메뉴 건너뛰기




Volumn 79, Issue , 2010, Pages 295-319

Biochemical principles of small RNA pathways

Author keywords

[No Author keywords available]

Indexed keywords

DICER; HELICASE; MICRORNA; PIWI INTERACTING RNA; SMALL INTERFERING RNA;

EID: 77953635299     PISSN: 00664154     EISSN: 00664154     Source Type: Book Series    
DOI: 10.1146/annurev.biochem.052208.151733     Document Type: Review
Times cited : (154)

References (154)
  • 2
    • 60149088848 scopus 로고    scopus 로고
    • Origins and mechanisms of mi RNAs and si RNAs
    • Carthew RW, Sontheimer EJ. 2009. Origins and mechanisms of miRNAs and siRNAs. Cell 136:642-55
    • (2009) Cell , vol.136 , pp. 642-55
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 3
    • 58749096360 scopus 로고    scopus 로고
    • On the road to reading the RNA-interference code
    • Siomi H, Siomi MC. 2009. On the road to reading the RNA-interference code. Nature 457:396-404
    • (2009) Nature , vol.457 , pp. 396-404
    • Siomi, H.1    Siomi, M.C.2
  • 4
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing RNAs: An expanding universe
    • Ghildiyal M, Zamore PD. 2009. Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 10:94-108
    • (2009) Nat. Rev. Genet. , vol.10 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 5
    • 65649092633 scopus 로고    scopus 로고
    • The genetic signatures of noncoding RNAs
    • Mattick JS. 2009. The genetic signatures of noncoding RNAs. PLoS Genet. 5:e1000459
    • (2009) PLoS Genet. , vol.5
    • Mattick, J.S.1
  • 6
    • 63349111149 scopus 로고    scopus 로고
    • Small RNAs and the control of transposons and viruses in Drosophila
    • van Rij RP, Berezikov E. 2009. Small RNAs and the control of transposons and viruses in Drosophila. Trends Microbiol. 17:163-71
    • (2009) Trends Microbiol. , vol.17 , pp. 163-71
    • Van Rij, R.P.1    Berezikov, E.2
  • 7
    • 60149098474 scopus 로고    scopus 로고
    • Small RNAs as guardians of the genome
    • Malone CD, Hannon GJ. 2009. Small RNAs as guardians of the genome. Cell 136:656-68
    • (2009) Cell , vol.136 , pp. 656-68
    • Malone, C.D.1    Hannon, G.J.2
  • 9
    • 50149095122 scopus 로고    scopus 로고
    • Endogenous small interfering RNAs in animals
    • Okamura K, Lai EC. 2008. Endogenous small interfering RNAs in animals. Nat. Rev. Mol. Cell Biol. 9:673-78
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 673-78
    • Okamura, K.1    Lai, E.C.2
  • 10
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
    • Napoli C, Lemieux C, Jorgensen R. 1990. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 2:279-89
    • (1990) Plant Cell , vol.2 , pp. 279-89
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 11
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. 1998. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-11
    • (1998) Nature , vol.391 , pp. 806-11
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 12
    • 0033615491 scopus 로고    scopus 로고
    • A species of small antisense RNA in posttranscriptional gene silencing in plants
    • Hamilton AJ, Baulcombe DC. 1999. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science 286:950-52
    • (1999) Science , vol.286 , pp. 950-52
    • Hamilton, A.J.1    Baulcombe, D.C.2
  • 14
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, Bartel DP. 2000. RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 101:25-33
    • (2000) Cell , vol.101 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 15
    • 0034673638 scopus 로고    scopus 로고
    • An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells
    • Hammond SM, Bernstein E, Beach D, Hannon GJ. 2000. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells. Nature 404:293-96
    • (2000) Nature , vol.404 , pp. 293-96
    • Hammond, S.M.1    Bernstein, E.2    Beach, D.3    Hannon, G.J.4
  • 16
    • 0035863097 scopus 로고    scopus 로고
    • RNA interference is mediated by 21- and 22-nucleotide RNAs
    • DOI 10.1101/gad.862301
    • Elbashir SM, Lendeckel W, Tuschl T. 2001. RNA interference is mediated by 21-and 22-nucleotide RNAs. Genes Dev. 15:188-200 (Pubitemid 32107664)
    • (2001) Genes and Development , vol.15 , Issue.2 , pp. 188-200
    • Elbashir, S.M.1    Lendeckel, W.2    Tuschl, T.3
  • 17
    • 0035803583 scopus 로고    scopus 로고
    • Functional anatomy ofsiRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate
    • Elbashir SM, Martinez J, Patkaniowska A, Lendeckel W, Tuschl T. 2001. Functional anatomy ofsiRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate. EMBO J. 20:6877-88
    • (2001) EMBO J. , vol.20 , pp. 6877-88
    • Elbashir, S.M.1    Martinez, J.2    Patkaniowska, A.3    Lendeckel, W.4    Tuschl, T.5
  • 18
    • 0036752955 scopus 로고    scopus 로고
    • Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways
    • Schwarz DS, Hutvagner G, Haley B, Zamore PD. 2002. Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways. Mol. Cell 10:537-48
    • (2002) Mol. Cell , vol.10 , pp. 537-48
    • Schwarz, D.S.1    Hutvagner, G.2    Haley, B.3    Zamore, P.D.4
  • 19
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. 2001. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411:494-98
    • (2001) Nature , vol.411 , pp. 494-98
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 20
    • 0023354166 scopus 로고
    • The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events
    • Ambros V, Horvitz HR. 1987. The lin-14 locus of Caenorhabditis elegans controls the time of expression of specific postembryonic developmental events. Genes Dev. 1:398-414
