-
1
-
-
0035189072
-
Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels
-
Bendotti C. Tortarolo M. Suchak S.K. Calvaresi N. Carvelli L. Bastone A. Rizzi M. Rattray M. Mennini T. Transgenic SOD1 G93A mice develop reduced GLT-1 in spinal cord without alterations in cerebrospinal fluid glutamate levels J. Neurochem. 79 2001 737 746
-
(2001)
J. Neurochem.
, vol.79
, pp. 737-746
-
-
Bendotti, C.1
Tortarolo, M.2
Suchak, S.K.3
Calvaresi, N.4
Carvelli, L.5
Bastone, A.6
Rizzi, M.7
Rattray, M.8
Mennini, T.9
-
2
-
-
0028097839
-
A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole. Study. Group
-
Bensimon G. Lacomblez L. Meininger V. A controlled trial of riluzole in amyotrophic lateral sclerosis. ALS/Riluzole. Study. Group N. Engl. J. Med. 330 1994 585 591
-
(1994)
N. Engl. J. Med.
, vol.330
, pp. 585-591
-
-
Bensimon, G.1
Lacomblez, L.2
Meininger, V.3
-
3
-
-
33749056809
-
ALS: a disease of motor neurons and their nonneuronal neighbors
-
Boillee S. Vande Velde C. Cleveland D.W. ALS: a disease of motor neurons and their nonneuronal neighbors Neuron 52 2006 39 59
-
(2006)
Neuron
, vol.52
, pp. 39-59
-
-
Boillee, S.1
Vande Velde, C.2
Cleveland, D.W.3
-
4
-
-
33744798774
-
Onset and progression in inherited ALS determined by motor neurons and microglia
-
Boillee S. Yamanaka K. Lobsiger C.S. Copeland N.G. Jenkins N.A. Kassiotis G. Kollias G. Cleveland D.W. Onset and progression in inherited ALS determined by motor neurons and microglia Science 312 2006 1389 1392
-
(2006)
Science
, vol.312
, pp. 1389-1392
-
-
Boillee, S.1
Yamanaka, K.2
Lobsiger, C.S.3
Copeland, N.G.4
Jenkins, N.A.5
Kassiotis, G.6
Kollias, G.7
Cleveland, D.W.8
-
5
-
-
0031051485
-
ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions
-
Bruijn L.I. Becher M.W. Lee M.K. Anderson K.L. Jenkins N.A. Copeland N.G. Sisodia S.S. Rothstein J.D. Borchelt D.R. Price D.L. Cleveland D.W. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions Neuron 18 1997 327 338
-
(1997)
Neuron
, vol.18
, pp. 327-338
-
-
Bruijn, L.I.1
Becher, M.W.2
Lee, M.K.3
Anderson, K.L.4
Jenkins, N.A.5
Copeland, N.G.6
Sisodia, S.S.7
Rothstein, J.D.8
Borchelt, D.R.9
Price, D.L.10
Cleveland, D.W.11
-
6
-
-
0034802145
-
RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis
-
Canton T. Bohme G.A. Boireau A. Bordier F. Mignani S. Jimonet P. Jahn G. Alavijeh M. Stygall J. Roberts S. Brealey C. Vuilhorgne M. Debono M.W. Le Guern S. Laville M. Briet D. Roux M. Stutzmann J.M. Pratt J. RPR 119990, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid antagonist: synthesis, pharmacological properties, and activity in an animal model of amyotrophic lateral sclerosis J. Pharmacol. Exp. Ther. 299 2001 314 322
-
(2001)
J. Pharmacol. Exp. Ther.
, vol.299
, pp. 314-322
-
-
Canton, T.1
Bohme, G.A.2
Boireau, A.3
Bordier, F.4
Mignani, S.5
Jimonet, P.6
Jahn, G.7
Alavijeh, M.8
Stygall, J.9
Roberts, S.10
Brealey, C.11
Vuilhorgne, M.12
Debono, M.W.13
Le Guern, S.14
Laville, M.15
Briet, D.16
Roux, M.17
Stutzmann, J.M.18
Pratt, J.19
-
7
-
-
0030015076
-
Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro
-
Carriedo S.G. Yin H.Z. Weiss J.H. Motor neurons are selectively vulnerable to AMPA/kainate receptor-mediated injury in vitro J. Neurosci. 16 1996 4069 4079
-
(1996)
