-
1
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13:2570-2580.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
2
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403:795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
3
-
-
28844469898
-
Increase in activity during calorie restriction requires SirT1
-
Chen D, Steele AD, Lindquist S, Guarente L Increase in activity during calorie restriction requires SirT1. Science 2005; 310:1641.
-
(2005)
Science
, vol.310
, pp. 1641
-
-
Chen, D.1
Steele, A.D.2
Lindquist, S.3
Guarente, L.4
-
4
-
-
36248975293
-
SIRT1 transgenic mice show phenotypes resembling calorie restriction
-
Bordone L, Cohen D, Robinson A, et al. SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell 2007; 6:759-767.
-
(2007)
Aging Cell
, vol.6
, pp. 759-767
-
-
Bordone, L.1
Cohen, D.2
Robinson, A.3
-
5
-
-
38649132337
-
-
Guarente L Mitochondria: a nexus for aging, calorie restriction, and sirtuins? Cell 2008; 132:171-176.
-
Guarente L Mitochondria: a nexus for aging, calorie restriction, and sirtuins? Cell 2008; 132:171-176.
-
-
-
-
6
-
-
39749087530
-
SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization
-
Han MK, Song EK, Guo Y, et al. SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization. Cell Stem Cell 2008; 2:241-251.
-
(2008)
Cell Stem Cell
, vol.2
, pp. 241-251
-
-
Han, M.K.1
Song, E.K.2
Guo, Y.3
-
7
-
-
0037359584
-
The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells
-
McBurney MW, Yang X, Jardine K, et al. The absence of SIR2alpha protein has no effect on global gene silencing in mouse embryonic stem cells. Mol Cancer Res 2003; 1:402-409.
-
(2003)
Mol Cancer Res
, vol.1
, pp. 402-409
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
-
8
-
-
41649094992
-
SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity
-
Narala SR, Allsopp RC, Wells TB, et al. SIRT1 acts as a nutrient-sensitive growth suppressor and its loss is associated with increased AMPK and telomerase activity. Mol Biol Cell 2008; 19:1210-1219.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 1210-1219
-
-
Narala, S.R.1
Allsopp, R.C.2
Wells, T.B.3
-
10
-
-
0032750220
-
-
Guarente L Diverse and dynamic functions of the Sir silencing complex. Nat Genet 1999; 23:281-285.
-
Guarente L Diverse and dynamic functions of the Sir silencing complex. Nat Genet 1999; 23:281-285.
-
-
-
-
11
-
-
33846924603
-
A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling
-
This study comments on the importance of the stem cell niche and mitotic spindle positioning in regulating self-renewal and differentiation
-
Mantel C, Broxmeyer HE. A new connection between the spindle checkpoint, asymmetric cell division and cytokine signaling. Cell Cycle 2007; 6:144-146. This study comments on the importance of the stem cell niche and mitotic spindle positioning in regulating self-renewal and differentiation.
-
(2007)
Cell Cycle
, vol.6
, pp. 144-146
-
-
Mantel, C.1
Broxmeyer, H.E.2
-
12
-
-
34547692981
-
Long-term propagation of distinct hematopoietic differentiation programs in vivo
-
Dykstra B, Kent D, Bowie M, et al. Long-term propagation of distinct hematopoietic differentiation programs in vivo. Cell Stem Cell 2007; 1:218-229.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 218-229
-
-
Dykstra, B.1
Kent, D.2
Bowie, M.3
-
13
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007; 8:703-713.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
DePinho, R.A.2
-
14
-
-
0033525558
-
Longevity, stress response, and cancer in aging telomerase-deficient mice
-
Rudolph KL, Chang S, Lee HW, et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 1999; 96:701-712.
-
(1999)
Cell
, vol.96
, pp. 701-712
-
-
Rudolph, K.L.1
Chang, S.2
Lee, H.W.3
-
15
-
-
0033153424
-
Disease states associated with telomerase deficiency appear earlier in mice with short telomeres
-
Herrera E, Samper E, Martin-Caballero J, et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J 1999; 18:2950-2960.
-
(1999)
EMBO J
, vol.18
, pp. 2950-2960
-
-
Herrera, E.1
Samper, E.2
Martin-Caballero, J.3
-
16
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR, Ju Z, Djojosubroto MW, et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 2007; 39:99-105.
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
-
18
-
-
0033553516
-
p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
-
Chin L, Artandi SE, Shen Q, et al. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 1999; 97:527-538.
-
(1999)
Cell
, vol.97
, pp. 527-538
-
-
Chin, L.1
Artandi, S.E.2
Shen, Q.3
-
19
-
-
0034632717
-
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
-
Artandi SE, Chang S, Lee SL, et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000; 406: 641-645.
-
(2000)
Nature
, vol.406
, pp. 641-645
-
-
Artandi, S.E.1
Chang, S.2
Lee, S.L.3
-
20
-
-
0027423154
-
SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
-
PalladinoF, LarocheT, Gilson E, et al. SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres. Cell 1993; 75:543-555.
