Mechanisms of hair graying: Incomplete melanocyte stem cell maintenance in the niche

Science

Volumn 307, Issue 5710, 2005, Pages 720-724

  Nishimura, Emi K ^a,c   Granter, Scott R ^b   Fisher, David E ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GROWTH KINETICS; PHYSIOLOGY;

APOPTOSIS; ECTOPIC PIGMENTATION; HAIR GRAYING; MELANOCYTE STEM CELLS; NICHE; TRANSCRIPTIONAL REGULATORS;

BIOLOGICAL ORGANS;

PROTEIN BCL 2;

BIOLOGY;

AGING; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL AGING; CELL DIFFERENTIATION; DORMANCY; ECOLOGICAL NICHE; GROWTH CURVE; HAIR COLOR; HAIR FOLLICLE; MELANOCYTE; MORPHOGENESIS; MOUSE; MUTATION; NONHUMAN; PIGMENTATION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; STEM CELL; TRANSGENIC MOUSE;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANIMALS; APOPTOSIS; CELL DIFFERENTIATION; CELL SHAPE; DNA-BINDING PROTEINS; HAIR COLOR; HAIR FOLLICLE; HUMANS; MELANINS; MELANOCYTES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROPHTHALMIA-ASSOCIATED TRANSCRIPTION FACTOR; MIDDLE AGED; MORPHOGENESIS; PROTO-ONCOGENE PROTEINS; STEM CELLS; TRANSCRIPTION FACTORS; VIBRISSAE;

EID: 13244287677     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1099593     Document Type: Article

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32. vit mice; A. Miller, C. Hershey, and Y. Choi for critical reading of the manuscript; members of the Fisher laboratory for helpful discussions; and D. Rowitch for sharing microscopes. E.K.N. wishes to thank Y. Miyachi for continuous encouragement and support. E.K.N. was supported by the Shiseido Award in 2002 and the Charles A. King Trust, Fleet National Bank, a Bank of America Company, co-trustee (Boston, MA). Supported by grant no. AR43369 from NIH to D.E.F. D.E.F. is the Nirenberg Fellow in pediatric oncology at Dana-Farber Cancer Institute.