메뉴 건너뛰기




Volumn 14, Issue 1-2, 2010, Pages 116-134

Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies

Author keywords

Aging; Anti aging therapies; Cancer therapies; Molecular targeting; Senescence; Skin cancer stem progenitor cells; Skin resident adult stem progenitor cells

Indexed keywords

ANTINEOPLASTIC AGENT;

EID: 77951956356     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2009.00885.x     Document Type: Review
Times cited : (30)

References (255)
  • 1
    • 3242799070 scopus 로고    scopus 로고
    • New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers
    • Mimeault M, Bonenfant D, Batra SK. New advances on the functions of epidermal growth factor receptor and ceramides in skin cell differentiation, disorders and cancers. Skin Pharmacol Physiol. 2004, 17:153-6.
    • (2004) Skin Pharmacol Physiol. , vol.17 , pp. 153-156
    • Mimeault, M.1    Bonenfant, D.2    Batra, S.K.3
  • 2
    • 33750592790 scopus 로고    scopus 로고
    • Recent advances on the significance of stem cells in tissue regeneration and cancer therapies
    • Mimeault M, Batra SK. Recent advances on the significance of stem cells in tissue regeneration and cancer therapies. Stem Cells. 2006, 24:2319-45.
    • (2006) Stem Cells. , vol.24 , pp. 2319-2345
    • Mimeault, M.1    Batra, S.K.2
  • 3
    • 33744522589 scopus 로고    scopus 로고
    • Prevention and treatment of skin aging
    • McCullough JL, Kelly KM. Prevention and treatment of skin aging. Ann NY Acad Sci. 2006, 1067:323-31.
    • (2006) Ann NY Acad Sci. , vol.1067 , pp. 323-331
    • McCullough, J.L.1    Kelly, K.M.2
  • 4
    • 39149093717 scopus 로고    scopus 로고
    • Epidermal stem cells in skin homeostasis and cutaneous carcinomas
    • Benitah SA. Epidermal stem cells in skin homeostasis and cutaneous carcinomas. Clin Transl Oncol. 2007, 9:760-6.
    • (2007) Clin Transl Oncol. , vol.9 , pp. 760-766
    • Benitah, S.A.1
  • 5
    • 43449136214 scopus 로고    scopus 로고
    • Frontiers in sebaceous gland biology and pathology
    • Zouboulis CC, Baron JM, Bohm M. Frontiers in sebaceous gland biology and pathology. Exp Dermatol. 2008, 17:542-51.
    • (2008) Exp Dermatol. , vol.17 , pp. 542-551
    • Zouboulis, C.C.1    Baron, J.M.2    Bohm, M.3
  • 6
    • 39149091017 scopus 로고    scopus 로고
    • Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation
    • Muller EJ, Williamson L, Kolly C. Outside-in signaling through integrins and cadherins: a central mechanism to control epidermal growth and differentiation. J Invest Dermatol. 2008, 128:501-16.
    • (2008) J Invest Dermatol. , vol.128 , pp. 501-516
    • Muller, E.J.1    Williamson, L.2    Kolly, C.3
  • 7
    • 38749143649 scopus 로고    scopus 로고
    • Skin stem cells: rising to the surface
    • Fuchs E. Skin stem cells: rising to the surface. J Cell Biol. 2008, 180:273-84.
    • (2008) J Cell Biol. , vol.180 , pp. 273-284
    • Fuchs, E.1
  • 8
    • 42149123306 scopus 로고    scopus 로고
    • More than one way to skin
    • Fuchs E, Horsley V. More than one way to skin. Genes Dev. 2008, 22:976-85.
    • (2008) Genes Dev. , vol.22 , pp. 976-985
    • Fuchs, E.1    Horsley, V.2
  • 9
    • 0347634454 scopus 로고    scopus 로고
    • Defining the epithelial stem cell niche in skin
    • Tumbar T, Guasch G, Greco V. Defining the epithelial stem cell niche in skin. Science. 2004, 303:359-63.
    • (2004) Science. , vol.303 , pp. 359-363
    • Tumbar, T.1    Guasch, G.2    Greco, V.3
  • 10
    • 21644473144 scopus 로고    scopus 로고
    • Location and phenotype of human adult keratinocyte stem cells of the skin
    • Webb A, Li A, Kaur P. Location and phenotype of human adult keratinocyte stem cells of the skin. Differentiation. 2004, 72:387-95.
    • (2004) Differentiation. , vol.72 , pp. 387-395
    • Webb, A.1    Li, A.2    Kaur, P.3
  • 11
    • 33745505758 scopus 로고    scopus 로고
    • Human side population keratinocytes exhibit long-term proliferative potential and a specific gene expression profile and can form a pluristratified epidermis
    • Larderet G, Fortunel NO, Vaigot P. Human side population keratinocytes exhibit long-term proliferative potential and a specific gene expression profile and can form a pluristratified epidermis. Stem Cells. 2006, 24:965-74.
    • (2006) Stem Cells. , vol.24 , pp. 965-974
    • Larderet, G.1    Fortunel, N.O.2    Vaigot, P.3
  • 12
    • 4444290010 scopus 로고    scopus 로고
    • Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche
    • Blanpain C, Lowry WE, Geoghegan A. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell. 2004, 118:635-48.
    • (2004) Cell. , vol.118 , pp. 635-648
    • Blanpain, C.1    Lowry, W.E.2    Geoghegan, A.3
  • 14
    • 28644451449 scopus 로고    scopus 로고
    • Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis
    • Ito M, Liu Y, Yang Z. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nat Med. 2005, 11:1351-4.
    • (2005) Nat Med. , vol.11 , pp. 1351-1354
    • Ito, M.1    Liu, Y.2    Yang, Z.3
  • 15
    • 34247631592 scopus 로고    scopus 로고
    • Epidermal stem cells arise from the hair follicle after wounding
    • Levy V, Lindon C, Zheng Y. Epidermal stem cells arise from the hair follicle after wounding. FASEB J. 2007, 21:1358-66.
    • (2007) FASEB J. , vol.21 , pp. 1358-1366
    • Levy, V.1    Lindon, C.2    Zheng, Y.3
  • 16
    • 28444486367 scopus 로고    scopus 로고
    • Stem cell niche: Structure and function
    • Li L, Xie T. Stem cell niche: Structure and function. Annu Rev Cell Dev Biol. 2005, 21:605-31.
    • (2005) Annu Rev Cell Dev Biol. , vol.21 , pp. 605-631
    • Li, L.1    Xie, T.2
  • 17
    • 33746729815 scopus 로고    scopus 로고
    • Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland
    • Horsley V, O'Carroll D, Tooze R. Blimp1 defines a progenitor population that governs cellular input to the sebaceous gland. Cell. 2006, 126:597-609.
    • (2006) Cell. , vol.126 , pp. 597-609
    • Horsley, V.1    O'Carroll, D.2    Tooze, R.3
  • 18
    • 0037171764 scopus 로고    scopus 로고
    • Dominant role of the niche in melanocyte stem-cell fate determination
    • Nishimura EK, Jordan SA, Oshima H. Dominant role of the niche in melanocyte stem-cell fate determination. Nature. 2002, 416:854-60.
    • (2002) Nature. , vol.416 , pp. 854-860
    • Nishimura, E.K.1    Jordan, S.A.2    Oshima, H.3
  • 19
    • 3843085863 scopus 로고    scopus 로고
    • Pluripotent neural crest stem cells in the adult hair follicle
    • Sieber-Blum M, Grim M, Hu YF. Pluripotent neural crest stem cells in the adult hair follicle. Dev Dyn. 2004, 231:258-69.
    • (2004) Dev Dyn. , vol.231 , pp. 258-269
    • Sieber-Blum, M.1    Grim, M.2    Hu, Y.F.3
  • 20
    • 33744768108 scopus 로고    scopus 로고
    • Isolation of a novel population of multipotent adult stem cells from human hair follicles
    • Yu H, Fang D, Kumar SM. Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am J Pathol. 2006, 168:1879-88.
    • (2006) Am J Pathol. , vol.168 , pp. 1879-1888
    • Yu, H.1    Fang, D.2    Kumar, S.M.3
  • 21
    • 13244287677 scopus 로고    scopus 로고
    • Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    • Nishimura EK, Granter SR, Fisher DE. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science. 2005, 307:720-4.
    • (2005) Science. , vol.307 , pp. 720-724
    • Nishimura, E.K.1    Granter, S.R.2    Fisher, D.E.3
  • 22
    • 23244452354 scopus 로고    scopus 로고
    • Stem cell depletion through epidermal deletion of Rac1
    • Benitah SA, Frye M, Glogauer M. Stem cell depletion through epidermal deletion of Rac1. Science. 2005, 309:933-5.
    • (2005) Science. , vol.309 , pp. 933-935
    • Benitah, S.A.1    Frye, M.2    Glogauer, M.3
  • 23
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol. 2007, 8:703-13.
    • (2007) Nat Rev Mol Cell Biol. , vol.8 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 24
    • 3242794264 scopus 로고    scopus 로고
    • Cellular senescence induced loss of stem cell proportion in the skin in vitro
    • Youn SW, Kim DS, Cho HJ. Cellular senescence induced loss of stem cell proportion in the skin in vitro. J Dermatol Sci. 2004, 35:113-23.
    • (2004) J Dermatol Sci. , vol.35 , pp. 113-123
    • Youn, S.W.1    Kim, D.S.2    Cho, H.J.3
  • 25
    • 14644419663 scopus 로고    scopus 로고
    • Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation - a review
    • Pillai S, Oresajo C, Hayward J. Ultraviolet radiation and skin aging: roles of reactive oxygen species, inflammation and protease activation, and strategies for prevention of inflammation-induced matrix degradation - a review. Int J Cosmet Sci. 2005, 27:17-34.
    • (2005) Int J Cosmet Sci. , vol.27 , pp. 17-34
    • Pillai, S.1    Oresajo, C.2    Hayward, J.3
  • 26
    • 33646715610 scopus 로고    scopus 로고
    • Cutaneous stem cells and wound healing
    • Roh C, Lyle S. Cutaneous stem cells and wound healing. Pediatr Res. 2006, 59:100R-3R.
    • (2006) Pediatr Res. , vol.59
    • Roh, C.1    Lyle, S.2
  • 27
    • 36849012500 scopus 로고    scopus 로고
    • Photoaging-associated changes in epidermal proliferative cell fractions in vivo
    • Kwon OS, Yoo HG, Han JH. Photoaging-associated changes in epidermal proliferative cell fractions in vivo. Arch Dermatol Res. 2008, 300:47-52.
    • (2008) Arch Dermatol Res. , vol.300 , pp. 47-52
    • Kwon, O.S.1    Yoo, H.G.2    Han, J.H.3
  • 28
    • 60949100188 scopus 로고    scopus 로고
    • Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
    • Mimeault M, Batra SK. Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. Aging Res Rev. 2009, 8:94-112.
    • (2009) Aging Res Rev. , vol.8 , pp. 94-112
    • Mimeault, M.1    Batra, S.K.2
  • 29
    • 46449084193 scopus 로고    scopus 로고
    • P53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts
    • Chen W, Kang J, Xia J. p53-related apoptosis resistance and tumor suppression activity in UVB-induced premature senescent human skin fibroblasts. Int J Mol Med. 2008, 21:645-53.
    • (2008) Int J Mol Med. , vol.21 , pp. 645-653
    • Chen, W.1    Kang, J.2    Xia, J.3
  • 30
    • 48449087073 scopus 로고    scopus 로고
    • Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging
    • Briganti S, Wlaschek M, Hinrichs C. Small molecular antioxidants effectively protect from PUVA-induced oxidative stress responses underlying fibroblast senescence and photoaging. Free Radic Biol Med. 2008, 45:636-44.
    • (2008) Free Radic Biol Med. , vol.45 , pp. 636-644
    • Briganti, S.1    Wlaschek, M.2    Hinrichs, C.3
  • 31
    • 34548068050 scopus 로고    scopus 로고
    • Enhancing cell longevity for cosmetic application: a complementary approach
    • Moreau M, Neveu M, Stephan S. Enhancing cell longevity for cosmetic application: a complementary approach. J Drugs Dermatol. 2007, 6:S14-9.
    • (2007) J Drugs Dermatol. , vol.6
    • Moreau, M.1    Neveu, M.2    Stephan, S.3
  • 32
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins-novel therapeutic targets to treat age-associated diseases
    • Lavu S, Boss O, Elliott PJ. Sirtuins-novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov. 2008, 7:841-53.
