MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice

Science

Volumn 326, Issue 5959, 2009, Pages 1549-1554

  Williams, Andrew H ^a   Valdez, Gregorio ^b   Moresi, Viviana ^a   Qi, Xiaoxia ^a   McAnally, John ^a   Elliott, Jeffrey L ^c   Bassel Duby, Rhonda ^a   Sanes, Joshua R ^b   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; HISTONE DEACETYLASE 4; MICRORNA; MICRORNA 206; UNCLASSIFIED DRUG;

INJURY; NERVOUS SYSTEM; NEUROLOGY; PATHOGENICITY; PROTEIN; RNA; RODENT; SIGNALING;

ACUTE DISEASE; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FIBROBLAST; GENETIC DISORDER; MOTONEURON; MOUSE; NERVE GROWTH; NERVE INJURY; NERVE REGENERATION; NEUROMUSCULAR SYNAPSE; NONHUMAN; PRIORITY JOURNAL; SKELETAL MUSCLE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AXONS; CARRIER PROTEINS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FIBROBLAST GROWTH FACTORS; HISTONE DEACETYLASES; MICE; MICE, TRANSGENIC; MICRORNAS; MOTOR NEURONS; MUSCLE DENERVATION; MUSCLE, SKELETAL; MYOD PROTEIN; MYOGENIN; NERVE REGENERATION; NEUROMUSCULAR JUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION;

MUS;

EID: 72149131804     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1181046     Document Type: Article

References (36)

1. L. I. Bruijn, T. M. Miller, D. W. Cleveland, Annu. Rev. Neurosci. 27, 723 (2004).
2. T. Dunckley et al., N. Engl. J. Med. 357, 775 (2007).
3. E. van Rooij, E. N. Olson, J. Clin. Invest. 117, 2369 (2007).
4. M. E. Gurney et al., Science 264, 1772 (1994).
5. M. Son et al., Proc. Natl. Acad. Sci. U.S.A. 104, 6072 (2007).
6. J. F. Chen et al., Nat. Genet. 38, 228 (2006).
7. P. K. Rao, R. M. Kumar, M. Farkhondeh, S. Baskerville, H. F. Lodish, Proc. Natl. Acad. Sci. U.S.A. 103, 8721 (2006).
8. Materials and methods are available as supporting material on Science Online.
9. S. Schiaffino, C. Reggiani, Physiol. Rev. 76, 371 (1996).
10. N. Liu et al., Proc. Natl. Acad. Sci. U.S.A. 104, 20844 (2007).
11. R. Eftimie, H. R. Brenner, A. Buonanno, Proc. Natl. Acad. Sci. U.S.A. 88, 1349 (1991).
12. M. A. Velleca, M. C. Wallace, J. P. Merlie, Mol. Cell. Biol. 14, 7095 (1994).
13. L. Schaeffer, A. de Kerchove d'Exaerde, J. P. Changeux, Neuron 31, 15 (2001).
14. M. A. Fox et al., Cell 129, 179 (2007).
15. M. R. Bennett, A. G. Pettigrew, Cold Spring Harb. Symp. Quant. Biol. 40, 409 (1976).
16. J. R. Sanes, J. W. Lichtman, Annu. Rev. Neurosci. 22, 389 (1999).
17. E. Frank, K. Gautvik, H. Sommerschild, Cold Spring Harb. Symp. Quant. Biol. 40, 275 (1976).
18. A. M. Schaefer, J. R. Sanes, J. W. Lichtman, J. Comp. Neurol. 490, 209 (2005).
19. G. Wohlfart, Neurology 7, 124 (1957).
20. B. P. Lewis, C. B. Burge, D. P. Bartel, Cell 120, 15 (2005).
21. T. J. Cohen et al., J. Biol. Chem. 282, 33752 (2007).
22. H. Tang et al., Mol. Biol. Cell 20, 1120 (2009).
23. M. A. Valencia-Sanchez, J. Liu, G. J. Hannon, R. Parker, Genes Dev. 20, 515 (2006).
24. A. M. Lohof, N. Y. Ip, M. M. Poo, Nature 363, 350 (1993).
25. H. Umemori, J. R. Sanes, J. Biol. Chem. 283, 34053 (2008).
26. H. D. Beer et al., Oncogene 24, 5269 (2005).
27. E. Frank, J. K. Jansen, T. Lono, R. H. Westgaard, J. Physiol. 247, 725 (1975).
28. J. R. Sanes, J. Covault, Trends Neurosci. 8, 523 (1985).
29. S. Pun, A. F. Santos, S. Saxena, L. Xu, P. Caroni, Nat. Neurosci. 9, 408 (2006).
30. T. J. Kwiatkowski Jr. et al., Science 323, 1205 (2009).
31. M. Neumann et al., Science 314, 130 (2006).
32. C. Vance et al., Science 323, 1208 (2009).
33. R. I. Gregory et al., Nature 432, 235 (2004).
34. C. Lagier-Tourenne, D. W. Cleveland, Cell 136, 1001 (2009).
35. D. J. Simon et al., Cell 133, 903 (2008).
36. We thank N. Liu, E. van Rooij, M. Arnold, G. Huang, Z. Paroo, and M. Potthoff for scientific discussions; J. Cabrera for graphics; J. Backs for HDAC4 conditional mice; M. Lewis for assistance with x-rays; and J. Richardson and J. Shelton for help with histology. Imaging was facilitated by the University of Texas Southwestern Small Animal Imaging Resource, which is supported in part by the National Cancer Institute U24 CA126608, the Simmons Cancer Center, and Department of Radiology at University of Texas Southwestern. A.H.W is supported by National Heart, Lung, and Blood Institute grant T32HL007360. G.V is supported by National Institute of Neurological Disorders and Stroke (NINDS) grant 1F32NS061464-01A1. J.R.S. is supported by grants from the National Institute on Aging and NINDS. E.N.O. is supported by grants from NIH, the Donald W. Reynolds Center for Clinical Cardiovascular Research, the Leducq Foundation, and the Robert A. Welch Foundation. E.N.O. is a cofounder of miRagen Therapeutics and holds equity in the company. A.H.W. and E.N.O. have filed a patent relating to this work. E.N.O. and J.R.S. dedicate this paper to their friend the late John Merlie, whose discovery of 7H4 (12) led directly to our work.