.C., Coffman, C.J., Lindquist, J.H., Oddone, E.Z., Allen, K.D. Kasarskis, E.J. (2008) Amyotrophic lateral sclerosis among 1991 Gulf War veterans: evidence for a time-limited outbreak. Neuroepidemiology, 31, 28 32.
-
(2008)
Neuroepidemiology
, vol.31
, pp. 28-32
-
-
Horner, R.D.1
Grambow, S.C.2
Coffman, C.J.3
Lindquist, J.H.4
Oddone, E.Z.5
Allen, K.D.6
Kasarskis, E.J.7
-
96
-
-
0037022339
-
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
-
Howland, D.S., Liu, J., She, Y., Goad, B., Maragakis, N.J., Kim, B., Erickson, J., Kulik, J., DeVito, L., Psaltis, G., DeGennaro, L.J., Cleveland, D.W. Rothstein, J.D. (2002) Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc. Natl Acad. Sci. USA, 99, 1604 1609.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 1604-1609
-
-
Howland, D.S.1
Liu, J.2
She, Y.3
Goad, B.4
Maragakis, N.J.5
Kim, B.6
Erickson, J.7
Kulik, J.8
Devito, L.9
Psaltis, G.10
Degennaro, L.J.11
Cleveland, D.W.12
Rothstein, J.D.13
-
97
-
-
0024411896
-
Glutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease
-
Hugon, J., Tabaraud, F., Rigaud, M., Vallat, J.M. Dumas, M. (1989) Glutamate dehydrogenase and aspartate aminotransferase in leukocytes of patients with motor neuron disease. Neurology, 39, 956 958.
-
(1989)
Neurology
, vol.39
, pp. 956-958
-
-
Hugon, J.1
Tabaraud, F.2
Rigaud, M.3
Vallat, J.M.4
Dumas, M.5
-
98
-
-
46749138739
-
Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Igaz, L.M., Kwong, L.K., Xu, Y., Truax, A.C., Uryu, K., Neumann, M., Clark, C.M., Elman, L.B., Miller, B.L., Grossman, M., McCluskey, L.F., Trojanowski, J.Q. Lee, V.M. (2008) Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Am. J. Pathol., 173, 182 194.
-
(2008)
Am. J. Pathol.
, vol.173
, pp. 182-194
-
-
Igaz, L.M.1
Kwong, L.K.2
Xu, Y.3
Truax, A.C.4
Uryu, K.5
Neumann, M.6
Clark, C.M.7
Elman, L.B.8
Miller, B.L.9
Grossman, M.10
McCluskey, L.F.11
Trojanowski, J.Q.12
Lee, V.M.13
-
99
-
-
67649797399
-
Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies
-
Igaz, L.M., Kwong, L.K., Chen-Plotkin, A., Winton, M.J., Unger, T.L., Xu, Y., Neumann, M., Trojanowski, J.Q. Lee, V.M. (2009) Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. J. Biol. Chem., 284, 8516 8524.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 8516-8524
-
-
Igaz, L.M.1
Kwong, L.K.2
Chen-Plotkin, A.3
Winton, M.J.4
Unger, T.L.5
Xu, Y.6
Neumann, M.7
Trojanowski, J.Q.8
Lee, V.M.9
-
100
-
-
13344261949
-
Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis
-
Ikonomidou, C., Qin Qin, Y., Labruyere, J. Olney, J.W. (1996) Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 55, 211 224.
-
(1996)
J. Neuropathol. Exp. Neurol.
, vol.55
, pp. 211-224
-
-
Ikonomidou, C.1
Qin Qin, Y.2
Labruyere, J.3
Olney, J.W.4
-
101
-
-
74049164709
-
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond
-
Ilieva, H., Polymenidou, M. Cleveland, D.W. (2009) Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol., 187, 761 772.
-
(2009)
J. Cell Biol.
, vol.187
, pp. 761-772
-
-
Ilieva, H.1
Polymenidou, M.2
Cleveland, D.W.3
-
102
-
-
48749088629
-
Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS
-
Inukai, Y., Nonaka, T., Arai, T., Yoshida, M., Hashizume, Y., Beach, T.G., Buratti, E., Baralle, F.E., Akiyama, H., Hisanaga, S. Hasegawa, M. (2008) Abnormal phosphorylation of Ser409/410 of TDP-43 in FTLD-U and ALS. FEBS Lett., 582, 2899 2904.
-
(2008)
FEBS Lett.
, vol.582
, pp. 2899-2904
-
-
Inukai, Y.1
Nonaka, T.2
Arai, T.3
Yoshida, M.4
Hashizume, Y.5
Beach, T.G.6
Buratti, E.7
Baralle, F.E.8
Akiyama, H.9
Hisanaga, S.10
Hasegawa, M.11
-
103
-
-
0034520591
-
Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1
-
Jaarsma, D., Haasdijk, E.D., Grashorn, J.A., Hawkins, R., van Duijn, W., Verspaget, H.W., London, J. Holstege, J.C. (2000) Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol Dis, 7, 623 643.
-
(2000)
Neurobiol Dis
, vol.7
, pp. 623-643
-
-
Jaarsma, D.1
Haasdijk, E.D.2
Grashorn, J.A.3
Hawkins, R.4
Van Duijn, W.5
Verspaget, H.W.6
London, J.7
Holstege, J.C.8
-
104
-
-
0034821922
-
CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations
-
Jaarsma, D., Rognoni, F., van Duijn, W., Verspaget, H.W., Haasdijk, E.D. Holstege, J.C. (2001) CuZn superoxide dismutase (SOD1) accumulates in vacuolated mitochondria in transgenic mice expressing amyotrophic lateral sclerosis-linked SOD1 mutations. Acta Neuropathol., 102, 293 305.
-
(2001)
Acta Neuropathol.
, vol.102
, pp. 293-305
-
-
Jaarsma, D.1
Rognoni, F.2
Van Duijn, W.3
Verspaget, H.W.4
Haasdijk, E.D.5
Holstege, J.C.6
-
105
-
-
67749133873
-
TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity
-
Johnson, B.S., Snead, D., Lee, J.J., McCaffery, J.M., Shorter, J. Gitler, A.D. (2009) TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity. J. Biol. Chem., 284, 20329 20339.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 20329-20339
-
-
Johnson, B.S.1
Snead, D.2
Lee, J.J.3
McCaffery, J.M.4
Shorter, J.5
Gitler, A.D.6
-
106
-
-
0033749379
-
Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis
-
Johnston, J.A., Dalton, M.J., Gurney, M.E. Kopito, R.R. (2000) Formation of high molecular weight complexes of mutant Cu, Zn-superoxide dismutase in a mouse model for familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 97, 12571 12576.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 12571-12576
-
-
Johnston, J.A.1
Dalton, M.J.2
Gurney, M.E.3
Kopito, R.R.4
-
107
-
-
33846295930
-
Amyotrophic lateral sclerosis in an urban setting: A population based study of inner city London
-
Johnston, C.A., Stanton, B.R., Turner, M.R., Gray, R., Blunt, A.H., Butt, D., Ampong, M.A., Shaw, C.E., Leigh, P.N. Al-Chalabi, A. (2006) Amyotrophic lateral sclerosis in an urban setting: a population based study of inner city London. J. Neurol., 253, 1642 1643.
-
(2006)
J. Neurol.
, vol.253
, pp. 1642-1643
-
-
Johnston, C.A.1
Stanton, B.R.2
Turner, M.R.3
Gray, R.4
Blunt, A.H.5
Butt, D.6
Ampong, M.A.7
Shaw, C.E.8
Leigh, P.N.9
Al-Chalabi, A.10
-
108
-
-
3042515545
-
Focal dysfunction of the proteasome: A pathogenic factor in a mouse model of amyotrophic lateral sclerosis
-
Kabashi, E., Agar, J.N., Taylor, D.M., Minotti, S. Durham, H.D. (2004) Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis. J. Neurochem., 89, 1325 1335.
-
(2004)
J. Neurochem.
, vol.89
, pp. 1325-1335
-
-
Kabashi, E.1
Agar, J.N.2
Taylor, D.M.3
Minotti, S.4
Durham, H.D.5
-
109
-
-
44649144579
-
Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis
-
Kabashi, E., Agar, J.N., Hong, Y., Taylor, D.M., Minotti, S., Figlewicz, D.A. Durham, H.D. (2008a) Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis. J. Neurochem., 105, 2353 2366.
-
(2008)
J. Neurochem.
, vol.105
, pp. 2353-2366
-
-
Kabashi, E.1
Agar, J.N.2
Hong, Y.3
Taylor, D.M.4
Minotti, S.5
Figlewicz, D.A.6
Durham, H.D.7
-
110
-
-
42649120983
-
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
-
Kabashi, E., Valdmanis, P.N., Dion, P., Spiegelman, D., McConkey, B.J., Vande Velde, C., Bouchard, J.P., Lacomblez, L., Pochigaeva, K., Salachas, F., Pradat, P.F., Camu, W., Meininger, V., Dupre, N. Rouleau, G.A. (2008b) TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis. Nat. Genet., 40, 572 574.
-
(2008)
Nat. Genet.
, vol.40
, pp. 572-574
-
-
Kabashi, E.1
Valdmanis, P.N.2
Dion, P.3
Spiegelman, D.4
McConkey, B.J.5
Vande Velde, C.6
Bouchard, J.P.7
Lacomblez, L.8
Pochigaeva, K.9
Salachas, F.10
Pradat, P.F.11
Camu, W.12
Meininger, V.13
Dupre, N.14
Rouleau, G.A.15
-
111
-
-
77950360176
-
Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
-
Kabashi, E., Lin, L., Tradewell, M.L., Dion, P.A., Bercier, V., Bourgouin, P., Rochefort, D., Bel Hadj, S., Durham, H.D., Vande Velde, C., Rouleau, G.A. Drapeau, P. (2010) Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo. Hum. Mol. Genet., 19, 671 683.
-
(2010)
Hum. Mol. Genet.
, vol.19
, pp. 671-683
-
-
Kabashi, E.1
Lin, L.2
Tradewell, M.L.3
Dion, P.A.4
Bercier, V.5
Bourgouin, P.6
Rochefort, D.7
Bel Hadj, S.8
Durham, H.D.9
Vande Velde, C.10
Rouleau, G.A.11
Drapeau, P.12
-
112
-
-
63349083295
-
Identification of casein kinase-1 phosphorylation sites on TDP-43
-
Kametani, F., Nonaka, T., Suzuki, T., Arai, T., Dohmae, N., Akiyama, H. Hasegawa, M. (2009) Identification of casein kinase-1 phosphorylation sites on TDP-43. Biochem. Biophys. Res. Commun., 382, 405 409.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.382
, pp. 405-409
-
-
Kametani, F.1
Nonaka, T.2
Suzuki, T.3
Arai, T.4
Dohmae, N.5
Akiyama, H.6
Hasegawa, M.7
-
113
-
-
66149156941
-
ER stress and unfolded protein response in amyotrophic lateral sclerosis
-
Kanekura, K., Suzuki, H., Aiso, S. Matsuoka, M. (2009) ER stress and unfolded protein response in amyotrophic lateral sclerosis. Mol. Neurobiol., 39, 81 89.
-
(2009)
Mol. Neurobiol.
, vol.39
, pp. 81-89
-
-
Kanekura, K.1
Suzuki, H.2
Aiso, S.3
Matsuoka, M.4
-
114
-
-
0038673599
-
Human spinal motoneurons express low relative abundance of GluR2 mRNA: An implication for excitotoxicity in ALS
-
Kawahara, Y., Kwak, S., Sun, H., Ito, K., Hashida, H., Aizawa, H., Jeong, S.Y. Kanazawa, I. (2003) Human spinal motoneurons express low relative abundance of GluR2 mRNA: an implication for excitotoxicity in ALS. J. Neurochem., 85, 680 689.
-
(2003)
J. Neurochem.
, vol.85
, pp. 680-689
-
-
Kawahara, Y.1
Kwak, S.2
Sun, H.3
Ito, K.4
Hashida, H.5
Aizawa, H.6
Jeong, S.Y.7
Kanazawa, I.8
-
115
-
-
1542378930
-
Glutamate receptors: RNA editing and death of motor neurons
-
Kawahara, Y., Ito, K., Sun, H., Aizawa, H., Kanazawa, I. Kwak, S. (2004) Glutamate receptors: RNA editing and death of motor neurons. Nature, 427, 801.
-
(2004)
Nature
, vol.427
, pp. 801
-
-
Kawahara, Y.1
Ito, K.2
Sun, H.3
Aizawa, H.4
Kanazawa, I.5
Kwak, S.6
-
116
-
-
58149373936
-
Control of motoneuron survival by angiogenin
-
Kieran, D., Sebastia, J., Greenway, M.J., King, M.A., Connaughton, D., Concannon, C.G., Fenner, B., Hardiman, O. Prehn, J.H. (2008) Control of motoneuron survival by angiogenin. J. Neurosci., 28, 14056 14061.
-
(2008)
J. Neurosci.
, vol.28
, pp. 14056-14061
-
-
Kieran, D.1
Sebastia, J.2
Greenway, M.J.3
King, M.A.4
Connaughton, D.5
Concannon, C.G.6
Fenner, B.7
Hardiman, O.8
Prehn, J.H.9
-
117
-
-
77953026500
-
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
-
Kraemer, B.C., Schuck, T., Wheeler, J.M., Robinson, L.C., Trojanowski, J.Q., Lee, V.M. Schellenberg, G.D. (2010) Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathol., 119, 409 419.
-
(2010)
Acta Neuropathol.
, vol.119
, pp. 409-419
-
-
Kraemer, B.C.1
Schuck, T.2
Wheeler, J.M.3
Robinson, L.C.4
Trojanowski, J.Q.5
Lee, V.M.6
Schellenberg, G.D.7
-
118
-
-
49549120206
-
Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis
-
Krishnan, J., Vannuvel, K., Andries, M., Waelkens, E., Robberecht, W. Van Den Bosch, L. (2008) Over-expression of Hsp27 does not influence disease in the mutant SOD1(G93A) mouse model of amyotrophic lateral sclerosis. J. Neurochem., 106, 2170 2183.
-
(2008)
J. Neurochem.
, vol.106
, pp. 2170-2183
-
-
Krishnan, J.1
Vannuvel, K.2
Andries, M.3
Waelkens, E.4
Robberecht, W.5
Van Den Bosch, L.6
-
119
-
-
0034142209
-
Male sterility and enhanced radiation sensitivity in TLS(-/-) mice
-
Kuroda, M., Sok, J., Webb, L., Baechtold, H., Urano, F., Yin, Y., Chung, P., de Rooij, D.G., Akhmedov, A., Ashley, T. Ron, D. (2000) Male sterility and enhanced radiation sensitivity in TLS(-/-) mice. EMBO J., 19, 453 462.
