Anti-aging properties of resveratrol: Review and report of a potent new antioxidant skin care formulation

Journal of Cosmetic Dermatology

Volumn 7, Issue 1, 2008, Pages 2-7

  Baxter, Richard A ^a  

^a NONE   (United States)

Author keywords

Antiaging; Antioxidant; Nutraceuticals; Polyphenols; Resveratrol

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; CATECHIN; CISPLATIN; DOXORUBICIN; ELLAGIC ACID; EPICATECHIN; EPIGALLOCATECHIN GALLATE; FAMAR; GALLIC ACID; GALLOCATECHIN; GLUTATHIONE TRANSFERASE; IDEBENONE; PHYTOESTROGEN; POLYPHENOL; POLYPHENOL DERIVATIVE; PREVAGE MD; RESVERATROL; RETINOL; SILYMARIN; SIRTUIN; SUPEROXIDE DISMUTASE; THEAFLAVIN; UNCLASSIFIED DRUG;

ALCOHOL CONSUMPTION; ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; BRAIN FUNCTION; BRAIN ISCHEMIA; BRAIN PROTECTION; CALORIC INTAKE; CUTANEOUS PARAMETERS; DOSE RESPONSE; DRUG POTENTIATION; DRUG STRUCTURE; HEART DISEASE; HUMAN; INFLUENZA; NONHUMAN; NUTRITIONAL ASSESSMENT; PHOTOAGING; PRIORITY JOURNAL; REVIEW; SKIN CANCER; SKIN CARE; SKIN INJURY; STRUCTURE ACTIVITY RELATION;

AGING; ALZHEIMER DISEASE; ANIMALS; ANTIOXIDANTS; HEART DISEASES; HUMANS; SIRTUINS; SKIN AGING; STILBENES; WINE;

EID: 38949161899     PISSN: 14732130     EISSN: 14732165     Source Type: Journal    
DOI: 10.1111/j.1473-2165.2008.00354.x     Document Type: Review

References (63)

