A Protein Interaction Map of Drosophila melanogaster

Science

Volumn 302, Issue 5651, 2003, Pages 1727-1736

  Giot, L ^a   Bader, J S ^a,d   Brouwer, C ^a   Chaudhuri, A ^a   Kuang, B ^a   Li, Y ^a   Hao, Y L ^a   Ooi, C E ^a   Godwin, B ^a   Vitols, E ^a   Vijayadamodar, G ^a   Pochart, P ^a   Machineni, H ^a   Welsh, M ^a   Kong, Y ^a   Zerhusen, B ^a   Malcolm, R ^a   Varrone, Z ^a   Collis, A ^a   Minto, M ^a   Burgess, S ^a   McDaniel, L ^a   Stimpson, E ^a   Spriggs, F ^a   Williams, J ^a   Neurath, K ^a   Ioime, N ^a   Agee, M ^a   Voss, E ^a   Furtak, K ^a   Renzulli, R ^a   Aanensen, N ^a   Carrolla, S ^a   Bickelhaupt, E ^a   Lazovatsky, Y ^a   DaSilva, A ^a   Zhong, J ^b   Stanyon, C A ^b   Finley Jr , R L ^b   White, K P ^c   Braverman, M ^a   Jarvie, T ^a   Gold, S ^a   Leach, M ^a   Knight, J ^a   Shimkets, R A ^a   McKenna, M P ^a   Chant, J ^a   Rothberg, J M ^a   more..

^a CURAGEN CORPORATION   (United States)

^b WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Johns Hopkins University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL METHODS; DNA; LIVING SYSTEMS STUDIES;

DRAFT MAP;

PROTEINS;

ADAPTOR PROTEIN; CALCIUM; CALMODULIN; CELL SURFACE RECEPTOR; COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE; DNA BINDING PROTEIN; EPIDERMAL GROWTH FACTOR RECEPTOR; G PROTEIN COUPLED RECEPTOR; GUANOSINE TRIPHOSPHATASE; HELIX LOOP HELIX PROTEIN; HOMEODOMAIN PROTEIN; NUCLEAR PROTEIN; PROTEIN TYROSINE KINASE; PROTEINASE; TRANSCRIPTION FACTOR;

BIOLOGY; DNA; PROTEIN;

ARTICLE; CELL CYCLE; CELLULAR DISTRIBUTION; DNA LIBRARY; DROSOPHILA MELANOGASTER; MOLECULAR CLONING; MOLECULAR MODEL; NONHUMAN; PHOTORECEPTOR; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA SPLICING; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

ANIMALS; CALCIUM; CELL CYCLE; CELL DIFFERENTIATION; CLONING, MOLECULAR; COMPUTATIONAL BIOLOGY; DNA, COMPLEMENTARY; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; GENES, INSECT; IMMUNITY, NATURAL; MATHEMATICS; MODELS, STATISTICAL; PHOTORECEPTORS, INVERTEBRATE; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; PROTEOME; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA SPLICING; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TWO-HYBRID SYSTEM TECHNIQUES;

DROSOPHILA MELANOGASTER; MELANOGASTER;

EID: 0345600247     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090289     Document Type: Article

References (60)