    • (2008) Nat Rev Drug Discov. , vol.7 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3
  • 33
    • 33646948539 scopus 로고    scopus 로고
    • Calorie restriction mimetics: an emerging research field
    • Ingram DK, Zhu M, Mamczarz J. Calorie restriction mimetics: an emerging research field. Aging Cell. 2006, 5:97-108.
    • (2006) Aging Cell. , vol.5 , pp. 97-108
    • Ingram, D.K.1    Zhu, M.2    Mamczarz, J.3
  • 34
    • 42049113213 scopus 로고    scopus 로고
    • Inhibitors of NAD+ dependent histone deacetylases (sirtuins)
    • Neugebauer RC, Sippl W, Jung M. Inhibitors of NAD+ dependent histone deacetylases (sirtuins). Curr Pharm Des. 2008, 14:562-73.
    • (2008) Curr Pharm Des. , vol.14 , pp. 562-573
    • Neugebauer, R.C.1    Sippl, W.2    Jung, M.3
  • 35
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: the in vivo evidence
    • Baur JA, Sinclair DA. Therapeutic potential of resveratrol: the in vivo evidence. Nat Rev Drug Discov. 2006, 5:493-506.
    • (2006) Nat Rev Drug Discov. , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 36
    • 34547882115 scopus 로고    scopus 로고
    • Resveratrol: a review of preclinical studies for human cancer prevention
    • Athar M, Back JH, Tang X. Resveratrol: a review of preclinical studies for human cancer prevention. Toxicol Appl Pharmacol. 2007, 224:274-83.
    • (2007) Toxicol Appl Pharmacol. , vol.224 , pp. 274-283
    • Athar, M.1    Back, J.H.2    Tang, X.3
  • 37
    • 38949161899 scopus 로고    scopus 로고
    • Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation
    • Baxter RA. Anti-aging properties of resveratrol: review and report of a potent new antioxidant skin care formulation. J Cosmet Dermatol. 2008, 7:2-7.
    • (2008) J Cosmet Dermatol. , vol.7 , pp. 2-7
    • Baxter, R.A.1
  • 38
    • 32244447211 scopus 로고    scopus 로고
    • Use of telomerase to create bioengineered tissues
    • Shay JW, Wright WE. Use of telomerase to create bioengineered tissues. Ann NY Acad Sci. 2005, 1057:479-91.
    • (2005) Ann NY Acad Sci. , vol.1057 , pp. 479-491
    • Shay, J.W.1    Wright, W.E.2
  • 39
    • 40549142165 scopus 로고    scopus 로고
    • Wound therapy by marrow mesenchymal cell transplantation
    • Yoshikawa T, Mitsuno H, Nonaka I. Wound therapy by marrow mesenchymal cell transplantation. Plast Reconstr Surg. 2008, 121:860-77.
    • (2008) Plast Reconstr Surg. , vol.121 , pp. 860-877
    • Yoshikawa, T.1    Mitsuno, H.2    Nonaka, I.3
  • 40
    • 38349150596 scopus 로고    scopus 로고
    • In vivo perfusion of human skin substitutes with microvessels formed by adult circulating endothelial progenitor cells
    • Kung EF, Wang F, Schechner JS. In vivo perfusion of human skin substitutes with microvessels formed by adult circulating endothelial progenitor cells. Dermatol Surg. 2008, 34:137-46.
    • (2008) Dermatol Surg. , vol.34 , pp. 137-146
    • Kung, E.F.1    Wang, F.2    Schechner, J.S.3
  • 41
    • 50449100799 scopus 로고    scopus 로고
    • Therapeutic potential of stem cells in skin repair and regeneration
    • Zhang CP, Fu XB. Therapeutic potential of stem cells in skin repair and regeneration. Chin J Traumatol. 2008, 11:209-21.
    • (2008) Chin J Traumatol. , vol.11 , pp. 209-221
    • Zhang, C.P.1    Fu, X.B.2
  • 42
    • 53149087075 scopus 로고    scopus 로고
    • Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging
    • Park BS, Jang KA, Sung JH. Adipose-derived stem cells and their secretory factors as a promising therapy for skin aging. Dermatol Surg. 2008, 34:1323-6.
    • (2008) Dermatol Surg. , vol.34 , pp. 1323-1326
    • Park, B.S.1    Jang, K.A.2    Sung, J.H.3
  • 43
    • 58849124929 scopus 로고    scopus 로고
    • A review of gene and stem cell therapy in cutaneous wound healing
    • Branski LK, Gauglitz GG, Herndon DN. A review of gene and stem cell therapy in cutaneous wound healing. Burns. 2008, 35:171-80.
    • (2008) Burns. , vol.35 , pp. 171-180
    • Branski, L.K.1    Gauglitz, G.G.2    Herndon, D.N.3
  • 44
    • 51849121584 scopus 로고    scopus 로고
    • Increased expression of an epidermal stem cell marker, cytokeratin 19, in cutaneous squamous cell carcinoma
    • Chen S, Takahara M, Kido M. Increased expression of an epidermal stem cell marker, cytokeratin 19, in cutaneous squamous cell carcinoma. Br J Dermatol. 2008, 159:952-5.
    • (2008) Br J Dermatol. , vol.159 , pp. 952-955
    • Chen, S.1    Takahara, M.2    Kido, M.3
  • 45
    • 35848929300 scopus 로고    scopus 로고
    • Correlations between the Sonic Hedgehog pathway and basal cell carcinoma
    • Lupi O. Correlations between the Sonic Hedgehog pathway and basal cell carcinoma. Int J Dermatol. 2007, 46:1113-7.
    • (2007) Int J Dermatol. , vol.46 , pp. 1113-1117
    • Lupi, O.1
  • 46
    • 42549100819 scopus 로고    scopus 로고
    • Loss of BMI-1 expression is associated with clinical progress of malignant melanoma
    • Bachmann IM, Puntervoll HE, Otte AP. Loss of BMI-1 expression is associated with clinical progress of malignant melanoma. Mod Pathol. 2008, 21:583-90.
    • (2008) Mod Pathol. , vol.21 , pp. 583-590
    • Bachmann, I.M.1    Puntervoll, H.E.2    Otte, A.P.3
  • 47
    • 33746650621 scopus 로고    scopus 로고
    • Hedgehog signalling in skin development and cancer
    • Athar M, Tang X, Lee JL. Hedgehog signalling in skin development and cancer. Exp Dermatol. 2006, 15:667-77.
    • (2006) Exp Dermatol. , vol.15 , pp. 667-677
    • Athar, M.1    Tang, X.2    Lee, J.L.3
  • 48
    • 42949142589 scopus 로고    scopus 로고
    • Apoptosis and pathogenesis of melanoma and nonmelanoma skin cancer
    • Erb P, Ji J, Kump E. Apoptosis and pathogenesis of melanoma and nonmelanoma skin cancer. Adv Exp Med Biol. 2008, 624:283-95.
    • (2008) Adv Exp Med Biol. , vol.624 , pp. 283-295
    • Erb, P.1    Ji, J.2    Kump, E.3
  • 49
    • 42949122558 scopus 로고    scopus 로고
    • UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer
    • Rass K, Reichrath J. UV damage and DNA repair in malignant melanoma and nonmelanoma skin cancer. Adv Exp Med Biol. 2008, 624:162-78.
    • (2008) Adv Exp Med Biol. , vol.624 , pp. 162-178
    • Rass, K.1    Reichrath, J.2
  • 50
    • 14044257121 scopus 로고    scopus 로고
    • Ultraviolet radiation and skin cancer: molecular mechanisms
    • Hussein MR. Ultraviolet radiation and skin cancer: molecular mechanisms. J Cutan Pathol. 2005, 32:191-205.
    • (2005) J Cutan Pathol. , vol.32 , pp. 191-205
    • Hussein, M.R.1
  • 51
    • 33748881058 scopus 로고    scopus 로고
    • Molecular biology of malignant melanoma and other cutaneous tumors
    • Pons M, Quintanilla M. Molecular biology of malignant melanoma and other cutaneous tumors. Clin Transl Oncol. 2006, 8:466-74.
    • (2006) Clin Transl Oncol. , vol.8 , pp. 466-474
    • Pons, M.1    Quintanilla, M.2
  • 52
    • 38349144890 scopus 로고    scopus 로고
    • Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers
    • Pacifico A, Goldberg LH, Peris K. Loss of CDKN2A and p14ARF expression occurs frequently in human nonmelanoma skin cancers. Br J Dermatol. 2008, 158:291-7.
    • (2008) Br J Dermatol. , vol.158 , pp. 291-297
    • Pacifico, A.1    Goldberg, L.H.2    Peris, K.3
  • 53
    • 33646257783 scopus 로고    scopus 로고
    • Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression
    • Liu ZJ, Xiao M, Balint K. Notch1 signaling promotes primary melanoma progression by activating mitogen-activated protein kinase/phosphatidylinositol 3-kinase-Akt pathways and up-regulating N-cadherin expression. Cancer Res. 2006, 66:4182-90.
    • (2006) Cancer Res. , vol.66 , pp. 4182-4190
    • Liu, Z.J.1    Xiao, M.2    Balint, K.3
  • 54
    • 0042887050 scopus 로고    scopus 로고
    • The genetics of malignant melanoma: lessons from mouse and man
    • Chin L. The genetics of malignant melanoma: lessons from mouse and man. Nat Rev Cancer. 2003, 3:559-70.
    • (2003) Nat Rev Cancer. , vol.3 , pp. 559-570
    • Chin, L.1
  • 55
    • 33846921781 scopus 로고    scopus 로고
    • Downregulation of cell cycle modulators p21, p27, p53, Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis: preliminary findings
    • Tchernev G, Orfanos CE. Downregulation of cell cycle modulators p21, p27, p53, Rb and proapoptotic Bcl-2-related proteins Bax and Bak in cutaneous melanoma is associated with worse patient prognosis: preliminary findings. J Cutan Pathol. 2007, 34:247-56.
    • (2007) J Cutan Pathol. , vol.34 , pp. 247-256
    • Tchernev, G.1    Orfanos, C.E.2
  • 56
    • 19944429892 scopus 로고    scopus 로고
    • Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle
    • Hutchin ME, Kariapper MS, Grachtchouk M. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 2005, 19:214-23.
    • (2005) Genes Dev. , vol.19 , pp. 214-223
    • Hutchin, M.E.1    Kariapper, M.S.2    Grachtchouk, M.3
  • 57
    • 41649089525 scopus 로고    scopus 로고
    • Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling
    • Malanchi I, Peinado H, Kassen D. Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling. Nature. 2008, 452:650-3.
    • (2008) Nature. , vol.452 , pp. 650-653
    • Malanchi, I.1    Peinado, H.2    Kassen, D.3
  • 58
    • 20144364789 scopus 로고    scopus 로고
    • ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma
    • Frank NY, Margaryan A, Huang Y. ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma. Cancer Res. 2005, 65:4320-33.
    • (2005) Cancer Res. , vol.65 , pp. 4320-4333
    • Frank, N.Y.1    Margaryan, A.2    Huang, Y.3
  • 59
    • 27144557960 scopus 로고    scopus 로고
    • A tumorigenic subpopulation with stem cell properties in melanomas
    • Fang D, Nguyen TK, Leishear K. A tumorigenic subpopulation with stem cell properties in melanomas. Cancer Res. 2005, 65:9328-37.
    • (2005) Cancer Res. , vol.65 , pp. 9328-9337
    • Fang, D.1    Nguyen, T.K.2    Leishear, K.3
  • 60
    • 39849100039 scopus 로고    scopus 로고
    • Isolation and identification of cancer stem-like cells from murine melanoma cell lines
    • Dou J, Pan M, Wen P. Isolation and identification of cancer stem-like cells from murine melanoma cell lines. Cell Mol Immunol. 2007, 4:467-2.
    • (2007) Cell Mol Immunol. , vol.4 , pp. 467-472
    • Dou, J.1    Pan, M.2    Wen, P.3
  • 61
    • 33847639310 scopus 로고    scopus 로고
    • Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential
    • Monzani E, Facchetti F, Galmozzi E. Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential. Eur J Cancer. 2007, 43:935-46.
    • (2007) Eur J Cancer. , vol.43 , pp. 935-946
    • Monzani, E.1    Facchetti, F.2    Galmozzi, E.3
  • 63
    • 38349165576 scopus 로고    scopus 로고
    • Identification of cells initiating human melanomas
    • Schatton T, Murphy GF, Frank NY. Identification of cells initiating human melanomas. Nature. 2008, 451:345-9.
