-
2
-
-
33749631593
-
Telomeres: Prognostic markers for solid tumours
-
Bisoffi M, Heaphy CM, Griffith JK (2006). Telomeres: prognostic markers for solid tumours. Int J Cancer 119: 2255-2260.
-
(2006)
Int J Cancer
, vol.119
, pp. 2255-2260
-
-
Bisoffi, M.1
Heaphy, C.M.2
Griffith, J.K.3
-
3
-
-
0025731583
-
Structure and function of telomeres
-
Blackburn EH (1991). Structure and function of telomeres. Nature 305: 569-573.
-
(1991)
Nature
, vol.305
, pp. 569-573
-
-
Blackburn, E.H.1
-
5
-
-
0034597794
-
Telomere states and cell fates
-
Blackburn EH (2000). Telomere states and cell fates. Nature 408: 53-56.
-
(2000)
Nature
, vol.408
, pp. 53-56
-
-
Blackburn, E.H.1
-
6
-
-
0035929353
-
Switching, signaling at the telomere
-
Blackburn EH (2001). Switching, signaling at the telomere. Cell 106: 661-673.
-
(2001)
Cell
, vol.106
, pp. 661-673
-
-
Blackburn, E.H.1
-
7
-
-
0030931491
-
Telomere shortening and tumour formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA et al. (1997). Telomere shortening and tumour formation by mouse cells lacking telomerase RNA. Cell 91: 25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
-
8
-
-
0038363599
-
Telomeres in cancer and aging: Lessons from the mouse
-
Blasco MA (2003). Telomeres in cancer and aging: lessons from the mouse. Cancer Lett 194: 183-188.
-
(2003)
Cancer Lett
, vol.194
, pp. 183-188
-
-
Blasco, M.A.1
-
9
-
-
1542649544
-
Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line
-
Brown T, Sigurdson E, Rogatko A, Broccoli D (2003). Telomerase inhibition using azidothymidine in the HT-29 colon cancer cell line. Ann Surg Oncol 10: 910-915.
-
(2003)
Ann Surg Oncol
, vol.10
, pp. 910-915
-
-
Brown, T.1
Sigurdson, E.2
Rogatko, A.3
Broccoli, D.4
-
10
-
-
33745638729
-
Telomerase peptide vaccination: A phase I/II study in patients with non-small cell lung cancer
-
Brunsvig PF, Aamdal S, Gjertsen MK, Kvalheim G, Markowski-Grimsrud CJ, Sve I et al. (2006). Telomerase peptide vaccination: a phase I/II study in patients with non-small cell lung cancer. Cancer Immunol Immunother 55: 1553-1564.
-
(2006)
Cancer Immunol Immunother
, vol.55
, pp. 1553-1564
-
-
Brunsvig, P.F.1
Aamdal, S.2
Gjertsen, M.K.3
Kvalheim, G.4
Markowski-Grimsrud, C.J.5
Sve, I.6
-
11
-
-
0029162563
-
Telomere elongation in immortal human cells without detectable telomerase activity
-
Bryan TM, Englezou A, Gupta J, Bacchetti S, Reddel RR (1995). Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J 14: 4240-4248.
-
(1995)
EMBO J
, vol.14
, pp. 4240-4248
-
-
Bryan, T.M.1
Englezou, A.2
Gupta, J.3
Bacchetti, S.4
Reddel, R.R.5
-
12
-
-
0031059778
-
Telomerase activity in normal and malignant mammalian tissues: Feasibility of telomerase as target for cancer chemotherapy
-
Burger AM, Bibby MC, Double JA (1997a). Telomerase activity in normal and malignant mammalian tissues: feasibility of telomerase as target for cancer chemotherapy. Br J Cancer 75: 516-522.
-
(1997)
Br J Cancer
, vol.75
, pp. 516-522
-
-
Burger, A.M.1
Bibby, M.C.2
Double, J.A.3
-
13
-
-
13944272246
-
The G-quadruplex interactive molecule BRACO19 inhibits tumour growth, consistent with telomere binding and interference with telomerase function
-
Burger AM, Dai F, Schultes CM, Reszka AP, Moore MJ, Double JA et al. (2005). The G-quadruplex interactive molecule BRACO19 inhibits tumour growth, consistent with telomere binding and interference with telomerase function. Cancer Res 65: 1489-1496.