    • (1987) Genes Dev. , vol.1 , pp. 398-414
    • Ambros, V.1    Horvitz, H.R.2
  • 21
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. 1993. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 75:843-54
    • (1993) Cell , vol.75 , pp. 843-54
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 22
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I, Ruvkun G. 1993. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 75:855-62
    • (1993) Cell , vol.75 , pp. 855-62
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 23
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, Pasquinelli AE, Bettinger JC, et al. 2000. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans. Nature 403:901-6
    • (2000) Nature , vol.403 , pp. 901-6
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3    Pasquinelli, A.E.4    Bettinger, J.C.5
  • 24
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • Olsen PH, Ambros V. 1999. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev. Biol. 216:671-80
    • (1999) Dev. Biol. , vol.216 , pp. 671-80
    • Olsen, P.H.1    Ambros, V.2
  • 25
    • 0034724519 scopus 로고    scopus 로고
    • Double-stranded RNA as a template for gene silencing
    • Bass BL. 2000. Double-stranded RNA as a template for gene silencing. Cell 101:235-38
    • (2000) Cell , vol.101 , pp. 235-38
    • Bass, B.L.1
  • 26
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E, Caudy AA, Hammond SM, Hannon GJ. 2001. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409:363-66
    • (2001) Nature , vol.409 , pp. 363-66
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 27
    • 0141868916 scopus 로고    scopus 로고
    • R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway
    • Liu Q, Rand TA, Kalidas S, Du F, Kim HE, et al. 2003. R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301:1921-25
    • (2003) Science , vol.301 , pp. 1921-25
    • Liu, Q.1    Rand, T.A.2    Kalidas, S.3    Du, F.4    Kim, H.E.5
  • 28
    • 0034597777 scopus 로고    scopus 로고
    • Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA
    • Pasquinelli AE, Reinhart BJ, Slack F, Martindale MQ, Kuroda MI, et al. 2000. Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature 408:86-89
    • (2000) Nature , vol.408 , pp. 86-89
    • Pasquinelli, A.E.1    Reinhart, B.J.2    Slack, F.3    Martindale, M.Q.4    Kuroda, M.I.5
  • 29
    • 0035800521 scopus 로고    scopus 로고
    • A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA
    • Hutvagner G, McLachlan J, Pasquinelli AE, Balint E, Tuschl T, Zamore PD. 2001. A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNA. Science 293:834-38
    • (2001) Science , vol.293 , pp. 834-38
    • Hutvagner, G.1    McLachlan, J.2    Pasquinelli, A.E.3    Balint, E.4    Tuschl, T.5    Zamore, P.D.6
  • 30
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • Lee YS, Nakahara K, Pham JW, Kim K, He Z, et al. 2004. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell 117:69-81
    • (2004) Cell , vol.117 , pp. 69-81
    • Lee, Y.S.1    Nakahara, K.2    Pham, J.W.3    Kim, K.4    He, Z.5
  • 31
    • 23044462450 scopus 로고    scopus 로고
    • Dicer-1 and R3D1-L catalyze Micro RNA maturation in Drosophila
    • Jiang F, Ye X, Liu X, Fincher L, McKearin D, Liu Q. 2005. Dicer-1 and R3D1-L catalyze Micro RNA maturation in Drosophila. Genes Dev. 19:1674-79
    • (2005) Genes Dev. , vol.19 , pp. 1674-79
    • Jiang, F.1    Ye, X.2    Liu, X.3    Fincher, L.4    McKearin, D.5    Liu, Q.6
  • 32
    • 0035807818 scopus 로고    scopus 로고
    • Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines
    • Billy E, Brondani V, Zhang H, Muller U, Filipowicz W. 2001. Specific interference with gene expression induced by long, double-stranded RNA in mouse embryonal teratocarcinoma cell lines. Proc. Natl. Acad. Sci. USA 98:14428-33
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 14428-33
    • Billy, E.1    Brondani, V.2    Zhang, H.3    Muller, U.4    Filipowicz, W.5
  • 34
    • 3142613181 scopus 로고    scopus 로고
    • Single processing center models for human Dicer and bacterial RNase III
    • Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W. 2004. Single processing center models for human Dicer and bacterial RNase III. Cell 118:57-68
    • (2004) Cell , vol.118 , pp. 57-68
    • Zhang, H.1    Kolb, F.A.2    Jaskiewicz, L.3    Westhof, E.4    Filipowicz, W.5
  • 35
    • 0035662491 scopus 로고    scopus 로고
    • Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage
    • Blaszczyk J, Tropea JE, Bubunenko M, Routzahn KM, Waugh DS, et al. 2001. Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage. Structure 9:1225-36
    • (2001) Structure , vol.9 , pp. 1225-36
    • Blaszczyk, J.1    Tropea, J.E.2    Bubunenko, M.3    Routzahn, K.M.4    Waugh, D.S.5
  • 36
    • 35349023128 scopus 로고    scopus 로고
    • Functional anatomy of the Drosophila Micro RNA-generating enzyme
    • Ye X, Paroo Z, Liu Q. 2007. Functional anatomy of the Drosophila Micro RNA-generating enzyme. J. Biol. Chem. 282:28373-78
    • (2007) J. Biol. Chem. , vol.282 , pp. 28373-78
    • Ye, X.1    Paroo, Z.2    Liu, Q.3
  • 37
    • 30844438338 scopus 로고    scopus 로고
    • Structural basis for double-stranded RNA processing by Dicer
    • Macrae IJ, Zhou K, Li F, Repic A, Brooks AN, et al. 2006. Structural basis for double-stranded RNA processing by Dicer. Science 311:195-98
    • (2006) Science , vol.311 , pp. 195-98
    • MacRae, I.J.1    Zhou, K.2    Li, F.3    Repic, A.4    Brooks, A.N.5
  • 39