    • (2008) Nature. , vol.451 , pp. 345-349
    • Schatton, T.1    Murphy, G.F.2    Frank, N.Y.3
  • 65
    • 58049201990 scopus 로고    scopus 로고
    • The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma
    • Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008, 26:3008-17.
    • (2008) Stem Cells. , vol.26 , pp. 3008-3017
    • Rappa, G.1    Fodstad, O.2    Lorico, A.3
  • 66
    • 20144375230 scopus 로고    scopus 로고
    • Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background
    • Ackermann J, Frutschi M, Kaloulis K. Metastasizing melanoma formation caused by expression of activated N-RasQ61K on an INK4a-deficient background. Cancer Res. 2005, 65:4005-11.
    • (2005) Cancer Res. , vol.65 , pp. 4005-4011
    • Ackermann, J.1    Frutschi, M.2    Kaloulis, K.3
  • 67
    • 36849073143 scopus 로고    scopus 로고
    • Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture
    • Lacina L, Dvorankova B, Smetana K. Marker profiling of normal keratinocytes identifies the stroma from squamous cell carcinoma of the oral cavity as a modulatory microenvironment in co-culture. Int J Radiat Biol. 2007, 83:837-48.
    • (2007) Int J Radiat Biol. , vol.83 , pp. 837-848
    • Lacina, L.1    Dvorankova, B.2    Smetana, K.3
  • 68
    • 44849121993 scopus 로고    scopus 로고
    • Alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation
    • Marsh D, Dickinson S, Neill GW. alpha vbeta 6 Integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation. Cancer Res. 2008, 68:3295-303.
    • (2008) Cancer Res. , vol.68 , pp. 3295-3303
    • Marsh, D.1    Dickinson, S.2    Neill, G.W.3
  • 69
    • 0036163492 scopus 로고    scopus 로고
    • Melanoma-stroma interactions: structural and functional aspects
    • Ruiter D, Bogenrieder T, Elder D. Melanoma-stroma interactions: structural and functional aspects. Lancet Oncol. 2002, 3:35-43.
    • (2002) Lancet Oncol. , vol.3 , pp. 35-43
    • Ruiter, D.1    Bogenrieder, T.2    Elder, D.3
  • 70
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt FM. Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J. 2002, 21:3919-26.
    • (2002) EMBO J. , vol.21 , pp. 3919-3926
    • Watt, F.M.1
  • 71
    • 44949254968 scopus 로고    scopus 로고
    • Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche
    • Kloepper JE, Tiede S, Brinckmann J. Immunophenotyping of the human bulge region: the quest to define useful in situ markers for human epithelial hair follicle stem cells and their niche. Exp Dermatol. 2008, 17:592-609.
    • (2008) Exp Dermatol. , vol.17 , pp. 592-609
    • Kloepper, J.E.1    Tiede, S.2    Brinckmann, J.3
  • 72
    • 47749103007 scopus 로고    scopus 로고
    • Epidermal stem cells - role in normal, wounded and pathological psoriatic and cancer skin
    • Kamstrup M, Faurschou A, Gniadecki R. Epidermal stem cells - role in normal, wounded and pathological psoriatic and cancer skin. Curr Stem Cell Res Ther. 2008, 3:146-50.
    • (2008) Curr Stem Cell Res Ther. , vol.3 , pp. 146-150
    • Kamstrup, M.1    Faurschou, A.2    Gniadecki, R.3
  • 74
    • 0033762498 scopus 로고    scopus 로고
    • The EGF receptor - an essential regulator of multiple epidermal functions
    • Jost M, Kari C, Rodeck U. The EGF receptor - an essential regulator of multiple epidermal functions. Eur J Dermatol. 2000, 10:505-10.
    • (2000) Eur J Dermatol. , vol.10 , pp. 505-510
    • Jost, M.1    Kari, C.2    Rodeck, U.3
  • 75
    • 33747047561 scopus 로고    scopus 로고
    • Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a reg ulator of stem cell quiescence
    • Jensen KB, Watt FM. Single-cell expression profiling of human epidermal stem and transit-amplifying cells: Lrig1 is a reg ulator of stem cell quiescence. Proc Natl Acad Sci USA. 2006, 103:11958-63.
    • (2006) Proc Natl Acad Sci USA. , vol.103 , pp. 11958-11963
    • Jensen, K.B.1    Watt, F.M.2
  • 76
    • 33645894992 scopus 로고    scopus 로고
    • Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation
    • Nguyen BC, Lefort K, Mandinova A. Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. Genes Dev. 2006, 20:1028-42.
    • (2006) Genes Dev. , vol.20 , pp. 1028-1042
    • Nguyen, B.C.1    Lefort, K.2    Mandinova, A.3
  • 77
    • 33750043466 scopus 로고    scopus 로고
    • P21WAF1/Cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the IGF-I gene
    • Devgan V, Nguyen BC, Oh H. p21WAF1/Cip1 suppresses keratinocyte differentiation independently of the cell cycle through transcriptional up-regulation of the IGF-I gene. J Biol Chem. 2006, 281:30463-70.
    • (2006) J Biol Chem. , vol.281 , pp. 30463-30470
    • Devgan, V.1    Nguyen, B.C.2    Oh, H.3
  • 78
    • 66249106736 scopus 로고    scopus 로고
    • IGFBP-2 Contributes to the proliferation of less proliferative cells in forming skin equivalents
    • Kim DS, Cho HJ, Yang SK. IGFBP-2 Contributes to the proliferation of less proliferative cells in forming skin equivalents. Tissue Eng Part A. 2009, 15:1075-80.
    • (2009) Tissue Eng Part A. , vol.15 , pp. 1075-1080
    • Kim, D.S.1    Cho, H.J.2    Yang, S.K.3
  • 79
    • 77951969948 scopus 로고    scopus 로고
    • P53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity
    • Okuyama R, Ogawa E, Nagoshi H. p53 homologue, p51/p63, maintains the immaturity of keratinocyte stem cells by inhibiting Notch1 activity. Oncogene. 2007, 27:848-56.
    • (2007) Oncogene. , vol.27 , pp. 848-856
    • Okuyama, R.1    Ogawa, E.2    Nagoshi, H.3
  • 80
    • 24644494270 scopus 로고    scopus 로고
    • Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    • Lechler T, Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature. 2005, 437:275-80.
    • (2005) Nature. , vol.437 , pp. 275-280
    • Lechler, T.1    Fuchs, E.2
  • 81
    • 4243138117 scopus 로고    scopus 로고
    • A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways
    • Okuyama R, Lefort K, Dotto GP. A dynamic model of keratinocyte stem cell renewal and differentiation: role of the p21WAF1/Cip1 and Notch1 signaling pathways. J Investig Dermatol Symp Proc. 2004, 9:248-52.
    • (2004) J Investig Dermatol Symp Proc. , vol.9 , pp. 248-252
    • Okuyama, R.1    Lefort, K.2    Dotto, G.P.3
  • 82
    • 33947166199 scopus 로고    scopus 로고
    • Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases
    • Lefort K, Mandinova A, Ostano P. Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. Genes Dev. 2007, 21:562-77.
    • (2007) Genes Dev. , vol.21 , pp. 562-577
    • Lefort, K.1    Mandinova, A.2    Ostano, P.3
  • 83
    • 48649093670 scopus 로고    scopus 로고
    • EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer
    • Kolev V, Mandinova A, Guinea-Viniegra J. EGFR signalling as a negative regulator of Notch1 gene transcription and function in proliferating keratinocytes and cancer. Nat Cell Biol. 2008, 10:902-11.
    • (2008) Nat Cell Biol. , vol.10 , pp. 902-911
    • Kolev, V.1    Mandinova, A.2    Guinea-Viniegra, J.3
  • 84
    • 0033537757 scopus 로고    scopus 로고
    • Limb and skin abnormalities in mice lacking IKKalpha
    • Takeda K, Takeuchi O, Tsujimura T. Limb and skin abnormalities in mice lacking IKKalpha. Science. 1999, 284:313-6.
    • (1999) Science. , vol.284 , pp. 313-316
    • Takeda, K.1    Takeuchi, O.2    Tsujimura, T.3
  • 85
    • 27644525123 scopus 로고    scopus 로고
    • Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse
    • Li Q, Lu Q, Estepa G, Verma IM. Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse. Proc Natl Acad Sci USA. 2005, 102:15977-82.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 15977-15982
    • Li, Q.1    Lu, Q.2    Estepa, G.3    Verma, I.M.4
  • 86
    • 33750441851 scopus 로고    scopus 로고
    • Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch
    • Richardson RJ, Dixon J, Malhotra S. Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet. 2006, 38:1329-34.
    • (2006) Nat Genet. , vol.38 , pp. 1329-1334
    • Richardson, R.J.1    Dixon, J.2    Malhotra, S.3
  • 87
    • 33750452339 scopus 로고    scopus 로고
    • Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6)
    • Ingraham CR, Kinoshita A, Kondo S. Abnormal skin, limb and craniofacial morphogenesis in mice deficient for interferon regulatory factor 6 (Irf6). Nat Genet. 2006, 38:1335-40.
    • (2006) Nat Genet. , vol.38 , pp. 1335-1340
    • Ingraham, C.R.1    Kinoshita, A.2    Kondo, S.3
  • 88
    • 34447333358 scopus 로고    scopus 로고
    • IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing
    • Zhu F, Xia X, Liu B. IKKalpha shields 14-3-3sigma, a G(2)/M cell cycle checkpoint gene, from hypermethylation, preventing its silencing. Mol Cell. 2007, 27:214-27.
    • (2007) Mol Cell. , vol.27 , pp. 214-227
    • Zhu, F.1    Xia, X.2    Liu, B.3
  • 89
    • 50349089030 scopus 로고    scopus 로고
    • IKKalpha is required to maintain skin homeostasis and prevent skin cancer
    • Liu B, Xia X, Zhu F. IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell. 2008, 14:212-25.
    • (2008) Cancer Cell. , vol.14 , pp. 212-225
    • Liu, B.1    Xia, X.2    Zhu, F.3
  • 90
    • 0031721687 scopus 로고    scopus 로고
    • The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells
    • 111 (Pt 21)
    • Lyle S, Christofidou-Solomidou M, Liu Y. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells. J Cell Sci. 1998, 3179-88. 111 (Pt 21)
    • (1998) J Cell Sci. , pp. 3179-3188
    • Lyle, S.1    Christofidou-Solomidou, M.2    Liu, Y.3
  • 91
    • 33644831550 scopus 로고    scopus 로고
    • In vitro differences between keratinocyte stem cells and transit-amplifying cells of the human hair follicle
    • Roh C, Tao Q, Photopoulos C. In vitro differences between keratinocyte stem cells and transit-amplifying cells of the human hair follicle. J Invest Dermatol. 2005, 125:1099-105.
    • (2005) J Invest Dermatol. , vol.125 , pp. 1099-1105
    • Roh, C.1    Tao, Q.2    Photopoulos, C.3
  • 92
    • 28444472423 scopus 로고    scopus 로고
    • Distinct stem cell populations regenerate the follicle and interfollicular epidermis
    • Levy V, Lindon C, Harfe BD. Distinct stem cell populations regenerate the follicle and interfollicular epidermis. Dev Cell. 2005, 9:855-61.
    • (2005) Dev Cell. , vol.9 , pp. 855-861
    • Levy, V.1    Lindon, C.2    Harfe, B.D.3
  • 93
    • 34249106502 scopus 로고    scopus 로고
    • Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
    • Ito M, Yang Z, Andl T. Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding. Nature. 2007, 447:316-20.
    • (2007) Nature. , vol.447 , pp. 316-320
    • Ito, M.1    Yang, Z.2    Andl, T.3
  • 94
    • 0344177195 scopus 로고    scopus 로고
    • Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34
    • Trempus CS, Morris RJ, Bortner CD. Enrichment for living murine keratinocytes from the hair follicle bulge with the cell surface marker CD34. J Invest Dermatol. 2003, 120:501-11.
    • (2003) J Invest Dermatol. , vol.120 , pp. 501-511
    • Trempus, C.S.1    Morris, R.J.2    Bortner, C.D.3
  • 95
    • 31044431832 scopus 로고    scopus 로고
    • Characterization and isolation of stem cell-enriched human hair follicle bulge cells
    • Ohyama M, Terunuma A, Tock CL. Characterization and isolation of stem cell-enriched human hair follicle bulge cells. J Clin Invest. 2006, 116:249-60.
