CXC chemokine receptor CXCR4 expression enhances tumorigenesis and angiogenesis of basal cell carcinoma

British Journal of Dermatology

Volumn 154, Issue 5, 2006, Pages 910-918

  Chen, G S ^a   Yu, H S ^b   Lan, C C E ^a   Chow, K C ^c   Lin, T Y ^c   Kok, L F ^c   Lu, M P ^c   Liu, C H ^c   Wu, M T ^c  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Basal cell carcinoma; CXCL12; CXCR4; Stromal derived factor 1; Tumorigenesis

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; NEUTRALIZING ANTIBODY; STROMAL CELL DERIVED FACTOR 1;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY SPECIFICITY; APOPTOSIS; ARTICLE; BASAL CELL CARCINOMA; CANCER CELL CULTURE; CANCER GROWTH; CANCER REGRESSION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; LYMPHOCYTE SUBPOPULATION; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETROVIRUS; SKIN CARCINOGENESIS; TISSUE SECTION; ULTRAVIOLET B RADIATION; VIRUS CARCINOGENESIS; XENOGRAFT;

ANIMALS; APOPTOSIS; CARCINOMA, BASAL CELL; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; CHEMOKINES, CXC; DISEASE PROGRESSION; FEMALE; HUMANS; MICE; MICE, NUDE; NEOPLASM PROTEINS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; RECEPTORS, CXCR4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SKIN NEOPLASMS; TRANSDUCTION, GENETIC; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED; ULTRAVIOLET RAYS;

EID: 33645819416     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2006.07150.x     Document Type: Article

References (38)