J. Neurosci.
, vol.16
, pp. 4069-4079
-
-
Carriedo, S.G.1
Yin, H.Z.2
Weiss, J.H.3
-
9
-
-
0141642203
-
Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice
-
Clement A.M. Nguyen M.D. Roberts E.A. Garcia M.L. Boillee S. Rule M. McMahon A.P. Doucette W. Siwek D. Ferrante R.J. Brown R.H. Jr. Julien J.P. Goldstein L.S. Cleveland D.W. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice Science 302 2003 113 117
-
(2003)
Science
, vol.302
, pp. 113-117
-
-
Clement, A.M.1
Nguyen, M.D.2
Roberts, E.A.3
Garcia, M.L.4
Boillee, S.5
Rule, M.6
McMahon, A.P.7
Doucette, W.8
Siwek, D.9
Ferrante, R.J.10
Brown, R.H.11
Julien, J.P.12
Goldstein, L.S.13
Cleveland, D.W.14
-
10
-
-
10744222650
-
A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis
-
Cudkowicz M.E. Shefner J.M. Schoenfeld D.A. Brown R.H. Jr. Johnson H. Qureshi M. Jacobs M. Rothstein J.D. Appel S.H. Pascuzzi R.M. Heiman-Patterson T.D. Donofrio P.D. David W.S. Russell J.A. Tandan R. Pioro E.P. Felice K.J. Rosenfeld J. Mandler R.N. Sachs G.M. Bradley W.G. Raynor E.M. Baquis G.D. Belsh J.M. Novella S. Goldstein J. Hulihan J. A randomized, placebo-controlled trial of topiramate in amyotrophic lateral sclerosis Neurology 61 2003 456 464
-
(2003)
Neurology
, vol.61
, pp. 456-464
-
-
Cudkowicz, M.E.1
Shefner, J.M.2
Schoenfeld, D.A.3
Brown, R.H.4
Johnson, H.5
Qureshi, M.6
Jacobs, M.7
Rothstein, J.D.8
Appel, S.H.9
Pascuzzi, R.M.10
Heiman-Patterson, T.D.11
Donofrio, P.D.12
David, W.S.13
Russell, J.A.14
Tandan, R.15
Pioro, E.P.16
Felice, K.J.17
Rosenfeld, J.18
Mandler, R.N.19
Sachs, G.M.20
Bradley, W.G.21
Raynor, E.M.22
Baquis, G.D.23
Belsh, J.M.24
Novella, S.25
Goldstein, J.26
Hulihan, J.27
more..
-
12
-
-
34247473080
-
Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model
-
Di Giorgio F.P. Carrasco M.A. Siao M.C. Maniatis T. Eggan K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model Nat. Neurosci. 10 2007 608 614
-
(2007)
Nat. Neurosci.
, vol.10
, pp. 608-614
-
-
Di Giorgio, F.P.1
Carrasco, M.A.2
Siao, M.C.3
Maniatis, T.4
Eggan, K.5
-
13
-
-
0027759524
-
Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine
-
Eisen A. Stewart H. Schulzer M. Cameron D. Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine Can. J. Neurol. Sci. 20 1993 297 301
-
(1993)
Can. J. Neurol. Sci.
, vol.20
, pp. 297-301
-
-
Eisen, A.1
Stewart, H.2
Schulzer, M.3
Cameron, D.4
-
14
-
-
5644229846
-
Neurotrophic factors and amyotrophic lateral sclerosis
-
Ekestern E. Neurotrophic factors and amyotrophic lateral sclerosis Neurodegener. Dis. 1 2004 88 100
-
(2004)
Neurodegener. Dis.
, vol.1
, pp. 88-100
-
-
Ekestern, E.1
-
16
-
-
0041421277
-
Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models
-
Ghadge G.D. Slusher B.S. Bodner A. Canto M.D. Wozniak K. Thomas A.G. Rojas C. Tsukamoto T. Majer P. Miller R.J. Monti A.L. Roos R.P. Glutamate carboxypeptidase II inhibition protects motor neurons from death in familial amyotrophic lateral sclerosis models Proc. Natl. Acad. Sci. U. S. A. 100 2003 9554 9559
-
(2003)
Proc. Natl. Acad. Sci. U. S. A.