    • (2006) J Clin Invest. , vol.116 , pp. 249-260
    • Ohyama, M.1    Terunuma, A.2    Tock, C.L.3
  • 96
    • 80051595616 scopus 로고    scopus 로고
    • Human hair follicle cells with the cell surface marker CD34 can regenerate new mouse hair follicles and located in the outer root sheath of immunodeficient nude mice
    • Lee S-H, Chung M-K, Sohn Y-J. Human hair follicle cells with the cell surface marker CD34 can regenerate new mouse hair follicles and located in the outer root sheath of immunodeficient nude mice. Int J of Stem cells. 2009, 1:70-81.
    • (2009) Int J of Stem cells. , vol.1 , pp. 70-81
    • Lee, S.-H.1    Chung, M.-K.2    Sohn, Y.-J.3
  • 97
    • 40349085766 scopus 로고    scopus 로고
    • The longest telomeres: a general signature of adult stem cell compartments
    • Flores I, Canela A, Vera E. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 2008, 22:654-67.
    • (2008) Genes Dev. , vol.22 , pp. 654-667
    • Flores, I.1    Canela, A.2    Vera, E.3
  • 98
    • 23844540299 scopus 로고    scopus 로고
    • Effects of telomerase and telomere length on epidermal stem cell behavior
    • Flores I, Cayuela ML, Blasco MA. Effects of telomerase and telomere length on epidermal stem cell behavior. Science. 2005, 309:1253-6.
    • (2005) Science. , vol.309 , pp. 1253-1256
    • Flores, I.1    Cayuela, M.L.2    Blasco, M.A.3
  • 99
    • 23944516520 scopus 로고    scopus 로고
    • Conditional telomerase induction causes proliferation of hair follicle stem cells
    • Sarin KY, Cheung P, Gilison D. Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature. 2005, 436:1048-52.
    • (2005) Nature. , vol.436 , pp. 1048-1052
    • Sarin, K.Y.1    Cheung, P.2    Gilison, D.3
  • 100
    • 38949156672 scopus 로고    scopus 로고
    • TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program
    • e10
    • Choi J, Southworth LK, Sarin KY. TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program. PLoS Genet. 2008, 4. e10
    • (2008) PLoS Genet. , vol.4
    • Choi, J.1    Southworth, L.K.2    Sarin, K.Y.3
  • 101
    • 36749002168 scopus 로고    scopus 로고
    • Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo
    • Rajaraman S, Choi J, Cheung P. Telomere uncapping in progenitor cells with critical telomere shortening is coupled to S-phase progression in vivo. Proc Natl Acad Sci USA. 2007, 104:17747-52.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 17747-17752
    • Rajaraman, S.1    Choi, J.2    Cheung, P.3
  • 102
    • 0032852267 scopus 로고    scopus 로고
    • Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin
    • Ghali L, Wong ST, Green J. Gli1 protein is expressed in basal cell carcinomas, outer root sheath keratinocytes and a subpopulation of mesenchymal cells in normal human skin. J Invest Dermatol. 1999, 113:595-9.
    • (1999) J Invest Dermatol. , vol.113 , pp. 595-599
    • Ghali, L.1    Wong, S.T.2    Green, J.3
  • 103
    • 0035907041 scopus 로고    scopus 로고
    • Beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
    • Huelsken J, Vogel R, Erdmann B. beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell. 2001, 105:533-45.
    • (2001) Cell. , vol.105 , pp. 533-545
    • Huelsken, J.1    Vogel, R.2    Erdmann, B.3
  • 104
    • 0037452751 scopus 로고    scopus 로고
    • Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells
    • Yamamoto N, Tanigaki K, Han H. Notch/RBP-J signaling regulates epidermis/hair fate determination of hair follicular stem cells. Curr Biol. 2003, 13:333-8.
    • (2003) Curr Biol. , vol.13 , pp. 333-338
    • Yamamoto, N.1    Tanigaki, K.2    Han, H.3
  • 105
    • 23244443556 scopus 로고    scopus 로고
    • Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment
    • Vidal VP, Chaboissier MC, Lutzkendorf S. Sox9 is essential for outer root sheath differentiation and the formation of the hair stem cell compartment. Curr Biol. 2005, 15:1340-51.
    • (2005) Curr Biol. , vol.15 , pp. 1340-1351
    • Vidal, V.P.1    Chaboissier, M.C.2    Lutzkendorf, S.3
  • 106
    • 33746951471 scopus 로고    scopus 로고
    • Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes
    • Kasper M, Schnidar H, Neill GW. Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes. Mol Cell Biol. 2006, 26:6283-98.
    • (2006) Mol Cell Biol. , vol.26 , pp. 6283-6298
    • Kasper, M.1    Schnidar, H.2    Neill, G.W.3
  • 107
    • 0032567078 scopus 로고    scopus 로고
    • De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin
    • Gat U, DasGupta R, Degenstein L. De Novo hair follicle morphogenesis and hair tumors in mice expressing a truncated beta-catenin in skin. Cell. 1998, 95:605-14.
    • (1998) Cell. , vol.95 , pp. 605-614
    • Gat, U.1    DasGupta, R.2    Degenstein, L.3
  • 108
    • 47649092996 scopus 로고    scopus 로고
    • Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate
    • Zhang Y, Andl T, Yang SH. Activation of beta-catenin signaling programs embryonic epidermis to hair follicle fate. Development. 2008, 135:2161-72.
    • (2008) Development. , vol.135 , pp. 2161-2172
    • Zhang, Y.1    Andl, T.2    Yang, S.H.3
  • 109
    • 33845892748 scopus 로고    scopus 로고
    • Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis
    • Estrach S, Ambler CA, Lo CC. Jagged 1 is a beta-catenin target gene required for ectopic hair follicle formation in adult epidermis. Development. 2006, 133:4427-38.
    • (2006) Development. , vol.133 , pp. 4427-4438
    • Estrach, S.1    Ambler, C.A.2    Lo, C.C.3
  • 110
    • 66149123318 scopus 로고    scopus 로고
    • Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    • Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development. 2009, 136:891-6.
    • (2009) Development. , vol.136 , pp. 891-896
    • Demehri, S.1    Kopan, R.2
  • 111
    • 31144462651 scopus 로고    scopus 로고
    • Molecular characterization of melanocyte stem cells in their niche
    • Osawa M, Egawa G, Mak SS. Molecular characterization of melanocyte stem cells in their niche. Development. 2005, 132:5589-99.
    • (2005) Development. , vol.132 , pp. 5589-5599
    • Osawa, M.1    Egawa, G.2    Mak, S.S.3
  • 112
    • 33747332544 scopus 로고    scopus 로고
    • Malignant melanoma: genetics and therapeutics in the genomic era
    • Chin L, Garraway LA, Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev. 2006, 20:2149-82.
    • (2006) Genes Dev. , vol.20 , pp. 2149-2182
    • Chin, L.1    Garraway, L.A.2    Fisher, D.E.3
  • 113
    • 51749102145 scopus 로고    scopus 로고
    • Melanoma, nevogenesis, and stem cell biology
    • Grichnik JM. Melanoma, nevogenesis, and stem cell biology. J Invest Dermatol. 2008, 128:2365-80.
    • (2008) J Invest Dermatol. , vol.128 , pp. 2365-2380
    • Grichnik, J.M.1
  • 114
    • 33749836943 scopus 로고    scopus 로고
    • Isolation and characterization of outer root sheath melanocytes of human hair follicles
    • Na GY, Paek SH, Park BC. Isolation and characterization of outer root sheath melanocytes of human hair follicles. Br J Dermatol. 2006, 155:902-9.
    • (2006) Br J Dermatol. , vol.155 , pp. 902-909
    • Na, G.Y.1    Paek, S.H.2    Park, B.C.3
  • 115
    • 34447327864 scopus 로고    scopus 로고
    • Generating quiescent stem cells
    • Nishikawa S, Osawa M. Generating quiescent stem cells. Pigment Cell Res. 2007, 20:263-70.
    • (2007) Pigment Cell Res. , vol.20 , pp. 263-270
    • Nishikawa, S.1    Osawa, M.2
  • 116
    • 33644783481 scopus 로고    scopus 로고
    • Indispensable role of Bcl2 in the development of the melanocyte stem cell
    • Mak SS, Moriyama M, Nishioka E. Indispensable role of Bcl2 in the development of the melanocyte stem cell. Dev Biol. 2006, 291:144-53.
    • (2006) Dev Biol. , vol.291 , pp. 144-153
    • Mak, S.S.1    Moriyama, M.2    Nishioka, E.3
  • 117
    • 53949094362 scopus 로고    scopus 로고
    • Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles
    • Aubin-Houzelstein G, Djian-Zaouche J, Bernex F. Melanoblasts' proper location and timed differentiation depend on Notch/RBP-J signaling in postnatal hair follicles. J Invest Dermatol. 2008, 128:2686-95.
    • (2008) J Invest Dermatol. , vol.128 , pp. 2686-2695
    • Aubin-Houzelstein, G.1    Djian-Zaouche, J.2    Bernex, F.3
  • 118
    • 41049101021 scopus 로고    scopus 로고
    • Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis
    • Kumano K, Masuda S, Sata M. Both Notch1 and Notch2 contribute to the regulation of melanocyte homeostasis. Pigment Cell Melanoma Res. 2008, 21:70-8.
    • (2008) Pigment Cell Melanoma Res. , vol.21 , pp. 70-78
    • Kumano, K.1    Masuda, S.2    Sata, M.3
  • 119
    • 33846258832 scopus 로고    scopus 로고
    • Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
    • Schouwey K, Delmas V, Larue L. Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner. Dev Dyn. 2007, 236:282-9.
    • (2007) Dev Dyn. , vol.236 , pp. 282-289
    • Schouwey, K.1    Delmas, V.2    Larue, L.3
  • 120
    • 33646411489 scopus 로고    scopus 로고
    • Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells
    • Moriyama M, Osawa M, Mak SS. Notch signaling via Hes1 transcription factor maintains survival of melanoblasts and melanocyte stem cells. J Cell Biol. 2006, 173:333-9.
    • (2006) J Cell Biol. , vol.173 , pp. 333-339
    • Moriyama, M.1    Osawa, M.2    Mak, S.S.3
  • 121
    • 61649113459 scopus 로고    scopus 로고
    • The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles
    • Belmadani A, Jung H, Ren D. The chemokine SDF-1/CXCL12 regulates the migration of melanocyte progenitors in mouse hair follicles. Differentiation. 2009, 77:395-411.
    • (2009) Differentiation. , vol.77 , pp. 395-411
    • Belmadani, A.1    Jung, H.2    Ren, D.3
  • 122
    • 56149119931 scopus 로고    scopus 로고
    • Inhibition of PAX3 by TGF-beta modulates melanocyte viability
    • Yang G, Li Y, Nishimura EK. Inhibition of PAX3 by TGF-beta modulates melanocyte viability. Mol Cell. 2008, 32:554-63.
    • (2008) Mol Cell. , vol.32 , pp. 554-563
    • Yang, G.1    Li, Y.2    Nishimura, E.K.3
  • 123
    • 58449089776 scopus 로고    scopus 로고
    • Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration
    • Jeon S, Kim NH, Kim JY. Stem cell factor induces ERM proteins phosphorylation through PI3K activation to mediate melanocyte proliferation and migration. Pigment Cell Melanoma Res. 2009, 22:77-85.
    • (2009) Pigment Cell Melanoma Res. , vol.22 , pp. 77-85
    • Jeon, S.1    Kim, N.H.2    Kim, J.Y.3
  • 124
    • 3843133252 scopus 로고    scopus 로고
    • The adult hair follicle: cradle for pluripotent neural crest stem cells
    • Sieber-Blum M, Grim M. The adult hair follicle: cradle for pluripotent neural crest stem cells. Birth Defects Res C Embryo Today. 2004, 72:162-72.
    • (2004) Birth Defects Res C Embryo Today. , vol.72 , pp. 162-172
    • Sieber-Blum, M.1    Grim, M.2
  • 125
    • 33845988328 scopus 로고    scopus 로고
    • An epidermal neural crest stem cell (EPI-NCSC) molecular signature
    • Hu YF, Zhang ZJ, Sieber-Blum M. An epidermal neural crest stem cell (EPI-NCSC) molecular signature. Stem Cells. 2006, 24:2692-702.
    • (2006) Stem Cells. , vol.24 , pp. 2692-2702
    • Hu, Y.F.1    Zhang, Z.J.2    Sieber-Blum, M.3
  • 126
    • 29244482591 scopus 로고    scopus 로고
    • Review: melanocyte migration and survival controlled by SCF/c-kit expression
    • Yoshida H, Kunisada T, Grimm T. Review: melanocyte migration and survival controlled by SCF/c-kit expression. J Investig Dermatol Symp Proc. 2001, 6:1-5.