-
(2000)
EMBO J.
, vol.19
, pp. 453-462
-
-
Kuroda, M.1
Sok, J.2
Webb, L.3
Baechtold, H.4
Urano, F.5
Yin, Y.6
Chung, P.7
De Rooij, D.G.8
Akhmedov, A.9
Ashley, T.10
Ron, D.11
-
120
-
-
61349156118
-
Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
-
Kwiatkowski, T.J. Jr., Bosco, D.A., Leclerc, A.L., Tamrazian, E., Vanderburg, C.R., Russ, C., Davis, A., Gilchrist, J., Kasarskis, E.J., Munsat, T., Valdmanis, P., Rouleau, G.A., Hosler, B.A., Cortelli, P., de Jong, P.J., Yoshinaga, Y., Haines, J.L., Pericak-Vance, M.A., Yan, J., Ticozzi, N., Siddique, T., McKenna-Yasek, D., Sapp, P.C., Horvitz, H.R., Landers, J.E. Brown, R.H. Jr. (2009) Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science, 323, 1205 1208.
-
(2009)
Science
, vol.323
, pp. 1205-1208
-
-
Kwiatkowski, Jr.T.J.1
Bosco, D.A.2
Leclerc, A.L.3
Tamrazian, E.4
Vanderburg, C.R.5
Russ, C.6
Davis, A.7
Gilchrist, J.8
Kasarskis, E.J.9
Munsat, T.10
Valdmanis, P.11
Rouleau, G.A.12
Hosler, B.A.13
Cortelli, P.14
De Jong, P.J.15
Yoshinaga, Y.16
Haines, J.L.17
Pericak-Vance, M.A.18
Yan, J.19
Ticozzi, N.20
Siddique, T.21
McKenna-Yasek, D.22
Sapp, P.C.23
Horvitz, H.R.24
Landers, J.E.25
Brown, Jr.R.H.26
more..
-
121
-
-
0029977337
-
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II
-
Lacomblez, L., Bensimon, G., Leigh, P.N., Guillet, P. Meininger, V. (1996) Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II. Lancet, 347, 1425 1431.
-
(1996)
Lancet
, vol.347
, pp. 1425-1431
-
-
Lacomblez, L.1
Bensimon, G.2
Leigh, P.N.3
Guillet, P.4
Meininger, V.5
-
122
-
-
62149141328
-
Rethinking ALS: The FUS about TDP-43
-
Lagier-Tourenne, C. Cleveland, D.W. (2009) Rethinking ALS: the FUS about TDP-43. Cell, 136, 1001 1004.
-
(2009)
Cell
, vol.136
, pp. 1001-1004
-
-
Lagier-Tourenne, C.1
Cleveland, D.W.2
-
123
-
-
39849107361
-
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking
-
Laird, F.M., Farah, M.H., Ackerley, S., Hoke, A., Maragakis, N., Rothstein, J.D., Griffin, J., Price, D.L., Martin, L.J. Wong, P.C. (2008) Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J. Neurosci., 28, 1997 2005.
-
(2008)
J. Neurosci.
, vol.28
, pp. 1997-2005
-
-
Laird, F.M.1
Farah, M.H.2
Ackerley, S.3
Hoke, A.4
Maragakis, N.5
Rothstein, J.D.6
Griffin, J.7
Price, D.L.8
Martin, L.J.9
Wong, P.C.10
-
124
-
-
33746634351
-
Another angiogenic gene linked to amyotrophic lateral sclerosis
-
Lambrechts, D., Lafuste, P., Carmeliet, P. Conway, E.M. (2006) Another angiogenic gene linked to amyotrophic lateral sclerosis. Trends Mol Med, 12, 345 347.
-
(2006)
Trends Mol Med
, vol.12
, pp. 345-347
-
-
Lambrechts, D.1
Lafuste, P.2
Carmeliet, P.3
Conway, E.M.4
-
125
-
-
72749106555
-
Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: Increased susceptibility in male carriers of the -2578AA genotype
-
Lambrechts, D., Poesen, K., Fernandez-Santiago, R., Al-Chalabi, A., Del Bo, R., Van Vught, P.W., Khan, S., Marklund, S.L., Brockington, A., van Marion, I., Anneser, J., Shaw, C., Ludolph, A.C., Leigh, N.P., Comi, G.P., Gasser, T., Shaw, P.J., Morrison, K.E., Andersen, P.M., Van den Berg, L.H., Thijs, V., Siddique, T., Robberecht, W. Carmeliet, P. (2009) Meta-analysis of vascular endothelial growth factor variations in amyotrophic lateral sclerosis: increased susceptibility in male carriers of the -2578AA genotype. J. Med. Genet., 46, 840 846.
-
(2009)
J. Med. Genet.
, vol.46
, pp. 840-846
-
-
Lambrechts, D.1
Poesen, K.2
Fernandez-Santiago, R.3
Al-Chalabi, A.4
Del Bo, R.5
Van Vught, P.W.6
Khan, S.7
Marklund, S.L.8
Brockington, A.9
Van Marion, I.10
Anneser, J.11
Shaw, C.12
Ludolph, A.C.13
Leigh, N.P.14
Comi, G.P.15
Gasser, T.16
Shaw, P.J.17
Morrison, K.E.18
Andersen, P.M.19
Van Den Berg, L.H.20
Thijs, V.21
Siddique, T.22
Robberecht, W.23
Carmeliet, P.24
more..
-
126
-
-
67049155508
-
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis
-
Landers, J.E., Melki, J., Meininger, V., Glass, J.D., van den Berg, L.H., van Es, M.A., Sapp, P.C., van Vught, P.W., McKenna-Yasek, D.M., Blauw, H.M., Cho, T.J., Polak, M., Shi, L., Wills, A.M., Broom, W.J., Ticozzi, N., Silani, V., Ozoguz, A., Rodriguez-Leyva, I., Veldink, J.H., Ivinson, A.J., Saris, C.G., Hosler, B.A., Barnes-Nessa, A., Couture, N., Wokke, J.H., Kwiatkowski, T.J. Jr., Ophoff, R.A., Cronin, S., Hardiman, O., Diekstra, F.P., Leigh, P.N., Shaw, C.E., Simpson, C.L., Hansen, V.K., Powell, J.F., Corcia, P., Salachas, F., Heath, S., Galan, P., Georges, F., Horvitz, H.R., Lathrop, M., Purcell, S., Al-Chalabi, A. Brown, R.H. Jr. (2009) Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 106, 9004 9009.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 9004-9009
-
-
Landers, J.E.1
Melki, J.2
Meininger, V.3
Glass, J.D.4
Van Den Berg, L.H.5
Van Es, M.A.6
Sapp, P.C.7
Van Vught, P.W.8
McKenna-Yasek, D.M.9
Blauw, H.M.10
Cho, T.J.11
Polak, M.12
Shi, L.13
Wills, A.M.14
Broom, W.J.15
Ticozzi, N.16
Silani, V.17
Ozoguz, A.18
Rodriguez-Leyva, I.19
Veldink, J.H.20
Ivinson, A.J.21
Saris, C.G.22
Hosler, B.A.23
Barnes-Nessa, A.24
Couture, N.25
Wokke, J.H.26
Kwiatkowski, Jr.T.J.27
Ophoff, R.A.28
Cronin, S.29
Hardiman, O.30
Diekstra, F.P.31
Leigh, P.N.32
Shaw, C.E.33
Simpson, C.L.34
Hansen, V.K.35
Powell, J.F.36
Corcia, P.37
Salachas, F.38
Heath, S.39
Galan, P.40
Georges, F.41
Horvitz, H.R.42
Lathrop, M.43
Purcell, S.44
Al-Chalabi, A.45
Brown, Jr.R.H.46
more..
-
127
-
-
34548740744
-
Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish
-
Lemmens, R., Van Hoecke, A., Hersmus, N., Geelen, V., D'Hollander, I., Thijs, V., Van Den Bosch, L., Carmeliet, P. Robberecht, W. (2007) Overexpression of mutant superoxide dismutase 1 causes a motor axonopathy in the zebrafish. Hum. Mol. Genet., 16, 2359 2365.
-
(2007)
Hum. Mol. Genet.
, vol.16
, pp. 2359-2365
-
-
Lemmens, R.1
Van Hoecke, A.2
Hersmus, N.3
Geelen, V.4
D'Hollander, I.5
Thijs, V.6
Van Den Bosch, L.7
Carmeliet, P.8
Robberecht, W.9
-
128
-
-
77952891717
-
RNA metabolism and the pathogenesis of motor neuron diseases
-
Lemmens, R., Moore, M.J., Al-Chalabi, A., Brown, R.H. Jr. Robberecht, W. (2010) RNA metabolism and the pathogenesis of motor neuron diseases. Trends Neurosci., 33, 249 258.
-
(2010)
Trends Neurosci.
, vol.33
, pp. 249-258
-
-
Lemmens, R.1
Moore, M.J.2
Al-Chalabi, A.3
Brown, Jr.R.H.4
Robberecht, W.5
-
129
-
-
54949126674
-
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
-
Lepore, A.C., Rauck, B., Dejea, C., Pardo, A.C., Rao, M.S., Rothstein, J.D. Maragakis, N.J. (2008) Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat. Neurosci., 11, 1294 1301.
-
(2008)
Nat. Neurosci.
, vol.11
, pp. 1294-1301
-
-
Lepore, A.C.1
Rauck, B.2
Dejea, C.3
Pardo, A.C.4
Rao, M.S.5
Rothstein, J.D.6
Maragakis, N.J.7
-
130
-
-
77649258646
-
A Drosophila model for TDP-43 proteinopathy
-
Li, Y., Ray, P., Rao, E.J., Shi, C., Guo, W., Chen, X., Woodruff, E.A. III., Fushimi, K. Wu, J.Y. (2010) A Drosophila model for TDP-43 proteinopathy. Proc. Natl Acad. Sci. USA, 107, 3169 3174.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3169-3174
-
-
Li, Y.1
Ray, P.2
Rao, E.J.3
Shi, C.4
Guo, W.5
Chen, X.6
Woodruff III, E.A.7
Fushimi, K.8
Wu, J.Y.9
-
131
-
-
7744220605
-
Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration
-
Lipton, A.M., White, C.L. III. Bigio, E.H. (2004) Frontotemporal lobar degeneration with motor neuron disease-type inclusions predominates in 76 cases of frontotemporal degeneration. Acta Neuropathol (Berl), 108, 379 385.
-
(2004)
Acta Neuropathol (Berl)
, vol.108
, pp. 379-385
-
-
Lipton, A.M.1
White III, C.L.2
Bigio, E.H.3
-
132
-
-
3242701496
-
Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria
-
Liu, J., Lillo, C., Jonsson, P.A., Vande Velde, C., Ward, C.M., Miller, T.M., Subramaniam, J.R., Rothstein, J.D., Marklund, S., Andersen, P.M., Brannstrom, T., Gredal, O., Wong, P.C., Williams, D.S. Cleveland, D.W. (2004) Toxicity of familial ALS-linked SOD1 mutants from selective recruitment to spinal mitochondria. Neuron, 43, 5 17.
-
(2004)
Neuron
, vol.43
, pp. 5-17
-
-
Liu, J.1
Lillo, C.2
Jonsson, P.A.3
Vande Velde, C.4
Ward, C.M.5
Miller, T.M.6
Subramaniam, J.R.7
Rothstein, J.D.8
Marklund, S.9
Andersen, P.M.10
Brannstrom, T.11
Gredal, O.12
Wong, P.C.13
Williams, D.S.14
Cleveland, D.W.15
-
133
-
-
18844444198
-
Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis
-
Liu, J., Shinobu, L.A., Ward, C.M., Young, D. Cleveland, D.W. (2005) Elevation of the Hsp70 chaperone does not effect toxicity in mouse models of familial amyotrophic lateral sclerosis. J. Neurochem., 93, 875 882.
-
(2005)
J. Neurochem.
, vol.93
, pp. 875-882
-
-
Liu, J.1
Shinobu, L.A.2
Ward, C.M.3
Young, D.4
Cleveland, D.W.5
-
134
-
-
63149141363
-
Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice
-
Lobsiger, C.S., Boillee, S., McAlonis-Downes, M., Khan, A.M., Feltri, M.L., Yamanaka, K. Cleveland, D.W. (2009) Schwann cells expressing dismutase active mutant SOD1 unexpectedly slow disease progression in ALS mice. Proc. Natl Acad. Sci. USA, 106, 4465 4470.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 4465-4470
-
-
Lobsiger, C.S.1
Boillee, S.2
McAlonis-Downes, M.3
Khan, A.M.4
Feltri, M.L.5
Yamanaka, K.6
Cleveland, D.W.7
-
135
-
-
2642559477
-
Characterization of amyotrophic lateral sclerosis and frontotemporal dementia
-
Lomen-Hoerth, C. (2004) Characterization of amyotrophic lateral sclerosis and frontotemporal dementia. Dement Geriatr Cogn Disord, 17, 337 341.
-
(2004)
Dement Geriatr Cogn Disord
, vol.17
, pp. 337-341
-
-
Lomen-Hoerth, C.1
-
136
-
-
23844441835
-
Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum
-
Mackenzie, I.R. Feldman, H.H. (2005) Ubiquitin immunohistochemistry suggests classic motor neuron disease, motor neuron disease with dementia, and frontotemporal dementia of the motor neuron disease type represent a clinicopathologic spectrum. J. Neuropathol. Exp. Neurol., 64, 730 739.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 730-739
-
-
MacKenzie, I.R.1
Feldman, H.H.2
-
137
-
-
34249946466
-
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
-
Mackenzie, I.R., Bigio, E.H., Ince, P.G., Geser, F., Neumann, M., Cairns, N.J., Kwong, L.K., Forman, M.S., Ravits, J., Stewart, H., Eisen, A., McClusky, L., Kretzschmar, H.A., Monoranu, C.M., Highley, J.R., Kirby, J., Siddique, T., Shaw, P.J., Lee, V.M. Trojanowski, J.Q. (2007) Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Ann. Neurol., 61, 427 434.
-
(2007)
Ann. Neurol.
