Oxidation-induced misfolding and aggregation of superoxide dismutase and its implications for amyotrophic lateral sclerosis

Journal of Biological Chemistry

Volumn 277, Issue 49, 2002, Pages 47551-47556

  Rakhit, Rishi ^a   Cunningham, Patricia ^b   Furtos Matei, Alexandra ^b   Dahan, Sophie ^b   Qi, Xiao Fei ^a   Crow, John P ^c   Cashman, Neil R ^b,d   Kondejewski, Leslie H ^b   Chakrabartty, Avijit ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b Caprion Pharmaceuticals   (Canada)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; OXIDATION; PATHOLOGY; PROTEINS;

AMYOTROPHIC LATERAL SCLEROSIS (ALS);

BIOCHEMISTRY;

COPPER ZINC SUPEROXIDE DISMUTASE;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CELL TYPE; CIRCULAR DICHROISM; ENZYME ACTIVE SITE; ENZYME METABOLISM; HALF LIFE TIME; HUMAN; INHIBITION KINETICS; METAL BINDING; MOTONEURON; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; TANDEM MASS SPECTROMETRY;

AMINO ACIDS; AMYOTROPHIC LATERAL SCLEROSIS; BINDING SITES; CHROMATOGRAPHY, LIQUID; CIRCULAR DICHROISM; ERYTHROCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; LIGHT; MICROSCOPY, ATOMIC FORCE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; NEURONS; OXYGEN; PROTEIN BINDING; PROTEIN FOLDING; SCATTERING, RADIATION; SUPEROXIDE DISMUTASE; THIAZOLES; ZINC;

EID: 0347155578     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M207356200     Document Type: Article

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