, vol.100
, pp. 9554-9559
-
-
Ghadge, G.D.1
Slusher, B.S.2
Bodner, A.3
Canto, M.D.4
Wozniak, K.5
Thomas, A.G.6
Rojas, C.7
Tsukamoto, T.8
Majer, P.9
Miller, R.J.10
Monti, A.L.11
Roos, R.P.12
-
17
-
-
0034651102
-
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
-
Gong Y.H. Parsadanian A.S. Andreeva A. Snider W.D. Elliott J.L. Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration J. Neurosci. 20 2000 660 665
-
(2000)
J. Neurosci.
, vol.20
, pp. 660-665
-
-
Gong, Y.H.1
Parsadanian, A.S.2
Andreeva, A.3
Snider, W.D.4
Elliott, J.L.5
-
18
-
-
34248592075
-
Role of mitochondria in kainate-induced fast Ca2+ transients in cultured spinal motor neurons
-
2+ transients in cultured spinal motor neurons Cell. Calcium. 42 2007 59 69
-
(2007)
Cell. Calcium.
, vol.42
, pp. 59-69
-
-
Grosskreutz, J.1
Haastert, K.2
Dewil, M.3
Van Damme, P.4
Callewaert, G.5
Robberecht, W.6
Dengler, R.7
Van Den Bosch, L.8
-
19
-
-
0141618315
-
Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice
-
Guo H. Lai L. Butchbach M.E. Stockinger M.P. Shan X. Bishop G.A. Lin C.L. Increased expression of the glial glutamate transporter EAAT2 modulates excitotoxicity and delays the onset but not the outcome of ALS in mice Hum. Mol. Genet. 12 2003 2519 2532
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 2519-2532
-
-
Guo, H.1
Lai, L.2
Butchbach, M.E.3
Stockinger, M.P.4
Shan, X.5
Bishop, G.A.6
Lin, C.L.7
-
20
-
-
0030050727
-
Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis
-
Gurney M.E. Cutting F.B. Zhai P. Doble A. Taylor C.P. Andrus P.K. Hall E.D. Benefit of vitamin E, riluzole, and gabapentin in a transgenic model of familial amyotrophic lateral sclerosis Ann. Neurol. 39 1996 147 157
-
(1996)
Ann. Neurol.
, vol.39
, pp. 147-157
-
-
Gurney, M.E.1
Cutting, F.B.2
Zhai, P.3
Doble, A.4
Taylor, C.P.5
Andrus, P.K.6
Hall, E.D.7
-
21
-
-
0028284779
-
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
-
Gurney M.E. Pu H. Chiu A.Y. Dal Canto M.C. Polchow C.Y. Alexander D.D. Caliendo J. Hentati A. Kwon Y.W. Deng H.X. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation Science 264 1994 1772 1775
-
(1994)
Science
, vol.264
, pp. 1772-1775
-
-
Gurney, M.E.1
Pu, H.2
Chiu, A.Y.3
Dal Canto, M.C.4
Polchow, C.Y.5
Alexander, D.D.6
Caliendo, J.7
Hentati, A.8
Kwon, Y.W.9
Deng, H.X.10
-
22
-
-
0032125587
-
Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS
-
Hall E.D. Oostveen J.A. Gurney M.E. Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS Glia 23 1998 249 256
-
(1998)
Glia
, vol.23
, pp. 249-256
-
-
Hall, E.D.1
Oostveen, J.A.2
Gurney, M.E.3
-
23
-
-
0037022339
-
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS)
-
Howland D.S. Liu J. She Y. Goad B. Maragakis N.J. Kim B. Erickson J. Kulik J. DeVito L. Psaltis G. DeGennaro L.J. Cleveland D.W. Rothstein J.D. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS) Proc. Natl. Acad. Sci. U. S. A. 99 2002 1604 1609
-
(2002)
Proc. Natl. Acad. Sci. U. S. A.
, vol.99
, pp. 1604-1609
-
-
Howland, D.S.1
Liu, J.2
She, Y.3
Goad, B.4
Maragakis, N.J.5
Kim, B.6
Erickson, J.7
Kulik, J.8
DeVito, L.9
Psaltis, G.10
DeGennaro, L.J.11
Cleveland, D.W.12
Rothstein, J.D.13
-
24
-
-
85120287408
-
-
Jones, T., 1999. An assessment of the efficacy and safety of LY300164 in patients with ALS/MND. Abstract ALS/MND.