, vol.61
, pp. 427-434
-
-
MacKenzie, I.R.1
Bigio, E.H.2
Ince, P.G.3
Geser, F.4
Neumann, M.5
Cairns, N.J.6
Kwong, L.K.7
Forman, M.S.8
Ravits, J.9
Stewart, H.10
Eisen, A.11
McClusky, L.12
Kretzschmar, H.A.13
Monoranu, C.M.14
Highley, J.R.15
Kirby, J.16
Siddique, T.17
Shaw, P.J.18
Lee, V.M.19
Trojanowski, J.Q.20
more..
-
138
-
-
77649187519
-
Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: An update
-
Mackenzie, I.R., Neumann, M., Bigio, E.H., Cairns, N.J., Alafuzoff, I., Kril, J., Kovacs, G.G., Ghetti, B., Halliday, G., Holm, I.E., Ince, P.G., Kamphorst, W., Revesz, T., Rozemuller, A.J., Kumar-Singh, S., Akiyama, H., Baborie, A., Spina, S., Dickson, D.W., Trojanowski, J.Q. Mann, D.M. (2010) Nomenclature and nosology for neuropathologic subtypes of frontotemporal lobar degeneration: an update. Acta Neuropathol., 119, 1 4.
-
(2010)
Acta Neuropathol.
, vol.119
, pp. 1-4
-
-
MacKenzie, I.R.1
Neumann, M.2
Bigio, E.H.3
Cairns, N.J.4
Alafuzoff, I.5
Kril, J.6
Kovacs, G.G.7
Ghetti, B.8
Halliday, G.9
Holm, I.E.10
Ince, P.G.11
Kamphorst, W.12
Revesz, T.13
Rozemuller, A.J.14
Kumar-Singh, S.15
Akiyama, H.16
Baborie, A.17
Spina, S.18
Dickson, D.W.19
Trojanowski, J.Q.20
Mann, D.M.21
more..
-
139
-
-
34948822926
-
Redox modifier genes in amyotrophic lateral sclerosis in mice
-
Marden, J.J., Harraz, M.M., Williams, A.J., Nelson, K., Luo, M., Paulson, H. Engelhardt, J.F. (2007) Redox modifier genes in amyotrophic lateral sclerosis in mice. J. Clin. Invest., 117, 2913 2919.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 2913-2919
-
-
Marden, J.J.1
Harraz, M.M.2
Williams, A.J.3
Nelson, K.4
Luo, M.5
Paulson, H.6
Engelhardt, J.F.7
-
140
-
-
70649097387
-
RNAi applications in therapy development for neurodegenerative disease
-
Maxwell, M.M. (2009) RNAi applications in therapy development for neurodegenerative disease. Curr. Pharm. Des., 15, 3977 3991.
-
(2009)
Curr. Pharm. Des.
, vol.15
, pp. 3977-3991
-
-
Maxwell, M.M.1
-
141
-
-
0033911099
-
A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene
-
Mersiyanova, I.V., Perepelov, A.V., Polyakov, A.V., Sitnikov, V.F., Dadali, E.L., Oparin, R.B., Petrin, A.N. Evgrafov, O.V. (2000) A new variant of Charcot-Marie-Tooth disease type 2 is probably the result of a mutation in the neurofilament-light gene. Am. J. Hum. Genet., 67, 37 46.
-
(2000)
Am. J. Hum. Genet.
, vol.67
, pp. 37-46
-
-
Mersiyanova, I.V.1
Perepelov, A.V.2
Polyakov, A.V.3
Sitnikov, V.F.4
Dadali, E.L.5
Oparin, R.B.6
Petrin, A.N.7
Evgrafov, O.V.8
-
142
-
-
36448955070
-
Microglia in the adult brain arise from Ly-6ChiCCR2 + monocytes only under defined host conditions
-
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.K., Mack, M., Heikenwalder, M., Bruck, W., Priller, J. Prinz, M. (2007) Microglia in the adult brain arise from Ly-6ChiCCR2 + monocytes only under defined host conditions. Nat. Neurosci., 10, 1544 1553.
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 1544-1553
-
-
Mildner, A.1
Schmidt, H.2
Nitsche, M.3
Merkler, D.4
Hanisch, U.K.5
MacK, M.6
Heikenwalder, M.7
Bruck, W.8
Priller, J.9
Prinz, M.10
-
143
-
-
33845876647
-
Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis
-
Miller, T.M., Kim, S.H., Yamanaka, K., Hester, M., Umapathi, P., Arnson, H., Rizo, L., Mendell, J.R., Gage, F.H., Cleveland, D.W. Kaspar, B.K. (2006) Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 103, 19546 19551.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 19546-19551
-
-
Miller, T.M.1
Kim, S.H.2
Yamanaka, K.3
Hester, M.4
Umapathi, P.5
Arnson, H.6
Rizo, L.7
Mendell, J.R.8
Gage, F.H.9
Cleveland, D.W.10
Kaspar, B.K.11
-
144
-
-
4143084861
-
Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS
-
Munch, C., Sedlmeier, R., Meyer, T., Homberg, V., Sperfeld, A.D., Kurt, A., Prudlo, J., Peraus, G., Hanemann, C.O., Stumm, G. Ludolph, A.C. (2004) Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS. Neurology, 63, 724 726.
-
(2004)
Neurology
, vol.63
, pp. 724-726
-
-
Munch, C.1
Sedlmeier, R.2
Meyer, T.3
Homberg, V.4
Sperfeld, A.D.5
Kurt, A.6
Prudlo, J.7
Peraus, G.8
Hanemann, C.O.9
Stumm, G.10
Ludolph, A.C.11
-
145
-
-
27644558934
-
Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD
-
Munch, C., Rosenbohm, A., Sperfeld, A.D., Uttner, I., Reske, S., Krause, B.J., Sedlmeier, R., Meyer, T., Hanemann, C.O., Stumm, G. Ludolph, A.C. (2005) Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD. Ann. Neurol., 58, 777 780.
-
(2005)
Ann. Neurol.
, vol.58
, pp. 777-780
-
-
Munch, C.1
Rosenbohm, A.2
Sperfeld, A.D.3
Uttner, I.4
Reske, S.5
Krause, B.J.6
Sedlmeier, R.7
Meyer, T.8
Hanemann, C.O.9
Stumm, G.10
Ludolph, A.C.11
-
146
-
-
34247475338
-
Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons
-
Nagai, M., Re, D.B., Nagata, T., Chalazonitis, A., Jessell, T.M., Wichterle, H. Przedborski, S. (2007) Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons. Nat. Neurosci., 10, 615 622.
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 615-622
-
-
Nagai, M.1
Re, D.B.2
Nagata, T.3
Chalazonitis, A.4
Jessell, T.M.5
Wichterle, H.6
Przedborski, S.7
-
147
-
-
0034528007
-
Classification and description of frontotemporal dementias
-
Neary, D., Snowden, J.S. Mann, D.M. (2000) Classification and description of frontotemporal dementias. Ann. N Y Acad. Sci., 920, 46 51.
-
(2000)
Ann. N y Acad. Sci.
, vol.920
, pp. 46-51
-
-
Neary, D.1
Snowden, J.S.2
Mann, D.M.3
-
148
-
-
26844447994
-
Frontotemporal dementia
-
Neary, D., Snowden, J. Mann, D. (2005) Frontotemporal dementia. Lancet Neurol, 4, 771 780.
-
(2005)
Lancet Neurol
, vol.4
, pp. 771-780
-
-
Neary, D.1
Snowden, J.2
Mann, D.3
-
149
-
-
33749632259
-
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
-
Neumann, M., Sampathu, D.M., Kwong, L.K., Truax, A.C., Micsenyi, M.C., Chou, T.T., Bruce, J., Schuck, T., Grossman, M., Clark, C.M., McCluskey, L.F., Miller, B.L., Masliah, E., Mackenzie, I.R., Feldman, H., Feiden, W., Kretzschmar, H.A., Trojanowski, J.Q. Lee, V.M. (2006) Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science, 314, 130 133.
-
(2006)
Science
, vol.314
, pp. 130-133
-
-
Neumann, M.1
Sampathu, D.M.2
Kwong, L.K.3
Truax, A.C.4
Micsenyi, M.C.5
Chou, T.T.6
Bruce, J.7
Schuck, T.8
Grossman, M.9
Clark, C.M.10
McCluskey, L.F.11
Miller, B.L.12
Masliah, E.13
MacKenzie, I.R.14
Feldman, H.15
Feiden, W.16
Kretzschmar, H.A.17
Trojanowski, J.Q.18
Lee, V.M.19
-
150
-
-
59249085091
-
Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies
-
Neumann, M., Kwong, L.K., Lee, E.B., Kremmer, E., Flatley, A., Xu, Y., Forman, M.S., Troost, D., Kretzschmar, H.A., Trojanowski, J.Q. Lee, V.M. (2009) Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathol., 117, 137 149.
-
(2009)
Acta Neuropathol.
, vol.117
, pp. 137-149
-
-
Neumann, M.1
Kwong, L.K.2
Lee, E.B.3
Kremmer, E.4
Flatley, A.5
Xu, Y.6
Forman, M.S.7
Troost, D.8
Kretzschmar, H.A.9
Trojanowski, J.Q.10
Lee, V.M.11
-
151
-
-
73649148708
-
Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43
-
Nishimoto, Y., Ito, D., Yagi, T., Nihei, Y., Tsunoda, Y. Suzuki, N. (2010) Characterization of alternative isoforms and inclusion body of the TAR DNA-binding protein-43. J. Biol. Chem., 285, 608 619.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 608-619
-
-
Nishimoto, Y.1
Ito, D.2
Yagi, T.3
Nihei, Y.4
Tsunoda, Y.5
Suzuki, N.6
-
152
-
-
6344257200
-
A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis
-
Nishimura, A.L., Mitne-Neto, M., Silva, H.C., Richieri-Costa, A., Middleton, S., Cascio, D., Kok, F., Oliveira, J.R., Gillingwater, T., Webb, J., Skehel, P. Zatz, M. (2004) A mutation in the vesicle-trafficking protein VAPB causes late-onset spinal muscular atrophy and amyotrophic lateral sclerosis. Am. J. Hum. Genet., 75, 822 831.
-
(2004)
Am. J. Hum. Genet.
, vol.75
, pp. 822-831
-
-
Nishimura, A.L.1
Mitne-Neto, M.2
Silva, H.C.3
Richieri-Costa, A.4
Middleton, S.5
Cascio, D.6
Kok, F.7
Oliveira, J.R.8
Gillingwater, T.9
Webb, J.10
Skehel, P.11
Zatz, M.12
-
153
-
-
44849124411
-
ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1
-
Nishitoh, H., Kadowaki, H., Nagai, A., Maruyama, T., Yokota, T., Fukutomi, H., Noguchi, T., Matsuzawa, A., Takeda, K. Ichijo, H. (2008) ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1. Genes Dev., 22, 1451 1464.
-
(2008)
Genes Dev.
, vol.22
, pp. 1451-1464
-
-
Nishitoh, H.1
Kadowaki, H.2
Nagai, A.3
Maruyama, T.4
Yokota, T.5
Fukutomi, H.6
Noguchi, T.7
Matsuzawa, A.8
Takeda, K.9
Ichijo, H.10
-
154
-
-
67650113333
-
Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43
-
Nonaka, T., Kametani, F., Arai, T., Akiyama, H. Hasegawa, M. (2009) Truncation and pathogenic mutations facilitate the formation of intracellular aggregates of TDP-43. Hum. Mol. Genet., 18, 3353 3364.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 3353-3364
-
-
Nonaka, T.1
Kametani, F.2
Arai, T.3
Akiyama, H.4
Hasegawa, M.5
-
155
-
-
74649086999
-
SOD1-associated ALS: A promising system for elucidating the origin of protein-misfolding disease
-
Nordlund, A. Oliveberg, M. (2008) SOD1-associated ALS: a promising system for elucidating the origin of protein-misfolding disease. HFSP J, 2, 354 364.
-
(2008)
HFSP J
, vol.2
, pp. 354-364
-
-
Nordlund, A.1
Oliveberg, M.2
-
156
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse, B., Moons, L., Storkebaum, E., Beck, H., Nuyens, D., Brusselmans, K., Van Dorpe, J., Hellings, P., Gorselink, M., Heymans, S., Theilmeier, G., Dewerchin, M., Laudenbach, V., Vermylen, P., Raat, H., Acker, T., Vleminckx, V., Van Den Bosch, L., Cashman, N., Fujisawa, H., Drost, M.R., Sciot, R., Bruyninckx, F., Hicklin, D.J., Ince, C., Gressens, P., Lupu, F., Plate, K.H., Robberecht, W., Herbert, J.M., Collen, D. Carmeliet, P. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet., 28, 131 138.
-
(2001)
Nat. Genet.
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
Beck, H.4
Nuyens, D.5
Brusselmans, K.6
Van Dorpe, J.7
Hellings, P.8
Gorselink, M.9
Heymans, S.10
Theilmeier, G.11
Dewerchin, M.12
Laudenbach, V.13
Vermylen, P.14
Raat, H.15
Acker, T.16
Vleminckx, V.17
Van Den Bosch, L.18
Cashman, N.19
Fujisawa, H.20
Drost, M.R.21
Sciot, R.22
Bruyninckx, F.23
Hicklin, D.J.24
Ince, C.25
Gressens, P.26
Lupu, F.27
Plate, K.H.28
Robberecht, W.29
Herbert, J.M.30
Collen, D.31
Carmeliet, P.32
more..
-
157
-
-
33749006845
-
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
-
Parkinson, N., Ince, P.G., Smith, M.O., Highley, R., Skibinski, G., Andersen, P.M., Morrison, K.E., Pall, H.S., Hardiman, O., Collinge, J., Shaw, P.J. Fisher, E.M. (2006) ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B). Neurology, 67, 1074 1077.
-
(2006)
Neurology
, vol.67
, pp. 1074-1077
-
-
Parkinson, N.1
Ince, P.G.2
Smith, M.O.3
Highley, R.4
Skibinski, G.5
Andersen, P.M.6
Morrison, K.E.7
Pall, H.S.8
Hardiman, O.9
Collinge, J.10
Shaw, P.J.11
Fisher, E.M.12
-
158
-
-
3242703300
-
Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria
-
Pasinelli, P., Belford, M.E., Lennon, N., Bacskai, B.J., Hyman, B.T., Trotti, D. Brown, R.H. Jr. (2004) Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron, 43, 19 30.
