Transient structural distortion of metal-free Cu/Zn superoxide dismutase triggers aberrant oligomerization

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 43, 2009, Pages 18273-18278

  Teilum, Kaare ^a,b   Smith, Melanie H ^a,d   Schulz, Eike ^a,e   Christensen, Lea C ^b   Solomentsev, Gleb ^a   Oliveberg, Mikael ^c   Akke, Mikael ^a  

^a LUND UNIVERSITY   (Sweden)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c STOCKHOLM UNIVERSITY   (Sweden)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Amyotrophic lateral sclerosis; Nuclear magnetic resonance relaxation; Protein misfolding

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; DIMER; DISULFIDE; METAL; OLIGOMER;

AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; CONFORMATION; DISEASE COURSE; DISPERSION; EXPERIMENT; GENETIC SUSCEPTIBILITY; KINETICS; METAL BINDING; MUTANT; NONHUMAN; OLIGOMERIZATION; OXIDATION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN EXPRESSION; PROTEIN STRUCTURE;

APOENZYMES; DISULFIDES; HUMANS; MODELS, MOLECULAR; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SUPEROXIDE DISMUTASE;

EID: 70849113863     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0907387106     Document Type: Article

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