Crystallographic and modeling studies of RNase III suggest a mechanism for double-stranded RNA cleavage

Structure

Volumn 9, Issue 12, 2001, Pages 1225-1236

  Blaszczyk, Jaroslaw ^a   Tropea, Joseph E ^a   Bubunenko, Mikhail ^a   Routzahn, Karen M ^a   Waugh, David S ^a   Court, Donald L ^a   Ji, Xinhua ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Compound active center; dsRNA; Endonuclease domain; RNA interference; RNA processing; RNase III

Indexed keywords

DIMER; DOUBLE STRANDED RNA; ENDONUCLEASE; LIGAND; MANGANESE; MONOMER; POLYPEPTIDE; RIBONUCLEASE III;

ACCURACY; ARTICLE; BINDING AFFINITY; BIOLOGY; COMPARATIVE STUDY; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DIMERIZATION; ENZYME ACTIVITY; ENZYME STRUCTURE; GENETICS; HYDROPHOBICITY; IMAGE ANALYSIS; MODEL; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN INTERACTION; RNA CLEAVAGE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; ENDORIBONUCLEASES; ESCHERICHIA COLI PROTEINS; LIGANDS; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEIC ACID CONFORMATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASE III; RNA, DOUBLE-STRANDED; SEQUENCE HOMOLOGY, AMINO ACID;

AQUIFEX AEOLICUS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA;

EID: 0035662491     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(01)00685-2     Document Type: Article

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