    • 5144225452 scopus 로고    scopus 로고
    • Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity
    • Rand TA, Ginalski K, Grishin NV, Wang X. 2004. Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity. Proc. Natl. Acad. Sci. USA 101:14385-89
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14385-89
    • Rand, T.A.1    Ginalski, K.2    Grishin, N.V.3    Wang, X.4
  • 40
    • 0037031576 scopus 로고    scopus 로고
    • Single-stranded antisense siRNAs guide target RNA cleavage in RNAi
    • Martinez J, Patkaniowska A, UrlaubH, Luhrmann R, Tuschl T. 2002. Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. Cell 110:563-74
    • (2002) Cell , vol.110 , pp. 563-74
    • Martinez, J.1    Patkaniowska, A.2    Urlaub, H.3    Luhrmann, R.4    Tuschl, T.5
  • 41
    • 0032717319 scopus 로고    scopus 로고
    • The rde-1 gene, RNA interference, and transposon silencing in C elegans
    • Tabara H, SarkissianM, Kelly WG, FleenorJ, GrishokA, et al. 1999. The rde-1 gene, RNA interference, and transposon silencing in C elegans. Cell 99:123-32
    • (1999) Cell , vol.99 , pp. 123-32
    • Tabara, H.1    Sarkissian, M.2    Kelly, W.G.3    Fleenor, J.4    Grishok, A.5
  • 42
    • 0030885595 scopus 로고    scopus 로고
    • Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa
    • Cogoni C, Macino G. 1997. Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa. Proc. Natl. Acad. Sci. USA 94:10233-38
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10233-38
    • Cogoni, C.1    MacIno, G.2
  • 43
    • 0034633770 scopus 로고    scopus 로고
    • AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals
    • Fagard M, Boutet S, Morel JB, Bellini C, Vaucheret H. 2000. AGO1, QDE-2, and RDE-1 are related proteins required for post-transcriptional gene silencing in plants, quelling in fungi, and RNA interference in animals. Proc. Natl. Acad. Sci. USA 97:11650-54
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 11650-54
    • Fagard, M.1    Boutet, S.2    Morel, J.B.3    Bellini, C.4    Vaucheret, H.5
  • 45
    • 2442495329 scopus 로고    scopus 로고
    • RISCisa 5'phosphomonoester-producing RNA endonuclease
    • Martinez J, Tuschl T. 2004. RISCisa 5'phosphomonoester-producing RNA endonuclease. GenesDev. 18:975-80
    • (2004) GenesDev. , vol.18 , pp. 975-80
    • Martinez, J.1    Tuschl, T.2
  • 48
    • 4444302947 scopus 로고    scopus 로고
    • Crystal structure of Argonaute and its implications for RISC slicer activity
    • Song JJ, Smith SK, Hannon GJ, Joshua-Tor L. 2004. Crystal structure of Argonaute and its implications for RISC slicer activity. Science 305:1434-37
    • (2004) Science , vol.305 , pp. 1434-37
    • Song, J.J.1    Smith, S.K.2    Hannon, G.J.3    Joshua-Tor, L.4
  • 50
    • 28444437427 scopus 로고    scopus 로고
    • Slicer function of Drosophila Argonautes and its involvement in RISC formation
    • Miyoshi K, Tsukumo H, Nagami T, SiomiH, SiomiMC. 2005. Slicer function of Drosophila Argonautes and its involvement in RISC formation. Genes Dev. 19:2837-48
    • (2005) Genes Dev. , vol.19 , pp. 2837-48
    • Miyoshi, K.1    Tsukumo, H.2    Nagami, T.3    Siomi, H.4    Siomi, M.C.5
  • 51
    • 3142729150 scopus 로고    scopus 로고
    • Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways
    • Okamura K, Ishizuka A, Siomi H, Siomi MC. 2004. Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathways. Genes Dev. 18:1655-66
    • (2004) Genes Dev. , vol.18 , pp. 1655-66
    • Okamura, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 52
    • 57749206034 scopus 로고    scopus 로고
    • Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex
    • Wang Y, Juranek S, Li H, Sheng G, Tuschl T, Patel DJ. 2008. Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature 456:921-26
    • (2008) Nature , vol.456 , pp. 921-26
    • Wang, Y.1    Juranek, S.2    Li, H.3    Sheng, G.4    Tuschl, T.5    Patel, D.J.6
  • 53
    • 56249145105 scopus 로고    scopus 로고
    • Structure of the guide-strand-containing argonaute silencing complex
    • Wang Y, Sheng G, Juranek S, Tuschl T, Patel DJ. 2008. Structure of the guide-strand-containing argonaute silencing complex. Nature 456:209-13
    • (2008) Nature , vol.456 , pp. 209-13
    • Wang, Y.1    Sheng, G.2    Juranek, S.3    Tuschl, T.4    Patel, D.J.5
  • 54
  • 55
    • 23944514849 scopus 로고    scopus 로고
    • Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation
    • Bagga S, Bracht J, Hunter S, Massirer K, Holtz J, et al. 2005. Regulation by let-7 and lin-4 miRNAs results in target mRNA degradation. Cell 122:553-63
    • (2005) Cell , vol.122 , pp. 553-63
    • Bagga, S.1    Bracht, J.2    Hunter, S.3    Massirer, K.4    Holtz, J.5
  • 56
    • 33750221973 scopus 로고    scopus 로고
    • Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells
    • Schmitter D, Filkowski J, Sewer A, Pillai RS, Oakeley EJ, et al. 2006. Effects of Dicer and Argonaute down-regulation on mRNA levels in human HEK293 cells. Nucleic Acids Res. 34:4801-15
    • (2006) Nucleic Acids Res. , vol.34 , pp. 4801-15
    • Schmitter, D.1    Filkowski, J.2    Sewer, A.3    Pillai, R.S.4    Oakeley, E.J.5
  • 57
    • 2142654329 scopus 로고    scopus 로고
    • Micro RNA-directed cleavage of HOXB8 mRNA
    • Yekta S, Shih IH, Bartel DP. 2004. Micro RNA-directed cleavage of HOXB8 mRNA. Science 304:594-96
    • (2004) Science , vol.304 , pp. 594-96
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 59
    • 74049129827 scopus 로고    scopus 로고
    • Micro RNAs mature with help from cancer biology