-
(1993)
Cell
, vol.75
, pp. 543-555
-
-
Palladino, F.1
Laroche, T.2
Gilson, E.3
-
21
-
-
0029048189
-
The carboxy termini of Sir4 and Rap1 affect Sir3 localization: Evidence for a multicomponent complex required for yeast telomeric silencing
-
Cockell M, Palladino F, LarocheT, et al. The carboxy termini of Sir4 and Rap1 affect Sir3 localization: evidence for a multicomponent complex required for yeast telomeric silencing. J Cell Biol 1995; 129:909-924.
-
(1995)
J Cell Biol
, vol.129
, pp. 909-924
-
-
Cockell, M.1
Palladino, F.2
LarocheT3
-
22
-
-
0037207475
-
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
-
McBurney MW, Yang X, Jardine K, et al. The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 2003; 23: 38-54.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 38-54
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
-
23
-
-
45549098657
-
-
BoilyG,Seifert EL, BevilacquaL, et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE 2008; 3:e1 759.
-
BoilyG,Seifert EL, BevilacquaL, et al. SirT1 regulates energy metabolism and response to caloric restriction in mice. PLoS ONE 2008; 3:e1 759.
-
-
-
-
24
-
-
17144429302
-
Calorie restriction, SIRT1 and metabolism: Understanding longevity
-
Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005; 6:298-305.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 298-305
-
-
Bordone, L.1
Guarente, L.2
-
25
-
-
13944253348
-
Calorie restriction: The SIR2 connection
-
Guarente L, Picard F. Calorie restriction: the SIR2 connection. Cell 2005; 120:473-482.
-
(2005)
Cell
, vol.120
, pp. 473-482
-
-
Guarente, L.1
Picard, F.2
-
27
-
-
0032889677
-
Redox regulation of cellular signalling
-
Kamata H, Hirata H. Redox regulation of cellular signalling. Cell Signal 1999; 11:1-14.
-
(1999)
Cell Signal
, vol.11
, pp. 1-14
-
-
Kamata, H.1
Hirata, H.2
-
28
-
-
1642330709
-
Oxygen sensing and oxidant/redox-related pathways
-
Haddad JJ. Oxygen sensing and oxidant/redox-related pathways. Biochem Biophys Res Commun 2004; 316:969-977.
-
(2004)
Biochem Biophys Res Commun
, vol.316
, pp. 969-977
-
-
Haddad, J.J.1
-
29
-
-
0035174294
-
Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species
-
Porwol T, Ehleben W, Brand V, Acker H. Tissue oxygen sensor function of NADPH oxidase isoforms, an unusual cytochrome aa3 and reactive oxygen species. Respir Physiol 2001; 128:331-348.
-
(2001)
Respir Physiol
, vol.128
, pp. 331-348
-
-
Porwol, T.1
Ehleben, W.2
Brand, V.3
Acker, H.4
-
30
-
-
27244435939
-
Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress
-
Chua KF, Mostoslavsky R, Lombard DB, et al. Mammalian SIRT1 limits replicative life span in response to chronic genotoxic stress. Cell Metab 2005; 2:67-76.
-
(2005)
Cell Metab
, vol.2
, pp. 67-76
-
-
Chua, K.F.1
Mostoslavsky, R.2
Lombard, D.B.3
-
31
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 2004; 303: 2011-2015.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
-
32
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M, Schiltz RL, Iezzi S, et al. Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell 2003; 12:51-62.
-
(2003)
Mol Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
-
33
-
-
33947710793
-
Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
-
Civitarese AE, Carling S, Heilbronn LK, et al. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med 2007; 4:e76.
-
(2007)
PLoS Med
, vol.4
-
-
Civitarese, A.E.1
Carling, S.2
Heilbronn, L.K.3
-
34
-
-
33845399894
-
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
-
Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell 2006; 127:1109-1122.
-
(2006)
Cell
, vol.127
, pp. 1109-1122
-
-
Lagouge, M.1
Argmann, C.2
Gerhart-Hines, Z.3
-
35
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, et al. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004; 305: 390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
-
36
-
-
18144411313
-
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}
-
Nemoto S, Fergusson MM, Finkel T. SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem 2005; 280:16456-16460.
-
(2005)
J Biol Chem
, vol.280
, pp. 16456-16460
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
37
-
-
14544282413
-
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1
-
Rodgers JT, Lerin C, Haas W, et al. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature 2005; 434:113-118.
-
(2005)
Nature
, vol.434
, pp. 113-118
-
-
Rodgers, J.T.1
Lerin, C.2
Haas, W.3
-
39
-
-
33846419112
-
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
-
Tothova Z, Kollipara R, Huntly BJ, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128:325-339.