-
(2005)
Cancer Res
, vol.65
, pp. 1489-1496
-
-
Burger, A.M.1
Dai, F.2
Schultes, C.M.3
Reszka, A.P.4
Moore, M.J.5
Double, J.A.6
-
14
-
-
0030993152
-
Inhibition of telomerase activity by cisplatin in human testicular cancer cells
-
Burger AM, Double JA, Newell DR (1997b). Inhibition of telomerase activity by cisplatin in human testicular cancer cells. Eur J Cancer 33: 638-644.
-
(1997)
Eur J Cancer
, vol.33
, pp. 638-644
-
-
Burger, A.M.1
Double, J.A.2
Newell, D.R.3
-
15
-
-
85052183865
-
-
Burger AM, Kelland LR (2006). Telomere targeting agents. In: Dawson N, Kelly (eds). Prostate Cancer: Translational and Emerging Therapies Chapter 12 Taylor & Francis Group, LLC: NY, pp 195-208.
-
Burger AM, Kelland LR (2006). Telomere targeting agents. In: Dawson N, Kelly (eds). Prostate Cancer: Translational and Emerging Therapies Chapter 12 Taylor & Francis Group, LLC: NY, pp 195-208.
-
-
-
-
16
-
-
0033397317
-
Telomerase in cancer diagnosis and therapy
-
Burger AM (1999). Telomerase in cancer diagnosis and therapy. BioDrugs 12: 413-422.
-
(1999)
BioDrugs
, vol.12
, pp. 413-422
-
-
Burger, A.M.1
-
17
-
-
33845603137
-
Highlights in experimental therapeutics
-
Burger AM (2007). Highlights in experimental therapeutics. Cancer Lett 245: 11-21.
-
(2007)
Cancer Lett
, vol.245
, pp. 11-21
-
-
Burger, A.M.1
-
19
-
-
27844521369
-
Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate (RHPS4) in vitro: Activity in human tumour cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents
-
Cookson JC, Dai F, Smith V, Heald RA, Laughton CA, Stevens MFG et al. (2005a). Pharmacodynamics of the G-quadruplex-stabilizing telomerase inhibitor 3,11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl] acridinium methosulfate (RHPS4) in vitro: activity in human tumour cells correlates with telomere length and can be enhanced, or antagonized, with cytotoxic agents. Mol Pharmacol 68: 1551-1558.
-
(2005)
Mol Pharmacol
, vol.68
, pp. 1551-1558
-
-
Cookson, J.C.1
Dai, F.2
Smith, V.3
Heald, R.A.4
Laughton, C.A.5
Stevens, M.F.G.6
-
20
-
-
27844466279
-
Antitumour polycyclic acridines, 17, synthesis, and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity
-
Cookson JC, Heald RA, Stevens MF (2005b). Antitumour polycyclic acridines, 17, synthesis, and pharmaceutical profiles of pentacyclic acridinium salts designed to destabilize telomeric integrity. J Med Chem 48: 7198-7207.
-
(2005)
J Med Chem
, vol.48
, pp. 7198-7207
-
-
Cookson, J.C.1
Heald, R.A.2
Stevens, M.F.3
-
21
-
-
0344441890
-
DNA damage checkpoint response in telomere-initiated senescence
-
d'Adda di Fagagna F, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, Von Zglinicki T et al. (2003). DNA damage checkpoint response in telomere-initiated senescence. Nature 426: 194-198.
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
d'Adda di Fagagna, F.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
-
22
-
-
4243937106
-
A highly selective telomerase inhibitor limiting human cancer cell proliferation
-
Damm K, Hemmann U, Garin-Chesa P, Hauel N, Kauffmann I, Priepke H et al. (2001). A highly selective telomerase inhibitor limiting human cancer cell proliferation. EMBO J 20: 6958-6968.
-
(2001)
EMBO J
, vol.20
, pp. 6958-6968
-
-
Damm, K.1
Hemmann, U.2
Garin-Chesa, P.3
Hauel, N.4
Kauffmann, I.5
Priepke, H.6
-
23
-
-
27544508080
-
Telomerase vaccination has no detectable effect on SCID-repopulating and colony forming activities in the bone marrow of cancer patients
-
Danet-Desnoyers GA, Luongo JL, Bonnet DA, Domchek SM, Vonderheide RH (2005). Telomerase vaccination has no detectable effect on SCID-repopulating and colony forming activities in the bone marrow of cancer patients. Exp Hematol 33: 1275-1280.
