Gene transfer demonstrates that muscle is not a primary target for non-cell-autonomous toxicity in familial amyotrophic lateral sclerosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 51, 2006, Pages 19546-19551

  Miller, Timothy M ^a,b   Kim, Soo H ^c,d   Yamanaka, Koji ^a   Hester, Mark ^d   Umapathi, Priya ^d   Arnson, Hannah ^d   Rizo, Liza ^d   Mendell, Jerry R ^c,d   Gage, Fred H ^e   Cleveland, Don W ^a,b   Kaspar, Brian K ^c,d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OHIO STATE UNIVERSITY   (United States)

^d THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^e SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

Adeno associated virus; G93A SOD1; Motor neuron; Myostatin; siRNA

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; FOLLISTATIN; MYOSTATIN; SMALL INTERFERING RNA;

ADENO ASSOCIATED VIRUS; AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE TRANSFER; GRIP STRENGTH; HUMAN; HUMAN CELL; MICROGLIA; MOTOR NEURON DISEASE; MOUSE; MUSCLE CELL; MUSCLE MASS; MUSCLE STRENGTH; MUTATION; NERVE CELL NECROSIS; NONHUMAN; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; CELL LINE; DEPENDOVIRUS; DISEASE PROGRESSION; FOLLISTATIN; GENETIC VECTORS; HAND STRENGTH; HUMANS; MICE; MOTOR NEURONS; MUSCLE, SKELETAL; MUTATION; RNA, SMALL INTERFERING; SUPEROXIDE DISMUTASE;

ADENO-ASSOCIATED VIRUS;

EID: 33845876647     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0609411103     Document Type: Article

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