1. Draelos ZD. What is anti-aging? J Cosmetic Dermatol 2007; 6: 73-4.
2. de Gray AD. The foreseeability of real anti-aging medicine: Focusing the debate. Exp Gerontol 2003; 38: 927-34.
3. Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging. Proc Nat Acad Sci USA 1993; 90: 7915-22.
4. National Institute on Aging. Aging Under the Microscope. NIH publication no. 02-2756. Bethesda, MD: NIH; 2002.
5. Burzynski SR. Aging: Gene silencing or gene activation? Med Hypotheses 2005; 64: 201-8.
6. Sauve AA, Schramm VL. SIR2: The biological mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. Curr Med Chem 2004; 11: 807-26.
7. Howitz KT, Bitterman KJ, Cohen HY et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 2003; 425: 191-6.
8. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domeneci L, Cellerino A. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr Biol, 2006; 16 (3): 296-300.
9. Baur JA, Pearson KJ, Price NL et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 144: 337-42.
10. Siemann E, Creasy L. Concentration of the phytoalexin resveratrol in wine. Am J Enol Vitic 1992; 43: 49-52.
11. Orallo F. Comparative studies of the antioxidant effects of cis- and trans-resveratrol. Curr Med Chem 2006; 13: 87-98.
12. Miura T, Muraoka S, Ikeda N, Watanabe M, Fujimoto Y. Antioxidative and prooxidative action of stilbene derivatives. Pharmacol Toxicol 2000; 86: 203-8.
13. Olas B, Wachowicz B. Resveratrol, a phenolic antioxidant with effects on blood platelet functions. Platelets 2005; 16: 251-60.
14. Stojanovic S, Sprinz H, Brede O. Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation. Arch Biochem Biophys 2001; 391: 79-89.
15. Li LH, Wu LJ, Tashiro SI, Onodera S, Uchiumi F, Ikejima T. Activation of the SIRT1 pathway and modulation of the cell cycle were involved in silymarin's protection against UV-induced A375-S2 cell apoptosis. J Asian Nat Prod Res 2007; 9: 245-52.
16. Toklu HZ, Tunah-Akbay T, Erkanh G, Yüksel M, Ercan F, Şener G. Silymarin, the antioxidant component of Silybum mairianum, protects against burn-induced oxidative skin injury. Burns 2007; 33: 908-16.
17. Deep G, Aggarwal R. Chemopreventive efficacy of silymarin in skin and prostate cancer. Integr Cancer Ther 2007; 6: 130-45.
18. Cordova A, Jackson L, Berke-Schlessel D, Sumpio B. The cardiovascular protective effect of red wine. J Am Coll Surg 2005; 200: 428-39.
19. Grønbaek M. Alcohol, type of alcohol, and all-cause and coronary heart disease mortality. Ann N Y Acad Sci 2002; 957: 16-20.
20. Renaud S, Guéguen R, Siest G, Salamon R. Wine, beer, and mortality in middleaged men from eastern France. Arch Intern Med 1999; 159: 1865-70.
21. Wallerath T, Deckert G, Ternes T et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation 2002; 106: 1652-8.
22. Corder R, Douthwaite JA, Lees DM et al. Endothelin-1 synthesis reduced by red wine. Nature 2001; 414: 863-4.
23. Frankel EN, Kanner J, German JB, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993; 341: 454-7.
24. Pace-Asciak CR, Hahn S, Diamandis EP, Soleas G, Goldberg DM. The red wine phenolic trans-resveratrol and quercetin block human platelet aggregation and eicosanoid synthesis. Clin Chim Acta 1995; 235: 207-14.
25. Anekonda TS. Resveratrol-a boon for treating Alzheimer's disease? Brain Res Rev 2006; 52: 316-26.
26. Marambaudl P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid C-peptides. J Biol Chem 2005; 280: 37377-82.
27. Savaskan E, Olivieri G, Meier F, Seifritz E, Wirz-Justice A, Müller-Spahn F. Red wine ingredient resveratrol protects from β-amyloid neurotoxicity. Gerontology 2003; 49: 380-3.
28. Tredici G, Miloso M, Nicolini G, Galbiati S, Cavaletti G, Bertelli A. Resveratrol, MAP kinases and neuronal cells: Might wine be a neuroprotectant? Drugs Exptl Clin Res 1999; 25: 99-103.
29. Dasgupta B, Milbrandt J. Resveratrol stimulates AMP kinase activity in neurons. Proc Nat Acad Sci USA 2007; 104: 7217-22.
30. Ates O, Cayli S, Altinoz E et al. Neuroprotection by resveratrol against traumatic brain injury in rats. Mol Cell Biochem 2007; 294: 137-44.
31. Wang Q, Xu J, Rottinghaus GE et al. Resveratrol protects gainst global ischemic injury in gerbils. Brain Res 2002; 958: 439-47.
32. Gehm BD, McAndrews JM, Chien PY, Jameson JL. Resveratrol, a polyphenolic compound found in grapes and red wine, is an agonist for the estrogen receptor. Proc Nat Acad Sci USA 1997; 94: 14138-43.
33. Calabrese G. Nonalcoholic compounds of wine: The phytoestrogen resveratrol and moderate red wine consumption during menopause. Drugs Exp Clin Res 1999; 25: 111-4.
34. Su JL, Yang CY, Zhao M, Kuo ML, Yen ML. Forkhead proteins is critical for BMP-2 regulation and anti-tumor activity of resveratrol. J Biol Chem 2007; 282: 19385-98.