    • (2001) J Investig Dermatol Symp Proc. , vol.6 , pp. 1-5
    • Yoshida, H.1    Kunisada, T.2    Grimm, T.3
  • 127
    • 40349088899 scopus 로고    scopus 로고
    • The Notch pathway: hair graying and pigment cell homeostasis
    • Schouwey K, Beermann F. The Notch pathway: hair graying and pigment cell homeostasis. Histol Histopathol. 2008, 23:609-19.
    • (2008) Histol Histopathol. , vol.23 , pp. 609-619
    • Schouwey, K.1    Beermann, F.2
  • 128
    • 27844547641 scopus 로고    scopus 로고
    • Molecular Dissection of Mesenchymal-Epithelial Interactions in the Hair Follicle
    • Rendl M, Lewis L, Fuchs E. Molecular Dissection of Mesenchymal-Epithelial Interactions in the Hair Follicle. PLoS Biol. 2005, 3:1910-24.
    • (2005) PLoS Biol. , vol.3 , pp. 1910-1924
    • Rendl, M.1    Lewis, L.2    Fuchs, E.3
  • 129
    • 1642619661 scopus 로고    scopus 로고
    • Characterization of multipotent adult stem cells from the skin: transforming growth factor-beta (TGF-beta) facilitates cell growth
    • Kawase Y, Yanagi Y, Takato T. Characterization of multipotent adult stem cells from the skin: transforming growth factor-beta (TGF-beta) facilitates cell growth. Exp Cell Res. 2004, 295:194-203.
    • (2004) Exp Cell Res. , vol.295 , pp. 194-203
    • Kawase, Y.1    Yanagi, Y.2    Takato, T.3
  • 130
    • 7944237574 scopus 로고    scopus 로고
    • A dermal niche for multipotent adult skin-derived precursor cells
    • Fernandes KJ, McKenzie IA Mill P. A dermal niche for multipotent adult skin-derived precursor cells. Nat Cell Biol. 2004, 6:1082-93.
    • (2004) Nat Cell Biol. , vol.6 , pp. 1082-1093
    • Fernandes, K.J.1    McKenzie, I.A.2    Mill, P.3
  • 131
    • 29144491391 scopus 로고    scopus 로고
    • Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves
    • Amoh Y, Li L, Campillo R. Implanted hair follicle stem cells form Schwann cells that support repair of severed peripheral nerves. Proc Natl Acad Sci USA. 2005, 102:17734-8.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 17734-17738
    • Amoh, Y.1    Li, L.2    Campillo, R.3
  • 132
    • 33845713892 scopus 로고    scopus 로고
    • Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin
    • Wong CE, Paratore C, Dours-Zimmermann MT. Neural crest-derived cells with stem cell features can be traced back to multiple lineages in the adult skin. J Cell Biol. 2006, 175:1005-15.
    • (2006) J Cell Biol. , vol.175 , pp. 1005-1015
    • Wong, C.E.1    Paratore, C.2    Dours-Zimmermann, M.T.3
  • 133
    • 0034848122 scopus 로고    scopus 로고
    • Isolation of multipotent adult stem cells from the dermis of mammalian skin
    • Toma JG, Akhavan M, Fernandes KJ. Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol. 2001, 3:778-84.
    • (2001) Nat Cell Biol. , vol.3 , pp. 778-784
    • Toma, J.G.1    Akhavan, M.2    Fernandes, K.J.3
  • 134
    • 3442892935 scopus 로고    scopus 로고
    • Human skin-derived stem cells migrate throughout forebrain and differentiate into astrocytes after injection into adult mouse brain
    • Belicchi M, Pisati F, Lopa R. Human skin-derived stem cells migrate throughout forebrain and differentiate into astrocytes after injection into adult mouse brain. J Neurosci Res. 2004, 77:475-86.
    • (2004) J Neurosci Res. , vol.77 , pp. 475-486
    • Belicchi, M.1    Pisati, F.2    Lopa, R.3
  • 135
    • 34547913091 scopus 로고    scopus 로고
    • Stem cells - A revolution in therapeutics-Recent advances on the stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies
    • Mimeault M, Hauke R, Batra SK. Stem cells - A revolution in therapeutics-Recent advances on the stem cell biology and their therapeutic applications in regenerative medicine and cancer therapies. Clin Pharmacol Ther. 2007, 82:252-64.
    • (2007) Clin Pharmacol Ther. , vol.82 , pp. 252-264
    • Mimeault, M.1    Hauke, R.2    Batra, S.K.3
  • 136
    • 54049104400 scopus 로고    scopus 로고
    • Multilineage differentiation potential of human dermal skin-derived fibroblasts
    • Lorenz K, Sicker M, Schmelzer E. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp Dermatol. 2008, 17:925-32.
    • (2008) Exp Dermatol. , vol.17 , pp. 925-932
    • Lorenz, K.1    Sicker, M.2    Schmelzer, E.3
  • 137
    • 33646673174 scopus 로고    scopus 로고
    • Vascular wall resident progenitor cells: a source for postnatal vasculogenesis
    • Zengin E, Chalajour F, Gehling UM. Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development. 2006, 133:1543-51.
    • (2006) Development. , vol.133 , pp. 1543-1551
    • Zengin, E.1    Chalajour, F.2    Gehling, U.M.3
  • 138
    • 4143102425 scopus 로고    scopus 로고
    • Endothelial progenitor cells for postnatal vasculogenesis
    • Asahara T, Kawamoto A. Endothelial progenitor cells for postnatal vasculogenesis. Am J Physiol Cell Physiol. 2004, 287:C572-9.
    • (2004) Am J Physiol Cell Physiol. , vol.287
    • Asahara, T.1    Kawamoto, A.2
  • 139
    • 34548133667 scopus 로고    scopus 로고
    • Bone marrow-derived stem cells in wound healing: a review
    • Wu Y, Wang J, Scott PG. Bone marrow-derived stem cells in wound healing: a review. Wound Repair Regen. 2007, 15:S18-26.
    • (2007) Wound Repair Regen. , vol.15
    • Wu, Y.1    Wang, J.2    Scott, P.G.3
  • 140
    • 44249117598 scopus 로고    scopus 로고
    • Looking older: fibroblast collapse and therapeutic implications
    • Fisher GJ, Varani J, Voorhees JJ. Looking older: fibroblast collapse and therapeutic implications. Arch Dermatol. 2008, 144:666-72.
    • (2008) Arch Dermatol. , vol.144 , pp. 666-672
    • Fisher, G.J.1    Varani, J.2    Voorhees, J.J.3
  • 141
    • 0038795172 scopus 로고    scopus 로고
    • Genetics of melanoma predisposition
    • Hayward NK. Genetics of melanoma predisposition. Oncogene. 2003, 22:3053-62.
    • (2003) Oncogene. , vol.22 , pp. 3053-3062
    • Hayward, N.K.1
  • 142
    • 33744775719 scopus 로고    scopus 로고
    • Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation
    • Varani J, Dame MK, Rittie L. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006, 168:1861-8.
    • (2006) Am J Pathol. , vol.168 , pp. 1861-1868
    • Varani, J.1    Dame, M.K.2    Rittie, L.3
  • 143
    • 47649125992 scopus 로고    scopus 로고
    • Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathways
    • Kang J, Chen W, Xia J. Extracellular matrix secreted by senescent fibroblasts induced by UVB promotes cell proliferation in HaCaT cells through PI3K/AKT and ERK signaling pathways. Int J Mol Med. 2008, 21:777-84.
    • (2008) Int J Mol Med. , vol.21 , pp. 777-784
    • Kang, J.1    Chen, W.2    Xia, J.3
  • 144
    • 38949144420 scopus 로고    scopus 로고
    • Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology
    • Borlon C, Vankoningsloo S, Godard P. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology. Mech Ageing Dev. 2008, 129:109-19.
    • (2008) Mech Ageing Dev. , vol.129 , pp. 109-119
    • Borlon, C.1    Vankoningsloo, S.2    Godard, P.3
  • 145
    • 0037421896 scopus 로고    scopus 로고
    • Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
    • Wong KK, Maser RS, Bachoo RM. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature. 2003, 421:643-8.
    • (2003) Nature. , vol.421 , pp. 643-648
    • Wong, K.K.1    Maser, R.S.2    Bachoo, R.M.3
  • 146
    • 47149112001 scopus 로고    scopus 로고
    • Telomere maintenance and human bone marrow failure
    • Calado RT, Young NS. Telomere maintenance and human bone marrow failure. Blood. 2008, 111:4446-55.
    • (2008) Blood. , vol.111 , pp. 4446-4455
    • Calado, R.T.1    Young, N.S.2
  • 147
    • 35648999925 scopus 로고    scopus 로고
    • Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations
    • Marrone A, Sokhal P, Walne A. Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations. Haematologica. 2007, 92:1013-20.
    • (2007) Haematologica. , vol.92 , pp. 1013-1020
    • Marrone, A.1    Sokhal, P.2    Walne, A.3
  • 148
    • 41649085578 scopus 로고    scopus 로고
    • Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis
    • Yamamoto K, Nihrane A, Aglipay J. Upregulated ATM gene expression and activated DNA crosslink-induced damage response checkpoint in Fanconi anemia: implications for carcinogenesis. Mol Med. 2008, 14:167-74.
    • (2008) Mol Med. , vol.14 , pp. 167-174
    • Yamamoto, K.1    Nihrane, A.2    Aglipay, J.3
  • 149
    • 42049090788 scopus 로고    scopus 로고
    • Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging
    • Meshorer E, Gruenbaum Y. Gone with the Wnt/Notch: stem cells in laminopathies, progeria, and aging. J Cell Biol. 2008, 181:9-13.
    • (2008) J Cell Biol. , vol.181 , pp. 9-13
    • Meshorer, E.1    Gruenbaum, Y.2
  • 150
    • 43149124203 scopus 로고    scopus 로고
    • Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing
    • Scaffidi P, Misteli T. Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing. Nat Cell Biol. 2008, 10:452-9.
    • (2008) Nat Cell Biol. , vol.10 , pp. 452-459
    • Scaffidi, P.1    Misteli, T.2
  • 151
    • 47749117475 scopus 로고    scopus 로고
    • Nucleotide excision repair and related human diseases
    • Bergoglio V, Magnaldo T. Nucleotide excision repair and related human diseases. Genome Dyn. 2006, 1:35-52.
    • (2006) Genome Dyn. , vol.1 , pp. 35-52
    • Bergoglio, V.1    Magnaldo, T.2
  • 152
    • 68249131322 scopus 로고    scopus 로고
    • Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells
    • Stout GJ, Blasco MA. Genetic dissection of the mechanisms underlying telomere-associated diseases: impact of the TRF2 telomeric protein on mouse epidermal stem cells. Dis Model Mech. 2009, 2:139-56.
    • (2009) Dis Model Mech. , vol.2 , pp. 139-156
    • Stout, G.J.1    Blasco, M.A.2
  • 154
    • 18044373421 scopus 로고    scopus 로고
    • Dyskeratosis congenita - a disease of dysfunctional telomere maintenance
    • 5
    • Mason PJ, Wilson DB, Bessler M. Dyskeratosis congenita - a disease of dysfunctional telomere maintenance. Curr Mol Med. 159-70. 5
    • Curr Mol Med. , pp. 159-170
    • Mason, P.J.1    Wilson, D.B.2    Bessler, M.3
  • 155
    • 38049024575 scopus 로고    scopus 로고
    • The role of DNA damage repair in aging of adult stem cells
    • Kenyon J, Gerson SL. The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Res. 2007, 35:7557-65.
    • (2007) Nucleic Acids Res. , vol.35 , pp. 7557-7565
    • Kenyon, J.1    Gerson, S.L.2
  • 156
    • 34250001450 scopus 로고    scopus 로고
    • DNA repair is limiting for haematopoietic stem cells during ageing
    • Nijnik A, Woodbine L, Marchetti C. DNA repair is limiting for haematopoietic stem cells during ageing. Nature. 2007, 447:686-90.
    • (2007) Nature. , vol.447 , pp. 686-690
    • Nijnik, A.1    Woodbine, L.2    Marchetti, C.3
  • 157
    • 51049112962 scopus 로고    scopus 로고
    • Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome
    • Chigancas V, Lima-Bessa KM, Stary A. Defective transcription/repair factor IIH recruitment to specific UV lesions in trichothiodystrophy syndrome. Cancer Res. 2008, 68:6074-83.
