The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells

Journal of Cell Science

Volumn 111, Issue 21, 1998, Pages 3179-3188

  Lyle, Stephen ^a   Christofidou Solomidou, Melpo ^a   Liu, Yaping ^a   Elder, David E ^a   Albelda, Steven ^a   Cotsarelis, George ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Cytokeratin 15; Cytokeratin 19; Hair follicle; Integrin; Label retaining cell; Stem cell

Indexed keywords

CD8 ANTIGEN; CYTOKERATIN; MONOCLONAL ANTIBODY;

ARTICLE; HAIR FOLLICLE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; KERATINOCYTE; MOLECULAR RECOGNITION; PRIORITY JOURNAL; STEM CELL;

ADULT; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; ANTIGENS, CD29; BIOLOGICAL MARKERS; DNA, COMPLEMENTARY; GENE LIBRARY; HAIR FOLLICLE; HUMANS; KERATINOCYTES; KERATINS; MICE; MICE, SCID; PROTEIN ISOFORMS; SCALP; STEM CELLS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0031721687     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Adams, J. C. and Watt, F. M. (1991). Expression of β1, β3, β4 and β5 integrins by human epidermal keratinocytes and non-differentiating keratinocytes. J. Cell Biol. 115, 829-841.
2. Al-Barwari, S. E. and Potten, C. S. (1976). Regeneration and dose-response characteristics of irradiated mouse dorsal epidermal cells. J. Radiat. Biol. 30, 201-216.
3. Altschul, S., Gish, W., Miller, W., Myers, E. and Lipman, D. (1990). Basic local alignment search tool. J. Mol. Biol. 215, 403-410.
4. Barrandon, Y. and Green, H. (1987). Three clonal types of keratinocyte with different capacities for multiplication. Proc. Nat. Acad. Sci. USA 84, 2302-2306.
5. Bickenbach, J. and Mackenzie, I. (1984). Identification and localisation of label retaining cells in hamster epithelium. J. Invest. Dermatol. 82, 618-622.
6. Clark, E. A. and Brugge, J. S. (1995). Integrins and signal transduction pathways: the road taken. Science 268, 233-239.
7. Christofidou-Solomidou, M., Longley, B. J., Whitacker-Menezes, D., Albelda, S. M. and Murphy, G. F. (1997). Human skin/SCID mouse chimeras as an in vivo model for human cutaneous mast cell hyperplasia. J. Invest. Dermatol. 109, 102-107.
8. Commo, S. and Bernard, B. A. (1997). Immunohistochemical analysis of tissue remodelling during the anagen-catagen transition of the human hair follicle. Br. J. Dermatol. 137, 31-38.
9. Cotsarelis, G. (1997). The hair follicle: dying for attention. Am. J. Pathol. 151, 1505-1509.
10. Cotsarelis, G., Cheng, S. Z., Dong, G., Sun, T. T. and Lavker, R. M. (1989). Existence of slow-cycling limbal epithelial basal cells that can be preferentially stimulated to proliferate: implications on epithelial stem cells. Cell 57, 201-209.
11. Cotsarelis, G., Sun, T. T. and Lavker, R. M. (1990). Label-retaining cells reside in the bulge area of pilosebaceous unit: implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61, 1329-1337.
12. Coulombe, P. A., Kopan, R. and Fuchs, E. (1989). Expression of keratin K14 in the epidermis and hair follicle: insights into complex programs of differentiation. J. Cell Biol. 109, 2295-2312.
13. Gerdes, J., Schwab, U., Lemke, H. and Stein, H. (1983). Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int. J. Cancer 31, 13-20.
14. Gilhar, A., Pillar, T. and Etzioni, A. (1988). The effect of topical cyclosporin on the immediate shedding of human scalp hair grafted onto nude mice. Br. J. Dermatol. 119, 767-770.
15. Headington, J. T. (1984). Transverse microscopic anatomy of the human scalp. Arch. Dermatol. 120, 449-456.
16. Heid, H. W., Moll, I. and Franke, W. W. (1988). Patterns of expression of tricocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles. Differentiation 37, 137-157.
17. Holbrook, K. A. and Minami, S. I. (1991). Hair follicle embryogenesis in the human: characterization of events in vivo and in vitro. Ann. NY Acad. Sci. 642, 167-196.
18. Jones, P. H. and Watt, F. M. (1993). Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression. Cell 73, 713-724.
19. Jones, P. H., Harper, S. and Watt, F. M. (1995). Stem cell patterning and fate in human epidermis. Cell 80, 83-93.
20. Kligman, A. M. (1959). The human hair cycle. J. Invest. Dermatol. 33, 307-316.
21. Keitel, T., Kramer, A., Wessner, H., Scholz, C., Schneider-Mergener, J. and Hohne, W. (1997). Crystallographic analysis of anti-p24 (HIV-1) monoclonal antibody cross-reactivity and polyspecificity. Cell 91, 811-820.
22. Kobayashi, K., Rochat, A. and Barrandon, Y. (1993). Segregation of keratinocyte colony forming cells in the bulge of the rat vibrissa. Proc. Nat. Acad. Sci. USA 90, 7391-7395.
23. Kramer, A., Keitel, T., Winkler, K., Stocklein, W., Hohne, W. and Schneider-Mergener, J. (1997). Molecular basis for the binding promiscuity of an anti-p24 (HIV-1) monoclonal antibody. Cell 91, 799-809.
24. Lane, E. B., Wilson, C. A., Hughes, B. R. and Leigh, I. M. (1991). Stem cells in hair follicles: cytoskeletal studies. Ann. NY Acad. Sci. 642, 197-213.