35. Nabel EG. The women's health initiative. Science 2006; 313: 1703.
36. Verdier-Sevrain S. Effect of estrogens on skin aging and the potential role of selective estrogen receptor modulators. Climacteric 2007; 10: 289-97.
37. Verdier-Sevrain S, Bonte F, Gilchrest B. Biology of estrogens in skin: implications for skin aging. Exp Dermatol 2006; 15: 83-94.
38. Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: Meta-analysis of randomised trials. Lancet 2003; 361: 2017-23.
39. Huang HY, Caballero B, Chang S et al. The efficacy and safety of multivitamin and mineral supplement use to prevent cancer and chronic disease in adults: A systematic review for a National Institutes of Health state-of-the-science conference. Ann Intern Med 2006; 145: 372-85.
40. Boothby LA, Doering PL. Vitamin C and vitamin E for Alzheimer's disease. Ann Pharmacother 2005; 39: 2073-80.
41. Leighton F, Cuevas A, Guasch V et al. Plasma polyphenols and antioxidants, oxidative DNA damage, and endothelial function in a diet and wine intervention study. Drugs Exp Clin Res 1999; 25: 133-41.
42. Frei B, Higdon JV. Antioxidant activities of tea polyphenols in vivo: evidence from animal studies. J Nutr 2003; 133: 3275S-84S.
43. Katiyar SK. Skin photoprotection by green tea: Antioxidant and immunomodulatory effects. Curr Drug Targets Immune Endocr Metab Disord 2003; 3: 234-42.
44. Yilmaz Y, Toledo RT. Major flavonoids in grape seeds and skins. antioxidant capacity of catechin, epicatechin, and gallic acid. J Agric Food Chem 2004; 52: 255-60.
45. McDaniel DH, Neudecker BA, Dinardo JC, Lewis JA, Maibach HI. Idebenone: a new antioxidant - part 1. Relative assessment of oxidative stress protection capacity compared to commonly known antioxidants. J Cosmet Dermatol 2005; 4: 10-7.
46. Afaq F, Mukhtar H. Botanical antioxidants in the prevention of photocarcinogenesis and photoaging. Exp Dermatol 2006; 15: 678-84.
47. Baliga MS, Katiyar SK. Chemoprevention of photocarcinogenesis by selected dietary botanicals. Photochem Photobiol Sci 2006; 5: 243-53.
48. Chen ML, Li J, Xiao WR et al. Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Jhong Nan Da Xue Xue Bao Yi Ban 2006; 31: 635-9.
49. Joe AK, Liu H, Suzui M, Vural ME, Xiao D, Weinstein IB. Resveratrol induces growth inhibition, S-phase arrest, apoptosis, and changes in biomarker expression in several human cancer cell lines. Clin Cancer Res 2002; 8: 893-903.
50. Delmas D, Lancon A, Colin D, Jannin B, Latruffe N. Resveratrol as a chemopreventive agent: A promising molecule for fighting cancer. Curr Drug Targets 2006; 7: 423-42.
51. Aggarwal BB, Bhardwaj A, Aggarwal RS, Seeram NP, Shishodia S, Takada Y. Role of resveratrol in prevention and therapy of cancer: Preclinical and clinical studies. Anticancer Res 2004; 25: 2783-840.
52. Fulda S, Debatin KM. Resveratrol modulation of signal transduction in apoptosis and cell survival: A mini-review. Cancer Detect Prev 2006; 30: 217-23.
53. Lanzilli G, Fuggetta MP, Tricarico M et al. Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Int J Oncol 2006; 28: 641-8.
54. Niles RM, McFarland M, Weimer WB, Redkar A, Fu WM, Meadows GG. Resveratrol is a potent inducer of apoptosis in human melanoma cells. Cancer Lett 2003; 190: 157-63.
55. Ulrich S, Wolter F, Stein JM. Molecular mechanisms of the chemopreventive effects of resveratrol and its analogs in carcinogenesis. Mol Nutr Food Res 2005; 49: 452-61.
56. Rezk YA, Balulad SS, Keller RS, Bennett JA. Use of resveratrol to improve the effectiveness of cisplatin and doxorubicin. study in human gynecologic cancer cell lines and rodent heart. Am J Obstet Gynecol 2006; 194: E23-6 epub 2006 April 21.
57. Garg AK, Buchholtz TA, Aggarwal BB. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal 2005; 7: 1630-47.
58. Langcake P, Pryce RJ. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection and injury. Physiol Plant Pathol 1976; 9: 77-86.
59. Palamara AT, Nencioni L, Aquilano K et al. Inhibition of influenza A virus replication by resveratrol. J Infect Dis 2005; 191: 1719-29.
60. Chan MM. Antimicrobial effect of resveratrol on dermatophytes and bacterial pathogens of the skin. Biochem Pharmacol 2002; 63: 99-104.
61. Vitaglione P, Sforza S, Galaverna G et al. Bioavailability of trans-resveratrol from red wine in humans. Mol Nutr Food Res 2005; 49: 495-504.
62. Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK. High absorption but low bioavailability of oral resveratrol in humans. Drug Metab Dispos 2004; 32: 1377-82.
63. Zhang G, Flach CR, Mendelsohn R. Tracking the dephosphorylation of resveratrol triphosphate in skin by confocal Raman microscopy. J Control Release 2007; [epub ahead of print].