Role of integrins in regulating epidermal adhesion, growth and differentiation

EMBO Journal

Volumn 21, Issue 15, 2002, Pages 3919-3926

  Watt, Fiona M ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Cancer; Differentiation; Epidermis; Integrins; Stem cells

Indexed keywords

INTEGRIN; INTEGRIN RECEPTOR;

ANIMAL CELL; CELL ADHESION; CELL DIFFERENTIATION; CELL GROWTH; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; EPIDERMIS; EXTRACELLULAR MATRIX; HOMEOSTASIS; HUMAN; HUMAN CELL; MAMMAL; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; STEM CELL;

ANIMALS; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL ADHESION; CELL DIFFERENTIATION; DERMATITIS; EPIDERMIS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; HYPERPLASIA; INTEGRINS; MAMMALS; MICE; NEOPLASM PROTEINS; SKIN NEOPLASMS; STEM CELLS;

ANIMALIA; MAMMALIA;

EID: 0036683057     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf399     Document Type: Review

References (76)

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3. Changing patterns of localization of putative stem cells in developing human hair follicles
4. α6β4 integrin abnormalities in junctional epidermolysis bullosa with pyloric atresia
5. Comparison of integrin, cadherin, and catenin expression in squamous cell carcinomas of the oral cavity
6. Are changes in integrin affinity and conformation overemphasized?
7. Selection and extended growth of murine epidermal stem cells in culture
8. 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos
9. Calcium-induced intercellular adhesion of keratinocytes does not involve accumulation of β1 integrins at cell-cell contacts and does not involve changes in the levels or phosphorylation of catenins
10. Skin and hair follicle integrity is crucially dependent on β1 integrin expression on keratinocytes
11. Expression of the β6 integrin in development, neoplasia and tissue repair suggests a role in epithelial remodeling
12. The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted
13. Suprabasal integrin expression in the epidermis of transgenic mice results in developmental defects and a phenotype resembling psoriasis
14. 2 integrin subunit deficient mouse: A multifaceted phenotype including defects of branching morphogenesis and homostasis
15. Epidermal Ras blockade demonstrates spatially localized Ras promotion of proliferation and inhibition of differentiation
16. α3β1 integrin is required for normal development of the epidermal basement membrane
17. α3β1 and α6β4 integrin receptors for laminin-5 are not essential for epidermal morphogenesis and homeostasis during skin development
18. Mouse keratinocytes immortalized with large T antigen acquire α3β1 integrin-dependent secretion of MMP-9/gelatinase B
19. β4 integrin is required for hemidesmosome formation, cell adhesion and cell survival
20. Loss α6 and β4 integrin subunits coincides with loss of basement membrane components in oral squamous cell carcinomas
21. Commitment to differentiation and expression of early differentiation markers in murine keratinocytes in vitro are regulated independently of extracellular calcium concentrations
22. Evidence that apoptosis and terminal differentiation of epidermal keratinocytes are distinct processes
23. Absence of the α6 integrin leads to epidermolysis bullosa and neonatal death in mice
24. Complexity and specificity of integrin signalling
25. The α3 laminin subunit, α6β4 and α3β1 integrin coordinately regulate wound healing in cultured epithelial cells and in the skin
26. Terminal differentiation of cultured human epidermal cells
27. A crucial role of β1 integrins for keratinocyte migration in vitro and during cutaneous wound repair
28. A role for mitogen-activated protein kinase activation by integrins in the pathogenesis of psoriasis
29. Immunolocalization of tenascin-C, α9 integrin subunit and αvβ6 integrin during wound healing in human oral mucosa
30. Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis
31. Integrin α2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen
32. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lungs and skin
33. Normal development, wound healing and adenovirus susceptibility in β5-deficient mice
34. Fatal bilateral chylothorax in mice lacking the integrin α9β1
35. β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin
36. The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: A new view based on whole mount labelling and lineage analysis
37. Integrin expression in normal, hyperplastic, dysplastic and malignant oral epithelium
38. Transfection of β4 integrin subunit into a neoplastic keratinocyte line fails to restore terminal differentiation capacity or influence proliferation
39. Restoration of αvβ5 integrin expression in neoplastic keratinocytes results in increased capacity for terminal differentiation and suppression of anchorage-independent growth
40. Changes in the expression of αv integrins in oral squamous cell carcinomas
41. Separation of human epidermal stem cells from transit amplifying cells on the basis of differences in integrin function and expression
42. Stem cell patterning and fate in human epidermis
43. β1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms
44. Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype
45. Integrin cytoplasmic domain-binding proteins
46. The C8/144B monoclonal antibody recognizes cytokeratin 15 and defines the location of human hair follicle stem cells
47. The intracellular functions of α6β4 integrin are regulated by EGF
48. The coupling of α6β4 integrin to Ras-MAP kinase pathways mediated by Shc controls keratinocyte proliferation
49. Towards a mechanistic understanding of tumor invasion-lessons from the α6β4 integrin
50. The α6β4 integrin and epithelial cell migration
51. The integrin αvβ6 binds and activates latent TGFβ1: A mechanism for regulating pulmonary inflammation and fibrosis
52. Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion
53. Integrin αvβ8. Interaction with vitronectin and functional divergence of the β8 cytoplasmic domain
54. RhoA function in lamellae formation and migration is regulated by the α6β4 integrin and cAMP metabolism
55. Influence of β1 integrins on epidermal squamous cell carcinoma formation in a transgenic mouse model: α3β1, but not α2β1, suppresses malignant conversion
56. Sequence and tissue distribution of the integrin α9 subunit, a novel partner of β1 that is widely distributed in epithelia and muscle
57. Conditional ablation of β1 integrin in skin: Severe defects in epidermal proliferation, basement membrane formation and hair follicle invagination
58. Analysis of cultured keratinocytes from a transgenic mouse model of psoriasis: Effects of suprabasal integrin expression on keratinocyte adhesion, proliferation and terminal differentiation
59. The human integrin α8β1 functions as a receptor for tenascin, fibronectin and vitronectin
60. Sequence and tissue distribution of the human integrin α8 subunit: A β1-assoicated α subunit expressed in smooth muscle cells
61. α9 and β8 integrin expression correlates with the merger of the developing mouse eyelids
62. 9 integrin in the cornea and changes in expression during corneal epithelial cell differentiation
63. Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins
64. Enrichment for murine keratinocyte stem cells based on cell surface phenotype
65. The suprabasal expression of α6β4 integrin is associated with a high risk for malignant progression in mouse skin carcinogenesis
66. αvβ6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
67. Function and interactions of integrins
68. Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice
69. The A9 antigen associated with aggressive human squamous carcinoma is structurally and functionally similar to the newly defined integrin α6β4
70. β8 integrins mediate interactions of chick sensory neurons with laminin-1, collagen IV and fibronectin
71. Deregulated expression of c-Myc depletes epidermal stem cells
72. Stem cell fate and patterning in mammalian epidermis
73. Keratinocyte integrins
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76. Signalling via β1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro