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Volumn 85, Issue 3, 2003, Pages 680-689

Human spinal motoneurons express low relative abundance of GluR2 mRNA: An implication for excitotoxicity in ALS

Author keywords

ALS; AMPA receptor; Excitotoxicity; GluR2; Quantitative RT PCR; RNA editing

Indexed keywords

AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 0038673599     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01703.x     Document Type: Article
Times cited : (114)

References (49)
  • 1
    • 0034659176 scopus 로고    scopus 로고
    • Basophilic cytoplasmic inclusions in a case of sporadic juvenile amyotrophic lateral sclerosis
    • Aizawa H., Kimura T., Hashimoto K., Yahara O., Okamoto K. and Kikuchi K. (2000) Basophilic cytoplasmic inclusions in a case of sporadic juvenile amyotrophic lateral sclerosis. J. Neurol. Sci. 176, 109-113.
    • (2000) J. Neurol. Sci. , vol.176 , pp. 109-113
    • Aizawa, H.1    Kimura, T.2    Hashimoto, K.3    Yahara, O.4    Okamoto, K.5    Kikuchi, K.6
  • 2
    • 0033577151 scopus 로고    scopus 로고
    • Cultured motor neurons possess calcium-permeable AMPA/kainate receptors
    • Bar-Peled O., O'Brien R. J., Morrison J. H. and Rothstein J. D. (1999) Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. Neuroreport 10, 855-859.
    • (1999) Neuroreport , vol.10 , pp. 855-859
    • Bar-Peled, O.1    O'Brien, R.J.2    Morrison, J.H.3    Rothstein, J.D.4
  • 3
    • 0033232538 scopus 로고    scopus 로고
    • 2+ permeation ofAMPA receptors in cerebellar neurons expressing Glu receptor 2
    • 2+ permeation ofAMPA receptors in cerebellar neurons expressing Glu receptor 2. J. Neurosci. 19, 9149-9159.
    • (1999) J. Neurosci. , vol.19 , pp. 9149-9159
    • Brorson, J.R.1    Zhang, Z.2    Vandenberghe, W.3
  • 4
    • 0029610443 scopus 로고
    • Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice
    • Brusa R., Zimmermann F., Koh D., Feldmeyer D., Gass P. and Seeburg P. and Sprengel R. (1995) Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science 270, 1677-1680.
    • (1995) Science , vol.270 , pp. 1677-1680
    • Brusa, R.1    Zimmermann, F.2    Koh, D.3    Feldmeyer, D.4    Gass, P.5    Seeburg, P.6    Sprengel, R.7
  • 6
    • 0030015076 scopus 로고    scopus 로고
    • Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
    • Carriedo S. G., Yin H. Z. and Weiss J. H. (1996) Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro. J. Neurosci. 16, 4069-4079.
    • (1996) J. Neurosci. , vol.16 , pp. 4069-4079
    • Carriedo, S.G.1    Yin, H.Z.2    Weiss, J.H.3
  • 7
    • 0035034993 scopus 로고    scopus 로고
    • Characteristics of AMPA receptor-mediated responses of cultured cortical and spinal cord neurones and their correlation to the expression of glutamate receptor subunits, GluR1-4
    • Dai W. M., Egebjerg J. and Lambert J. D. (2001) Characteristics of AMPA receptor-mediated responses of cultured cortical and spinal cord neurones and their correlation to the expression of glutamate receptor subunits, GluR1-4. Br. J. Pharmacol. 132, 1859-1875.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 1859-1875
    • Dai, W.M.1    Egebjerg, J.2    Lambert, J.D.3
  • 8
  • 10
    • 0027467438 scopus 로고
    • Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception
    • Furuyama T., Kiyama H., Sato K., Park H. T., Maeno H. and Takagi H. and Tohyama M. (1993) Region-specific expression of subunits of ionotropic glutamate receptors (AMPA-type, KA-type and NMDA receptors) in the rat spinal cord with special reference to nociception. Brain. Res. Mol. Brain. Res. 18, 141-151.
    • (1993) Brain. Res. Mol. Brain. Res. , vol.18 , pp. 141-151
    • Furuyama, T.1    Kiyama, H.2    Sato, K.3    Park, H.T.4    Maeno, H.5    Takagi, H.6    Tohyama, M.7
  • 12
    • 0037198702 scopus 로고    scopus 로고
    • RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum
    • Greger I. H., Khatri L. and Ziff E. B. (2002) RNA editing at arg607 controls AMPA receptor exit from the endoplasmic reticulum. Neuron 34, 759-772.
    • (2002) Neuron , vol.34 , pp. 759-772
    • Greger, I.H.1    Khatri, L.2    Ziff, E.B.3
  • 13
    • 0033985186 scopus 로고    scopus 로고
    • Characterization of the AMPA-activated receptors present on motoneurons
    • Greig A., Donevan S. D., Mujtaba T. J., Parks T. N. and Rao M. S. (2000) Characterization of the AMPA-activated receptors present on motoneurons. J. Neurochem. 74, 179-191.
    • (2000) J. Neurochem. , vol.74 , pp. 179-191
    • Greig, A.1    Donevan, S.D.2    Mujtaba, T.J.3    Parks, T.N.4    Rao, M.S.5
  • 14
    • 0033565995 scopus 로고    scopus 로고
    • Alterations in AMPA receptor subunit expression after experimental spinal cord contusion injury
    • Grossman S. D., Wolfe B. B., Yasuda R. P. and Wrathall J. R. (1999) Alterations in AMPA receptor subunit expression after experimental spinal cord contusion injury. J. Neurosci. 19, 5711-5720.
    • (1999) J. Neurosci. , vol.19 , pp. 5711-5720
    • Grossman, S.D.1    Wolfe, B.B.2    Yasuda, R.P.3    Wrathall, J.R.4
  • 18
    • 0025923461 scopus 로고
    • 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition
    • 2+ permeability of KA-AMPA-gated glutamate receptor channels depends on subunit composition. Science 252, 851-853.
    • (1991) Science , vol.252 , pp. 851-853
    • Hollmann, M.1    Hartley, M.2    Heinemann, S.3
  • 20
    • 0028179583 scopus 로고
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression
    • 2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron 12, 1281-1289.
    • (1994) Neuron , vol.12 , pp. 1281-1289
    • Jonas, P.1    Racca, C.2    Sakmann, B.3    Seeburg, P.H.4    Monyer, H.5
  • 22
    • 0028981783 scopus 로고
    • 2+-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification
    • 2+-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification. J. Physiol. 486, 305-312.
    • (1995) J. Physiol. , vol.486 , pp. 305-312
    • Koh, D.S.1    Burnashev, N.2    Jonas, P.3
  • 23
    • 0029071674 scopus 로고
    • Acute and late neurotoxicity in the rat spinal cord in vivo induced by glutamate receptor agonists
    • Kwak S. and Nakamura R. (1995) Acute and late neurotoxicity in the rat spinal cord in vivo induced by glutamate receptor agonists. J. Neurol. Sci. 129 (Suppl.), 99-103.
    • (1995) J. Neurol. Sci. , vol.129 , Issue.SUPPL. , pp. 99-103
    • Kwak, S.1    Nakamura, R.2
  • 24
    • 0026787858 scopus 로고
    • AMPA receptor subunits expressed by single Purkinje cells
    • Lambolez B., Audinat E., Bochet P., Crepel F. and Rossier J. (1992) AMPA receptor subunits expressed by single Purkinje cells. Neuron 9, 247-258.
    • (1992) Neuron , vol.9 , pp. 247-258
    • Lambolez, B.1    Audinat, E.2    Bochet, P.3    Crepel, F.4    Rossier, J.5
  • 25
    • 0029969618 scopus 로고    scopus 로고
    • Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons
    • Lambolez B., Ropert N., Perrais D., Rossier J. and Hestrin S. (1996) Correlation between kinetics and RNA splicing of alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors in neocortical neurons. Proc. Natl Acad. Sci. USA 93, 1797-1802.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 1797-1802
    • Lambolez, B.1    Ropert, N.2    Perrais, D.3    Rossier, J.4    Hestrin, S.5
  • 26
    • 0034989861 scopus 로고    scopus 로고
    • GluR2 AMPA receptor subunit expression in motoneurons at low and high risk for degeneration in amyotrophic lateral sclerosis
    • Laslo P., Lipski J., Nicholson L. F., Miles G. B. and Funk G. D. (2001) GluR2 AMPA receptor subunit expression in motoneurons at low and high risk for degeneration in amyotrophic lateral sclerosis. Exp. Neurol. 169, 461-471.
    • (2001) Exp. Neurol. , vol.169 , pp. 461-471