-
(2004)
Neuron
, vol.43
, pp. 19-30
-
-
Pasinelli, P.1
Belford, M.E.2
Lennon, N.3
Bacskai, B.J.4
Hyman, B.T.5
Trotti, D.6
Brown, Jr.R.H.7
-
159
-
-
17044403380
-
Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells
-
Patel, Y.J., Payne Smith, M.D., de Belleroche, J. Latchman, D.S. (2005) Hsp27 and Hsp70 administered in combination have a potent protective effect against FALS-associated SOD1-mutant-induced cell death in mammalian neuronal cells. Brain Res. Mol. Brain Res., 134, 256 274.
-
(2005)
Brain Res. Mol. Brain Res.
, vol.134
, pp. 256-274
-
-
Patel, Y.J.1
Payne Smith, M.D.2
De Belleroche, J.3
Latchman, D.S.4
-
160
-
-
77649252528
-
Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis
-
Pesiridis, G.S., Lee, V.M. Trojanowski, J.Q. (2009) Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Hum. Mol. Genet., 18, R156 R162.
-
(2009)
Hum. Mol. Genet.
, vol.18
-
-
Pesiridis, G.S.1
Lee, V.M.2
Trojanowski, J.Q.3
-
161
-
-
35248823549
-
Cognitive impairment in amyotrophic lateral sclerosis
-
DOI 10.1016/S1474-4422(07)70265-X, PII S147444220770265X
-
Phukan, J., Pender, N.P. Hardiman, O. (2007) Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol, 6, 994 1003. (Pubitemid 47562321)
-
(2007)
Lancet Neurology
, vol.6
, Issue.11
, pp. 994-1003
-
-
Phukan, J.1
Pender, N.P.2
Hardiman, O.3
-
162
-
-
0033551415
-
1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla
-
Pioro, E.P., Majors, A.W., Mitsumoto, H., Nelson, D.R. Ng, T.C. (1999) 1H-MRS evidence of neurodegeneration and excess glutamate + glutamine in ALS medulla. Neurology, 53, 71 79.
-
(1999)
Neurology
, vol.53
, pp. 71-79
-
-
Pioro, E.P.1
Majors, A.W.2
Mitsumoto, H.3
Nelson, D.R.4
Ng, T.C.5
-
163
-
-
54849424014
-
Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration
-
Poesen, K., Lambrechts, D., Van Damme, P., Dhondt, J., Bender, F., Frank, N., Bogaert, E., Claes, B., Heylen, L., Verheyen, A., Raes, K., Tjwa, M., Eriksson, U., Shibuya, M., Nuydens, R., Van Den Bosch, L., Meert, T., D'Hooge, R., Sendtner, M., Robberecht, W. Carmeliet, P. (2008) Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration. J. Neurosci., 28, 10451 10459.
-
(2008)
J. Neurosci.
, vol.28
, pp. 10451-10459
-
-
Poesen, K.1
Lambrechts, D.2
Van Damme, P.3
Dhondt, J.4
Bender, F.5
Frank, N.6
Bogaert, E.7
Claes, B.8
Heylen, L.9
Verheyen, A.10
Raes, K.11
Tjwa, M.12
Eriksson, U.13
Shibuya, M.14
Nuydens, R.15
Van Den Bosch, L.16
Meert, T.17
D'Hooge, R.18
Sendtner, M.19
Robberecht, W.20
Carmeliet, P.21
more..
-
164
-
-
0036241663
-
Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo
-
Pokholok, D.K., Hannett, N.M. Young, R.A. (2002) Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo. Mol. Cell, 9, 799 809.
-
(2002)
Mol. Cell
, vol.9
, pp. 799-809
-
-
Pokholok, D.K.1
Hannett, N.M.2
Young, R.A.3
-
165
-
-
0037382240
-
Mutant dynactin in motor neuron disease
-
Puls, I., Jonnakuty, C., LaMonte, B.H., Holzbaur, E.L., Tokito, M., Mann, E., Floeter, M.K., Bidus, K., Drayna, D., Oh, S.J., Brown, R.H. Jr., Ludlow, C.L. Fischbeck, K.H. (2003) Mutant dynactin in motor neuron disease. Nat. Genet., 33, 455 456.
-
(2003)
Nat. Genet.
, vol.33
, pp. 455-456
-
-
Puls, I.1
Jonnakuty, C.2
Lamonte, B.H.3
Holzbaur, E.L.4
Tokito, M.5
Mann, E.6
Floeter, M.K.7
Bidus, K.8
Drayna, D.9
Oh, S.J.10
Brown, Jr.R.H.11
Ludlow, C.L.12
Fischbeck, K.H.13
-
166
-
-
0347155578
-
Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis
-
Rakhit, R., Cunningham, P., Furtos-Matei, A., Dahan, S., Qi, X.F., Crow, J.P., Cashman, N.R., Kondejewski, L.H. Chakrabartty, A. (2002) Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis. J. Biol. Chem., 277, 47551 47556.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47551-47556
-
-
Rakhit, R.1
Cunningham, P.2
Furtos-Matei, A.3
Dahan, S.4
Qi, X.F.5
Crow, J.P.6
Cashman, N.R.7
Kondejewski, L.H.8
Chakrabartty, A.9
-
167
-
-
20244381261
-
Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model
-
Ralph, G.S., Radcliffe, P.A., Day, D.M., Carthy, J.M., Leroux, M.A., Lee, D.C., Wong, L.F., Bilsland, L.G., Greensmith, L., Kingsman, S.M., Mitrophanous, K.A., Mazarakis, N.D. Azzouz, M. (2005) Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model. Nat. Med., 11, 429 433.
-
(2005)
Nat. Med.
, vol.11
, pp. 429-433
-
-
Ralph, G.S.1
Radcliffe, P.A.2
Day, D.M.3
Carthy, J.M.4
Leroux, M.A.5
Lee, D.C.6
Wong, L.F.7
Bilsland, L.G.8
Greensmith, L.9
Kingsman, S.M.10
Mitrophanous, K.A.11
Mazarakis, N.D.12
Azzouz, M.13
-
168
-
-
0345269737
-
Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
-
Rao, S.D., Yin, H.Z. Weiss, J.H. (2003) Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons. J. Neurosci., 23, 2627 2633.
-
(2003)
J. Neurosci.
, vol.23
, pp. 2627-2633
-
-
Rao, S.D.1
Yin, H.Z.2
Weiss, J.H.3
-
169
-
-
33747191785
-
BMAA selectively injures motor neurons via AMPA/kainate receptor activation
-
Rao, S.D., Banack, S.A., Cox, P.A. Weiss, J.H. (2006) BMAA selectively injures motor neurons via AMPA/kainate receptor activation. Exp. Neurol., 201, 244 252.
-
(2006)
Exp. Neurol.
, vol.201
, pp. 244-252
-
-
Rao, S.D.1
Banack, S.A.2
Cox, P.A.3
Weiss, J.H.4
-
170
-
-
17644383664
-
Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS
-
Raoul, C., Abbas-Terki, T., Bensadoun, J.C., Guillot, S., Haase, G., Szulc, J., Henderson, C.E. Aebischer, P. (2005) Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS. Nat. Med., 11, 423 428.
-
(2005)
Nat. Med.
, vol.11
, pp. 423-428
-
-
Raoul, C.1
Abbas-Terki, T.2
Bensadoun, J.C.3
Guillot, S.4
Haase, G.5
Szulc, J.6
Henderson, C.E.7
Aebischer, P.8
-
171
-
-
0037062609
-
The prevalence of frontotemporal dementia
-
Ratnavalli, E., Brayne, C., Dawson, K. Hodges, J.R. (2002) The prevalence of frontotemporal dementia. Neurology, 58, 1615 1621.
-
(2002)
Neurology
, vol.58
, pp. 1615-1621
-
-
Ratnavalli, E.1
Brayne, C.2
Dawson, K.3
Hodges, J.R.4
-
172
-
-
15844393658
-
Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury
-
Reaume, A.G., Elliott, J.L., Hoffman, E.K., Kowall, N.W., Ferrante, R.J., Siwek, D.F., Wilcox, H.M., Flood, D.G., Beal, M.F., Brown, R.H. Jr., Scott, R.W. Snider, W.D. (1996) Motor neurons in Cu/Zn superoxide dismutase-deficient mice develop normally but exhibit enhanced cell death after axonal injury. Nat. Genet., 13, 43 47.
-
(1996)
Nat. Genet.
, vol.13
, pp. 43-47
-
-
Reaume, A.G.1
Elliott, J.L.2
Hoffman, E.K.3
Kowall, N.W.4
Ferrante, R.J.5
Siwek, D.F.6
Wilcox, H.M.7
Flood, D.G.8
Beal, M.F.9
Brown, Jr.R.H.10
Scott, R.W.11
Snider, W.D.12
-
173
-
-
32944476045
-
The G93C mutation in superoxide dismutase 1: Clinicopathologic phenotype and prognosis
-
Regal, L., Vanopdenbosch, L., Tilkin, P., Van den Bosch, L., Thijs, V., Sciot, R. Robberecht, W. (2006) The G93C mutation in superoxide dismutase 1: clinicopathologic phenotype and prognosis. Arch. Neurol., 63, 262 267.
-
(2006)
Arch. Neurol.
, vol.63
, pp. 262-267
-
-
Regal, L.1
Vanopdenbosch, L.2
Tilkin, P.3
Van Den Bosch, L.4
Thijs, V.5
Sciot, R.6
Robberecht, W.7
-
174
-
-
18644365196
-
A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10)
-
Reid, E., Kloos, M., Ashley-Koch, A., Hughes, L., Bevan, S., Svenson, I.K., Graham, F.L., Gaskell, P.C., Dearlove, A., Pericak-Vance, M.A., Rubinsztein, D.C. Marchuk, D.A. (2002) A kinesin heavy chain (KIF5A) mutation in hereditary spastic paraplegia (SPG10). Am. J. Hum. Genet., 71, 1189 1194.
-
(2002)
Am. J. Hum. Genet.
, vol.71
, pp. 1189-1194
-
-
Reid, E.1
Kloos, M.2
Ashley-Koch, A.3
Hughes, L.4
Bevan, S.5
Svenson, I.K.6
Graham, F.L.7
Gaskell, P.C.8
Dearlove, A.9
Pericak-Vance, M.A.10
Rubinsztein, D.C.11
Marchuk, D.A.12
-
175
-
-
0033349884
-
UNC-13 is required for synaptic vesicle fusion in C. elegans
-
Richmond, J.E., Davis, W.S. Jorgensen, E.M. (1999) UNC-13 is required for synaptic vesicle fusion in C. elegans. Nat. Neurosci., 2, 959 964.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 959-964
-
-
Richmond, J.E.1
Davis, W.S.2
Jorgensen, E.M.3
-
176
-
-
0028888945
-
Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
-
Ripps, M.E., Huntley, G.W., Hof, P.R., Morrison, J.H. Gordon, J.W. (1995) Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 92, 689 693.
-
(1995)
Proc. Natl Acad. Sci. USA
, vol.92
, pp. 689-693
-
-
Ripps, M.E.1
Huntley, G.W.2
Hof, P.R.3
Morrison, J.H.4
Gordon, J.W.5
-
177
-
-
0027952571
-
Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis
-
Robberecht, W., Sapp, P., Viaene, M.K., Rosen, D., McKenna-Yasek, D., Haines, J., Horvitz, R., Theys, P. Brown, R. Jr. (1994) Cu/Zn superoxide dismutase activity in familial and sporadic amyotrophic lateral sclerosis. J. Neurochem., 62, 384 387.
-
(1994)
J. Neurochem.
, vol.62
, pp. 384-387
-
-
Robberecht, W.1
Sapp, P.2
Viaene, M.K.3
Rosen, D.4
McKenna-Yasek, D.5
Haines, J.6
Horvitz, R.7
Theys, P.8
Brown, Jr.R.9
-
178
-
-
0029854883
-
D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis
-
Robberecht, W., Aguirre, T., Van den Bosch, L., Tilkin, P., Cassiman, J.J. Matthijs, G. (1996) D90A heterozygosity in the SOD1 gene is associated with familial and apparently sporadic amyotrophic lateral sclerosis. Neurology, 47, 1336 1339.
-
(1996)
Neurology
, vol.47
, pp. 1336-1339
-
-
Robberecht, W.1
Aguirre, T.2
Van Den Bosch, L.3
Tilkin, P.4
Cassiman, J.J.5
Matthijs, G.6
-
179
-
-
34249313704
-
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS
-
Robertson, J., Sanelli, T., Xiao, S., Yang, W., Horne, P., Hammond, R., Pioro, E.P. Strong, M.J. (2007) Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS. Neurosci. Lett., 420, 128 132.
-
(2007)
Neurosci. Lett.
, vol.420
, pp. 128-132
-
-
Robertson, J.1
Sanelli, T.2
Xiao, S.3
Yang, W.4
Horne, P.5
Hammond, R.6
Pioro, E.P.7
Strong, M.J.8
-
180
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen, D.R., Siddique, T., Patterson, D., Figlewicz, D.A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J.P., Deng, H.X. et al. (1993) Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature, 362, 59 62.
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
-
181
-
-
0028343223
-
A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis
-
Rosen, D.R., Bowling, A.C., Patterson, D., Usdin, T.B., Sapp, P., Mezey, E., McKenna-Yasek, D., O'Regan, J., Rahmani, Z., Ferrante, R.J. et al. (1994) A frequent ala 4 to val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis. Hum. Mol. Genet., 3, 981 987.
-
(1994)
Hum. Mol. Genet.
, vol.3
, pp. 981-987
-
-
Rosen, D.R.1
Bowling, A.C.2
Patterson, D.3
Usdin, T.B.4
Sapp, P.5
Mezey, E.6
McKenna-Yasek, D.7
O'Regan, J.8
Rahmani, Z.9
Ferrante, R.J.10
-
182
-
-
0037204063
-
Differential control of vesicle priming and short-term plasticity by Munc13 isoforms
-
Rosenmund, C., Sigler, A., Augustin, I., Reim, K., Brose, N. Rhee, J.S. (2002) Differential control of vesicle priming and short-term plasticity by Munc13 isoforms. Neuron, 33, 411 424.
-
(2002)
Neuron
, vol.33
, pp. 411-424
-
-
Rosenmund, C.1
Sigler, A.2
Augustin, I.3
Reim, K.4
Brose, N.5
Rhee, J.S.6
-
183
-
-
0026597010
-
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
-
Rothstein, J.D., Martin, L.J. Kuncl, R.W. (1992) Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N. Engl. J. Med., 326, 1464 1468.
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1464-1468
-
-
Rothstein, J.D.1
Martin, L.J.2
Kuncl, R.W.3
-
184
-
-
0027274623
-
Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
-
Rothstein, J.D., Jin, L., Dykes-Hoberg, M. Kuncl, R.W. (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl Acad. Sci. USA, 90, 6591 6595.