    • Paroo Z, Pertsemlidis A. 2009. Micro RNAs mature with help from cancer biology. Genome Biol. 10:310
    • (2009) Genome Biol. , vol.10 , pp. 310
    • Paroo, Z.1    Pertsemlidis, A.2
  • 60
    • 34249282243 scopus 로고    scopus 로고
    • Drosophila miR2 induces pseudopolysomes and inhibits translation initiation
    • Thermann R, Hentze MW. 2007. Drosophila miR2 induces pseudopolysomes and inhibits translation initiation. Nature 447:875-78
    • (2007) Nature , vol.447 , pp. 875-78
    • Thermann, R.1    Hentze, M.W.2
  • 61
    • 34547623022 scopus 로고    scopus 로고
    • Let-7 Micro RNA-mediated mRNA deadeny-lation and translational repression in a mammalian cell-free system
    • Wakiyama M, Takimoto K, Ohara O, Yokoyama S. 2007. Let-7 Micro RNA-mediated mRNA deadeny-lation and translational repression in a mammalian cell-free system. Genes Dev. 21:1857-62
    • (2007) Genes Dev. , vol.21 , pp. 1857-62
    • Wakiyama, M.1    Takimoto, K.2    Ohara, O.3    Yokoyama, S.4
  • 62
    • 33746581711 scopus 로고    scopus 로고
    • Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes
    • Liu X, Jiang F, Kalidas S, Smith D, Liu Q. 2006. Dicer-2 and R2D2 coordinately bind siRNA to promote assembly of the siRISC complexes. RNA 12:1514-20
    • (2006) RNA , vol.12 , pp. 1514-20
    • Liu, X.1    Jiang, F.2    Kalidas, S.3    Smith, D.4    Liu, Q.5
  • 63
    • 1842766252 scopus 로고    scopus 로고
    • A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila
    • Pham JW, Pellino JL, Lee YS, Carthew RW, Sontheimer EJ. 2004. A Dicer-2-dependent 80S complex cleaves targeted mRNAs during RNAi in Drosophila. Cell 117:83-94
    • (2004) Cell , vol.117 , pp. 83-94
    • Pham, J.W.1    Pellino, J.L.2    Lee, Y.S.3    Carthew, R.W.4    Sontheimer, E.J.5
  • 64
    • 1642603943 scopus 로고    scopus 로고
    • RISC assembly defects in the Drosophila RNAi mutant armitage
    • Tomari Y, Du T, Haley B, Schwarz DS, Bennett R, et al. 2004. RISC assembly defects in the Drosophila RNAi mutant armitage. Cell 116:831-41
    • (2004) Cell , vol.116 , pp. 831-41
    • Tomari, Y.1    Du, T.2    Haley, B.3    Schwarz, D.S.4    Bennett, R.5
  • 66
    • 0142165224 scopus 로고    scopus 로고
    • Functional siRNAs and miRNAs exhibit strand bias
    • Khvorova A, Reynolds A, Jayasena SD. 2003. Functional siRNAs and miRNAs exhibit strand bias. Cell 115:209-16
    • (2003) Cell , vol.115 , pp. 209-16
    • Khvorova, A.1    Reynolds, A.2    Jayasena, S.D.3
  • 68
    • 0035798415 scopus 로고    scopus 로고
    • ATP requirements and small interfering RNA structure in the RNA interference pathway
    • Nykanen A, Haley B, Zamore PD. 2001. ATP requirements and small interfering RNA structure in the RNA interference pathway. Cell 107:309-21
    • (2001) Cell , vol.107 , pp. 309-21
    • Nykanen, A.1    Haley, B.2    Zamore, P.D.3
  • 70
    • 34248576287 scopus 로고    scopus 로고
    • RNA helicase A interacts with RISC in human cells and functions in RISC loading
    • Robb GB, Rana TM. 2007. RNA helicase A interacts with RISC in human cells and functions in RISC loading. Mol. Cell 26:523-37
    • (2007) Mol. Cell , vol.26 , pp. 523-37
    • Robb, G.B.1    Rana, T.M.2
  • 71
    • 27744506761 scopus 로고    scopus 로고
    • Argonaute2 cleaves the antiguide strand of siRNA during RISC activation
    • Rand TA, Petersen S, Du F, Wang X. 2005. Argonaute2 cleaves the antiguide strand of siRNA during RISC activation. Cell 123:621-29
    • (2005) Cell , vol.123 , pp. 621-29
    • Rand, T.A.1    Petersen, S.2    Du, F.3    Wang, X.4
  • 72
    • 68449090733 scopus 로고    scopus 로고
    • C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation
    • Liu Y, Ye X, Jiang F, Liang C, Chen D, et al. 2009. C3PO, an endoribonuclease that promotes RNAi by facilitating RISC activation. Science 325:750-53
    • (2009) Science , vol.325 , pp. 750-53
    • Liu, Y.1    Ye, X.2    Jiang, F.3    Liang, C.4    Chen, D.5
  • 73
    • 33845890037 scopus 로고    scopus 로고
    • Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes
    • Kim K, Lee YS, Carthew RW. 2007. Conversion of pre-RISC to holo-RISC by Ago2 during assembly of RNAi complexes. RNA 13:22-29
    • (2007) RNA , vol.13 , pp. 22-29
    • Kim, K.1    Lee, Y.S.2    Carthew, R.W.3
  • 74
    • 33947153420 scopus 로고    scopus 로고
    • QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands
    • Maiti M, Lee HC, Liu Y. 2007. QIP, a putative exonuclease, interacts with the Neurospora Argonaute protein and facilitates conversion of duplex siRNA into single strands. Genes Dev. 21:590-600
    • (2007) Genes Dev. , vol.21 , pp. 590-600
    • Maiti, M.1    Lee, H.C.2    Liu, Y.3
  • 75
    • 33947319204 scopus 로고    scopus 로고
    • Biochemical mechanisms of the RNA-induced silencing complex
    • Paroo Z, Liu Q, Wang X. 2007. Biochemical mechanisms of the RNA-induced silencing complex. Cell Res. 17:187-94
    • (2007) Cell Res. , vol.17 , pp. 187-94
    • Paroo, Z.1    Liu, Q.2    Wang, X.3
  • 76
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples Micro RNA biogenesis and posttranscriptional gene silencing
    • Gregory RI, Chendrimada TP, Cooch N, Shiekhattar R. 2005. Human RISC couples Micro RNA biogenesis and posttranscriptional gene silencing. Cell 123:631-40
    • (2005) Cell , vol.123 , pp. 631-40
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 77
    • 29144431656 scopus 로고    scopus 로고
    • A human, ATP-independent, RISC assembly machine fueled by pre-miRNA
    • Maniataki E, Mourelatos Z. 2005. A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. Genes Dev. 19:2979-90
