Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration, and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1

Neurobiology of Disease

Volumn 7, Issue 6, 2000, Pages 623-643

  Jaarsma, D ^a   Haasdijk, E D ^a   Grashorn, J A C ^a   Hawkins, R ^a   Van Duijn, W ^a   Verspaget, H W ^a   London, J ^a   Holstege, J C ^a  

^a ERASMUS UNIVERSITY ROTTERDAM   (Netherlands)

Author keywords

Aging; Amyotrophic lateral sclerosis; Electron microscopy; Neurodegenerative disease; Oxidative stress; Spinal cord

Indexed keywords

SUPEROXIDE DISMUTASE;

AGING; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN STEM; CELL VACUOLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; FEMALE; GENE EXPRESSION; GENE MUTATION; MALE; MITOCHONDRION; MOTOR NEURON DISEASE; MOUSE; NERVE CELL NECROSIS; NERVE FIBER DEGENERATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SPINAL CORD MOTONEURON; SPINOCEREBELLAR TRACT; SUBICULUM; TRANSGENIC MOUSE;

EID: 0034520591     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2000.0299     Document Type: Article

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