Cutaneous cancer stem cell maintenance is dependent on β-catenin signalling

Nature

Volumn 452, Issue 7187, 2008, Pages 650-653

  Malanchi, Ilaria ^a   Peinado, Hector ^b   Kassen, Deepika ^a   Hussenet, Thomas ^a   Metzger, Daniel ^c   Chambon, Pierre ^c   Huber, Marcel ^d   Hohl, Daniel ^d   Cano, Amparo ^b   Birchmeier, Walter ^e   Huelsken, Joerg ^a  

^a EPFL   (Switzerland)

^b INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

^c INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; TAMOXIFEN;

CANCER; GENE EXPRESSION; HOMEOSTASIS; MORPHOGENESIS; PROTEIN; RODENT; SKIN; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL POPULATION; CELL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; GENE DELETION; HUMAN; HUMAN CELL; MORPHOGENESIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SKIN CANCER; SQUAMOUS CELL CARCINOMA; TUMOR REGRESSION;

MURINAE;

EID: 41649089525     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature06835     Document Type: Article

References (32)

1. Ito, M. et al. Stem cells in the hair follicle bulge contribute to wound repair but not to homeostasis of the epidermis. Nature Med. 11, 1351-1354 (2005).
2. Al-Hajj, M., Becker, M. W., Wicha, M., Weissman, I. & Clarke, M. F. Therapeutic implications of cancer stem cells. Curr. Opin. Genet. Dev. 14, 43-47 (2004).
3. Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843-850 (2005).
4. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Stem cells, cancer, and cancer stem cells. Nature 414, 105-111 (2001).
5. Mackenzie, I. C. Retroviral transduction of murine epidermal stem cells demonstrates clonal units of epidermal structure. J. Invest. Dermatol. 109, 377-383 (1997).
6. Trempus, C. S. et al. CD34 expression by hair follicle stem cells is required for skin tumor development in mice. Cancer Res. 67, 4173-4181 (2007).
7. Blanpain, C., Lowry, W. E., Geoghegan, A., Polak, L. & Fuchs, E. Self-renewal, multipotency, and the existence of two cell populations within an epithelial stem cell niche. Cell 118, 635-648 (2004).
8. Tumbar, T. et al. Defining the epithelial stem cell niche in skin. Science 303, 359-363 (2004).
9. Liu, Y., Lyle, S., Yang, Z. & Cotsarelis, G. Keratin 15 promoter targets putative epithelial stem cells in the hair follicle bulge. J. Invest. Dermatol. 121, 963-968 (2003).
10. Quintanilla, M., Brown, K., Ramsden, M. & Balmain, A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature 322, 78-80 (1986).
11. Hermann, P. C. et al. Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1, 313-323 (2007).
12. Gaspar, C. et al. Intracellular β-catenin accumulation underlies cancer stemness and metastatic behaviour in an Apc mouse model for mammary tumorigenesis. Nature. (submitted).
13. Al-Hajj, M., Wicha, M. S., Benito-Hernandez, A., Morrison, S. J. & Clarke, M. F. Prospective identification of tumorigenic breast cancer cells. Proc. Natl Acad. Sci. USA 100, 3983-3988 (2003).
14. O'Brien, C. A., Pollett, A., Gallinger, S. & Dick, J. E. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110 (2007).
15. Morris, R. J. Keratinocyte stem cells: targets for cutaneous carcinogens. J. Clin. Invest. 106, 3-8 (2000).
16. Huelsken, J., Vogel, R., Erdmann, B., Cotsarelis, G. & Birchmeier, W. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105, 533-545 (2001).
17. Merrill, B. J., Gat, U., DasGupta, R. & Fuchs, E. Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev. 15, 1688-1705 (2001).
18. Andl, T., Reddy, S. T., Gaddapara, T. & Millar, S. E. Wnt signals are required for the initiation of hair follicle development. Dev. Cell 2, 643-653 (2002).
19. Niemann, C., Owens, D. M., Huelsken, J., Birchmeier, W. & Watt, F. M. Expression of ΔNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumours. Development 129, 95-109 (2002).
20. Chan, E. F., Gat, U., McNiff, J. M. & Fuchs, E. A common human skin tumour is caused by activating mutations in β-catenin. Nature Genet. 21, 410-413 (1999).
21. Lustig, B. et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol. Cell. Biol. 22, 1184-1193 (2002).
22. Leder, A., Kuo, A., Cardiff, R. D., Sinn, E. & Leder, P. v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid. Proc. Natl Acad. Sci. USA 87, 9178-9182 (1990).
23. Brasanac, D., Boricic, I., Todorovic, V., Tomanovic, N. & Radojevic, S. Cyclin A and β-catenin expression in actinic keratosis, Bowen's disease and invasive squamous cell carcinoma of the skin. Br. J. Dermatol. 153, 1166-1175 (2005).
24. Doglioni, C. et al. Alterations of b-catenin pathway in non-melanoma skin tumors: loss of α-ABC nuclear reactivity correlates with the presence of β-catenin gene mutation. Am. J. Pathol. 163, 2277-2287 (2003).
25. Papadavid, E., Pignatelli, M., Zakynthinos, S., Krausz, T. & Chu, A. C. Abnormal immunoreactivity of the E-cadherin/catenin (α-, β-, and γ-) complex in premalignant and malignant non-melanocytic skin tumours. J. Pathol. 196, 154-162 (2002).
26. Cip1 gene. Genes Dev. 20, 2024-2029 (2006).
27. Harada, N. et al. Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene. EMBO J. 18, 5931-5942 (1999).
28. Li, M. et al. Skin abnormalities generated by temporally controlled RXRα mutations in mouse epidermis. Nature 407, 633-636 (2000).
29. Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
30. van de Wetering, M. et al. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 4, 609-615 (2003).
31. Lichti, U. et al. In vivo regulation of murine hair growth: insights from grafting defined cell populations onto nude mice. J. Invest. Dermatol. 101, 124-129 (1993).
32. Batlle, E. et al. β-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB. Cell 111, 251-263 (2002).