    • (2008) Cancer Res. , vol.68 , pp. 6074-6083
    • Chigancas, V.1    Lima-Bessa, K.M.2    Stary, A.3
  • 158
    • 55549138062 scopus 로고    scopus 로고
    • Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
    • Redondo P, Prieto J, Munoz IG. Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases. Nature. 2008, 456:107-11.
    • (2008) Nature. , vol.456 , pp. 107-111
    • Redondo, P.1    Prieto, J.2    Munoz, I.G.3
  • 159
  • 160
    • 0037115414 scopus 로고    scopus 로고
    • Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients
    • Couve-Privat S, Bouadjar B, Avril MF. Significantly high levels of ultraviolet-specific mutations in the smoothened gene in basal cell carcinomas from DNA repair-deficient xeroderma pigmentosum patients. Cancer Res. 2002, 62:7186-9.
    • (2002) Cancer Res. , vol.62 , pp. 7186-7189
    • Couve-Privat, S.1    Bouadjar, B.2    Avril, M.F.3
  • 161
    • 0034732878 scopus 로고    scopus 로고
    • UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients
    • Ya-Grosjean L, Sarasin A. UV-specific mutations of the human patched gene in basal cell carcinomas from normal individuals and xeroderma pigmentosum patients. Mutat Res. 2000, 450:193-9.
    • (2000) Mutat Res. , vol.450 , pp. 193-199
    • Ya-Grosjean, L.1    Sarasin, A.2
  • 162
    • 34047221962 scopus 로고    scopus 로고
    • Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency
    • Nijhof JG, van Pelt C, Mulder AA. Epidermal stem and progenitor cells in murine epidermis accumulate UV damage despite NER proficiency. Carcinogenesis. 2007, 28:792-800.
    • (2007) Carcinogenesis. , vol.28 , pp. 792-800
    • Nijhof, J.G.1    van Pelt, C.2    Mulder, A.A.3
  • 163
    • 35548999281 scopus 로고    scopus 로고
    • Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres
    • Siegl-Cachedenier I, Flores I, Klatt P. Telomerase reverses epidermal hair follicle stem cell defects and loss of long-term survival associated with critically short telomeres. J Cell Biol. 2007, 179:277-90.
    • (2007) J Cell Biol. , vol.179 , pp. 277-290
    • Siegl-Cachedenier, I.1    Flores, I.2    Klatt, P.3
  • 164
    • 42049117585 scopus 로고    scopus 로고
    • Nuclear envelope defects cause stem cell dysfunction in premature-aging mice
    • Espada J, Varela I, Flores I. Nuclear envelope defects cause stem cell dysfunction in premature-aging mice. J Cell Biol. 2008, 181:27-35.
    • (2008) J Cell Biol. , vol.181 , pp. 27-35
    • Espada, J.1    Varela, I.2    Flores, I.3
  • 165
    • 33748948208 scopus 로고    scopus 로고
    • DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse
    • Sommer M, Poliak N, Upadhyay S. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle. 2006, 5:2005-11.
    • (2006) Cell Cycle. , vol.5 , pp. 2005-2011
    • Sommer, M.1    Poliak, N.2    Upadhyay, S.3
  • 166
    • 0035514046 scopus 로고    scopus 로고
    • Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim
    • Bouillet P, Cory S, Zhang LC. Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim. Dev Cell. 2001, 1:645-53.
    • (2001) Dev Cell. , vol.1 , pp. 645-653
    • Bouillet, P.1    Cory, S.2    Zhang, L.C.3
  • 167
    • 0038819652 scopus 로고    scopus 로고
    • The INK4a/ARF locus and melanoma
    • Sharpless E, Chin L. The INK4a/ARF locus and melanoma. Oncogene. 2003, 22:3092-8.
    • (2003) Oncogene. , vol.22 , pp. 3092-3098
    • Sharpless, E.1    Chin, L.2
  • 168
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • Lowe SW, Cepero E, Evan G. Intrinsic tumour suppression. Nature. 2004, 432:307-15.
    • (2004) Nature. , vol.432 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 169
    • 33747885052 scopus 로고    scopus 로고
    • Ras mutation promotes p53 activation and apoptosis of skin keratinocytes
    • Zhao Y, Chaiswing L, Bakthavatchalu V. Ras mutation promotes p53 activation and apoptosis of skin keratinocytes. Carcinogenesis. 2006, 27:1692-8.
    • (2006) Carcinogenesis. , vol.27 , pp. 1692-1698
    • Zhao, Y.1    Chaiswing, L.2    Bakthavatchalu, V.3
  • 170
    • 0343228751 scopus 로고    scopus 로고
    • Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis
    • Gonzalez-Suarez E, Samper E, Flores JM. Telomerase-deficient mice with short telomeres are resistant to skin tumorigenesis. Nat Genet. 2000, 26:114-7.
    • (2000) Nat Genet. , vol.26 , pp. 114-117
    • Gonzalez-Suarez, E.1    Samper, E.2    Flores, J.M.3
  • 171
    • 34247860915 scopus 로고    scopus 로고
    • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    • Cosme-Blanco W, Shen MF, Lazar AJ. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 2007, 8:497-503.
    • (2007) EMBO Rep. , vol.8 , pp. 497-503
    • Cosme-Blanco, W.1    Shen, M.F.2    Lazar, A.J.3
  • 172
    • 27144515686 scopus 로고    scopus 로고
    • XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer
    • Munoz P, Blanco R, Flores JM. XPF nuclease-dependent telomere loss and increased DNA damage in mice overexpressing TRF2 result in premature aging and cancer. Nat Genet. 2005, 37:1063-71.
    • (2005) Nat Genet. , vol.37 , pp. 1063-1071
    • Munoz, P.1    Blanco, R.2    Flores, J.M.3
  • 173
    • 36349031033 scopus 로고    scopus 로고
    • Activation of epidermal akt by diverse mouse skin tumor promoters
    • Lu J, Rho O, Wilker E. Activation of epidermal akt by diverse mouse skin tumor promoters. Mol Cancer Res. 2007, 5:1342-52.
    • (2007) Mol Cancer Res. , vol.5 , pp. 1342-1352
    • Lu, J.1    Rho, O.2    Wilker, E.3
  • 174
    • 36549085004 scopus 로고    scopus 로고
    • The genome and epigenome of malignant melanoma
    • Dahl C, Guldberg P. The genome and epigenome of malignant melanoma. APMIS. 2007, 115:1161-76.
    • (2007) APMIS. , vol.115 , pp. 1161-1176
    • Dahl, C.1    Guldberg, P.2
  • 175
    • 50449084075 scopus 로고    scopus 로고
    • Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling
    • Yang SH, Andl T, Grachtchouk V. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling. Nat Genet. 2008, 40:1130-5.
    • (2008) Nat Genet. , vol.40 , pp. 1130-1135
    • Yang, S.H.1    Andl, T.2    Grachtchouk, V.3
  • 176
    • 60949100188 scopus 로고    scopus 로고
    • Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications
    • Mimeault M, Batra SK. Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. Ageing Res Rev. 2009, 8:94-112.
    • (2009) Ageing Res Rev. , vol.8 , pp. 94-112
    • Mimeault, M.1    Batra, S.K.2
  • 177
    • 0037418002 scopus 로고    scopus 로고
    • Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model
    • Kannan K, Sharpless NE, Xu J. Components of the Rb pathway are critical targets of UV mutagenesis in a murine melanoma model. Proc Natl Acad Sci USA. 2003, 100:1221-5.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 1221-1225
    • Kannan, K.1    Sharpless, N.E.2    Xu, J.3
  • 178
    • 0034980383 scopus 로고    scopus 로고
    • Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin
    • Shimizu T, Izumi H, Oga A. Epidermal growth factor receptor overexpression and genetic aberrations in metastatic squamous-cell carcinoma of the skin. Dermatology. 2001, 202:203-6.
    • (2001) Dermatology. , vol.202 , pp. 203-206
    • Shimizu, T.1    Izumi, H.2    Oga, A.3
  • 179
    • 40549128662 scopus 로고    scopus 로고
    • SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms
    • Vidal VP, Ortonne N, Schedl A. SOX9 expression is a general marker of basal cell carcinoma and adnexal-related neoplasms. J Cutan Pathol. 2008, 35:373-9.
    • (2008) J Cutan Pathol. , vol.35 , pp. 373-379
    • Vidal, V.P.1    Ortonne, N.2    Schedl, A.3
  • 180
    • 51349161304 scopus 로고    scopus 로고
    • G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation
    • Tanese K, Fukuma M, Yamada T. G-protein-coupled receptor GPR49 is up-regulated in basal cell carcinoma and promotes cell proliferation and tumor formation. Am J Pathol. 2008, 173:835-43.
    • (2008) Am J Pathol. , vol.173 , pp. 835-843
    • Tanese, K.1    Fukuma, M.2    Yamada, T.3
  • 181
    • 0031837549 scopus 로고    scopus 로고
    • Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome
    • Aszterbaum M, Rothman A, Johnson RL. Identification of mutations in the human PATCHED gene in sporadic basal cell carcinomas and in patients with the basal cell nevus syndrome. J Invest Dermatol. 1998, 110:885-8.
    • (1998) J Invest Dermatol. , vol.110 , pp. 885-888
    • Aszterbaum, M.1    Rothman, A.2    Johnson, R.L.3
  • 182
    • 9244221172 scopus 로고    scopus 로고
    • Tissue repair and stem cell renewal in carcinogenesis
    • Beachy PA, Karhadkar SS, Berman DM. Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004, 432:324-31.
    • (2004) Nature. , vol.432 , pp. 324-331
    • Beachy, P.A.1    Karhadkar, S.S.2    Berman, D.M.3
  • 183
    • 31644445651 scopus 로고    scopus 로고
    • Basal cell carcinoma: biology, morphology and clinical implications
    • Crowson AN. Basal cell carcinoma: biology, morphology and clinical implications. Mod Pathol. 2006, 19:S127-47.
    • (2006) Mod Pathol. , vol.19
    • Crowson, A.N.1
  • 184
    • 33846448533 scopus 로고    scopus 로고
    • Expression of BMI-1 in normal skin and inflammatory and neoplastic skin lesions
    • Reinisch CM, Uthman A, Erovic BM. Expression of BMI-1 in normal skin and inflammatory and neoplastic skin lesions. J Cutan Pathol. 2007, 34:174-80.
    • (2007) J Cutan Pathol. , vol.34 , pp. 174-180
    • Reinisch, C.M.1    Uthman, A.2    Erovic, B.M.3
  • 185
    • 0032694528 scopus 로고    scopus 로고
    • Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice
    • Aszterbaum M, Epstein J, Oro A. Ultraviolet and ionizing radiation enhance the growth of BCCs and trichoblastomas in patched heterozygous knockout mice. Nat Med. 1999, 5:1285-91.
    • (1999) Nat Med. , vol.5 , pp. 1285-1291
    • Aszterbaum, M.1    Epstein, J.2    Oro, A.3
  • 186
    • 10744221671 scopus 로고    scopus 로고
    • Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice
    • Mancuso M, Pazzaglia S, Tanori M. Basal cell carcinoma and its development: insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res. 2004, 64:934-41.
    • (2004) Cancer Res. , vol.64 , pp. 934-941
    • Mancuso, M.1    Pazzaglia, S.2    Tanori, M.3
  • 187
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
    • Dahmane N, Lee J, Robins P. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature. 1997, 389:876-81.
    • (1997) Nature. , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3
  • 188
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
    • Fan H, Oro AE, Scott MP. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat Med. 1997, 3:788-92.
    • (1997) Nat Med. , vol.3 , pp. 788-792
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3
  • 189
    • 0037444064 scopus 로고    scopus 로고
    • Hair cycle regulation of Hedgehog signal reception
    • Oro AE, Higgins K. Hair cycle regulation of Hedgehog signal reception. Dev Biol. 2003, 255:238-48.
    • (2003) Dev Biol. , vol.255 , pp. 238-248
    • Oro, A.E.1    Higgins, K.2
  • 190
    • 0037844870 scopus 로고    scopus 로고
    • The magnitude of hedgehog signaling activity defines skin tumor phenotype
    • Grachtchouk V, Grachtchouk M, Lowe L. The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J. 2003, 22:2741-51.