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
-
40
-
-
22544446192
-
Characterization of mitochondrial and extramitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity
-
Piccoli C, Ria R, Scrima R, et al. Characterization of mitochondrial and extramitochondrial oxygen consuming reactions in human hematopoietic stem cells. Novel evidence of the occurrence of NAD(P)H oxidase activity. J Biol Chem 2005; 280:26467-26476.
-
(2005)
J Biol Chem
, vol.280
, pp. 26467-26476
-
-
Piccoli, C.1
Ria, R.2
Scrima, R.3
-
41
-
-
0142195931
-
Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction
-
Chen J, Astle CM, Harrison DE. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol 2003; 31:1097-1103.
-
(2003)
Exp Hematol
, vol.31
, pp. 1097-1103
-
-
Chen, J.1
Astle, C.M.2
Harrison, D.E.3
-
42
-
-
38949159709
-
Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated
-
Ertl RP, Chen J, Astle CM, et al. Effects of dietary restriction on hematopoietic stem-cell aging are genetically regulated. Blood 2008; 111:1709-1716.
-
(2008)
Blood
, vol.111
, pp. 1709-1716
-
-
Ertl, R.P.1
Chen, J.2
Astle, C.M.3
-
43
-
-
21544467270
-
Cell intrinsic alterations underlie hematopoietic stem cell aging
-
Rossi DJ, Bryder D, Zahn JM, et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci USA 2005; 102:9194-9199.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 9194-9199
-
-
Rossi, D.J.1
Bryder, D.2
Zahn, J.M.3
-
44
-
-
0029813378
-
The aging of hematopoietic stem cells
-
Morrison SJ, Wandycz AM, Akashi K, et al. The aging of hematopoietic stem cells. Nat Med 1996; 2:1011-1016.
-
(1996)
Nat Med
, vol.2
, pp. 1011-1016
-
-
Morrison, S.J.1
Wandycz, A.M.2
Akashi, K.3
-
45
-
-
0034613690
-
Age-associated characteristics of murine hematopoietic stem cells
-
Sudo K, Ema H, Morita Y, Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000; 192:1273-1280.
-
(2000)
J Exp Med
, vol.192
, pp. 1273-1280
-
-
Sudo, K.1
Ema, H.2
Morita, Y.3
Nakauchi, H.4
-
46
-
-
34147099672
-
Age-dependent increase in side population distribution within hematopoiesis: Implications for our understanding of the mechanism of aging
-
Pearce DJ, Anjos-Afonso F, Ridler CM, et al. Age-dependent increase in side population distribution within hematopoiesis: implications for our understanding of the mechanism of aging. Stem Cells 2007; 25:828-835.
-
(2007)
Stem Cells
, vol.25
, pp. 828-835
-
-
Pearce, D.J.1
Anjos-Afonso, F.2
Ridler, C.M.3
-
47
-
-
0033562357
-
Dynamic changes in mouse hematopoietic stem cell numbers during aging
-
de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999; 93:3294-3301.
-
(1999)
Blood
, vol.93
, pp. 3294-3301
-
-
de Haan, G.1
Van Zant, G.2
-
48
-
-
0018376665
-
Proliferative capacity of erythropoietic stem cell lines and aging: An overview
-
Harrison DE. Proliferative capacity of erythropoietic stem cell lines and aging: an overview. Mech Aging Dev 1979; 9:409-426.
-
(1979)
Mech Aging Dev
, vol.9
, pp. 409-426
-
-
Harrison, D.E.1
-
49
-
-
1342264308
-
Mammalian SIRT1 repressesforkhead transcription factors
-
MottaMC, DivechaN, LemieuxM, et al. Mammalian SIRT1 repressesforkhead transcription factors. Cell 2004; 116:551-563.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
MottaMC1
DivechaN2
LemieuxM3
-
50
-
-
42349085704
-
SirT1 contributes critically to the redox-dependent fate of neural progenitors
-
Prozorovski T, Schulze-Topphoff U, Glumm R, et al. SirT1 contributes critically to the redox-dependent fate of neural progenitors. Nat Cell Biol 2008; 10:385-394.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 385-394
-
-
Prozorovski, T.1
Schulze-Topphoff, U.2
Glumm, R.3
-
51
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, et al. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23:2369-2380.
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
-
52
-
-
22144457305
-
A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation
-
Lee NK, Choi YG, Baik JY, et al. A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation. Blood 2005; 106:852-859.
-
(2005)
Blood
, vol.106
, pp. 852-859
-
-
Lee, N.K.1
Choi, Y.G.2
Baik, J.Y.3
-
53
-
-
0032100452
-
Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux
-
Kim M, Cooper DD, Hayes SF, Spangrude GJ. Rhodamine-123 staining in hematopoietic stem cells of young mice indicates mitochondrial activation rather than dye efflux. Blood 1998; 91:4106-4117.
-
(1998)
Blood
, vol.91
, pp. 4106-4117
-
-
Kim, M.1
Cooper, D.D.2
Hayes, S.F.3
Spangrude, G.J.4
|