-
-
-
-
25
-
-
0036406903
-
Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis
-
Kriz J. Nguyen M.D. Julien J.P. Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis Neurobiol. Dis. 10 2002 268 278
-
(2002)
Neurobiol. Dis.
, vol.10
, pp. 268-278
-
-
Kriz, J.1
Nguyen, M.D.2
Julien, J.P.3
-
26
-
-
0025868659
-
Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain
-
Kushner P.D. Stephenson D.T. Wright S. Reactive astrogliosis is widespread in the subcortical white matter of amyotrophic lateral sclerosis brain J. Neuropathol. Exp. Neurol. 50 1991 263 277
-
(1991)
J. Neuropathol. Exp. Neurol.
, vol.50
, pp. 263-277
-
-
Kushner, P.D.1
Stephenson, D.T.2
Wright, S.3
-
27
-
-
0029977337
-
Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II
-
Lacomblez L. Bensimon G. Leigh P.N. Guillet P. Meininger V. Dose-ranging study of riluzole in amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis/Riluzole Study Group II Lancet 347 1996 1425 1431
-
(1996)
Lancet
, vol.347
, pp. 1425-1431
-
-
Lacomblez, L.1
Bensimon, G.2
Leigh, P.N.3
Guillet, P.4
Meininger, V.5
-
28
-
-
0037096354
-
Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease
-
Lino M.M. Schneider C. Caroni P. Accumulation of SOD1 mutants in postnatal motoneurons does not cause motoneuron pathology or motoneuron disease J. Neurosci. 22 2002 4825 4832
-
(2002)
J. Neurosci.
, vol.22
, pp. 4825-4832
-
-
Lino, M.M.1
Schneider, C.2
Caroni, P.3
-
30
-
-
10544254257
-
Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group
-
Miller R.G. Moore D. Young L.A. Armon C. Barohn R.J. Bromberg M.B. Bryan W.W. Gelinas D.F. Mendoza M.C. Neville H.E. Parry G.J. Petajan J.H. Ravits J.M. Ringel S.P. Ross M.A. Placebo-controlled trial of gabapentin in patients with amyotrophic lateral sclerosis. WALS Study Group. Western Amyotrophic Lateral Sclerosis Study Group Neurology 47 1996 1383 1388
-
(1996)
Neurology
, vol.47
, pp. 1383-1388
-
-
Miller, R.G.1
Moore, D.2
Young, L.A.3
Armon, C.4
Barohn, R.J.5
Bromberg, M.B.6
Bryan, W.W.7
Gelinas, D.F.8
Mendoza, M.C.9
Neville, H.E.10
Parry, G.J.11
Petajan, J.H.12
Ravits, J.M.13
Ringel, S.P.14
Ross, M.A.15
-
31
-
-
0035836649
-
Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis
-
Miller R.G. Moore D.H. 2nd Gelinas D.F. Dronsky V. Mendoza M. Barohn R.J. Bryan W. Ravits J. Yuen E. Neville H. Ringel S. Bromberg M. Petajan J. Amato A.A. Jackson C. Johnson W. Mandler R. Bosch P. Smith B. Graves M. Ross M. Sorenson E.J. Kelkar P. Parry G. Olney R. Phase III randomized trial of gabapentin in patients with amyotrophic lateral sclerosis Neurology 56 2001 843 848
-
(2001)
Neurology
, vol.56
, pp. 843-848
-
-
Miller, R.G.1
Moore, D.H.2
Gelinas, D.F.3
Dronsky, V.4
Mendoza, M.5
Barohn, R.J.6
Bryan, W.7
Ravits, J.8
Yuen, E.9
Neville, H.10
Ringel, S.11
Bromberg, M.12
Petajan, J.13
Amato, A.A.14
Jackson, C.15
Johnson, W.16
Mandler, R.17
Bosch, P.18
Smith, B.19
Graves, M.20
Ross, M.21
Sorenson, E.J.22
Kelkar, P.23
Parry, G.24
Olney, R.25
more..