-
(1993)
Proc. Natl Acad. Sci. USA
, vol.90
, pp. 6591-6595
-
-
Rothstein, J.D.1
Jin, L.2
Dykes-Hoberg, M.3
Kuncl, R.W.4
-
185
-
-
0029030610
-
Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis
-
Rothstein, J.D., Van Kammen, M., Levey, A.I., Martin, L.J. Kuncl, R.W. (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol., 38, 73 84.
-
(1995)
Ann. Neurol.
, vol.38
, pp. 73-84
-
-
Rothstein, J.D.1
Van Kammen, M.2
Levey, A.I.3
Martin, L.J.4
Kuncl, R.W.5
-
186
-
-
19944428649
-
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
-
Rothstein, J.D., Patel, S., Regan, M.R., Haenggeli, C., Huang, Y.H., Bergles, D.E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D.S., Toan, S.V., Bruijn, L.I., Su, Z.Z., Gupta, P. Fisher, P.B. (2005) Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature, 433, 73 77.
-
(2005)
Nature
, vol.433
, pp. 73-77
-
-
Rothstein, J.D.1
Patel, S.2
Regan, M.R.3
Haenggeli, C.4
Huang, Y.H.5
Bergles, D.E.6
Jin, L.7
Dykes Hoberg, M.8
Vidensky, S.9
Chung, D.S.10
Toan, S.V.11
Bruijn, L.I.12
Su, Z.Z.13
Gupta, P.14
Fisher, P.B.15
-
188
-
-
0034615835
-
Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity
-
Saroff, D., Delfs, J., Kuznetsov, D. Geula, C. (2000) Selective vulnerability of spinal cord motor neurons to non-NMDA toxicity. Neuroreport, 11, 1117 1121.
-
(2000)
Neuroreport
, vol.11
, pp. 1117-1121
-
-
Saroff, D.1
Delfs, J.2
Kuznetsov, D.3
Geula, C.4
-
189
-
-
67349164383
-
A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice
-
Saxena, S., Cabuy, E. Caroni, P. (2009) A role for motoneuron subtype-selective ER stress in disease manifestations of FALS mice. Nat. Neurosci., 12, 627 636.
-
(2009)
Nat. Neurosci.
, vol.12
, pp. 627-636
-
-
Saxena, S.1
Cabuy, E.2
Caroni, P.3
-
190
-
-
34347245619
-
Progranulin mutations and ALS or ALS-FTD phenotypes
-
Schymick, J., Yang, Y., Andersen, P., Vonsattel, J., Greenway, M., Momeni, P., Elder, J., Chio, A., Restagno, G., Robberecht, W., Dahlberg, C., Mukherjee, O., Goate, A., Graff-Radford, N., Caselli, R., Hutton, M., Gass, J., Cannon, A., Rademakers, R., Singleton, A., Hardiman, O., Rothstein, J., Hardy, J. Traynor, B. (2007a) Progranulin mutations and ALS or ALS-FTD phenotypes. J. Neurol. Neurosurg. Psychiatry, 78, 754 756.
-
(2007)
J. Neurol. Neurosurg. Psychiatry
, vol.78
, pp. 754-756
-
-
Schymick, J.1
Yang, Y.2
Andersen, P.3
Vonsattel, J.4
Greenway, M.5
Momeni, P.6
Elder, J.7
Chio, A.8
Restagno, G.9
Robberecht, W.10
Dahlberg, C.11
Mukherjee, O.12
Goate, A.13
Graff-Radford, N.14
Caselli, R.15
Hutton, M.16
Gass, J.17
Cannon, A.18
Rademakers, R.19
Singleton, A.20
Hardiman, O.21
Rothstein, J.22
Hardy, J.23
Traynor, B.24
more..
-
191
-
-
33847622526
-
Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: First stage analysis and public release of data
-
Schymick, J.C., Scholz, S.W., Fung, H.C., Britton, A., Arepalli, S., Gibbs, J.R., Lombardo, F., Matarin, M., Kasperaviciute, D., Hernandez, D.G., Crews, C., Bruijn, L., Rothstein, J., Mora, G., Restagno, G., Chio, A., Singleton, A., Hardy, J. Traynor, B.J. (2007b) Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol, 6, 322 328.
-
(2007)
Lancet Neurol
, vol.6
, pp. 322-328
-
-
Schymick, J.C.1
Scholz, S.W.2
Fung, H.C.3
Britton, A.4
Arepalli, S.5
Gibbs, J.R.6
Lombardo, F.7
Matarin, M.8
Kasperaviciute, D.9
Hernandez, D.G.10
Crews, C.11
Bruijn, L.12
Rothstein, J.13
Mora, G.14
Restagno, G.15
Chio, A.16
Singleton, A.17
Hardy, J.18
Traynor, B.J.19
-
192
-
-
69049110867
-
Angiogenin protects motoneurons against hypoxic injury
-
Sebastia, J., Kieran, D., Breen, B., King, M.A., Netteland, D.F., Joyce, D., Fitzpatrick, S.F., Taylor, C.T. Prehn, J.H. (2009) Angiogenin protects motoneurons against hypoxic injury. Cell Death Differ., 16, 1238 1247.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1238-1247
-
-
Sebastia, J.1
Kieran, D.2
Breen, B.3
King, M.A.4
Netteland, D.F.5
Joyce, D.6
Fitzpatrick, S.F.7
Taylor, C.T.8
Prehn, J.H.9
-
193
-
-
77949878273
-
TDP-43 is a developmentally regulated protein essential for early embryonic development
-
Sephton, C.F., Good, S.K., Atkin, S., Dewey, C.M., Mayer, P. III., Herz, J. Yu, G. (2010) TDP-43 is a developmentally regulated protein essential for early embryonic development. J. Biol. Chem., 285, 6826 6834.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 6826-6834
-
-
Sephton, C.F.1
Good, S.K.2
Atkin, S.3
Dewey, C.M.4
Mayer III, P.5
Herz, J.6
Yu, G.7
-
194
-
-
65149101697
-
Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS
-
Shan, X., Vocadlo, D. Krieger, C. (2009) Mislocalization of TDP-43 in the G93A mutant SOD1 transgenic mouse model of ALS. Neurosci. Lett., 458, 70 74.
-
(2009)
Neurosci. Lett.
, vol.458
, pp. 70-74
-
-
Shan, X.1
Vocadlo, D.2
Krieger, C.3
-
195
-
-
33846678063
-
How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein?
-
Shaw, B.F. Valentine, J.S. (2007) How do ALS-associated mutations in superoxide dismutase 1 promote aggregation of the protein? Trends Biochem. Sci., 32, 78 85.
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 78-85
-
-
Shaw, B.F.1
Valentine, J.S.2
-
196
-
-
71849118179
-
Mitochondrial dysfunction in amyotrophic lateral sclerosis
-
Shi, P., Gal, J., Kwinter, D.M., Liu, X. Zhu, H. (2010) Mitochondrial dysfunction in amyotrophic lateral sclerosis. Biochim. Biophys. Acta, 1802, 45 51.
-
(2010)
Biochim. Biophys. Acta
, vol.1802
, pp. 45-51
-
-
Shi, P.1
Gal, J.2
Kwinter, D.M.3
Liu, X.4
Zhu, H.5
-
197
-
-
46949108172
-
Genetics of amyotrophic lateral sclerosis
-
vii
-
Siddique, N. Siddique, T. (2008) Genetics of amyotrophic lateral sclerosis. Phys Med Rehabil Clin N Am, 19, 429 439, vii.
-
(2008)
Phys Med Rehabil Clin N Am
, vol.19
, pp. 429-439
-
-
Siddique, N.1
Siddique, T.2
-
198
-
-
67649871266
-
A common molecular basis for membrane docking and functional priming of synaptic vesicles
-
Siksou, L., Varoqueaux, F., Pascual, O., Triller, A., Brose, N. Marty, S. (2009) A common molecular basis for membrane docking and functional priming of synaptic vesicles. Eur. J. Neurosci., 30, 49 56.
-
(2009)
Eur. J. Neurosci.
, vol.30
, pp. 49-56
-
-
Siksou, L.1
Varoqueaux, F.2
Pascual, O.3
Triller, A.4
Brose, N.5
Marty, S.6
-
199
-
-
58749097964
-
Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration
-
Simpson, C.L., Lemmens, R., Miskiewicz, K., Broom, W.J., Hansen, V.K., van Vught, P.W., Landers, J.E., Sapp, P., Van Den Bosch, L., Knight, J., Neale, B.M., Turner, M.R., Veldink, J.H., Ophoff, R.A., Tripathi, V.B., Beleza, A., Shah, M.N., Proitsi, P., Van Hoecke, A., Carmeliet, P., Horvitz, H.R., Leigh, P.N., Shaw, C.E., van den Berg, L.H., Sham, P.C., Powell, J.F., Verstreken, P., Brown, R.H. Jr., Robberecht, W. Al-Chalabi, A. (2009) Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration. Hum. Mol. Genet., 18, 472 481.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 472-481
-
-
Simpson, C.L.1
Lemmens, R.2
Miskiewicz, K.3
Broom, W.J.4
Hansen, V.K.5
Van Vught, P.W.6
Landers, J.E.7
Sapp, P.8
Van Den Bosch, L.9
Knight, J.10
Neale, B.M.11
Turner, M.R.12
Veldink, J.H.13
Ophoff, R.A.14
Tripathi, V.B.15
Beleza, A.16
Shah, M.N.17
Proitsi, P.18
Van Hoecke, A.19
Carmeliet, P.20
Horvitz, H.R.21
Leigh, P.N.22
Shaw, C.E.23
Van Den Berg, L.H.24
Sham, P.C.25
Powell, J.F.26
Verstreken, P.27
Brown, Jr.R.H.28
Robberecht, W.29
Al-Chalabi, A.30
more..
-
200
-
-
0035089807
-
Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia
-
Slaugenhaupt, S.A., Blumenfeld, A., Gill, S.P., Leyne, M., Mull, J., Cuajungco, M.P., Liebert, C.B., Chadwick, B., Idelson, M., Reznik, L., Robbins, C., Makalowska, I., Brownstein, M., Krappmann, D., Scheidereit, C., Maayan, C., Axelrod, F.B. Gusella, J.F. (2001) Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia. Am. J. Hum. Genet., 68, 598 605.
-
(2001)
Am. J. Hum. Genet.
, vol.68
, pp. 598-605
-
-
Slaugenhaupt, S.A.1
Blumenfeld, A.2
Gill, S.P.3
Leyne, M.4
Mull, J.5
Cuajungco, M.P.6
Liebert, C.B.7
Chadwick, B.8
Idelson, M.9
Reznik, L.10
Robbins, C.11
Makalowska, I.12
Brownstein, M.13
Krappmann, D.14
Scheidereit, C.15
Maayan, C.16
Axelrod, F.B.17
Gusella, J.F.18
-
201
-
-
42049120518
-
Progranulin genetic variability contributes to amyotrophic lateral sclerosis
-
Sleegers, K., Brouwers, N., Maurer-Stroh, S., van Es, M.A., Van Damme, P., van Vught, P.W., van der Zee, J., Serneels, S., De Pooter, T., Van den Broeck, M., Cruts, M., Schymkowitz, J., De Jonghe, P., Rousseau, F., van den Berg, L.H., Robberecht, W. Van Broeckhoven, C. (2008) Progranulin genetic variability contributes to amyotrophic lateral sclerosis. Neurology, 71, 253 259.
-
(2008)
Neurology
, vol.71
, pp. 253-259
-
-
Sleegers, K.1
Brouwers, N.2
Maurer-Stroh, S.3
Van Es, M.A.4
Van Damme, P.5
Van Vught, P.W.6
Van Der Zee, J.7
Serneels, S.8
De Pooter, T.9
Van Den Broeck, M.10
Cruts, M.11
Schymkowitz, J.12
De Jonghe, P.13
Rousseau, F.14
Van Den Berg, L.H.15
Robberecht, W.16
Van Broeckhoven, C.17
-
202
-
-
33746667851
-
Antisense oligonucleotide therapy for neurodegenerative disease
-
Smith, R.A., Miller, T.M., Yamanaka, K., Monia, B.P., Condon, T.P., Hung, G., Lobsiger, C.S., Ward, C.M., McAlonis-Downes, M., Wei, H., Wancewicz, E.V., Bennett, C.F. Cleveland, D.W. (2006) Antisense oligonucleotide therapy for neurodegenerative disease. J. Clin. Invest., 116, 2290 2296.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 2290-2296
-
-
Smith, R.A.1
Miller, T.M.2
Yamanaka, K.3
Monia, B.P.4
Condon, T.P.5
Hung, G.6
Lobsiger, C.S.7
Ward, C.M.8
McAlonis-Downes, M.9
Wei, H.10
Wancewicz, E.V.11
Bennett, C.F.12
Cleveland, D.W.13
-
203
-
-
76749123484
-
The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation
-
Solinger, J.A., Paolinelli, R., Kloss, H., Scorza, F.B., Marchesi, S., Sauder, U., Mitsushima, D., Capuani, F., Sturzenbaum, S.R. Cassata, G. (2010) The Caenorhabditis elegans Elongator complex regulates neuronal alpha-tubulin acetylation. PLoS Genet, 6, e1000820.
-
(2010)
PLoS Genet
, vol.6
, pp. 1000820
-
-
Solinger, J.A.1
Paolinelli, R.2
Kloss, H.3
Scorza, F.B.4
Marchesi, S.5
Sauder, U.6
Mitsushima, D.7
Capuani, F.8
Sturzenbaum, S.R.9
Cassata, G.10
-
204
-
-
34047224991
-
Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation
-
Spina, S., Murrell, J.R., Huey, E.D., Wassermann, E.M., Pietrini, P., Baraibar, M.A., Barbeito, A.G., Troncoso, J.C., Vidal, R., Ghetti, B. Grafman, J. (2007) Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation. Neurology, 68, 820 827.
-
(2007)
Neurology
, vol.68
, pp. 820-827
-
-
Spina, S.1
Murrell, J.R.2
Huey, E.D.3
Wassermann, E.M.4
Pietrini, P.5
Baraibar, M.A.6
Barbeito, A.G.7
Troncoso, J.C.8
Vidal, R.9
Ghetti, B.10
Grafman, J.11
-
205
-
-
41149180753
-
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
-
Sreedharan, J., Blair, I.P., Tripathi, V.B., Hu, X., Vance, C., Rogelj, B., Ackerley, S., Durnall, J.C., Williams, K.L., Buratti, E., Baralle, F., de Belleroche, J., Mitchell, J.D., Leigh, P.N., Al-Chalabi, A., Miller, C.C., Nicholson, G. Shaw, C.E. (2008) TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science, 319, 1668 1672.