    • (2005) Genes Dev. , vol.19 , pp. 2979-90
    • Maniataki, E.1    Mourelatos, Z.2
  • 83
    • 20544465679 scopus 로고    scopus 로고
    • MiRNAs: Whys and wherefores of miRNA-mediated regulation
    • Lai EC. 2005. miRNAs: whys and wherefores of miRNA-mediated regulation. Curr. Biol. 15:R458-60
    • (2005) Curr. Biol. , vol.15
    • Lai, E.C.1
  • 84
    • 0037009364 scopus 로고    scopus 로고
    • Micro RNA maturation: Stepwise processing and sub-cellular localization
    • Lee Y, Jeon K, Lee JT, Kim S, Kim VN. 2002. Micro RNA maturation: stepwise processing and sub-cellular localization. EMBO J. 21:4663-70
    • (2002) EMBO J. , vol.21 , pp. 4663-70
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 86
    • 9344235449 scopus 로고    scopus 로고
    • Humanmicro RNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs
    • Cai X, Hagedorn CH, Cullen BR. 2004. Humanmicro RNAs are processed from capped, polyadenylated transcripts that can also function as mRNAs. RNA 10:1957-66
    • (2004) RNA , vol.10 , pp. 1957-66
    • Cai, X.1    Hagedorn, C.H.2    Cullen, B.R.3
  • 87
    • 8144225486 scopus 로고    scopus 로고
    • Micro RNA genes are transcribed by RNA polymerase II
    • Lee Y, Kim M, Han J, Yeom KH, Lee S, et al. 2004. Micro RNA genes are transcribed by RNA polymerase II. EMBO J. 23:4051-60
    • (2004) EMBO J. , vol.23 , pp. 4051-60
    • Lee, Y.1    Kim, M.2    Han, J.3    Yeom, K.H.4    Lee, S.5
  • 88
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates Micro RNA processing
    • Lee Y, Ahn C, Han J, Choi H, Kim J, et al. 2003. The nuclear RNase III Drosha initiates Micro RNA processing. Nature 425:415-19
    • (2003) Nature , vol.425 , pp. 415-19
    • Lee, Y.1    Ahn, C.2    Han, J.3    Choi, H.4    Kim, J.5
  • 89
    • 0034711308 scopus 로고    scopus 로고
    • Human RNase III is a 160-kDa protein involved in preribosomal RNA processing
    • Wu H, Xu H, Miraglia LJ, Crooke ST. 2000. Human RNase III is a 160-kDa protein involved in preribosomal RNA processing. J. Biol. Chem. 275:36957-65
    • (2000) J. Biol. Chem. , vol.275 , pp. 36957-65
    • Wu, H.1    Xu, H.2    Miraglia, L.J.3    Crooke, S.T.4
  • 90
    • 34447107760 scopus 로고    scopus 로고
    • The mirtron pathway generates Micro RNA-class regulatory RNAs in Drosophila
    • Okamura K, Hagen JW, Duan H, Tyler DM, Lai EC.2007. The mirtron pathway generates Micro RNA-class regulatory RNAs in Drosophila. Cell 130:89-100
    • (2007) Cell , vol.130 , pp. 89-100
    • Okamura, K.1    Hagen, J.W.2    Duan, H.3    Tyler, D.M.4    Lai, E.C.5
  • 91
    • 34447097693 scopus 로고    scopus 로고
    • Intronic Micro RNA precursors that bypass Drosha processing
    • Ruby JG, Jan CH, Bartel DP. 2007. Intronic Micro RNA precursors that bypass Drosha processing. Nature 448:83-86
    • (2007) Nature , vol.448 , pp. 83-86
    • Ruby, J.G.1    Jan, C.H.2    Bartel, D.P.3
  • 94
    • 0347361541 scopus 로고    scopus 로고
    • Exportin-5 mediates the nuclear export of preMicro RNAs and short hairpin RNAs
    • Yi R, Qin Y, Macara IG, Cullen BR. 2003. Exportin-5 mediates the nuclear export of preMicro RNAs and short hairpin RNAs. Genes Dev. 17:3011-16
    • (2003) Genes Dev. , vol.17 , pp. 3011-16
    • Yi, R.1    Qin, Y.2    MacAra, I.G.3    Cullen, B.R.4
  • 95
    • 12844285548 scopus 로고    scopus 로고
    • Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and Micro RNAs
    • Yi R, Doehle BP, Qin Y, Macara IG, Cullen BR. 2005. Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and Micro RNAs. RNA 11:220-26
    • (2005) RNA , vol.11 , pp. 220-26
    • Yi, R.1    Doehle, B.P.2    Qin, Y.3    MacAra, I.G.4    Cullen, B.R.5
  • 97
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack MT, Czaplinski K, Gorlich D. 2004. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10:185-91
    • (2004) RNA , vol.10 , pp. 185-91
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 98
    • 0037188904 scopus 로고    scopus 로고
    • The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans
    • Tabara H, Yigit E, Siomi H, Mello CC. 2002. The dsRNA binding protein RDE-4 interacts with RDE-1, DCR-1, and a DExH-box helicase to direct RNAi in C. elegans. Cell 109:861-71
    • (2002) Cell , vol.109 , pp. 861-71
    • Tabara, H.1    Yigit, E.2    Siomi, H.3    Mello, C.C.4
  • 99
    • 22744433240 scopus 로고    scopus 로고
    • Normal Micro RNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
    • Förstemann K, Tomari Y, Du T, Vagin VV, Denli AM, et al. 2005. Normal Micro RNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein. PLoS Biol. 3:e236
    • (2005) PLoS Biol. , vol.3
    • Förstemann, K.1    Tomari, Y.2    Du, T.3    Vagin, V.V.4    Denli, A.M.5
  • 100
    • 22744454230 scopus 로고    scopus 로고
    • Processing of premicro RNAs by the Dicer-1-Loquacious complex in Drosophila cells
    • Saito K, Ishizuka A, Siomi H, Siomi MC. 2005. Processing of premicro RNAs by the Dicer-1-Loquacious complex in Drosophila cells. PLoS Biol. 3:e235
    • (2005) PLoS Biol. , vol.3
    • Saito, K.1    Ishizuka, A.2    Siomi, H.3    Siomi, M.C.4
  • 101
    • 36249019204 scopus 로고    scopus 로고
    • Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes
    • Liu X, Park JK, Jiang F, Liu Y, McKearin D, Liu Q. 2007. Dicer-1, but not Loquacious, is critical for assembly of miRNA-induced silencing complexes. RNA 13:2324-29
    • (2007) RNA , vol.13 , pp. 2324-29
    • Liu, X.1    Park, J.K.2    Jiang, F.3    Liu, Y.4    McKearin, D.5    Liu, Q.6