-
33
-
-
22844452812
-
Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis
-
Nagano I. Ilieva H. Shiote M. Murakami T. Yokoyama M. Shoji M. Abe K. Therapeutic benefit of intrathecal injection of insulin-like growth factor-1 in a mouse model of amyotrophic lateral sclerosis J. Neurol. Sci. 235 2005 61 68
-
(2005)
J. Neurol. Sci.
, vol.235
, pp. 61-68
-
-
Nagano, I.1
Ilieva, H.2
Shiote, M.3
Murakami, T.4
Yokoyama, M.5
Shoji, M.6
Abe, K.7
-
34
-
-
0034978562
-
Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration
-
Oosthuyse B. Moons L. Storkebaum E. Beck H. Nuyens D. Brusselmans K. Van Dorpe J. Hellings P. Gorselink M. Heymans S. Theilmeier G. Dewerchin M. Laudenbach V. Vermylen P. Raat H. Acker T. Vleminckx V. Van Den Bosch L. Cashman N. Fujisawa H. Drost M.R. Sciot R. Bruyninckx F. Hicklin D.J. Ince C. Gressens P. Lupu F. Plate K.H. Robberecht W. Herbert J.M. Collen D. Carmeliet P. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration Nat. Genet. 28 2001 131 138
-
(2001)
Nat. Genet.
, vol.28
, pp. 131-138
-
-
Oosthuyse, B.1
Moons, L.2
Storkebaum, E.3
Beck, H.4
Nuyens, D.5
Brusselmans, K.6
Van Dorpe, J.7
Hellings, P.8
Gorselink, M.9
Heymans, S.10
Theilmeier, G.11
Dewerchin, M.12
Laudenbach, V.13
Vermylen, P.14
Raat, H.15
Acker, T.16
Vleminckx, V.17
Van Den Bosch, L.18
Cashman, N.19
Fujisawa, H.20
Drost, M.R.21
Sciot, R.22
Bruyninckx, F.23
Hicklin, D.J.24
Ince, C.25
Gressens, P.26
Lupu, F.27
Plate, K.H.28
Robberecht, W.29
Herbert, J.M.30
Collen, D.31
Carmeliet, P.32
more..
-
35
-
-
0033569575
-
Calcium dynamics and buffering in motoneurones of the mouse spinal cord
-
Palecek J. Lips M.B. Keller B.U. Calcium dynamics and buffering in motoneurones of the mouse spinal cord J. Physiol. 520 Pt 2 1999 485 502 520. Pt
-
(1999)
J. Physiol.
, vol.520 Pt 2
, pp. 485-502
-
-
Palecek, J.1
Lips, M.B.2
Keller, B.U.3
-
36
-
-
1942423576
-
Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis
-
Pehar M. Cassina P. Vargas M.R. Castellanos R. Viera L. Beckman J.S. Estevez A.G. Barbeito L. Astrocytic production of nerve growth factor in motor neuron apoptosis: implications for amyotrophic lateral sclerosis J. Neurochem. 89 2004 464 473
-
(2004)
J. Neurochem.
, vol.89
, pp. 464-473
-
-
Pehar, M.1
Cassina, P.2
Vargas, M.R.3
Castellanos, R.4
Viera, L.5
Beckman, J.S.6
Estevez, A.G.7
Barbeito, L.8
-
37
-
-
0035873076
-
Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment
-
Pramatarova A. Laganiere J. Roussel J. Brisebois K. Rouleau G. Neuron-specific expression of mutant superoxide dismutase 1 in transgenic mice does not lead to motor impairment J. Neurosci. 21 2001 3369 3374
-
(2001)
J. Neurosci.
, vol.21
, pp. 3369-3374
-
-
Pramatarova, A.1
Laganiere, J.2
Roussel, J.3
Brisebois, K.4
Rouleau, G.5
-
38
-
-
0346156083
-
Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis
-
Rao C.V. Weiss J.H. Excitotoxic and oxidative cross-talk between motor neurons and glia in ALS pathogenesis Trends Neurosci. 27 2004 17 23
-
(2004)
Trends Neurosci.