-
(2008)
Science
, vol.319
, pp. 1668-1672
-
-
Sreedharan, J.1
Blair, I.P.2
Tripathi, V.B.3
Hu, X.4
Vance, C.5
Rogelj, B.6
Ackerley, S.7
Durnall, J.C.8
Williams, K.L.9
Buratti, E.10
Baralle, F.11
De Belleroche, J.12
Mitchell, J.D.13
Leigh, P.N.14
Al-Chalabi, A.15
Miller, C.C.16
Nicholson, G.17
Shaw, C.E.18
-
206
-
-
16644382257
-
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
-
Storkebaum, E., Lambrechts, D., Dewerchin, M., Moreno-Murciano, M.P., Appelmans, S., Oh, H., Van Damme, P., Rutten, B., Man, W.Y., De Mol, M., Wyns, S., Manka, D., Vermeulen, K., Van Den Bosch, L., Mertens, N., Schmitz, C., Robberecht, W., Conway, E.M., Collen, D., Moons, L. Carmeliet, P. (2005) Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci., 8, 85 92.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 85-92
-
-
Storkebaum, E.1
Lambrechts, D.2
Dewerchin, M.3
Moreno-Murciano, M.P.4
Appelmans, S.5
Oh, H.6
Van Damme, P.7
Rutten, B.8
Man, W.Y.9
De Mol, M.10
Wyns, S.11
Manka, D.12
Vermeulen, K.13
Van Den Bosch, L.14
Mertens, N.15
Schmitz, C.16
Robberecht, W.17
Conway, E.M.18
Collen, D.19
Moons, L.20
Carmeliet, P.21
more..
-
207
-
-
71049166754
-
The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS)
-
Strong, M.J. (2010) The evidence for altered RNA metabolism in amyotrophic lateral sclerosis (ALS). J. Neurol. Sci., 288, 1 12.
-
(2010)
J. Neurol. Sci.
, vol.288
, pp. 1-12
-
-
Strong, M.J.1
-
208
-
-
34249751076
-
TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein
-
DOI 10.1016/j.mcn.2007.03.007, PII S1044743107000784
-
Strong, M.J., Volkening, K., Hammond, R., Yang, W., Strong, W., Leystra-Lantz, C. Shoesmith, C. (2007) TDP43 is a human low molecular weight neurofilament (hNFL) mRNA-binding protein. Mol. Cell. Neurosci., 35, 320 327. (Pubitemid 46843567)
-
(2007)
Molecular and Cellular Neuroscience
, vol.35
, Issue.2
, pp. 320-327
-
-
Strong, M.J.1
Volkening, K.2
Hammond, R.3
Yang, W.4
Strong, W.5
Leystra-Lantz, C.6
Shoesmith, C.7
-
209
-
-
37549019664
-
Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons
-
Subramanian, V., Crabtree, B. Acharya, K.R. (2008) Human angiogenin is a neuroprotective factor and amyotrophic lateral sclerosis associated angiogenin variants affect neurite extension/pathfinding and survival of motor neurons. Hum. Mol. Genet., 17, 130 149.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 130-149
-
-
Subramanian, V.1
Crabtree, B.2
Acharya, K.R.3
-
210
-
-
64049116333
-
Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis
-
Sumi, H., Kato, S., Mochimaru, Y., Fujimura, H., Etoh, M. Sakoda, S. (2009) Nuclear TAR DNA binding protein 43 expression in spinal cord neurons correlates with the clinical course in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 68, 37 47.
-
(2009)
J. Neuropathol. Exp. Neurol.
, vol.68
, pp. 37-47
-
-
Sumi, H.1
Kato, S.2
Mochimaru, Y.3
Fujimura, H.4
Etoh, M.5
Sakoda, S.6
-
211
-
-
58549088349
-
ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB
-
Suzuki, H., Kanekura, K., Levine, T.P., Kohno, K., Olkkonen, V.M., Aiso, S. Matsuoka, M. (2009) ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB. J. Neurochem., 108, 973 985.
-
(2009)
J. Neurochem.
, vol.108
, pp. 973-985
-
-
Suzuki, H.1
Kanekura, K.2
Levine, T.P.3
Kohno, K.4
Olkkonen, V.M.5
Aiso, S.6
Matsuoka, M.7
-
212
-
-
77951712967
-
FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion
-
Suzuki, N., Aoki, M., Warita, H., Kato, M., Mizuno, H., Shimakura, N., Akiyama, T., Furuya, H., Hokonohara, T., Iwaki, A., Togashi, S., Konno, H. Itoyama, Y. (2010) FALS with FUS mutation in Japan, with early onset, rapid progress and basophilic inclusion. J. Hum. Genet., 55, 252 254.
-
(2010)
J. Hum. Genet.
, vol.55
, pp. 252-254
-
-
Suzuki, N.1
Aoki, M.2
Warita, H.3
Kato, M.4
Mizuno, H.5
Shimakura, N.6
Akiyama, T.7
Furuya, H.8
Hokonohara, T.9
Iwaki, A.10
Togashi, S.11
Konno, H.12
Itoyama, Y.13
-
213
-
-
34247606414
-
TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation
-
Tan, C.F., Eguchi, H., Tagawa, A., Onodera, O., Iwasaki, T., Tsujino, A., Nishizawa, M., Kakita, A. Takahashi, H. (2007) TDP-43 immunoreactivity in neuronal inclusions in familial amyotrophic lateral sclerosis with or without SOD1 gene mutation. Acta Neuropathol., 113, 535 542.
-
(2007)
Acta Neuropathol.
, vol.113
, pp. 535-542
-
-
Tan, C.F.1
Eguchi, H.2
Tagawa, A.3
Onodera, O.4
Iwasaki, T.5
Tsujino, A.6
Nishizawa, M.7
Kakita, A.8
Takahashi, H.9
-
214
-
-
5444222849
-
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model
-
Tateno, M., Sadakata, H., Tanaka, M., Itohara, S., Shin, R.M., Miura, M., Masuda, M., Aosaki, T., Urushitani, M., Misawa, H. Takahashi, R. (2004) Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model. Hum. Mol. Genet., 13, 2183 2196.
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2183-2196
-
-
Tateno, M.1
Sadakata, H.2
Tanaka, M.3
Itohara, S.4
Shin, R.M.5
Miura, M.6
Masuda, M.7
Aosaki, T.8
Urushitani, M.9
Misawa, H.10
Takahashi, R.11
-
215
-
-
70849113863
-
Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization
-
Teilum, K., Smith, M.H., Schulz, E., Christensen, L.C., Solomentsev, G., Oliveberg, M. Akke, M. (2009) Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization. Proc. Natl Acad. Sci. USA, 106, 18273 18278.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 18273-18278
-
-
Teilum, K.1
Smith, M.H.2
Schulz, E.3
Christensen, L.C.4
Solomentsev, G.5
Oliveberg, M.6
Akke, M.7
-
216
-
-
34848904785
-
Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates
-
Teuling, E., Ahmed, S., Haasdijk, E., Demmers, J., Steinmetz, M.O., Akhmanova, A., Jaarsma, D. Hoogenraad, C.C. (2007) Motor neuron disease-associated mutant vesicle-associated membrane protein-associated protein (VAP) B recruits wild-type VAPs into endoplasmic reticulum-derived tubular aggregates. J. Neurosci., 27, 9801 9815.
-
(2007)
J. Neurosci.
, vol.27
, pp. 9801-9815
-
-
Teuling, E.1
Ahmed, S.2
Haasdijk, E.3
Demmers, J.4
Steinmetz, M.O.5
Akhmanova, A.6
Jaarsma, D.7
Hoogenraad, C.C.8
-
217
-
-
70350156915
-
Mutational analysis of TARDBP in neurodegenerative diseases
-
Ticozzi, N., Leclerc, A.L., van Blitterswijk, M., Keagle, P., McKenna-Yasek, D.M., Sapp, P.C., Silani, V., Wills, A.M., Brown, R.H. Jr. Landers, J.E. (2009a) Mutational analysis of TARDBP in neurodegenerative diseases. Neurobiol. Aging, 73, 1180 1185.
-
(2009)
Neurobiol. Aging
, vol.73
, pp. 1180-1185
-
-
Ticozzi, N.1
Leclerc, A.L.2
Van Blitterswijk, M.3
Keagle, P.4
McKenna-Yasek, D.M.5
Sapp, P.C.6
Silani, V.7
Wills, A.M.8
Brown, Jr.R.H.9
Landers, J.E.10
-
218
-
-
70350156915
-
Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort
-
Ticozzi, N., Silani, V., LeClerc, A.L., Keagle, P., Gellera, C., Ratti, A., Taroni, F., Kwiatkowski, T.J. Jr., McKenna-Yasek, D.M., Sapp, P.C., Brown, R.H. Jr. Landers, J.E. (2009b) Analysis of FUS gene mutation in familial amyotrophic lateral sclerosis within an Italian cohort. Neurology, 73, 1180 1185.
-
(2009)
Neurology
, vol.73
, pp. 1180-1185
-
-
Ticozzi, N.1
Silani, V.2
Leclerc, A.L.3
Keagle, P.4
Gellera, C.5
Ratti, A.6
Taroni, F.7
Kwiatkowski, Jr.T.J.8
McKenna-Yasek, D.M.9
Sapp, P.C.10
Brown, Jr.R.H.11
Landers, J.E.12
-
219
-
-
30344437262
-
Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease
-
Tortarolo, M., Grignaschi, G., Calvaresi, N., Zennaro, E., Spaltro, G., Colovic, M., Fracasso, C., Guiso, G., Elger, B., Schneider, H., Seilheimer, B., Caccia, S. Bendotti, C. (2006) Glutamate AMPA receptors change in motor neurons of SOD1G93A transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amytrophic lateral sclerosis-like disease. J. Neurosci. Res., 83, 134 146.
-
(2006)
J. Neurosci. Res.
, vol.83
, pp. 134-146
-
-
Tortarolo, M.1
Grignaschi, G.2
Calvaresi, N.3
Zennaro, E.4
Spaltro, G.5
Colovic, M.6
Fracasso, C.7
Guiso, G.8
Elger, B.9
Schneider, H.10
Seilheimer, B.11
Caccia, S.12
Bendotti, C.13
-
220
-
-
44349169012
-
Systemic AAV6 delivery mediating RNA interference against SOD1: Neuromuscular transduction does not alter disease progression in fALS mice
-
Towne, C., Raoul, C., Schneider, B.L. Aebischer, P. (2008) Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice. Mol Ther, 16, 1018 1025.
-
(2008)
Mol Ther
, vol.16
, pp. 1018-1025
-
-
Towne, C.1
Raoul, C.2
Schneider, B.L.3
Aebischer, P.4
-
221
-
-
42049091220
-
Molecular insights and therapeutic targets in amyotrophic lateral sclerosis
-
Tripathi, V.B. Al-Chalabi, A. (2008) Molecular insights and therapeutic targets in amyotrophic lateral sclerosis. CNS Neurol Disord Drug Targets, 7, 11 19.
-
(2008)
CNS Neurol Disord Drug Targets
, vol.7
, pp. 11-19
-
-
Tripathi, V.B.1
Al-Chalabi, A.2
-
222
-
-
0033366461
-
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
-
Trotti, D., Rolfs, A., Danbolt, N.C., Brown, R.H. Jr. Hediger, M.A. (1999) SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter. Nat. Neurosci., 2, 427 433.
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 427-433
-
-
Trotti, D.1
Rolfs, A.2
Danbolt, N.C.3
Brown, Jr.R.H.4
Hediger, M.A.5
-
223
-
-
43449099127
-
The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors
-
Tsuda, H., Han, S.M., Yang, Y., Tong, C., Lin, Y.Q., Mohan, K., Haueter, C., Zoghbi, A., Harati, Y., Kwan, J., Miller, M.A. Bellen, H.J. (2008) The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors. Cell, 133, 963 977.
-
(2008)
Cell
, vol.133
, pp. 963-977
-
-
Tsuda, H.1
Han, S.M.2
Yang, Y.3
Tong, C.4
Lin, Y.Q.5
Mohan, K.6
Haueter, C.7
Zoghbi, A.8
Harati, Y.9
Kwan, J.10
Miller, M.A.11
Bellen, H.J.12
-
224
-
-
42249102078
-
Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS
-
Turner, B.J. Talbot, K. (2008) Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS. Prog. Neurobiol., 85, 94 134.
-
(2008)
Prog. Neurobiol.
, vol.85
, pp. 94-134
-
-
Turner, B.J.1
Talbot, K.2
-
225
-
-
0036892683
-
Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis
-
Urushitani, M., Kurisu, J., Tsukita, K. Takahashi, R. (2002) Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis. J. Neurochem., 83, 1030 1042.
-
(2002)
J. Neurochem.
, vol.83
, pp. 1030-1042
-
-
Urushitani, M.1
Kurisu, J.2
Tsukita, K.3
Takahashi, R.4
-
226
-
-
29444443348
-
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
-
Urushitani, M., Sik, A., Sakurai, T., Nukina, N., Takahashi, R. Julien, J.P. (2006) Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis. Nat. Neurosci., 9, 108 118.
-
(2006)
Nat. Neurosci.
, vol.9
, pp. 108-118
-
-
Urushitani, M.1
Sik, A.2
Sakurai, T.3
Nukina, N.4
Takahashi, R.5
Julien, J.P.6
-
227
-
-
33847787621
-
Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis
-
Urushitani, M., Ezzi, S.A. Julien, J.P. (2007) Therapeutic effects of immunization with mutant superoxide dismutase in mice models of amyotrophic lateral sclerosis. Proc. Natl Acad. Sci. USA, 104, 2495 2500.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 2495-2500
-
-
Urushitani, M.1
Ezzi, S.A.2
Julien, J.P.3
-
228
-
-
64649086140
-
Recent advances in the genetics of amyotrophic lateral sclerosis
-
Valdmanis, P.N., Daoud, H., Dion, P.A. Rouleau, G.A. (2009) Recent advances in the genetics of amyotrophic lateral sclerosis. Curr Neurol Neurosci Rep, 9, 198 205.
-
(2009)
Curr Neurol Neurosci Rep
, vol.9
, pp. 198-205
-
-
Valdmanis, P.N.1
Daoud, H.2
Dion, P.A.3
Rouleau, G.A.4
-
229
-
-
70349660069
-
Recent advances in motor neuron disease
-
Van Damme, P. Robberecht, W. (2009) Recent advances in motor neuron disease. Curr. Opin. Neurol., 22, 486 492.