  • 102
    • 23644433363 scopus 로고    scopus 로고
    • TRBP recruits the Dicer complex to Ago2 for Micro RNA processing and gene silencing
    • Chendrimada TP, Gregory RI, Kumaraswamy E, Norman J, Cooch N, et al. 2005. TRBP recruits the Dicer complex to Ago2 for Micro RNA processing and gene silencing. Nature 436:740-44
    • (2005) Nature , vol.436 , pp. 740-44
    • Chendrimada, T.P.1    Gregory, R.I.2    Kumaraswamy, E.3    Norman, J.4    Cooch, N.5
  • 103
    • 27144550559 scopus 로고    scopus 로고
    • TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing
    • Haase AD, Jaskiewicz L, Zhang H, Laine S, Sack R, et al. 2005. TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing. EMBO Rep. 6:961-67
    • (2005) EMBO Rep. , vol.6 , pp. 961-67
    • Haase, A.D.1    Jaskiewicz, L.2    Zhang, H.3    Laine, S.4    Sack, R.5
  • 104
    • 70349577785 scopus 로고    scopus 로고
    • Phosphorylation of the human Micro RNA-generating complex mediates MAPK/Erk signaling
    • Paroo Z, Ye X, Chen S, Liu Q. 2009. Phosphorylation of the human Micro RNA-generating complex mediates MAPK/Erk signaling. Cell 139:112-22
    • (2009) Cell , vol.139 , pp. 112-22
    • Paroo, Z.1    Ye, X.2    Chen, S.3    Liu, Q.4
  • 106
  • 108
    • 10644234841 scopus 로고    scopus 로고
    • The Drosha-DGCR8 complex in primary Micro RNA processing
    • Han J, Lee Y, Yeom KH, Kim YK, Jin H, Kim VN. 2004. The Drosha-DGCR8 complex in primary Micro RNA processing. Genes Dev. 18:3016-27
    • (2004) Genes Dev. , vol.18 , pp. 3016-27
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Kim, Y.K.4    Jin, H.5    Kim, V.N.6
  • 110
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
    • Landthaler M, Yalcin A, Tuschl T. 2004. The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis. Curr. Biol. 14:2162-7
    • (2004) Curr. Biol. , vol.14 , pp. 2162-7
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 111
    • 33744520104 scopus 로고    scopus 로고
    • Molecular basis for the recognition of primary Micro RNAs by the Drosha-DGCR8 complex
    • Han J, Lee Y, Yeom KH, Nam JW, Heo I, et al. 2006. Molecular basis for the recognition of primary Micro RNAs by the Drosha-DGCR8 complex. Cell 125:887-901
    • (2006) Cell , vol.125 , pp. 887-901
    • Han, J.1    Lee, Y.2    Yeom, K.H.3    Nam, J.W.4    Heo, I.5
  • 112
    • 58149097010 scopus 로고    scopus 로고
    • Posttranscriptional crossregulation between Drosha and DGCR8
    • Han J, Pedersen JS, Kwon SC, Belair CD, Kim YK, et al. 2009. Posttranscriptional crossregulation between Drosha and DGCR8. Cell 136:75-84
    • (2009) Cell , vol.136 , pp. 75-84
    • Han, J.1    Pedersen, J.S.2    Kwon, S.C.3    Belair, C.D.4    Kim, Y.K.5
  • 113
    • 44649136660 scopus 로고    scopus 로고
    • Autoinhibition of human Dicer by its internal helicase domain
    • Ma E, MacRae IJ, Kirsch JF, Doudna JA. 2008. Autoinhibition of human Dicer by its internal helicase domain. J. Mol. Biol. 380:237-43
    • (2008) J. Mol. Biol. , vol.380 , pp. 237-43
    • Ma, E.1    MacRae, I.J.2    Kirsch, J.F.3    Doudna, J.A.4
  • 114
    • 61349127117 scopus 로고    scopus 로고
    • A TARBP2 mutation in human cancer impairs Micro RNA processing and DICER1 function
    • Melo SA, Ropero S, Moutinho C, Aaltonen LA, Yamamoto H, et al. 2009. A TARBP2 mutation in human cancer impairs Micro RNA processing and DICER1 function. Nat Genet. 41:365-70
    • (2009) Nat Genet. , vol.41 , pp. 365-70
    • Melo, S.A.1    Ropero, S.2    Moutinho, C.3    Aaltonen, L.A.4    Yamamoto, H.5
  • 115
  • 116
    • 34247593034 scopus 로고    scopus 로고
    • Impaired Micro RNA processing enhances cellular transformation and tumorigenesis
    • Kumar MS, Lu J, Mercer KL, Golub TR, Jacks T. 2007. Impaired Micro RNA processing enhances cellular transformation and tumorigenesis. Nat. Genet. 39:673-77
    • (2007) Nat. Genet. , vol.39 , pp. 673-77
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3    Golub, T.R.4    Jacks, T.5
  • 117
    • 33846527241 scopus 로고    scopus 로고
    • Distinct populations of primary and secondary effectors during RNAi in C. elegans
    • Pak J, Fire A. 2007. Distinct populations of primary and secondary effectors during RNAi in C. elegans. Science 315:241-44
    • (2007) Science , vol.315 , pp. 241-44
    • Pak, J.1    Fire, A.2
  • 118
    • 33750824034 scopus 로고    scopus 로고
    • Analysis of the C elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi
    • Ygit E, Batista PJ, Bei Y, Pang KM, Chen CC, et al. 2006. Analysis of the C elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. Cell 127:747-57
    • (2006) Cell , vol.127 , pp. 747-57
    • Ygit, E.1    Batista, P.J.2    Bei, Y.3    Pang, K.M.4    Chen, C.C.5
  • 119
    • 37149049127 scopus 로고    scopus 로고
    • In vitro analyses of the production and activity of secondary small interfering RNAs in C elegans
    • Aoki K, Moriguchi H, Yoshioka T, Okawa K, Tabara H. 2007. In vitro analyses of the production and activity of secondary small interfering RNAs in C elegans. EMBO J. 26:5007-19
    • (2007) EMBO J. , vol.26 , pp. 5007-19
    • Aoki, K.1    Moriguchi, H.2    Yoshioka, T.3    Okawa, K.4    Tabara, H.5
  • 120
    • 58749097426 scopus 로고    scopus 로고
    • Small RNAs in transcriptional gene silencing and genome defense
    • Moazed D. 2009. Small RNAs in transcriptional gene silencing and genome defense. Nature 457:413-20
    • (2009) Nature , vol.457 , pp. 413-20
    • Moazed, D.1
  • 121
    • 66149084316 scopus 로고    scopus 로고
    • QiRNA is a new type of small interfering RNA induced by DNA damage
