Copper-binding-site-null SOD1 causes ALS in transgenic mice: Aggregates of non-native SOD1 delineate a common feature

Human Molecular Genetics

Volumn 12, Issue 21, 2003, Pages 2753-2764

  Wang, Jiou ^a   Slunt, Hilda ^a   Gonzales, Victoria ^a   Fromholt, David ^a   Coonfield, Michael ^a   Copeland, Neal G ^b   Jenkins, Nancy A ^b   Borchelt, David R ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA CRYSTALLIN; ANTIOXIDANT; CHAPERONE; COPPER; COPPER ZINC SUPEROXIDE DISMUTASE; DETERGENT; HEAT SHOCK PROTEIN 25; HISTIDINE; OLIGOMER; PEPTIDE FRAGMENT; RECOMBINANT PROTEIN; UBIQUITIN;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CULTURE; CLINICAL FEATURE; CONTROLLED STUDY; COVALENT BOND; FAMILIAL DISEASE; GENE EXPRESSION; GENE MUTATION; GENETIC ANALYSIS; GENETIC VARIABILITY; HUMAN; HUMAN TISSUE; MOLECULAR STABILITY; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN MODIFICATION; SOLUBILITY; TOXICOLOGY; TRANSGENIC MOUSE; WILD TYPE;

ALPHA-CRYSTALLIN B CHAIN; AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; AXONS; BINDING SITES; CELLS, CULTURED; COPPER; HISTIDINE; HUMANS; INTERMEDIATE FILAMENT PROTEINS; MICE; MICE, TRANSGENIC; MOTOR NEURONS; MUTATION; NERVE TISSUE PROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; SPINAL CORD; SUPEROXIDE DISMUTASE;

ANIMALIA; MUS MUSCULUS;

EID: 0242524455     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/ddg312     Document Type: Article

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