1. E. Phizicky, P. I. Bastiaens, H. Zhu, M. Snyder, S. Fields, Nature 422, 208 (2003).
2. T. Ito et al., Proc. Natl. Acad. Sci. U.S.A. 98, 4569 (2001).
3. P. Uetz et al., Nature 403, 623 (2000).
4. M. D. Adams et al., Science 287, 2185 (2000).
5. G. M. Rubin et al., Science 287, 2222 (2000).
6. Materials and methods are available as supporting material on Science Online.
7. E. Ravasz, A. L. Somera, D. A. Mongru, Z. N. Oltvai, A. L. Barabasi, Science 297, 1551 (2002).
8. D. S. Goldberg, F. P. Roth, Proc. Natl. Acad. Sci. U.S.A. 100, 4372 (2003).
9. J. S. Bader, A. Chaudhuri, J. Chant, Nature Biotechnol., in press.
10. A. C. Gavin et al., Nature 415, 141 (2002).
11. Y. Ho et al., Nature 415, 180 (2002).
12. S. Maslov, K. Sneppen, Science 296, 910 (2002).
13. E. Sprinzak, H. Margatit, J. Mol. Biol. 311, 681 (2001).
14. D. J. Watts, S. H. Strogatz, Nature 393, 440 (1998).
15. H. Jeong, S. P. Mason, A. L. Barabasi, Z. N. Oltvai, Nature 411, 41 (2001).
16. A. L. Barabasi, R. Albert, Science 286, 509 (1999).
17. M. Ashburner et al., Nature Genet. 25, 25 (2000).
18. L. T. Reiter, L. Potocki, S. Chien, M. Gribskov, E. Bier, Genome Res. 11, 1114 (2001).
19. B. W. Baron et al., Proc. Natl. Acad. Sci. U.S.A. 90, 5262 (1993).
20. P. G. Hogan, L. Chen, J. Nardone, A. Rao, Genes Dev. 17, 2205 (2003).
21. A. J. Courey, S. Jia, Genes Dev. 15, 2786 (2001).
22. G. Jimenez, C. P. Verrijzer, D. Ish-Horowicz, Mol. Cell. Biol. 19, 2080 (1999).
23. G. Jimenez, A. Guichet, A. Ephrussi, J. Casanova, Genes Dev. 14, 224 (2000).
24. K. Jagla, M. Bellard, M. Frasch, Bioessays 23, 125 (2001).
25. P. Graham, J. K. Penn, P. Schedl, Bioessays 25, 1 (2003).
26. B. R. Graveley, Cell 109, 409 (2002).
27. C. Du, M. E. McGuffin, B. Dauwalder, L. Rabinow, W. Mattox, Mol. Cell 2, 741 (1998).
28. Y. J. Kim, P. Zuo, J. L. Manley, B. S. Baker, Genes Dev. 6, 2569 (1992).
29. K. W. Lynch, T. Manlatis, Genes Dev. 10, 2089 (1996).
30. V. Heinrichs, B. S. Baker, Proc. Natl. Acad. Sci. U.S.A. 94, 115 (1997).
31. L. Aravind, E. V. Koonin, Trends Biochem. Sci. 24, 342 (1999).
32. B. Guglielmi, M. Werner, J. Biol. Chem. 277, 35712 (2002).
33. S. M. Feller, H. Wecklein, M. Lewitzky, E. Kibler, T. Raabe, Mech. Dev. 116, 129 (2002).
34. J. P. Olivier et al., Cell 73, 179 (1993).
35. D. Cai, S. Dhe-Paganon, P. A. Melendez, J. Lee, S. E. Shoelson, J. Biol. Chem. 278, 25323 (2003).
36. E. Yus-Najera, I. Santana-Castro, A. Villarroel, J. Biol. Chem. 277, 28545 (2002).
37. A. Sotkis et al., Cell Commun. Adhes. 8, 277 (2001).
38. C. Peracchia, A. Sotkis, X. G. Wang, L. L. Peracchia, A. Persechini, J. Biol. Chem. 275, 26220 (2000).
39. R. J. Deshaies, Annu. Rev. Cell Dev. Biol. 15, 435 (1999).
40. R. M. Feldman, C. C. Correll, K. B. Kaplan, R. J. Deshaies, Cell 91, 221 (1997).
41. E. T. Kipreos, M. Pagano, Genome Biol. 1, REVIEWS3002 (2000).
42. D. Skowyra, K. L. Craig, M. Tyers, S. J. Elledge, J. W. Harper, Cell 91, 209 (1997).
43. C. Bai et al., Cell 86, 263 (1996).
44. J. P. Wing et al., Nature Cell Biol. 4, 451 (2002).
45. X. Dong et al., Genes Dev. 11, 94 (1997).
46. R. Grosskortenhaus, F. Sprenger, Dev. Cell 2, 29 (2002).
47. D. Ganoth et al., Nature Cell Biol. 3, 321 (2001).
48. D. Sitry et al., J. Biol. Chem. 277, 42233 (2002).
49. A. Christich et al., Curr. Biol. 12, 137 (2002).
50. J. P. Wing et al., Curr. Biol. 12, 131 (2002).
51. L. Raj et al., Curr. Biol. 10, 1265 (2000).
52. J. A. Hoffmann, J. M. Reichhart, Nature Immunol. 3, 121 (2002).
53. R. S. Khush, W. D. Cornwell, J. N. Uram, B. Lemaitre, Curr. Biol. 12, 1728 (2002).
54. S. M. Kaech, C. W. Whitfield, S. K. Kim, Cell 94, 761 (1998).
55. Z. C. Lai, S. D. Harrison, F. Karim, Y. Li, G. M. Rubin, Proc. Natl. Acad. Sci. U.S.A. 93, 5025 (1996).
56. S. Li, R. W. Carthew, Z. C. Lai, Cell 90, 469 (1997).
57. S. Li, C. Xu, R. W. Carthew, Mol. Cell. Biol. 22, 6854 (2002)
58. C. Pazman, C. A. Mayes, M. Fanto, S. R. Haynes, M. Mlodzik, Development 127, 1715 (2000).
59. Accession numbers are as follows: BIND IDs 24880 to 45318.
60. We thank our colleagues at CuraGen, in particular those in the genomics facility who performed all the sequencing and prepared the cDNA libraries described in this work. We also thank S. Hossain and members of the Finley laboratory for technical assistance with Drosophila cultures and RNA preparations. J.Z., C.A.S, and R.L.F. were supported by NIH grant HG01536 (to R.L.F.). The interactions are also available at our Web sites www.curagen.com and www.jhubiomed.org.