25. Lavker, R. and Sun, T.-T. (1982). Heterogeneity in epidermal basal keratinocytes: morphological and functional correlations. Science 215, 1239-1241.
26. Leube, R. E., Bader, B. L., Bosch, F. X., Zimbelmann, R., Achtstaetter, T. and Franke, W. W. (1988). Molecular characterization and expression of the stratification-related cytokeratins 4 and 15. J. Cell Biol. 106, 1249-1261.
27. Li, A., Simmons, P. J. and Kaur, P. (1998). Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proc. Natl. Acad. Sci. USA 95, 3902-3907.
28. Lloyd, C., Yu, Q.-C., Cheng, J., Turksen, K., Degenstein, L., Hutton, E. and Fuchs, E. (1995). The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14. J. Cell Biol. 129, 1329-1344.
29. Mason, D. Y., Cordell, J. L., Gaulard, P., Tse, A. G. D. and Brown, M. H. (1992). Immunohistological detection of human cytotoxic/suppressor T cells using antibodies to a CD8 peptide sequence. J. Clin. Pathol. 45, 1084-1088.
30. Michel, M., Torok, N., Godbout, M.-J., Lussier, M., Pierrete, G., Royal, A. and Germain, L. (1996). Keratin 19 as a biochemical marker of skin stem cells in vivo and in vitro: keratin 19 expressing cells are differentially localized in function of anatomic sites, and their number varies with donor age and culture stage. J. Cell Sci. 109, 1017-1028.
31. Moll, I. (1995). Proliferative potential of different keratinocytes of plucked human hair follicles. J. Invest. Dermatol. 105, 14-21.
32. Moll, I. (1996). Differential epithelial outgrowth of plucked and microdissected human hair follicles in explant culture. Arch. Dermatol. Res. 288, 604-610.
33. Morris, R., Fischer, S. and Slaga, T. (1985). Evidence that the centrally and peripherally located cells in the murine epidermal proliferative unit are two distinct cell populations. J. Invest. Dermatol. 84, 277-281.
34. Morris, R. J., Coulter, K., Tryson, K. and Steinberg, S. R. (1997). Evidence that cutaneous carcinogen-initiated epithelial cells from mice are quiescent rather than actively cycling. Cancer Res. 57, 3436-3443
35. Paus, R. (1996). Control of the hair cycle and hair diseases as cycling disorders. Curr. Opin. Dermatol. 3, 248-258.
36. Potten, C. (1974). The epidermal proliferative unit: the possible role of the central basal cell. Cell Tissue Kinet. 7, 77-88.
37. Potten, C., Schofield, R. and Lajtha, L. (1979). A comparison of cell replacement in bone marrow, testis and three regions of surface epithelium. Biochem Biophys Acta 560, 281-299.
38. Potten, C. and Morris, R. (1988). Epithelial stem cells in vivo. J. Cell Sci. Suppl. 10, 45-62.
39. Quesenberry, P. and Levitt, L. (1979). Hematopoietic stem cells. N. Eng. J. Med. 301, 819-823.
40. Rochat, A., Kobayashi, K. and Barrandon, Y. (1994). Location of stem-cells of human hair-follicles by clonal analysis. Cell 0076, 1063-1073.
41. Schermer, A., Galvin, S. and Sun, T.-T. (1986). Differentiation-related expression of a major 64K corneal keratin in vivo and in culture suggests limbal location of corneal epithelial stem cells. J. Cell Biol. 103, 49-62.
42. Schirren, C. G., Burgdorf, W. H. C., Sander, C. A. and Plewig, G. (1997). Fetal and adult hair follicle: an immunohistochemical study to anticytokeratin antibodies in formalin-fixed and paraffin-embedded tissue. Am. J. Dermatopathol. 19, 334-340.
43. Silver, A., Chase, H. and Arsenault, C. (1969). Early anagen initiated by plucking compared with early spontaneous anagen. Germany: Pergamon Press.
44. Silver, A. F. and Chase, H. B. (1970). DNA synthesis in the adult hair germ during dormancy (telogen) and activation (early anagen). Dev. Biol. 21, 440-451.
45. Van Neste, D., de Brouwer, B., Tetelin, C. and Bonfils, A. (1996). Testosterone conditioned nude mice: an improved model for experimental monitoring of human hair production by androgen dependent balding scalp grafts. In Hair Research for the Next Millenium (ed. D. Van Neste and V. A. Randall), pp. 319-326. New York: Elsevior Science B.V.
46. Weinberg, W. and Yuspa, S. (1997). An antibody to p53 recognizes soluble keratins in epidermal keratinocyte cultures under differentiating, but not proliferating, conditions. J. Invest. Dermatol. 109, 611-612.
47. Wilson, C., Cotsarelis, G., Wei, Z. G., Fryer, E., Margolis-Fryer, J., Ostead, M., Tokarek, R., Sun, T. T. and Lavker, R. M. (1994). Cells within the bulge region of mouse hair follicle transiently proliferate during early anagen: heterogeneity and functional differences of various hair cycles. Differentiation 55, 127-136.
48. Wright, N. and Alison, M. (1984). The biology of epithelial cell populations. Oxford: Clarendon Press.
49. Yang, J. S., Lavker, R. M. and Sun, T. T. (1993). Upper human hair follicle contains a subpopulation of keratinocytes with superior in vitro proliferative potential. J. Invest. Dermatol. 101, 652-659.