, vol.27
, pp. 17-23
-
-
Rao, C.V.1
Weiss, J.H.2
-
39
-
-
0345269737
-
Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons
-
Rao S.D. Yin H.Z. Weiss J.H. Disruption of glial glutamate transport by reactive oxygen species produced in motor neurons J. Neurosci. 23 2003 2627 2633
-
(2003)
J. Neurosci.
, vol.23
, pp. 2627-2633
-
-
Rao, S.D.1
Yin, H.Z.2
Weiss, J.H.3
-
40
-
-
0027401203
-
Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
-
Rosen D.R. Siddique T. Patterson D. Figlewicz D.A. Sapp P. Hentati A. Donaldson D. Goto J. O'Regan J.P. Deng H.X. Rahmani Z. Krizus A. McKenna-Yasek D. Cayabyab A. Gaston S.M. Berger R. Tanzi R.E. Halperin J.J. Herzfeldt B. Van den Bergh R. Hung W.Y. Bird T. Deng G. Mulder D.W. Smyth C. Laing N.G. Soriano E. Pericak-Vance M.A. Haines J. Rouleau G.A. Gusella J.S. Horvitz H.R. Brown R.H. Jr. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature 362 1993 59 62
-
(1993)
Nature
, vol.362
, pp. 59-62
-
-
Rosen, D.R.1
Siddique, T.2
Patterson, D.3
Figlewicz, D.A.4
Sapp, P.5
Hentati, A.6
Donaldson, D.7
Goto, J.8
O'Regan, J.P.9
Deng, H.X.10
Rahmani, Z.11
Krizus, A.12
McKenna-Yasek, D.13
Cayabyab, A.14
Gaston, S.M.15
Berger, R.16
Tanzi, R.E.17
Halperin, J.J.18
Herzfeldt, B.19
Van den Bergh, R.20
Hung, W.Y.21
Bird, T.22
Deng, G.23
Mulder, D.W.24
Smyth, C.25
Laing, N.G.26
Soriano, E.27
Pericak-Vance, M.A.28
Haines, J.29
Rouleau, G.A.30
Gusella, J.S.31
Horvitz, H.R.32
Brown, R.H.33
more..
-
41
-
-
0026597010
-
Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis
-
Rothstein J.D. Martin L.J. Kuncl R.W. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis N. Engl. J. Med. 326 1992 1464 1468
-
(1992)
N. Engl. J. Med.
, vol.326
, pp. 1464-1468
-
-
Rothstein, J.D.1
Martin, L.J.2
Kuncl, R.W.3
-
43
-
-
13344286293
-
Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate
-
Rothstein J.D. Dykes-Hoberg M. Pardo C.A. Bristol L.A. Jin L. Kuncl R.W. Kanai Y. Hediger M.A. Wang Y. Schielke J.P. Welty D.F. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate Neuron. 16 1996 675 686
-
(1996)
Neuron.
, vol.16
, pp. 675-686
-
-
Rothstein, J.D.1
Dykes-Hoberg, M.2
Pardo, C.A.3
Bristol, L.A.4
Jin, L.5
Kuncl, R.W.6
Kanai, Y.7
Hediger, M.A.8
Wang, Y.9
Schielke, J.P.10
Welty, D.F.11
-
44
-
-
19944428649
-
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
-
Rothstein J.D. Patel S. Regan M.R. Haenggeli C. Huang Y.H. Bergles D.E. Jin L. Dykes-Hoberg M. Vidensky S. Chung D.S. Toan S.V. Bruijn L.I. Su Z.Z. Gupta P. Fisher P.B. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression Nature 433 2005 73 77
-
(2005)
Nature
, vol.433
, pp. 73-77
-
-
Rothstein, J.D.1
Patel, S.2
Regan, M.R.3
Haenggeli, C.4
Huang, Y.H.5
Bergles, D.E.6
Jin, L.7
Dykes-Hoberg, M.8
Vidensky, S.9
Chung, D.S.10
Toan, S.V.11
Bruijn, L.I.12
Su, Z.Z.13
Gupta, P.14
Fisher, P.B.15
-
45
-
-
0033938202
-
Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis
-
Sasaki S. Komori T. Iwata M. Excitatory amino acid transporter 1 and 2 immunoreactivity in the spinal cord in amyotrophic lateral sclerosis Acta Neuropathol. (Berl). 100 2000 138 144
-
(2000)
Acta Neuropathol. (Berl).
, vol.100
, pp. 138-144
-
-
Sasaki, S.1
Komori, T.2
Iwata, M.3
-
46
-
-
0028168346
-
[3H]d-aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study
-
3H] d -aspartate binding sites in the normal human spinal cord and changes in motor neuron disease: a quantitative autoradiographic study Brain. Res. 655 1994 195 201
-
(1994)
Brain. Res.