-
(2009)
Curr. Opin. Neurol.
, vol.22
, pp. 486-492
-
-
Van Damme, P.1
Robberecht, W.2
-
230
-
-
0036713846
-
GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity
-
Van Damme, P., Van Den Bosch, L., Van Houtte, E., Callewaert, G. Robberecht, W. (2002) GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity. J. Neurophysiol., 88, 1279 1287.
-
(2002)
J. Neurophysiol.
, vol.88
, pp. 1279-1287
-
-
Van Damme, P.1
Van Den Bosch, L.2
Van Houtte, E.3
Callewaert, G.4
Robberecht, W.5
-
231
-
-
0037986558
-
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
-
Van Damme, P., Leyssen, M., Callewaert, G., Robberecht, W. Van Den Bosch, L. (2003) The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis. Neurosci. Lett., 343, 81 84.
-
(2003)
Neurosci. Lett.
, vol.343
, pp. 81-84
-
-
Van Damme, P.1
Leyssen, M.2
Callewaert, G.3
Robberecht, W.4
Van Den Bosch, L.5
-
232
-
-
22244460463
-
GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis
-
Van Damme, P., Braeken, D., Callewaert, G., Robberecht, W. Van Den Bosch, L. (2005) GluR2 deficiency accelerates motor neuron degeneration in a mouse model of amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol., 64, 605 612.
-
(2005)
J. Neuropathol. Exp. Neurol.
, vol.64
, pp. 605-612
-
-
Van Damme, P.1
Braeken, D.2
Callewaert, G.3
Robberecht, W.4
Van Den Bosch, L.5
-
233
-
-
35548983991
-
From the Cover: Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
-
Van Damme, P., Bogaert, E., Dewil, M., Hersmus, N., Kiraly, D., Scheveneels, W., Bockx, I., Braeken, D., Verpoorten, N., Verhoeven, K., Timmerman, V., Herijgers, P., Callewaert, G., Carmeliet, P., Van Den Bosch, L. Robberecht, W. (2007) From the Cover: astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity. Proc. Natl Acad. Sci. USA, 104, 14825 14830.
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 14825-14830
-
-
Van Damme, P.1
Bogaert, E.2
Dewil, M.3
Hersmus, N.4
Kiraly, D.5
Scheveneels, W.6
Bockx, I.7
Braeken, D.8
Verpoorten, N.9
Verhoeven, K.10
Timmerman, V.11
Herijgers, P.12
Callewaert, G.13
Carmeliet, P.14
Van Den Bosch, L.15
Robberecht, W.16
-
234
-
-
42749097816
-
Crosstalk between astrocytes and motor neurons: What is the message?
-
Van Den Bosch, L. Robberecht, W. (2008) Crosstalk between astrocytes and motor neurons: what is the message? Exp. Neurol., 211, 1 6.
-
(2008)
Exp. Neurol.
, vol.211
, pp. 1-6
-
-
Van Den Bosch, L.1
Robberecht, W.2
-
236
-
-
0036219315
-
Protective effect of parvalbumin on excitotoxic motor neuron death
-
Van Den Bosch, L., Schwaller, B., Vleminckx, V., Meijers, B., Stork, S., Ruehlicke, T., Van Houtte, E., Klaassen, H., Celio, M.R., Missiaen, L., Robberecht, W. Berchtold, M.W. (2002) Protective effect of parvalbumin on excitotoxic motor neuron death. Exp. Neurol., 174, 150 161.
-
(2002)
Exp. Neurol.
, vol.174
, pp. 150-161
-
-
Van Den Bosch, L.1
Schwaller, B.2
Vleminckx, V.3
Meijers, B.4
Stork, S.5
Ruehlicke, T.6
Van Houtte, E.7
Klaassen, H.8
Celio, M.R.9
Missiaen, L.10
Robberecht, W.11
Berchtold, M.W.12
-
237
-
-
4444377607
-
Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
-
Van Den Bosch, L., Storkebaum, E., Vleminckx, V., Moons, L., Vanopdenbosch, L., Scheveneels, W., Carmeliet, P. Robberecht, W. (2004) Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol Dis, 17, 21 28.
-
(2004)
Neurobiol Dis
, vol.17
, pp. 21-28
-
-
Van Den Bosch, L.1
Storkebaum, E.2
Vleminckx, V.3
Moons, L.4
Vanopdenbosch, L.5
Scheveneels, W.6
Carmeliet, P.7
Robberecht, W.8
-
238
-
-
33751229311
-
The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis
-
Van Den Bosch, L., Van Damme, P., Bogaert, E. Robberecht, W. (2006) The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim. Biophys. Acta, 1762, 1068 1082.
-
(2006)
Biochim. Biophys. Acta
, vol.1762
, pp. 1068-1082
-
-
Van Den Bosch, L.1
Van Damme, P.2
Bogaert, E.3
Robberecht, W.4
-
239
-
-
76349115779
-
Genetic contribution of FUS to frontotemporal lobar degeneration
-
Van Langenhove, T., van der Zee, J., Sleegers, K., Engelborghs, S., Vandenberghe, R., Gijselinck, I., Van den Broeck, M., Mattheijssens, M., Peeters, K., De Deyn, P.P., Cruts, M. Van Broeckhoven, C. (2010) Genetic contribution of FUS to frontotemporal lobar degeneration. Neurology, 74, 366 371.
-
(2010)
Neurology
, vol.74
, pp. 366-371
-
-
Van Langenhove, T.1
Van Der Zee, J.2
Sleegers, K.3
Engelborghs, S.4
Vandenberghe, R.5
Gijselinck, I.6
Van Den Broeck, M.7
Mattheijssens, M.8
Peeters, K.9
De Deyn, P.P.10
Cruts, M.11
Van Broeckhoven, C.12
-
240
-
-
61349162349
-
Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
-
Vance, C., Rogelj, B., Hortobagyi, T., De Vos, K.J., Nishimura, A.L., Sreedharan, J., Hu, X., Smith, B., Ruddy, D., Wright, P., Ganesalingam, J., Williams, K.L., Tripathi, V., Al-Saraj, S., Al-Chalabi, A., Leigh, P.N., Blair, I.P., Nicholson, G., de Belleroche, J., Gallo, J.M., Miller, C.C. Shaw, C.E. (2009) Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science, 323, 1208 1211.
-
(2009)
Science
, vol.323
, pp. 1208-1211
-
-
Vance, C.1
Rogelj, B.2
Hortobagyi, T.3
De Vos, K.J.4
Nishimura, A.L.5
Sreedharan, J.6
Hu, X.7
Smith, B.8
Ruddy, D.9
Wright, P.10
Ganesalingam, J.11
Williams, K.L.12
Tripathi, V.13
Al-Saraj, S.14
Al-Chalabi, A.15
Leigh, P.N.16
Blair, I.P.17
Nicholson, G.18
De Belleroche, J.19
Gallo, J.M.20
Miller, C.C.21
Shaw, C.E.22
more..
-
241
-
-
41649086378
-
Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria
-
Vande Velde, C., Miller, T.M., Cashman, N.R. Cleveland, D.W. (2008) Selective association of misfolded ALS-linked mutant SOD1 with the cytoplasmic face of mitochondria. Proc. Natl Acad. Sci. USA, 105, 4022 4027.
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 4022-4027
-
-
Vande Velde, C.1
Miller, T.M.2
Cashman, N.R.3
Cleveland, D.W.4
-
242
-
-
0034212794
-
Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)- related motoneurone disease
-
Vanselow, B.K. Keller, B.U. (2000) Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)- related motoneurone disease. J. Physiol., 525 (Pt 2 433 445.
-
(2000)
J. Physiol.
, vol.525
, Issue.PART 2
, pp. 433-445
-
-
Vanselow, B.K.1
Keller, B.U.2
-
243
-
-
58149379610
-
Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis
-
Vargas, M.R., Johnson, D.A., Sirkis, D.W., Messing, A. Johnson, J.A. (2008) Nrf2 activation in astrocytes protects against neurodegeneration in mouse models of familial amyotrophic lateral sclerosis. J. Neurosci., 28, 13574 13581.
-
(2008)
J. Neurosci.
, vol.28
, pp. 13574-13581
-
-
Vargas, M.R.1
Johnson, D.A.2
Sirkis, D.W.3
Messing, A.4
Johnson, J.A.5
-
244
-
-
0037172972
-
Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming
-
Varoqueaux, F., Sigler, A., Rhee, J.S., Brose, N., Enk, C., Reim, K. Rosenmund, C. (2002) Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc. Natl Acad. Sci. USA, 99, 9037 9042.
-
(2002)
Proc. Natl Acad. Sci. USA
, vol.99
, pp. 9037-9042
-
-
Varoqueaux, F.1
Sigler, A.2
Rhee, J.S.3
Brose, N.4
Enk, C.5
Reim, K.6
Rosenmund, C.7
-
245
-
-
21744434371
-
Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse
-
Varoqueaux, F., Sons, M.S., Plomp, J.J. Brose, N. (2005) Aberrant morphology and residual transmitter release at the Munc13-deficient mouse neuromuscular synapse. Mol. Cell. Biol., 25, 5973 5984.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5973-5984
-
-
Varoqueaux, F.1
Sons, M.S.2
Plomp, J.J.3
Brose, N.4
-
246
-
-
67649470543
-
Characterization of DCTN1 genetic variability in neurodegeneration
-
Vilarino-Guell, C., Wider, C., Soto-Ortolaza, A.I., Cobb, S.A., Kachergus, J.M., Keeling, B.H., Dachsel, J.C., Hulihan, M.M., Dickson, D.W., Wszolek, Z.K., Uitti, R.J., Graff-Radford, N.R., Boeve, B.F., Josephs, K.A., Miller, B., Boylan, K.B., Gwinn, K., Adler, C.H., Aasly, J.O., Hentati, F., Destee, A., Krygowska-Wajs, A., Chartier-Harlin, M.C., Ross, O.A., Rademakers, R. Farrer, M.J. (2009) Characterization of DCTN1 genetic variability in neurodegeneration. Neurology, 72, 2024 2028.
-
(2009)
Neurology
, vol.72
, pp. 2024-2028
-
-
Vilarino-Guell, C.1
Wider, C.2
Soto-Ortolaza, A.I.3
Cobb, S.A.4
Kachergus, J.M.5
Keeling, B.H.6
Dachsel, J.C.7
Hulihan, M.M.8
Dickson, D.W.9
Wszolek, Z.K.10
Uitti, R.J.11
Graff-Radford, N.R.12
Boeve, B.F.13
Josephs, K.A.14
Miller, B.15
Boylan, K.B.16
Gwinn, K.17
Adler, C.H.18
Aasly, J.O.19
Hentati, F.20
Destee, A.21
Krygowska-Wajs, A.22
Chartier-Harlin, M.C.23
Ross, O.A.24
Rademakers, R.25
Farrer, M.J.26
more..
-
247
-
-
74549206672
-
BMAA - An unusual cyanobacterial neurotoxin
-
Vyas, K.J. Weiss, J.H. (2009) BMAA - an unusual cyanobacterial neurotoxin. Amyotroph Lateral Scler, 10 (Suppl 2 50 55.
-
(2009)
Amyotroph Lateral Scler
, vol.10
, Issue.SUPPL. 2
, pp. 50-55
-
-
Vyas, K.J.1
Weiss, J.H.2
-
248
-
-
0036199623
-
High molecular weight complexes of mutant superoxide dismutase 1: Age-dependent and tissue-specific accumulation
-
Wang, J., Xu, G. Borchelt, D.R. (2002) High molecular weight complexes of mutant superoxide dismutase 1: age-dependent and tissue-specific accumulation. Neurobiol Dis, 9, 139 148.
-
(2002)
Neurobiol Dis
, vol.9
, pp. 139-148
-
-
Wang, J.1
Xu, G.2
Borchelt, D.R.3
-
249
-
-
0242524455
-
Copper-binding-site-null SOD1 causes ALS in transgenic mice: Aggregates of non-native SOD1 delineate a common feature
-
Wang, J., Slunt, H., Gonzales, V., Fromholt, D., Coonfield, M., Copeland, N.G., Jenkins, N.A. Borchelt, D.R. (2003) Copper-binding-site-null SOD1 causes ALS in transgenic mice: aggregates of non-native SOD1 delineate a common feature. Hum. Mol. Genet., 12, 2753 2764.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2753-2764
-
-
Wang, J.1
Slunt, H.2
Gonzales, V.3
Fromholt, D.4
Coonfield, M.5
Copeland, N.G.6
Jenkins, N.A.7
Borchelt, D.R.8
-
250
-
-
33846221802
-
Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice
-
Wang, Y., Mao, X.O., Xie, L., Banwait, S., Marti, H.H., Greenberg, D.A. Jin, K. (2007) Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J. Neurosci., 27, 304 307.
-
(2007)
J. Neurosci.
, vol.27
, pp. 304-307
-
-
Wang, Y.1
Mao, X.O.2
Xie, L.3
Banwait, S.4
Marti, H.H.5
Greenberg, D.A.6
Jin, K.7
-
251
-
-
46649093597
-
Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription
-
Wang, X., Arai, S., Song, X., Reichart, D., Du, K., Pascual, G., Tempst, P., Rosenfeld, M.G., Glass, C.K. Kurokawa, R. (2008) Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature, 454, 126 130.
-
(2008)
Nature
, vol.454
, pp. 126-130
-
-
Wang, X.1
Arai, S.2
Song, X.3
Reichart, D.4
Du, K.5
Pascual, G.6
Tempst, P.7
Rosenfeld, M.G.8
Glass, C.K.9
Kurokawa, R.10
-
252
-
-
59249098430
-
An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans
-
Wang, J., Farr, G.W., Hall, D.H., Li, F., Furtak, K., Dreier, L. Horwich, A.L. (2009a) An ALS-linked mutant SOD1 produces a locomotor defect associated with aggregation and synaptic dysfunction when expressed in neurons of Caenorhabditis elegans. PLoS Genet, 5, e1000350.
-
(2009)
PLoS Genet
, vol.5
, pp. 1000350
-
-
Wang, J.1
Farr, G.W.2
Hall, D.H.3
Li, F.4
Furtak, K.5
Dreier, L.6
Horwich, A.L.7
-
253
-
-
64549124726
-
Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse
-
Wang, L., Deng, H.X., Grisotti, G., Zhai, H., Siddique, T. Roos, R.P. (2009b) Wild-type SOD1 overexpression accelerates disease onset of a G85R SOD1 mouse. Hum. Mol. Genet., 18, 1642 1651.