    • (2003) EMBO J. , vol.22 , pp. 2741-2751
    • Grachtchouk, V.1    Grachtchouk, M.2    Lowe, L.3
  • 191
    • 0034724219 scopus 로고    scopus 로고
    • Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
    • Nilsson M, Unden AB, Krause D. Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1. Proc Natl Acad Sci USA. 2000, 97:3438-43.
    • (2000) Proc Natl Acad Sci USA. , vol.97 , pp. 3438-3443
    • Nilsson, M.1    Unden, A.B.2    Krause, D.3
  • 192
    • 5644264887 scopus 로고    scopus 로고
    • Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis
    • Athar M, Li C, Tang X. Inhibition of smoothened signaling prevents ultraviolet B-induced basal cell carcinomas through regulation of Fas expression and apoptosis. Cancer Res. 2004, 64:7545-52.
    • (2004) Cancer Res. , vol.64 , pp. 7545-7552
    • Athar, M.1    Li, C.2    Tang, X.3
  • 193
    • 0037370310 scopus 로고    scopus 로고
    • Notch1 functions as a tumor suppressor in mouse skin
    • Nicolas M, Wolfer A, Raj K. Notch1 functions as a tumor suppressor in mouse skin. Nat Genet. 2003, 33:416-21.
    • (2003) Nat Genet. , vol.33 , pp. 416-421
    • Nicolas, M.1    Wolfer, A.2    Raj, K.3
  • 194
    • 0030876833 scopus 로고    scopus 로고
    • Developmental genes and cancer: role of patched in basal cell carcinoma of the skin
    • Gailani MR, Bale AE. Developmental genes and cancer: role of patched in basal cell carcinoma of the skin. J Natl Cancer Inst. 1997, 89:1103-9.
    • (1997) J Natl Cancer Inst. , vol.89 , pp. 1103-1109
    • Gailani, M.R.1    Bale, A.E.2
  • 195
    • 20144387312 scopus 로고    scopus 로고
    • Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes
    • Chen KG, Szakacs G, Annereau JP. Principal expression of two mRNA isoforms (ABCB 5alpha and ABCB 5beta) of the ATP-binding cassette transporter gene ABCB 5 in melanoma cells and melanocytes. Pigment Cell Res. 2005, 18:102-12.
    • (2005) Pigment Cell Res. , vol.18 , pp. 102-112
    • Chen, K.G.1    Szakacs, G.2    Annereau, J.P.3
  • 196
    • 33750302541 scopus 로고    scopus 로고
    • SP analysis may be used to identify cancer stem cell populations
    • Hadnagy A, Gaboury L, Beaulieu R. SP analysis may be used to identify cancer stem cell populations. Exp Cell Res. 2006, 312:3701-10.
    • (2006) Exp Cell Res. , vol.312 , pp. 3701-3710
    • Hadnagy, A.1    Gaboury, L.2    Beaulieu, R.3
  • 197
    • 33845702260 scopus 로고    scopus 로고
    • Increased expression of stem cell markers in malignant melanoma
    • Klein WM, Wu BP, Zhao S. Increased expression of stem cell markers in malignant melanoma. Mod Pathol. 2007, 20:102-7.
    • (2007) Mod Pathol. , vol.20 , pp. 102-107
    • Klein, W.M.1    Wu, B.P.2    Zhao, S.3
  • 198
    • 47749100122 scopus 로고    scopus 로고
    • Identification of progenitor cancer stem cell in lentigo maligna melanoma
    • Bongiorno MR, Doukaki S, Malleo F. Identification of progenitor cancer stem cell in lentigo maligna melanoma. Dermatol Ther. 2008, 21:S1-5.
    • (2008) Dermatol Ther. , vol.21
    • Bongiorno, M.R.1    Doukaki, S.2    Malleo, F.3
  • 199
    • 47749107233 scopus 로고    scopus 로고
    • Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma
    • Strizzi L, Abbott DE, Salomon DS. Potential for cripto-1 in defining stem cell-like characteristics in human malignant melanoma. Cell Cycle. 2008, 7:1931-5.
    • (2008) Cell Cycle. , vol.7 , pp. 1931-1935
    • Strizzi, L.1    Abbott, D.E.2    Salomon, D.S.3
  • 200
    • 35248845990 scopus 로고    scopus 로고
    • The many faces of Notch signaling in skin-derived cells
    • Pinnix CC, Herlyn M. The many faces of Notch signaling in skin-derived cells. Pigment Cell Res. 2007, 20:458-65.
    • (2007) Pigment Cell Res. , vol.20 , pp. 458-465
    • Pinnix, C.C.1    Herlyn, M.2
  • 201
    • 33747192833 scopus 로고    scopus 로고
    • Cellular senescence in naevi and immortalisation in melanoma: a role for p16
    • Gray-Schopfer VC, Cheong SC, Chong H. Cellular senescence in naevi and immortalisation in melanoma: a role for p16. Br J Cancer. 2006, 95:496-505.
    • (2006) Br J Cancer. , vol.95 , pp. 496-505
    • Gray-Schopfer, V.C.1    Cheong, S.C.2    Chong, H.3
  • 202
    • 18144365866 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor signaling in RAS-driven melanoma
    • Bardeesy N, Kim M, Xu J. Role of epidermal growth factor receptor signaling in RAS-driven melanoma. Mol Cell Biol. 2005, 25:4176-88.
    • (2005) Mol Cell Biol. , vol.25 , pp. 4176-4188
    • Bardeesy, N.1    Kim, M.2    Xu, J.3
  • 203
    • 0036528247 scopus 로고    scopus 로고
    • Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma
    • Weeraratna AT, Jiang Y, Hostetter G. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell. 2002, 1:279-88.
    • (2002) Cancer Cell. , vol.1 , pp. 279-288
    • Weeraratna, A.T.1    Jiang, Y.2    Hostetter, G.3
  • 204
    • 63249105225 scopus 로고    scopus 로고
    • Oncogenic Braf induces melanocyte senescence and melanoma in mice
    • Dhomen N, Reis-Filho JS, da Rocha DS. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell. 2009, 15:294-303.
    • (2009) Cancer Cell. , vol.15 , pp. 294-303
    • Dhomen, N.1    Reis-Filho, J.S.2    da Rocha, D.S.3
  • 205
    • 27844567142 scopus 로고    scopus 로고
    • Distinct sets of genetic alterations in melanoma
    • Curtin JA, Fridlyand J, Kageshita T. Distinct sets of genetic alterations in melanoma. N Engl J Med. 2005, 353:2135-47.
    • (2005) N Engl J Med. , vol.353 , pp. 2135-2147
    • Curtin, J.A.1    Fridlyand, J.2    Kageshita, T.3
  • 206
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin JA, Busam K, Pinkel D. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006, 24:4340-6.
    • (2006) J Clin Oncol. , vol.24 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3
  • 207
    • 17144399192 scopus 로고    scopus 로고
    • Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival
    • Grafstrom E, Egyhazi S, Ringborg U. Biallelic deletions in INK4 in cutaneous melanoma are common and associated with decreased survival. Clin Cancer Res. 2005, 11:2991-7.
    • (2005) Clin Cancer Res. , vol.11 , pp. 2991-2997
    • Grafstrom, E.1    Egyhazi, S.2    Ringborg, U.3
  • 208
    • 33746263912 scopus 로고    scopus 로고
    • BRAF and NRAS mutations in melanoma and melanocytic nevi
    • Poynter JN, Elder JT, Fullen DR. BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res. 16:267-73.
    • Melanoma Res. , vol.16 , pp. 267-273
    • Poynter, J.N.1    Elder, J.T.2    Fullen, D.R.3
  • 209
    • 34447515273 scopus 로고    scopus 로고
    • Genomic profiling of malignant melanoma using tiling-resolution arrayCGH
    • Jonsson G, Dahl C, Staaf J. Genomic profiling of malignant melanoma using tiling-resolution arrayCGH. Oncogene. 2007, 26:4738-48.
    • (2007) Oncogene. , vol.26 , pp. 4738-4748
    • Jonsson, G.1    Dahl, C.2    Staaf, J.3
  • 210
    • 48649085443 scopus 로고    scopus 로고
    • Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression
    • Smalley KS, Contractor R, Nguyen TK. Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression. Cancer Res. 2008, 68:5743-52.
    • (2008) Cancer Res. , vol.68 , pp. 5743-5752
    • Smalley, K.S.1    Contractor, R.2    Nguyen, T.K.3
  • 211
    • 57349143739 scopus 로고    scopus 로고
    • Efficient tumour formation by single human melanoma cells
    • Quintana E, Shackleton M, Sabel MS. Efficient tumour formation by single human melanoma cells. Nature. 2008, 456:593-8.
    • (2008) Nature. , vol.456 , pp. 593-598
    • Quintana, E.1    Shackleton, M.2    Sabel, M.S.3
  • 213
    • 19944433088 scopus 로고    scopus 로고
    • A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages
    • Bellizzi D, Rose G, Cavalcante P. A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics. 2005, 85:258-63.
    • (2005) Genomics. , vol.85 , pp. 258-263
    • Bellizzi, D.1    Rose, G.2    Cavalcante, P.3
  • 214
    • 0030695138 scopus 로고    scopus 로고
    • Pathophysiology of premature skin aging induced by ultraviolet light
    • Fisher GJ, Wang ZQ, Datta SC. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 1997, 337:1419-28.
    • (1997) N Engl J Med. , vol.337 , pp. 1419-1428
    • Fisher, G.J.1    Wang, Z.Q.2    Datta, S.C.3
  • 215
    • 4143050290 scopus 로고    scopus 로고
    • The interaction between FOXO and SIRT1: tipping the balance towards survival
    • Giannakou ME, Partridge L. The interaction between FOXO and SIRT1: tipping the balance towards survival. Trends Cell Biol. 2004, 14:408-12.
    • (2004) Trends Cell Biol. , vol.14 , pp. 408-412
    • Giannakou, M.E.1    Partridge, L.2
  • 216
    • 47149091117 scopus 로고    scopus 로고
    • Sirtuin 1, stem cells, aging, and stem cell aging
    • Mantel C, Broxmeyer HE. Sirtuin 1, stem cells, aging, and stem cell aging. Curr Opin Hematol. 15:326-31.
    • Curr Opin Hematol. , vol.15 , pp. 326-331
    • Mantel, C.1    Broxmeyer, H.E.2
  • 217
    • 33750887809 scopus 로고    scopus 로고
    • The role of NAD+ dependent histone deacetylases (sirtuins) in ageing
    • Trapp J, Jung M. The role of NAD+ dependent histone deacetylases (sirtuins) in ageing. Curr Drug Targets. 2006, 7:1553-60.
    • (2006) Curr Drug Targets. , vol.7 , pp. 1553-1560
    • Trapp, J.1    Jung, M.2
  • 218
    • 33846059079 scopus 로고    scopus 로고
    • Resveratrol enhances UVA-induced DNA damage in HaCaT human keratinocytes
    • Seve M, Chimienti F, Devergnas S. Resveratrol enhances UVA-induced DNA damage in HaCaT human keratinocytes. Med Chem. 2005, 1:629-33.
    • (2005) Med Chem. , vol.1 , pp. 629-633
    • Seve, M.1    Chimienti, F.2    Devergnas, S.3
  • 219
    • 58549110032 scopus 로고    scopus 로고
    • A rare repigmentation pattern in a vitiligo patient: a clue to an epidermal stem-cell reservoir of melanocytes
    • Davids LM, du Toit E, Kidson SH. A rare repigmentation pattern in a vitiligo patient: a clue to an epidermal stem-cell reservoir of melanocytes. Clin Exp Dermatol. 2009, 34:246-8.
    • (2009) Clin Exp Dermatol. , vol.34 , pp. 246-248
    • Davids, L.M.1    du Toit, E.2    Kidson, S.H.3
  • 220
    • 48049115777 scopus 로고    scopus 로고
    • Skin and hair: models for exploring organ regeneration
    • Yu BD, Mukhopadhyay A, Wong C. Skin and hair: models for exploring organ regeneration. Hum Mol Genet. 2008, 17:R54-9.
    • (2008) Hum Mol Genet. , vol.17
    • Yu, B.D.1    Mukhopadhyay, A.2    Wong, C.3
  • 221
    • 33847220364 scopus 로고    scopus 로고
    • Melanoma biology and new targeted therapy
    • Gray-Schopfer V, Wellbrock C, Marais R. Melanoma biology and new targeted therapy. Nature. 2007, 445:851-7.