    • Laslo, P.1    Lipski, J.2    Nicholson, L.F.3    Miles, G.B.4    Funk, G.D.5
  • 29
    • 0025804443 scopus 로고
    • Glutamate-operated channels: Developmentally early and mature forms arise by alternative splicing
    • Monyer H., Seeburg P. H. and Wisden W. (1991) Glutamate-operated channels: developmentally early and mature forms arise by alternative splicing. Neuron 6, 799-810.
    • (1991) Neuron , vol.6 , pp. 799-810
    • Monyer, H.1    Seeburg, P.H.2    Wisden, W.3
  • 30
    • 0032527065 scopus 로고    scopus 로고
    • Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice
    • Morrison B. M., Janssen W. G., Gordon J. W. and Morrison J. H. (1998) Light and electron microscopic distribution of the AMPA receptor subunit, GluR2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice. J. Comp. Neurol. 395, 523-534.
    • (1998) J. Comp. Neurol. , vol.395 , pp. 523-534
    • Morrison, B.M.1    Janssen, W.G.2    Gordon, J.W.3    Morrison, J.H.4
  • 31
    • 0027932640 scopus 로고
    • Late-onset selective neuronal damage in the rat spinal cord induced by continuous intrathecal administration of AMPA
    • Nakamura R., Kamakura K. and Kwak S. (1994) Late-onset selective neuronal damage in the rat spinal cord induced by continuous intrathecal administration of AMPA. Brain Res. 654, 279-285.
    • (1994) Brain Res. , vol.654 , pp. 279-285
    • Nakamura, R.1    Kamakura, K.2    Kwak, S.3
  • 32
    • 0034869177 scopus 로고    scopus 로고
    • Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons
    • Passafaro M., Piech V. and Sheng M. (2001) Subunit-specific temporal and spatial patterns of AMPA receptor exocytosis in hippocampal neurons. Nat. Neurosci. 4, 917-926.
    • (2001) Nat. Neurosci. , vol.4 , pp. 917-926
    • Passafaro, M.1    Piech, V.2    Sheng, M.3
  • 35
    • 0027274623 scopus 로고
    • Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
    • Rothstein J. D., Jin L., Dykes-Hoberg M. and Kuncl R. W. (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl Acad. Sci. USA 90, 6591-6595.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 6591-6595
    • Rothstein, J.D.1    Jin, L.2    Dykes-Hoberg, M.3    Kuncl, R.W.4
  • 36
    • 0033524824 scopus 로고    scopus 로고
    • Low expression of GluR2 AMPA receptor subunit protein by human motor neurons
    • Shaw P. J., Williams T. L., Slade J. Y., Eggett C. J. and Ince P. G. (1999) Low expression of GluR2 AMPA receptor subunit protein by human motor neurons. Neuroreport 10, 261-265.
    • (1999) Neuroreport , vol.10 , pp. 261-265
    • Shaw, P.J.1    Williams, T.L.2    Slade, J.Y.3    Eggett, C.J.4    Ince, P.G.5
  • 37
    • 0035805143 scopus 로고    scopus 로고
    • Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons
    • Shi S., Hayashi Y., Esteban J. A. and Malinow R. (2001) Subunit-specific rules governing AMPA receptor trafficking to synapses in hippocampal pyramidal neurons. Cell 105, 331-343.
    • (2001) Cell , vol.105 , pp. 331-343
    • Shi, S.1    Hayashi, Y.2    Esteban, J.A.3    Malinow, R.4
  • 38
    • 0025995296 scopus 로고
    • RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
    • Sommer B., Köhler M., Sprengel R. and Seeberg P. (1991) RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
    • (1991) Cell , vol.67 , pp. 11-19
    • Sommer, B.1    Köhler, M.2    Sprengel, R.3    Seeberg, P.4
  • 39
    • 0034017670 scopus 로고    scopus 로고
    • Quantification of mRNA in single oocytes and embryos by real-time rapid-cycle fluorescence-monitored RT-PCR
    • Steuerwald N., Cohen J., Herrera R. J. and Brenner C. A. (2000) Quantification of mRNA in single oocytes and embryos by real-time rapid-cycle fluorescence-monitored RT-PCR. Mol. Hum. Reprod. 6, 448-453.
    • (2000) Mol. Hum. Reprod. , vol.6 , pp. 448-453
    • Steuerwald, N.1    Cohen, J.2    Herrera, R.J.3    Brenner, C.A.4
  • 40