-
(2009)
Hum. Mol. Genet.
, vol.18
, pp. 1642-1651
-
-
Wang, L.1
Deng, H.X.2
Grisotti, G.3
Zhai, H.4
Siddique, T.5
Roos, R.P.6
-
254
-
-
73249152831
-
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
-
Wegorzewska, I., Bell, S., Cairns, N.J., Miller, T.M. Baloh, R.H. (2009) TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration. Proc. Natl Acad. Sci. USA, 106, 18809 18814.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 18809-18814
-
-
Wegorzewska, I.1
Bell, S.2
Cairns, N.J.3
Miller, T.M.4
Baloh, R.H.5
-
255
-
-
0345169048
-
Post-translational modifications regulate microtubule function
-
Westermann, S. Weber, K. (2003) Post-translational modifications regulate microtubule function. Nat. Rev. Mol. Cell Biol., 4, 938 947.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 938-947
-
-
Westermann, S.1
Weber, K.2
-
256
-
-
34250018546
-
Three soccer playing friends with simultaneous amyotrophic lateral sclerosis
-
Wicks, P., Ganesalingham, J., Collin, C., Prevett, M., Leigh, N.P. Al-Chalabi, A. (2007) Three soccer playing friends with simultaneous amyotrophic lateral sclerosis. Amyotroph Lateral Scler, 8, 177 179.
-
(2007)
Amyotroph Lateral Scler
, vol.8
, pp. 177-179
-
-
Wicks, P.1
Ganesalingham, J.2
Collin, C.3
Prevett, M.4
Leigh, N.P.5
Al-Chalabi, A.6
-
257
-
-
72149131804
-
MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
-
Williams, A.H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J.L., Bassel-Duby, R., Sanes, J.R. Olson, E.N. (2009) MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice. Science, 326, 1549 1554.
-
(2009)
Science
, vol.326
, pp. 1549-1554
-
-
Williams, A.H.1
Valdez, G.2
Moresi, V.3
Qi, X.4
McAnally, J.5
Elliott, J.L.6
Bassel-Duby, R.7
Sanes, J.R.8
Olson, E.N.9
-
258
-
-
68249141410
-
A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS
-
Wills, A.M., Cronin, S., Slowik, A., Kasperaviciute, D., Van Es, M.A., Morahan, J.M., Valdmanis, P.N., Meininger, V., Melki, J., Shaw, C.E., Rouleau, G.A., Fisher, E.M., Shaw, P.J., Morrison, K.E., Pamphlett, R., Van den Berg, L.H., Figlewicz, D.A., Andersen, P.M., Al-Chalabi, A., Hardiman, O., Purcell, S., Landers, J.E. Brown, R.H. Jr. (2009) A large-scale international meta-analysis of paraoxonase gene polymorphisms in sporadic ALS. Neurology, 73, 16 24.
-
(2009)
Neurology
, vol.73
, pp. 16-24
-
-
Wills, A.M.1
Cronin, S.2
Slowik, A.3
Kasperaviciute, D.4
Van Es, M.A.5
Morahan, J.M.6
Valdmanis, P.N.7
Meininger, V.8
Melki, J.9
Shaw, C.E.10
Rouleau, G.A.11
Fisher, E.M.12
Shaw, P.J.13
Morrison, K.E.14
Pamphlett, R.15
Van Den Berg, L.H.16
Figlewicz, D.A.17
Andersen, P.M.18
Al-Chalabi, A.19
Hardiman, O.20
Purcell, S.21
Landers, J.E.22
Brown, Jr.R.H.23
more..
-
259
-
-
77649269011
-
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
-
Wils, H., Kleinberger, G., Janssens, J., Pereson, S., Joris, G., Cuijt, I., Smits, V., Groote, C.C., Van Broeckhoven, C. Kumar-Singh, S. (2010) TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration. Proc. Natl Acad. Sci. USA, 107, 3858 3863.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3858-3863
-
-
Wils, H.1
Kleinberger, G.2
Janssens, J.3
Pereson, S.4
Joris, G.5
Cuijt, I.6
Smits, V.7
Groote, C.C.8
Van Broeckhoven, C.9
Kumar-Singh, S.10
-
260
-
-
44749091997
-
Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation
-
Winton, M.J., Igaz, L.M., Wong, M.M., Kwong, L.K., Trojanowski, J.Q. Lee, V.M. (2008) Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. J. Biol. Chem., 283, 13302 13309.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 13302-13309
-
-
Winton, M.J.1
Igaz, L.M.2
Wong, M.M.3
Kwong, L.K.4
Trojanowski, J.Q.5
Lee, V.M.6
-
261
-
-
43049132896
-
Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation
-
Witan, H., Kern, A., Koziollek-Drechsler, I., Wade, R., Behl, C. Clement, A.M. (2008) Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation. Hum. Mol. Genet., 17, 1373 1385.
-
(2008)
Hum. Mol. Genet.
, vol.17
, pp. 1373-1385
-
-
Witan, H.1
Kern, A.2
Koziollek-Drechsler, I.3
Wade, R.4
Behl, C.5
Clement, A.M.6
-
262
-
-
0029053881
-
An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
-
Wong, P.C., Pardo, C.A., Borchelt, D.R., Lee, M.K., Copeland, N.G., Jenkins, N.A., Sisodia, S.S., Cleveland, D.W. Price, D.L. (1995) An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria. Neuron, 14, 1105 1116.
-
(1995)
Neuron
, vol.14
, pp. 1105-1116
-
-
Wong, P.C.1
Pardo, C.A.2
Borchelt, D.R.3
Lee, M.K.4
Copeland, N.G.5
Jenkins, N.A.6
Sisodia, S.S.7
Cleveland, D.W.8
Price, D.L.9
-
263
-
-
33747201641
-
Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo
-
Xia, X., Zhou, H., Huang, Y. Xu, Z. (2006) Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo. Neurobiol Dis, 23, 578 586.
-
(2006)
Neurobiol Dis
, vol.23
, pp. 578-586
-
-
Xia, X.1
Zhou, H.2
Huang, Y.3
Xu, Z.4
-
264
-
-
39749188753
-
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
-
Yamanaka, K., Chun, S.J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D.H., Takahashi, R., Misawa, H. Cleveland, D.W. (2008) Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci., 11, 251 253.
-
(2008)
Nat. Neurosci.
, vol.11
, pp. 251-253
-
-
Yamanaka, K.1
Chun, S.J.2
Boillee, S.3
Fujimori-Tonou, N.4
Yamashita, H.5
Gutmann, D.H.6
Takahashi, R.7
Misawa, H.8
Cleveland, D.W.9
-
265
-
-
62549128641
-
Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1
-
Yang, Y., Gozen, O., Watkins, A., Lorenzini, I., Lepore, A., Gao, Y., Vidensky, S., Brennan, J., Poulsen, D., Won Park, J., Li Jeon, N., Robinson, M.B. Rothstein, J.D. (2009) Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron, 61, 880 894.
-
(2009)
Neuron
, vol.61
, pp. 880-894
-
-
Yang, Y.1
Gozen, O.2
Watkins, A.3
Lorenzini, I.4
Lepore, A.5
Gao, Y.6
Vidensky, S.7
Brennan, J.8
Poulsen, D.9
Won Park, J.10
Li Jeon, N.11
Robinson, M.B.12
Rothstein, J.D.13
-
266
-
-
34548752918
-
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS
-
Yin, H.Z., Tang, D.T. Weiss, J.H. (2007) Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS. Exp. Neurol., 207, 177 185.
-
(2007)
Exp. Neurol.
, vol.207
, pp. 177-185
-
-
Yin, H.Z.1
Tang, D.T.2
Weiss, J.H.3
-
267
-
-
42949094584
-
TDP-43 mutation in familial amyotrophic lateral sclerosis
-
DOI 10.1002/ana.21392
-
Yokoseki, A., Shiga, A., Tan, C.F., Tagawa, A., Kaneko, H., Koyama, A., Eguchi, H., Tsujino, A., Ikeuchi, T., Kakita, A., Okamoto, K., Nishizawa, M., Takahashi, H. Onodera, O. (2008) TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann. Neurol., 63, 538 542. (Pubitemid 351614721)
-
(2008)
Annals of Neurology
, vol.63
, Issue.4
, pp. 538-542
-
-
Yokoseki, A.1
Shiga, A.2
Tan, C.-F.3
Tagawa, A.4
Kaneko, H.5
Koyama, A.6
Eguchi, H.7
Tsujino, A.8
Ikeuchi, T.9
Kakita, A.10
Okamoto, K.11
Nishizawa, M.12
Takahashi, H.13
Onodera, O.14
-
268
-
-
33751428390
-
Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines
-
Yoshimura, A., Fujii, R., Watanabe, Y., Okabe, S., Fukui, K. Takumi, T. (2006) Myosin-Va facilitates the accumulation of mRNA/protein complex in dendritic spines. Curr. Biol., 16, 2345 2351.
-
(2006)
Curr. Biol.
, vol.16
, pp. 2345-2351
-
-
Yoshimura, A.1
Fujii, R.2
Watanabe, Y.3
Okabe, S.4
Fukui, K.5
Takumi, T.6
-
269
-
-
20944443640
-
A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease
-
Zarranz, J.J., Ferrer, I., Lezcano, E., Forcadas, M.I., Eizaguirre, B., Atares, B., Puig, B., Gomez-Esteban, J.C., Fernandez-Maiztegui, C., Rouco, I., Perez-Concha, T., Fernandez, M., Rodriguez, O., Rodriguez-Martinez, A.B., de Pancorbo, M.M., Pastor, P. Perez-Tur, J. (2005) A novel mutation (K317M) in the MAPT gene causes FTDP and motor neuron disease. Neurology, 64, 1578 1585.
-
(2005)
Neurology
, vol.64
, pp. 1578-1585
-
-
Zarranz, J.J.1
Ferrer, I.2
Lezcano, E.3
Forcadas, M.I.4
Eizaguirre, B.5
Atares, B.6
Puig, B.7
Gomez-Esteban, J.C.8
Fernandez-Maiztegui, C.9
Rouco, I.10
Perez-Concha, T.11
Fernandez, M.12
Rodriguez, O.13
Rodriguez-Martinez, A.B.14
De Pancorbo, M.M.15
Pastor, P.16
Perez-Tur, J.17
-
270
-
-
34848921202
-
Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43
-
Zhang, Y.J., Xu, Y.F., Dickey, C.A., Buratti, E., Baralle, F., Bailey, R., Pickering-Brown, S., Dickson, D. Petrucelli, L. (2007) Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. J. Neurosci., 27, 10530 10534.
-
(2007)
J. Neurosci.
, vol.27
, pp. 10530-10534
-
-
Zhang, Y.J.1
Xu, Y.F.2
Dickey, C.A.3
Buratti, E.4
Baralle, F.5
Bailey, R.6
Pickering-Brown, S.7
Dickson, D.8
Petrucelli, L.9
-
271
-
-
66149114101
-
Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
-
Zhang, Y.J., Xu, Y.F., Cook, C., Gendron, T.F., Roettges, P., Link, C.D., Lin, W.L., Tong, J., Castanedes-Casey, M., Ash, P., Gass, J., Rangachari, V., Buratti, E., Baralle, F., Golde, T.E., Dickson, D.W. Petrucelli, L. (2009) Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proc. Natl Acad. Sci. USA, 106, 7607 7612.
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 7607-7612
-
-
Zhang, Y.J.1
Xu, Y.F.2
Cook, C.3
Gendron, T.F.4
Roettges, P.5
Link, C.D.6
Lin, W.L.7
Tong, J.8
Castanedes-Casey, M.9
Ash, P.10
Gass, J.11
Rangachari, V.12
Buratti, E.13
Baralle, F.14
Golde, T.E.15
Dickson, D.W.16
Petrucelli, L.17
-
272
-
-
73149105494
-
Extracellular mutant SOD1 induces microglial-mediated motoneuron injury
-
Zhao, W., Beers, D.R., Henkel, J.S., Zhang, W., Urushitani, M., Julien, J.P. Appel, S.H. (2010) Extracellular mutant SOD1 induces microglial-mediated motoneuron injury. Glia, 58, 231 243.
-
(2010)
Glia
, vol.58
, pp. 231-243
-
-
Zhao, W.1
Beers, D.R.2
Henkel, J.S.3
Zhang, W.4
Urushitani, M.5
Julien, J.P.6
Appel, S.H.7
-
273
-
-
41149097086
-
ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration
-
Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M.K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D.W. Zlokovic, B.V. (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat. Neurosci., 11, 420 422.
-
(2008)
Nat. Neurosci.
, vol.11
, pp. 420-422
-
-
Zhong, Z.1
Deane, R.2
Ali, Z.3
Parisi, M.4
Shapovalov, Y.5
O'Banion, M.K.6
Stojanovic, K.7
Sagare, A.8
Boillee, S.9
Cleveland, D.W.10
Zlokovic, B.V.11
-
274
-
-
70449433875
-
Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells
-
Zhong, Z., Ilieva, H., Hallagan, L., Bell, R., Singh, I., Paquette, N., Thiyagarajan, M., Deane, R., Fernandez, J.A., Lane, S., Zlokovic, A.B., Liu, T., Griffin, J.H., Chow, N., Castellino, F.J., Stojanovic, K., Cleveland, D.W. Zlokovic, B.V. (2009) Activated protein C therapy slows ALS-like disease in mice by transcriptionally inhibiting SOD1 in motor neurons and microglia cells. J. Clin. Invest., 119, 3437 3449.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 3437-3449
-
-
Zhong, Z.1
Ilieva, H.2
Hallagan, L.3
Bell, R.4
Singh, I.5
Paquette, N.6
Thiyagarajan, M.7
Deane, R.8
Fernandez, J.A.9
Lane, S.10
Zlokovic, A.B.11
Liu, T.12
Griffin, J.H.13
Chow, N.14
Castellino, F.J.15
Stojanovic, K.16
Cleveland, D.W.17
Zlokovic, B.V.18
-
275
-
-
0030746523
-
TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling
-
Zinszner, H., Sok, J., Immanuel, D., Yin, Y. Ron, D. (1997) TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling. J. Cell Sci., 110 (Pt 15 1741 1750.
-
(1997)
J. Cell Sci.
, vol.110
, Issue.PART 15
, pp. 1741-1750
-
-
Zinszner, H.1
Sok, J.2
Immanuel, D.3
Yin, Y.4
Ron, D.5
|