    • (2007) Nature. , vol.445 , pp. 851-857
    • Gray-Schopfer, V.1    Wellbrock, C.2    Marais, R.3
  • 222
    • 35648999534 scopus 로고    scopus 로고
    • Recent advances on cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers
    • Mimeault M, Hauke R, Mehta PP. Recent advances on cancer stem/progenitor cell research: therapeutic implications for overcoming resistance to the most aggressive cancers. J Mol Cell Med. 2007, 11:981-1011.
    • (2007) J Mol Cell Med. , vol.11 , pp. 981-1011
    • Mimeault, M.1    Hauke, R.2    Mehta, P.P.3
  • 223
    • 58149232517 scopus 로고    scopus 로고
    • Recent advances on the development of novel anti-cancer drugs targeting cancer stem/progenitor cells
    • Mimeault M, Batra SK. Recent advances on the development of novel anti-cancer drugs targeting cancer stem/progenitor cells. Drug Develop Res. 2008, 69:415-30.
    • (2008) Drug Develop Res. , vol.69 , pp. 415-430
    • Mimeault, M.1    Batra, S.K.2
  • 224
    • 35348872467 scopus 로고    scopus 로고
    • Novel Hedgehog pathway targets against basal cell carcinoma
    • Tang JY, So PL, Epstein EH. Novel Hedgehog pathway targets against basal cell carcinoma. Toxicol Appl Pharmacol. 2006, 224:257-64.
    • (2006) Toxicol Appl Pharmacol. , vol.224 , pp. 257-264
    • Tang, J.Y.1    So, P.L.2    Epstein, E.H.3
  • 225
    • 58149288674 scopus 로고    scopus 로고
    • UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines
    • Singh B, Schneider M, Knyazev P. UV-induced EGFR signal transactivation is dependent on proligand shedding by activated metalloproteases in skin cancer cell lines. Int J Cancer. 2009, 124:531-9.
    • (2009) Int J Cancer. , vol.124 , pp. 531-539
    • Singh, B.1    Schneider, M.2    Knyazev, P.3
  • 226
    • 34347226348 scopus 로고    scopus 로고
    • Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
    • Stecca B, Mas C, Clement V. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. Proc Natl Acad Sci USA. 2007, 104:5895-00.
    • (2007) Proc Natl Acad Sci USA. , vol.104 , pp. 5895-5900
    • Stecca, B.1    Mas, C.2    Clement, V.3
  • 228
    • 34548472626 scopus 로고    scopus 로고
    • Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth
    • Remsberg JR, Lou H, Tarasov SG. Structural analogues of smoothened intracellular loops as potent inhibitors of Hedgehog pathway and cancer cell growth. J Med Chem. 2007, 50:4534-8.
    • (2007) J Med Chem. , vol.50 , pp. 4534-4538
    • Remsberg, J.R.1    Lou, H.2    Tarasov, S.G.3
  • 229
    • 33645819416 scopus 로고    scopus 로고
    • CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma
    • Chen GS, Yu HS, Lan CC. CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma. Br J Dermatol. 2006, 154:910-8.
    • (2006) Br J Dermatol. , vol.154 , pp. 910-918
    • Chen, G.S.1    Yu, H.S.2    Lan, C.C.3
  • 230
    • 53049084660 scopus 로고    scopus 로고
    • CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2
    • Kim Y, Lee YS, Choe J. CD44-epidermal growth factor receptor interaction mediates hyaluronic acid-promoted cell motility by activating protein kinase C signaling involving Akt, Rac1, Phox, reactive oxygen species, focal adhesion kinase, and MMP-2. J Biol Chem. 2008, 283:22513-28.
    • (2008) J Biol Chem. , vol.283 , pp. 22513-22528
    • Kim, Y.1    Lee, Y.S.2    Choe, J.3
  • 231
    • 24344483143 scopus 로고    scopus 로고
    • Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid
    • Qiu L, Wang Q, Di W. Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid. Int J Oncol. 2005, 27:823-30.
    • (2005) Int J Oncol. , vol.27 , pp. 823-830
    • Qiu, L.1    Wang, Q.2    Di, W.3
  • 232
    • 35348958935 scopus 로고    scopus 로고
    • Role of telomeres and telomerase in genomic instability, senescence and cancer
    • Deng Y, Chang S. Role of telomeres and telomerase in genomic instability, senescence and cancer. Lab Invest. 2007, 87:1071-6.
    • (2007) Lab Invest. , vol.87 , pp. 1071-1076
    • Deng, Y.1    Chang, S.2
  • 233
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • Harley CB. Telomerase and cancer therapeutics. Nat Rev Cancer. 2008, 8:167-79.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 167-179
    • Harley, C.B.1
  • 234
    • 39449092745 scopus 로고    scopus 로고
    • Targeting telomerase for cancer therapeutics
    • Shay JW, Keith WN. Targeting telomerase for cancer therapeutics. Br J Cancer. 2008, 98:677-83.
    • (2008) Br J Cancer. , vol.98 , pp. 677-683
    • Shay, J.W.1    Keith, W.N.2
  • 235
    • 36448955418 scopus 로고    scopus 로고
    • Telomerase and its potential for therapeutic intervention
    • Phatak P, Burger AM. Telomerase and its potential for therapeutic intervention. Br J Pharmacol. 2007, 152:1003-11.
    • (2007) Br J Pharmacol. , vol.152 , pp. 1003-1011
    • Phatak, P.1    Burger, A.M.2
  • 236
    • 34047143340 scopus 로고    scopus 로고
    • Telomerase immunity from bench to bedside: round one
    • Cortez-Gonzalez X, Zanetti M. Telomerase immunity from bench to bedside: round one. J Transl Med. 2007, 5:12.
    • (2007) J Transl Med. , vol.5 , pp. 12
    • Cortez-Gonzalez, X.1    Zanetti, M.2
  • 237
    • 33846448142 scopus 로고    scopus 로고
    • Cholesterol, statins and cancer
    • Brown AJ. Cholesterol, statins and cancer. Clin Exp Pharmacol Physiol. 2007, 34:135-41.
    • (2007) Clin Exp Pharmacol Physiol. , vol.34 , pp. 135-141
    • Brown, A.J.1
  • 238
    • 0344953585 scopus 로고    scopus 로고
    • A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis
    • Cooper MK, Wassif CA, Krakowiak PA. A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet. 2003, 33:508-13.
    • (2003) Nat Genet. , vol.33 , pp. 508-513
    • Cooper, M.K.1    Wassif, C.A.2    Krakowiak, P.A.3
  • 239
    • 33747332214 scopus 로고    scopus 로고
    • Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion
    • e232
    • Bijlsma MF, Spek CA, Zivkovic D. Repression of smoothened by patched-dependent (pro-) vitamin D3 secretion. PLoS Biol. 2006, 4. e232
    • (2006) PLoS Biol. , vol.4
    • Bijlsma, M.F.1    Spek, C.A.2    Zivkovic, D.3
  • 240
    • 0037447269 scopus 로고    scopus 로고
    • Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions
    • Williams JA, Guicherit OM, Zaharian BI. Identification of a small molecule inhibitor of the hedgehog signaling pathway: effects on basal cell carcinoma-like lesions. Proc Natl Acad Sci USA. 2003, 100:4616-21.
    • (2003) Proc Natl Acad Sci USA. , vol.100 , pp. 4616-4621
    • Williams, J.A.1    Guicherit, O.M.2    Zaharian, B.I.3
  • 241
    • 52649111039 scopus 로고    scopus 로고
    • Basal cell carcinomas: attack of the hedgehog
    • Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer. 2008, 8:743-54.
    • (2008) Nat Rev Cancer. , vol.8 , pp. 743-754
    • Epstein, E.H.1
  • 242
    • 44449108114 scopus 로고    scopus 로고
    • Hedgehog drugs begin to show results
    • Garber K. Hedgehog drugs begin to show results. J Natl Cancer Inst. 2008, 100:692-7.
    • (2008) J Natl Cancer Inst. , vol.100 , pp. 692-697
    • Garber, K.1
  • 243
    • 42949128595 scopus 로고    scopus 로고
    • Major response to imatinib mesylate in KIT-mutated melanoma
    • Hodi FS, Friedlander P, Corless CL. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol. 2008, 26:2046-51.
    • (2008) J Clin Oncol. , vol.26 , pp. 2046-2051
    • Hodi, F.S.1    Friedlander, P.2    Corless, C.L.3
  • 244
    • 13144300126 scopus 로고    scopus 로고
    • The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours
    • Knight LA, Di Nicolantonio F, Whitehouse P. The in vitro effect of gefitinib ('Iressa') alone and in combination with cytotoxic chemotherapy on human solid tumours. BMC Cancer. 2004, 4:83.
    • (2004) BMC Cancer. , vol.4 , pp. 83
    • Knight, L.A.1    Di Nicolantonio, F.2    Whitehouse, P.3
  • 245
    • 41949142373 scopus 로고    scopus 로고
    • Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells
    • Postovit LM, Margaryan NV, Seftor EA. Human embryonic stem cell microenvironment suppresses the tumorigenic phenotype of aggressive cancer cells. Proc Natl Acad Sci USA. 2008, 105:4329-34.
    • (2008) Proc Natl Acad Sci USA. , vol.105 , pp. 4329-4334
    • Postovit, L.M.1    Margaryan, N.V.2    Seftor, E.A.3
  • 247
    • 0028268636 scopus 로고
    • Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody
    • Guo Y, Ma J, Wang J. Inhibition of human melanoma growth and metastasis in vivo by anti-CD44 monoclonal antibody. Cancer Res. 1994, 54:1561-5.
    • (1994) Cancer Res. , vol.54 , pp. 1561-1565
    • Guo, Y.1    Ma, J.2    Wang, J.3
  • 248
    • 0035821780 scopus 로고    scopus 로고
    • Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid
    • Ahrens T, Sleeman JP, Schempp CM. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene. 2001, 20:3399-408.
    • (2001) Oncogene. , vol.20 , pp. 3399-3408
    • Ahrens, T.1    Sleeman, J.P.2    Schempp, C.M.3
  • 249
    • 0028216487 scopus 로고
    • Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development
    • Bartolazzi A, Peach R, Aruffo A. Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development. J Exp Med. 1994, 180:53-66.
    • (1994) J Exp Med. , vol.180 , pp. 53-66
    • Bartolazzi, A.1    Peach, R.2    Aruffo, A.3
  • 250
    • 47249113549 scopus 로고    scopus 로고
    • Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage
    • Yokoyama S, Feige E, Poling LL. Pharmacologic suppression of MITF expression via HDAC inhibitors in the melanocyte lineage. Pigment Cell Melanoma Res. 2008, 21:457-63.
    • (2008) Pigment Cell Melanoma Res. , vol.21 , pp. 457-463
    • Yokoyama, S.1    Feige, E.2    Poling, L.L.3
  • 251
  • 252
    • 27444442651 scopus 로고    scopus 로고
    • Dendritic cells: tools and targets for antitumor vaccination
    • den Brok MH, Nierkens S, Figdor CG. Dendritic cells: tools and targets for antitumor vaccination. Expert Rev Vaccines. 2005, 4:699-710.
    • (2005) Expert Rev Vaccines. , vol.4 , pp. 699-710
    • den Brok, M.H.1    Nierkens, S.2    Figdor, C.G.3
  • 253
    • 40949121440 scopus 로고    scopus 로고
    • Cancer testis antigens in human melanoma stem cells: Expression, distribution, and methylation status
    • Sigalotti L, Covre A, Zabierowski S. Cancer testis antigens in human melanoma stem cells: Expression, distribution, and methylation status. J Cell Physiol. 2008, 215:287-91.
    • (2008) J Cell Physiol. , vol.215 , pp. 287-291
    • Sigalotti, L.1    Covre, A.2    Zabierowski, S.3
  • 254
    • 33846443750 scopus 로고    scopus 로고
    • Development of a tumor-selective approach to treat metastatic cancer
    • e23
    • Aboody KS, Bush RA, Garcia E. Development of a tumor-selective approach to treat metastatic cancer. PLoS ONE. 2006, 1. e23
    • (2006) PLoS ONE. , vol.1
    • Aboody, K.S.1    Bush, R.A.2    Garcia, E.3
  • 255
    • 68549107867 scopus 로고    scopus 로고
    • Cancer/testis antigens can be immunological targets in clonogenic CD133(+) melanoma cells
    • Gedye C, Quirk J, Browning J. Cancer/testis antigens can be immunological targets in clonogenic CD133(+) melanoma cells. Cancer Immunol Immunother. 2009, 58:1635-46.
    • (2009) Cancer Immunol Immunother. , vol.58 , pp. 1635-1646
    • Gedye, C.1    Quirk, J.2    Browning, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.