, vol.655
, pp. 195-201
-
-
Shaw, P.J.1
Chinnery, R.M.2
Ince, P.G.3
-
47
-
-
16644382257
-
Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS
-
Storkebaum E. Lambrechts D. Dewerchin M. Moreno-Murciano M.P. Appelmans S. Oh H. Van Damme P. Rutten B. Man W.Y. De Mol M. Wyns S. Manka D. Vermeulen K. Van Den Bosch L. Mertens N. Schmitz C. Robberecht W. Conway E.M. Collen D. Moons L. Carmeliet P. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS Nat. Neurosci. 8 2005 85 92
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 85-92
-
-
Storkebaum, E.1
Lambrechts, D.2
Dewerchin, M.3
Moreno-Murciano, M.P.4
Appelmans, S.5
Oh, H.6
Van Damme, P.7
Rutten, B.8
Man, W.Y.9
De Mol, M.10
Wyns, S.11
Manka, D.12
Vermeulen, K.13
Van Den Bosch, L.14
Mertens, N.15
Schmitz, C.16
Robberecht, W.17
Conway, E.M.18
Collen, D.19
Moons, L.20
Carmeliet, P.21
more..
-
48
-
-
5444222849
-
Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model
-
Tateno M. Sadakata H. Tanaka M. Itohara S. Shin R.M. Miura M. Masuda M. Aosaki T. Urushitani M. Misawa H. Takahashi R. Calcium-permeable AMPA receptors promote misfolding of mutant SOD1 protein and development of amyotrophic lateral sclerosis in a transgenic mouse model Hum. Mol. Genet. 13 2004 2183 2196
-
(2004)
Hum. Mol. Genet.
, vol.13
, pp. 2183-2196
-
-
Tateno, M.1
Sadakata, H.2
Tanaka, M.3
Itohara, S.4
Shin, R.M.5
Miura, M.6
Masuda, M.7
Aosaki, T.8
Urushitani, M.9
Misawa, H.10
Takahashi, R.11
-
49
-
-
30344437262
-
Glutamate AMPA receptors change in motor neurons of SOD1(G93A) transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amyotrophic lateral sclerosis-like disease
-
Tortarolo M. Grignaschi G. Calvaresi N. Zennaro E. Spaltro G. Colovic M. Fracasso C. Guiso G. Elger B. Schneider H. Seilheimer B. Caccia S. Bendotti C. Glutamate AMPA receptors change in motor neurons of SOD1(G93A) transgenic mice and their inhibition by a noncompetitive antagonist ameliorates the progression of amyotrophic lateral sclerosis-like disease J. Neurosci. Res. 83 2006 134 146
-
(2006)
J. Neurosci. Res.
, vol.83
, pp. 134-146
-
-
Tortarolo, M.1
Grignaschi, G.2
Calvaresi, N.3
Zennaro, E.4
Spaltro, G.5
Colovic, M.6
Fracasso, C.7
Guiso, G.8
Elger, B.9
Schneider, H.10
Seilheimer, B.11
Caccia, S.12
Bendotti, C.13
-
51
-
-
0033366461
-
SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter
-
Trotti D. Rolfs A. Danbolt N.C. Brown R.H. Jr. Hediger M.A. SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nat. Neurosci. 2 1999 427 433
-
(1999)
Nat. Neurosci.
, vol.2
, pp. 427-433
-
-
Trotti, D.1
Rolfs, A.2
Danbolt, N.C.3
Brown, R.H.4
Hediger, M.A.5
-
52
-
-
29444443348
-
Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis
-
Urushitani M. Sik A. Sakurai T. Nukina N. Takahashi R. Julien J.P. Chromogranin-mediated secretion of mutant superoxide dismutase proteins linked to amyotrophic lateral sclerosis Nat. Neurosci. 9 2006 108 118
-
(2006)
Nat. Neurosci.
, vol.9
, pp. 108-118
-
-
Urushitani, M.1
Sik, A.2
Sakurai, T.3
Nukina, N.4
Takahashi, R.5
Julien, J.P.6
-
53
-
-
0037986558
-
The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis
-
Van Damme P. Leyssen M. Callewaert G. Robberecht W. Van Den Bosch L. The AMPA receptor antagonist NBQX prolongs survival in a transgenic mouse model of amyotrophic lateral sclerosis Neurosci. Lett. 343 2003 81 84
-
(2003)
Neurosci. Lett.