    • Lee HC, Chang SS, Choudhary S, Aalto AP, Maiti M, et al. 2009. qiRNA is a new type of small interfering RNA induced by DNA damage. Nature 459:274-77
    • (2009) Nature , vol.459 , pp. 274-77
    • Lee, H.C.1    Chang, S.S.2    Choudhary, S.3    Aalto, A.P.4    Maiti, M.5
  • 122
    • 70349147889 scopus 로고    scopus 로고
    • Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
    • Zhou R, Czech B, Brennecke J, Sachidanandam R, Wohlschlegel JA, et al. 2009. Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA 15:1886-95
    • (2009) RNA , vol.15 , pp. 1886-95
    • Zhou, R.1    Czech, B.2    Brennecke, J.3    Sachidanandam, R.4    Wohlschlegel, J.A.5
  • 123
    • 70350569212 scopus 로고    scopus 로고
    • Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences
    • Hartig JV, Esslinger S, Bottcher R, Saito K, Forstemann K. 2009. Endo-siRNAs depend on a new isoform of loquacious and target artificially introduced, high-copy sequences. EMBO J. 28:2932-44
    • (2009) EMBO J. , vol.28 , pp. 2932-44
    • Hartig, J.V.1    Esslinger, S.2    Bottcher, R.3    Saito, K.4    Forstemann, K.5
  • 125
    • 33947273235 scopus 로고    scopus 로고
    • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila
    • Brennecke J, Aravin AA, Stark A, Dus M, Kellis M, et al. 2007. Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila. Cell 128:1089-103
    • (2007) Cell , vol.128 , pp. 1089-103
    • Brennecke, J.1    Aravin, A.A.2    Stark, A.3    Dus, M.4    Kellis, M.5
  • 126
    • 33947390781 scopus 로고    scopus 로고
    • A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila
    • Gunawardane LS, Saito K, Nishida KM, Miyoshi K, Kawamura Y, et al. 2007. A slicer-mediated mechanism for repeat-associated siRNA 5' end formation in Drosophila. Science 315:1587-90
    • (2007) Science , vol.315 , pp. 1587-90
    • Gunawardane, L.S.1    Saito, K.2    Nishida, K.M.3    Miyoshi, K.4    Kawamura, Y.5
  • 127
    • 65549118489 scopus 로고    scopus 로고
    • Collapse of germline piRNAs in the absence of Argonaute 3 reveals somatic piRNAs in flies
    • Li C, Vagin VV, Lee S, Xu J, Ma S, et al. 2009. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Cell 137:509-21
    • (2009) Cell , vol.137 , pp. 509-21
    • Li, C.1    Vagin, V.V.2    Lee, S.3    Xu, J.4    Ma, S.5
  • 128
    • 0037031152 scopus 로고    scopus 로고
    • Loss of the putative RNA-directed RNA polymerase RRF-3 makes C elegans hypersensitive to RNAi
    • Simmer F, TijstermanM, Parrish S, Koushika SP, Nonet ML, et al. 2002. Loss of the putative RNA-directed RNA polymerase RRF-3 makes C elegans hypersensitive to RNAi. Curr. Biol. 12:1317-19
    • (2002) Curr. Biol. , vol.12 , pp. 1317-19
    • Simmer, F.1    Tijsterman, M.2    Parrish, S.3    Koushika, S.P.4    Nonet, M.L.5
  • 129
    • 1342346710 scopus 로고    scopus 로고
    • A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans
    • Kennedy S, Wang D, RuvkunG 2004. A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 427:645-49
    • (2004) Nature , vol.427 , pp. 645-49
    • Kennedy, S.1    Wang, D.2    Ruvkun, G.3
  • 130
    • 52949091512 scopus 로고    scopus 로고
    • Trans-splicing in C elegans generates the negative RNAi regulator ERI-6/7
    • Fischer SE, Butler MD, Pan Q, Ruvkun G 2008. Trans-splicing in C elegans generates the negative RNAi regulator ERI-6/7. Nature 455:491-96
    • (2008) Nature , vol.455 , pp. 491-96
    • Fischer, S.E.1    Butler, M.D.2    Pan, Q.3    Ruvkun, G.4
  • 133
    • 33745623128 scopus 로고    scopus 로고
    • Post-transcriptional regulation of Micro RNA expression
    • Obernosterer G, Leuschner PJ, Alenius M, Martinez J. 2006. Post-transcriptional regulation of Micro RNA expression. RNA 12:1161-67
    • (2006) RNA , vol.12 , pp. 1161-67
    • Obernosterer, G.1    Leuschner, P.J.2    Alenius, M.3    Martinez, J.4
  • 134
    • 38049046644 scopus 로고    scopus 로고
    • Systematic evaluation of Micro RNA processing patterns in tissues, cell lines, and tumors
    • Lee EJ, BaekM, Gusev Y, Brackett DJ, Nuovo GJ, Schmittgen TD. 2008. Systematic evaluation of Micro RNA processing patterns in tissues, cell lines, and tumors. RNA 14:35-42
    • (2008) RNA , vol.14 , pp. 35-42
    • Lee, E.J.1    Baekm Gusev, Y.2    Brackett, D.J.3    Nuovo, G.J.4    Schmittgen, T.D.5
  • 135
    • 40849108663 scopus 로고    scopus 로고
    • Selective blockade of Micro RNA processing by Lin28
    • Viswanathan SR, Daley GQ, Gregory RI. 2008. Selective blockade of Micro RNA processing by Lin28. Science 320:97-100
    • (2008) Science , vol.320 , pp. 97-100
    • Viswanathan, S.R.1    Daley, G.Q.2    Gregory, R.I.3
  • 136
    • 47949100595 scopus 로고    scopus 로고
    • Lin-28 interaction with the Let-7 precursor loop mediates regulated Micro RNA processing
    • Newman MA, Thomson JM, Hammond SM. 2008. Lin-28 interaction with the Let-7 precursor loop mediates regulated Micro RNA processing. RNA 14:1539-49
    • (2008) RNA , vol.14 , pp. 1539-49
    • Newman, M.A.1    Thomson, J.M.2    Hammond, S.M.3
  • 137
    • 52049124806 scopus 로고    scopus 로고
    • Determinants of mi-croRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28
    • Piskounova E, Viswanathan SR, Janas M, LaPierre RJ, Daley GQ, et al. 2008. Determinants of mi-croRNA processing inhibition by the developmentally regulated RNA-binding protein Lin28. J. Biol. Chem. 283:21310-14
    • (2008) J. Biol. Chem. , vol.283 , pp. 21310-14
    • Piskounova, E.1    Viswanathan, S.R.2    Janas, M.3    La Pierre, R.J.4    Daley, G.Q.5