    • 0032752054 scopus 로고    scopus 로고
    • Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis
    • Takuma H., Kwak S., Yoshizawa T. and Kanazawa I. (1999) Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis. Ann. Neurol. 46, 806-815.
    • (1999) Ann. Neurol. , vol.46 , pp. 806-815
    • Takuma, H.1    Kwak, S.2    Yoshizawa, T.3    Kanazawa, I.4
  • 41
    • 0027141312 scopus 로고
    • The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
    • Tölle T. R., Berthele A, Zieglgänsberger W., Seeburg P. H. and Wisden W. (1993) The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray. J. Neurosci. 13, 5009-5028.
    • (1993) J. Neurosci. , vol.13 , pp. 5009-5028
    • Tölle, T.R.1    Berthele, A.2    Zieglgänsberger, W.3    Seeburg, P.H.4    Wisden, W.5
  • 42
    • 0030561278 scopus 로고    scopus 로고
    • Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization
    • Tomiyama M., Rodriguez-Puertas R., Cortes R., Christnacher A., Sommer B., Pazos A., Palacios J. and Mengod G. (1996) Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization. Neuroscience 75, 901-915.
    • (1996) Neuroscience , vol.75 , pp. 901-915
    • Tomiyama, M.1    Rodriguez-Puertas, R.2    Cortes, R.3    Christnacher, A.4    Sommer, B.5    Pazos, A.6    Palacios, J.7    Mengod, G.8
  • 43
    • 0034967926 scopus 로고    scopus 로고
    • Absolute quantification of AMPA receptor subunit mRNAs in single hippocampal neurons
    • Tsuzuki K., Lambolez B., Rossier J. and Ozawa S. (2001) Absolute quantification of AMPA receptor subunit mRNAs in single hippocampal neurons. J. Neurochem. 77, 1650-1659.
    • (2001) J. Neurochem. , vol.77 , pp. 1650-1659
    • Tsuzuki, K.1    Lambolez, B.2    Rossier, J.3    Ozawa, S.4
  • 44
    • 0034307730 scopus 로고    scopus 로고
    • AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability
    • Vandenberghe W., Ihle E. C., Patrieau D. K., Robberecht W. and Brorson J. R. (2000a) AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability. J. Neurosci. 20, 7158-7166.
    • (2000) J. Neurosci. , vol.20 , pp. 7158-7166
    • Vandenberghe, W.1    Ihle, E.C.2    Patrieau, D.K.3    Robberecht, W.4    Brorson, J.R.5
  • 45
    • 0033993642 scopus 로고    scopus 로고
    • AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability
    • Vandenberghe W., Robberecht W. and Brorson J. (2000b) AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability. J. Neurosci. 20, 123-132.
    • (2000) J. Neurosci. , vol.20 , pp. 123-132
    • Vandenberghe, W.1    Robberecht, W.2    Brorson, J.3
  • 46
    • 0025879427 scopus 로고
    • Structural determinants of ion flow through recombinant glutamate receptor channels
    • Verdoorn T., Burnashev N., Monye R. H., Seeburg P. and Sakmann B. (1991) Structural determinants of ion flow through recombinant glutamate receptor channels. Science 252, 1715-1718.
    • (1991) Science , vol.252 , pp. 1715-1718
    • Verdoorn, T.1    Burnashev, N.2    Monye, R.H.3    Seeburg, P.4    Sakmann, B.5
  • 47
    • 0029851596 scopus 로고    scopus 로고
    • Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord
    • Virgo L., Samarasinghe S. and de Belleroche J. (1996) Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord. Neuroreport 7, 2507-2511.
    • (1996) Neuroreport , vol.7 , pp. 2507-2511
    • Virgo, L.1    Samarasinghe, S.2    De Belleroche, J.3
  • 48
    • 0030789347 scopus 로고    scopus 로고
    • Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis
    • Williams T., Day N., Ince P., Kamboj R. and Shaw P. (1997) Calcium-permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: a molecular determinant of selective vulnerability in amyotrophic lateral sclerosis. Ann. Neurol. 42, 200-207.
    • (1997) Ann. Neurol. , vol.42 , pp. 200-207
    • Williams, T.1    Day, N.2    Ince, P.3    Kamboj, R.4    Shaw, P.5


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