, vol.343
, pp. 81-84
-
-
Van Damme, P.1
Leyssen, M.2
Callewaert, G.3
Robberecht, W.4
Van Den Bosch, L.5
-
55
-
-
35548983991
-
Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity
-
Van Damme P. Bogaert E. Dewil M. Hersmus N. Kiraly D. Scheveneels W. Bockx I. Braeken D. Verpoorten N. Verhoeven K. Timmerman V. Herijgers P. Callewaert G. Carmeliet P. Van Den Bosch L. Robberecht W. Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity Proc. Natl. Acad. Sci. U. S. A. 104 2007 14825 14830
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 14825-14830
-
-
Van Damme, P.1
Bogaert, E.2
Dewil, M.3
Hersmus, N.4
Kiraly, D.5
Scheveneels, W.6
Bockx, I.7
Braeken, D.8
Verpoorten, N.9
Verhoeven, K.10
Timmerman, V.11
Herijgers, P.12
Callewaert, G.13
Carmeliet, P.14
Van Den Bosch, L.15
Robberecht, W.16
-
57
-
-
0037067009
-
Minocycline delays disease onset and mortality in a transgenic model of ALS
-
Van Den Bosch L. Tilkin P. Lemmens G. Robberecht W. Minocycline delays disease onset and mortality in a transgenic model of ALS Neuroreport 13 2002 1067 1070
-
(2002)
Neuroreport
, vol.13
, pp. 1067-1070
-
-
Van Den Bosch, L.1
Tilkin, P.2
Lemmens, G.3
Robberecht, W.4
-
58
-
-
0036239183
-
An alpha-mercaptoacrylic acid derivative (PD150606) inhibits selective motor neuron death via inhibition of kainate-induced Ca2+ influx and not via calpain inhibition
-
2+ influx and not via calpain inhibition Neuropharmacology 42 2002 706 713
-
(2002)
Neuropharmacology
, vol.42
, pp. 706-713
-
-
Van Den Bosch, L.1
Van Damme, P.2
Vleminckx, V.3
Van Houtte, E.4
Lemmens, G.5
Missiaen, L.6
Callewaert, G.7
Robberecht, W.8
-
59
-
-
4444377607
-
Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration
-
Van Den Bosch L. Storkebaum E. Vleminckx V. Moons L. Vanopdenbosch L. Scheveneels W. Carmeliet P. Robberecht W. Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration Neurobiol. Dis. 17 2004 21 28
-
(2004)
Neurobiol. Dis.
, vol.17
, pp. 21-28
-
-
Van Den Bosch, L.1
Storkebaum, E.2
Vleminckx, V.3
Moons, L.4
Vanopdenbosch, L.5
Scheveneels, W.6
Carmeliet, P.7
Robberecht, W.8
-
61
-
-
0032487656
-
Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system
-
Vandenberghe W. Van Den Bosch L. Robberecht W. Glial cells potentiate kainate-induced neuronal death in a motoneuron-enriched spinal coculture system Brain. Res. 807 1998 1 10
-
(1998)
Brain. Res.
, vol.807
, pp. 1-10
-
-
Vandenberghe, W.1
Van Den Bosch, L.2
Robberecht, W.3
-
62
-
-
85120263003
-
-
Yamanaka, K., Chun, S.J., Boillee, S., Fujimori-Tonou, N., Yamashita, H., Gutmann, D.H., Takahashi, R., Misawa, H., Cleveland, D.W., in press. Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis. Nat. Neurosci. (published online 3 February 2008). doi:10.1038/nn2047 .
-
-
-
-
63
-
-
34548752918
-
Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS
-
Yin H.Z. Tang D.T. Weiss J.H. Intrathecal infusion of a Ca(2+)-permeable AMPA channel blocker slows loss of both motor neurons and of the astrocyte glutamate transporter, GLT-1 in a mutant SOD1 rat model of ALS Exp. Neurol. 207 2007 177 185
-
(2007)
Exp. Neurol.
, vol.207
, pp. 177-185
-
-
Yin, H.Z.1
Tang, D.T.2
Weiss, J.H.3
|