Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice

Human Molecular Genetics

Volumn 12, Issue 19, 2003, Pages 2519-2532

  Guo, Hong ^a   Lai, Liching ^a   Butchbach E R , Matthew ^a   Stockinger, Michael P ^a   Shan, Xiu ^a   Bishop, Georgia A ^a   Lin, Chien Liang G ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; SODIUM ION; SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CELL DEATH; CELL MEMBRANE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DISEASE COURSE; ENZYME ACTIVATION; ENZYME LOCALIZATION; GENE OVEREXPRESSION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; LIFESPAN; MALE; MORPHOLOGY; MOTONEURON; MOUSE; NERVE CELL DEGENERATION; NERVE FIBER; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BRAIN; CASPASES; CELL DEATH; CELL MEMBRANE; CROSSES, GENETIC; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; EXCITATORY AMINO ACID TRANSPORTER 2; GENE EXPRESSION; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTAMIC ACID; MICE; MICE, TRANSGENIC; MOTOR NEURONS; PROMOTER REGIONS (GENETICS); SPINAL CORD; SUPEROXIDE DISMUTASE; TIME FACTORS; TRANSGENES;

ANIMALIA; MUS MUSCULUS;

EID: 0141618315     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg267     Document Type: Article

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