  • 138
    • 48649103982 scopus 로고    scopus 로고
    • A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment
    • Rybak A, Fuchs H, Smirnova L, Brandt C, Pohl EE, et al. 2008. A feedback loop comprising lin-28 and let-7 controls pre-let-7 maturation during neural stem-cell commitment. Nat. Cell Biol. 10:987-93
    • (2008) Nat. Cell Biol. , vol.10 , pp. 987-93
    • Rybak, A.1    Fuchs, H.2    Smirnova, L.3    Brandt, C.4    Pohl, E.E.5
  • 139
    • 53949088050 scopus 로고    scopus 로고
    • Lin28 mediates the terminal uridylation of let-7 precursor Micro RNA
    • Heo I, Joo C, Cho J, Ha M, Han J, Kim VN. 2008. Lin28 mediates the terminal uridylation of let-7 precursor Micro RNA. Mol. Cell 32:276-84
    • (2008) Mol. Cell , vol.32 , pp. 276-84
    • Heo, I.1    Joo, C.2    Cho, J.3    Ha, M.4    Han, J.5    Kim, V.N.6
  • 140
    • 68749102148 scopus 로고    scopus 로고
    • TUT4 inconcert with Lin28 suppresses Micro RNA biogenesis through pre-Micro RNA uridylation
    • Heo I, Joo C, Kim YK, Ha M, Yoon MJ, et al. 2009. TUT4 inconcert with Lin28 suppresses Micro RNA biogenesis through pre-Micro RNA uridylation. Cell 138:696-708
    • (2009) Cell , vol.138 , pp. 696-708
    • Heo, I.1    Joo, C.2    Kim, Y.K.3    Ha, M.4    Yoon, M.J.5
  • 142
    • 34447115822 scopus 로고    scopus 로고
    • The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a
    • Guil S, Cáceres JF. 2007. The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a. Nat. Struct. Mol. Biol. 14:591-96
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 591-96
    • Guil, S.1    Cáceres, J.F.2
  • 143
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated mi-croRNA maturation
    • Davis BN, Hilyard AC, Lagna G, Hata A. 2008. SMAD proteins control DROSHA-mediated mi-croRNA maturation. Nature 454:56-61
    • (2008) Nature , vol.454 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 144
    • 67649277689 scopus 로고    scopus 로고
    • The RNA-binding protein KSRP promotes the biogenesis of a subset of Micro RNAs
    • Trabucchi M, Briata P, Garcia-Mayoral M, Haase AD, Filipowicz W, et al. 2009. The RNA-binding protein KSRP promotes the biogenesis of a subset of Micro RNAs. Nature 459:1010-14
    • (2009) Nature , vol.459 , pp. 1010-14
    • Trabucchi, M.1    Briata, P.2    Garcia-Mayoral, M.3    Haase, A.D.4    Filipowicz, W.5
  • 147
    • 59349087552 scopus 로고    scopus 로고
    • Importin 8 is a gene silencing factor that targets Argonaute proteins to distinct mRNAs
    • Weinmann L, Hock J, Ivacevic T, Ohrt T, Mutze J, et al. 2009. Importin 8 is a gene silencing factor that targets Argonaute proteins to distinct mRNAs. Cell 136:496-507
    • (2009) Cell , vol.136 , pp. 496-507
    • Weinmann, L.1    Hock, J.2    Ivacevic, T.3    Ohrt, T.4    Mutze, J.5
  • 149
    • 67349281394 scopus 로고    scopus 로고
    • Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability
    • Kirino Y, Kim N, de Planell-Saguer M, Khandros E, Chiorean S, et al. 2009. Arginine methylation of Piwi proteins catalysed by dPRMT5 is required for Ago3 and Aub stability. Nat. Cell Biol. 11:652-58
    • (2009) Nat. Cell Biol. , vol.11 , pp. 652-58
    • Kirino, Y.1    Kim, N.2    De Planell-Saguer, M.3    Khandros, E.4    Chiorean, S.5
  • 150
    • 68149164399 scopus 로고    scopus 로고
    • Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members
    • Vagin VV, Wohlschlegel J, Qu J, Jonsson Z, Huang X, et al. 2009. Proteomic analysis of murine Piwi proteins reveals a role for arginine methylation in specifying interaction with Tudor family members. Genes Dev. 23:1749-62
    • (2009) Genes Dev. , vol.23 , pp. 1749-62
    • Vagin, V.V.1    Wohlschlegel, J.2    Qu, J.3    Jonsson, Z.4    Huang, X.5
  • 151
    • 67349141725 scopus 로고    scopus 로고
    • Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile
    • Reuter M, Chuma S, Tanaka T, Franz T, Stark A, Pillai RS. 2009. Loss of the Mili-interacting Tudor domain-containing protein-1 activates transposons and alters the Mili-associated small RNA profile. Nat. Struct. Mol. Biol. 16:639-46
    • (2009) Nat. Struct. Mol. Biol. , vol.16 , pp. 639-46
    • Reuter, M.1    Chuma, S.2    Tanaka, T.3    Franz, T.4    Stark, A.5    Pillai, R.S.6
  • 152
    • 60549104367 scopus 로고    scopus 로고
    • Raf kinase inhibitory protein suppresses a metastasis signaling cascade involving LIN28 and let-7
    • Dangi-Garimella S, Yun J, Eves EM, Newman M, Erkeland SJ, et al. 2009. Raf kinase inhibitory protein suppresses a metastasis signaling cascade involving LIN28 and let-7. EMBO J. 28:347-58
    • (2009) EMBO J. , vol.28 , pp. 347-58
    • Dangi-Garimella, S.1    Yun, J.2    Eves, E.M.3    Newman, M.4    Erkeland, S.J.5
  • 153
    • 48249114811 scopus 로고    scopus 로고
    • Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies
    • Zeng Y, Sankala H, Zhang X, Graves PR. 2008. Phosphorylation of Argonaute 2 at serine-387 facilitates its localization to processing bodies. Biochem. J. 413:429-36
    • (2008) Biochem. J. , vol.413 , pp. 429-36
    • Zeng, Y.1    Sankala, H.2    Zhang, X.3    Graves, P.R.4
  • 154
    • 36749026906 scopus 로고    scopus 로고
    • Switching from repression to activation: Micro RNAs can up-regulate translation
    • Vasudevan S, Tong Y, Steitz JA. 2007. Switching from repression to activation: Micro RNAs can up-regulate translation. Science 318:1931-34
    • (2007) Science , vol.318 , pp. 1931-34
    • Vasudevan, S.1    Tong, Y.2    Steitz, J.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.