1. Baggiolini M. Chemokines in pathology and medicine. J Intern Med 2001 250 91 104.
2. Rossi D Zlotnik A. The biology of chemokines and their receptors. Annu Rev Immunol 2000 18 217 42.
3. Bleul CC Wu L Hoxie JA et al. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc Natl Acad Sci USA 1997 94 1925 30.
4. Gupta SK Lysko PG Pillarisetti K et al. Chemokine receptors in human endothelial cells. Functional expression of CXCR4 and its transcriptional regulation by inflammatory cytokines. J Biol Chem 1998 273 4282 7.
5. Hesselgesser J Halks-Miller M DelVecchio V et al. CD4-independent association between HIV-1 gp120 and CXCR4: functional chemokine receptors are expressed in human neurons. Curr Biol 1997 7 112 21.
6. Murdoch C. CXCR4: chemokine receptor extraordinaire. Immunol Rev 2000 177 175 84.
7. Horuk R. Chemokine receptors. Cytokine Growth Factor Rev 2001 12 313 35.
8. Müller A Homey B Soto H et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001 410 50 6.
9. Murakami T Maki W Cardones AR et al. Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. Cancer Res 2002 62 7328 34.
10. Taichman RS Cooper C Keller ET et al. Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res 2002 62 1832 7.
11. Koshiba T Hosotani R Miyamoto Y et al. Expression of stromal cell-derived factor 1 and CXCR4 ligand receptor system in pancreatic cancer: a possible role for tumor progression. Clin Cancer Res 2000 6 3530 5.
12. Burger M Glodek A Hartmann T et al. Functional expression of CXCR4 (CD184) on small-cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells. Oncogene 2003 22 8093 101.
13. Zhou Y Larsen PH Hao C et al. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J Biol Chem 2002 277 49481 7.
14. Miller DL Weinstock MA. Nonmelanoma skin cancer in the United States: incidence. J Am Acad Dermatol 1994 30 774 8.
15. Gloster HM Jr. Brodland DG. The epidemiology of skin cancer. Dermatol Surg 1996 22 217 26.
16. Gailani MR Leffell DJ Ziegler A et al. Relationship between sunlight exposure and a key genetic alteration in basal cell carcinoma. J Natl Cancer Inst 1996 88 349 54.
17. Jee SH Shen SC Chiu HC et al. Overexpression of interleukin-6 in human basal cell carcinoma cell lines increases anti-apoptotic activity and tumorigenic potency. Oncogene 2001 20 198 208.
18. Unden AB Zaphiropoulos PG Bruce K et al. Human patched (PTCH) mRNA is overexpressed consistently in tumor cells of both familial and sporadic basal cell carcinoma. Cancer Res 1997 57 2336 40.
19. Oro AE Higgins KM Hu Z et al. Basal cell carcinomas in mice overexpressing sonic hedgehog. Science 1997 276 817 21.
20. Taipale J Beachy PA. The Hedgehog and Wnt signalling pathways in cancer. Nature 2001 411 349 54.
21. Murakami T Nakajima T Koyanagi Y et al. A small molecule CXCR4 inhibitor that blocks T cell line-tropic HIV-1 infection. J Exp Med 1997 186 1389 93.
22. Chiang LC Chiang W Yu HS et al. Establishment and characterization of a continuous human basal cell carcinoma cell line from facial skin (I). Cytological behavior of early passages. Gaoxiong Yi Xue Ke Xue Za Zhi 1994 10 170 6.
23. Yu HS Kao CH Yu CL. Coexistence and relationship of antikeratinocyte and antimelanocyte antibodies in patients with non-segmental-type vitiligo. J Invest Dermatol 1993 100 823 8.
24. Ades EW Candal FJ Swerlick RA et al. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J Invest Dermatol 1992 99 683 90.
25. Lamouille S Mallet C Feige JJ et al. Activin receptor-like kinase 1 is implicated in the maturation phase of angiogenesis. Blood 2002 100 4495 501.
26. Saeki H Wu MT Olasz E et al. A migratory population of skin-derived dendritic cells expresses CXCR5, responds to B lymphocyte chemoattractant in vitro, and co-localizes to B cell zones in lymph nodes in vivo. Eur J Immunol 2000 30 2808 14.
27. Hsu NY Ho HC Chow KC et al. Overexpression of dihydrodiol dehydrogenase as a prognostic marker of non-small cell lung cancer. Cancer Res 2001 61 2727 31.
28. Wiley HE Gonzalez EB Maki W et al. Expression of CC chemokine receptor-7 and regional lymph node metastasis of B16 murine melanoma. J Natl Cancer Inst 2001 93 1638 43.
29. Ishiyama M Tominaga H Shiga M et al. A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet. Biol Pharm Bull 1996 19 1518 20.
30. Donovan D Brown NJ Bishop ET et al. Comparison of three in vitro human 'angiogenesis' assays with capillaries formed in vivo. Angiogenesis 2001 4 113 21.
31. Pablos JL Amara A Bouloc A et al. Stromal-cell derived factor is expressed by dendritic cells and endothelium in human skin. Am J Pathol 1999 155 1577 86.
32. Broxmeyer HE Kohli L Kim CH et al. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and G(alpha)i proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol 2003 73 630 8.
33. Barbero S Bonavia R Bajetto A et al. Stromal cell-derived factor 1alpha stimulates human glioblastoma cell growth through the activation of both extracellular signal-regulated kinases 1/2 and Akt. Cancer Res 2003 63 1969 74.
34. Mirshahi F Pourtau J Li H et al. SDF-1 activity on microvascular endothelial cells: consequences on angiogenesis in in vitro and in vivo models. Thromb Res 2000 99 587 94.
35. Salcedo R Wasserman K Young HA et al. Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: in vivo neovascularization induced by stromal-derived factor-1alpha. Am J Pathol 1999 154 1125 35.
36. Salvucci O Yao L Villalba S et al. Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002 99 2703 11.
37. Bachelder RE Wendt MA Mercurio AM. Vascular endothelial growth factor promotes breast carcinoma invasion in an autocrine manner by regulating the chemokine receptor CXCR4. Cancer Res 2002 62 7203 6.
38. Tiffany HL Lautens LL Gao JL et al. Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309. J Exp Med 1997 186 165 70.