GluR2-dependent properties of AMPA receptors determine the selective vulnerability of motor neurons to excitotoxicity

Journal of Neurophysiology

Volumn 88, Issue 3, 2002, Pages 1279-1287

  Van Damme, P ^a   Van Den Bosch, L ^a   Van Houtte, E ^a   Callewaert, G ^a   Robberecht, W ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; CALCIUM ION; GLUTAMATE RECEPTOR; MESSENGER RNA; POLYAMINE; RECEPTOR SUBTYPE;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CALCIUM TRANSPORT; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EMBRYO; MOTONEURON; NEUROTOXICITY; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR SENSITIVITY; SPINAL CORD DORSAL HORN; SPINAL CORD MOTONEURON;

EID: 0036713846     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.2002.88.3.1279     Document Type: Article

References (61)

1. Axotomy-induced change in the properties of (S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor channels in rat motoneurons
2. The role of calcium-binding proteins in selective motoneuron vulnerability in amyotrophic lateral sclerosis
3. Cultured motor neurons possess calcium-permeable AMPA/kainate receptors
4. Parvalbumin overexpression alters immune-mediated increases in intracellular calcium, and delays disease onset in a transgenic model of familial amyotrophic lateral sclerosis
5. A single amino acid determines the subunit-specific spider toxin block of α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor channels
6. Molecular cloning and functional expression of glutamate receptor subunit genes
7. Selective antagonism of native and cloned kainate and NMDA receptors by polyamine-containing toxins
8. Divalent ion permeability of AMPA receptor channels is dominated by the edited form of a single subunit
9. AMPA exposures induce mitochondrial Ca(2+) overload and ROS generation in spinal motor neurons in vitro
10. 2+ dependent
11. Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
12. Ionotropic glutamate receptor subunit distribution on hypoglossal motoneuronal pools in the rat
13. 2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors
14. Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B
15. 2+ permeability of AMPA receptors in principal neurons and interneurons in rat CNS
16. 2+-impermeable AMPA receptors on embryonic rat dorsal horn neurons
17. Characterization of the AMPA-activated receptors present on motoneurons
18. AMPA receptor function is altered in GLUR2-deficient mice
19. Argiotoxin detects molecular differences in AMPA receptor channels
20. 2+ permeability of KAAMPA-gated glutamate receptor channels depends on subunit composition
21. Kainic acid induces early and delayed degenerative neuronal changes in rat spinal cord
22. Identification of a site in glutamate receptor subunits that controls calcium permeability
23. Motor neuron degeneration induced by excitotoxin agonists has features in common with those seen in the SOD-1 transgenic mouse model of amyotrophic lateral sclerosis
24. Parvalbumin and calbindin D-28k in the human motor system and in motor neuron disease
25. Enhanced LTP in mice deficient in the AMPA receptor GluR 2
26. Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels
27. Intracellular spermine confers rectification on rat calcium-permeable AMPA and kainate receptors
28. 2+-permeable AMPA receptors in rat brain by intracellular polyamines generates double rectification
29. 2+-permeable AMPA receptors in cultured rat hippocampal neurons
30. Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration
31. Endogenous calcium buffering in motoneurones of the nucleus hypoglossus from mouse
32. Activity-related calcium dynamics in motoneurons of the nucleus hypoglossus from mouse
33. Light and electron microscopic distribution of the AMPA receptor subunit, GluR 2, in the spinal cord of control and G86R mutant superoxide dismutase transgenic mice
34. Two types of kainate response in cultured rat hippocampal neurons
35. Calcium dynamics and buffering in motoneurones of the mouse spinal cord
36. RNA editing of the glutamate receptor subunits GluR 2 and GluR6 in human brain tissue
37. Selective RNA editing and subunit assembly of native glutamate receptors
38. Excitotoxicity hypothesis
39. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity
40. Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches
41. Glutamate, excitotoxicity, and amyotrophic lateral sclerosis
42. Low expression of GluR2 AMPA receptor subunit protein by human motor neurons
43. Strain-dependent differences in calcium signaling predict excitotoxicity in murine hippocampal neurons
44. RNA editing in brain controls a determinant of ion flow in glutamate-gated channels
45. Single-channel properties of recombinant AMPA receptors depend on RNA editing, splice variation, and subunit composition
46. Reduction of GluR2 RNA editing, a molecular change that increases calcium influx through AMPA receptors, selective in the spinal ventral gray of patients with amyotrophic lateral sclerosis
47. Sensitivity of AMPA receptors to pentobarbital
48. The differential expression of 16 NMDA and non-NMDA receptor subunits in the rat spinal cord and in periaqueductal gray
49. Differential regional distribution of AMPA receptor subunit messenger RNAs in the human spinal cord as visualized by in situ hybridization
50. + channel blockade in cultured rat spinal cord motoneurons
51. AMPA receptor current density, not desensitization, predicts selective motoneuron vulnerability
52. AMPA receptor calcium permeability, GluR2 expression, and selective motoneuron vulnerability
53. Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system
54. Protective effect of parvalbumin on excitotoxic motor neuron death
55. 2+ influx and not via calpain inhibition
56. 2+-permeable AMPA receptors and selective vulnerability of motor neurons
57. Calcium dynamics and buffering in oculomotor neurones from mouse that are particularly resistant during amyotrophic lateral sclerosis (ALS)-related motoneurone disease
58. Structural determinants of ion flow through recombinant glutamate receptor channels
59. Analysis of AMPA receptor subunit mRNA expression in control and ALS spinal cord
60. Calciumpermeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptors: A molecular determinant of selective vulnerability in amyotrophic lateral sclerosis
61. The sensitivity of AMPA-selective glutamate receptor channels to pentobarbital is determined by a single amino acid residue of the α2 subunit