-
(2005)
Exp Hematol
, vol.33
, pp. 1275-1280
-
-
Danet-Desnoyers, G.A.1
Luongo, J.L.2
Bonnet, D.A.3
Domchek, S.M.4
Vonderheide, R.H.5
-
24
-
-
0037148277
-
Protection of mammalian telomeres
-
De Lange T (2002). Protection of mammalian telomeres. Oncogene 21: 532-540.
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
25
-
-
24744446474
-
In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor
-
Dikmen ZG, Gellert GC, Jackson S, Gryaznov S, Tressler R, Dogan P et al. (2005). In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res 65: 7866-7873.
-
(2005)
Cancer Res
, vol.65
, pp. 7866-7873
-
-
Dikmen, Z.G.1
Gellert, G.C.2
Jackson, S.3
Gryaznov, S.4
Tressler, R.5
Dogan, P.6
-
26
-
-
34249006299
-
ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models
-
Donawho CK, Luo Y, Penning TD, Bauch JL, Bouska JJ, Bontcheva-Diaz VD et al. (2007). ABT-888, an orally active poly(ADP-ribose) polymerase inhibitor that potentiates DNA-damaging agents in preclinical tumor models. Clin Cancer Res 13: 2728-2737.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2728-2737
-
-
Donawho, C.K.1
Luo, Y.2
Penning, T.D.3
Bauch, J.L.4
Bouska, J.J.5
Bontcheva-Diaz, V.D.6
-
27
-
-
0027520196
-
Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein
-
Fang G, Czech TR (1993). Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein. Biochemistry 32: 11646-11657.
-
(1993)
Biochemistry
, vol.32
, pp. 11646-11657
-
-
Fang, G.1
Czech, T.R.2
-
28
-
-
0025312728
-
A genetic model for colorectal carcinogenesis
-
Fearon EA, Vogelstein BA (1990). A genetic model for colorectal carcinogenesis. Cell 61: 759-767.
-
(1990)
Cell
, vol.61
, pp. 759-767
-
-
Fearon, E.A.1
Vogelstein, B.A.2
-
29
-
-
0029096515
-
The RNA component of human telomerase
-
Feng J, Funk WD, Wang SS, Weinrich AA, Avilon CP, Chiu CP et al. (1995). The RNA component of human telomerase. Science 269: 1236-1241.
-
(1995)
Science
, vol.269
, pp. 1236-1241
-
-
Feng, J.1
Funk, W.D.2
Wang, S.S.3
Weinrich, A.A.4
Avilon, C.P.5
Chiu, C.P.6
-
30
-
-
33747603204
-
Telomere content correlates with stage and prognosis in breast cancer
-
Fordyce CA, Heaphy CM, Bisoffi M, Wyaco JL, Joste NE, Mangalik A et al. (2006). Telomere content correlates with stage and prognosis in breast cancer. Breast Cancer Res Treat 99: 193-202.
-
(2006)
Breast Cancer Res Treat
, vol.99
, pp. 193-202
-
-
Fordyce, C.A.1
Heaphy, C.M.2
Bisoffi, M.3
Wyaco, J.L.4
Joste, N.E.5
Mangalik, A.6
-
31
-
-
12544254587
-
Association between cancer-free survival and telomere DNA content in prostate tumours
-
Fordyce CA, Heaphy CM, Joste NE, Smith AY, Hunt WC, Griffith JK (2005). Association between cancer-free survival and telomere DNA content in prostate tumours. J Urol 173: 610-614.
-
(2005)
J Urol
, vol.173
, pp. 610-614
-
-
Fordyce, C.A.1
Heaphy, C.M.2
Joste, N.E.3
Smith, A.Y.4
Hunt, W.C.5
Griffith, J.K.6
-
32
-
-
0035844136
-
Stable association of hsp90 and p23, but not hsp70, with active human telomerase
-
Forsythe HL, Jarvis JL, Turner JW, Elmore LW, Holt SE (2001). Stable association of hsp90 and p23, but not hsp70, with active human telomerase. J Biol Chem 276: 15571-15574.
-
(2001)
J Biol Chem
, vol.276
, pp. 15571-15574
-
-
Forsythe, H.L.1
Jarvis, J.L.2
Turner, J.W.3
Elmore, L.W.4
Holt, S.E.5
-
33
-
-
33645244083
-
Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer
-
Gellert GC, Dikmen ZG, Wright WE, Gryaznov S, Shay JW (2006). Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Res Treat 96: 73-81.
-
(2006)
Breast Cancer Res Treat
, vol.96
, pp. 73-81
-
-
Gellert, G.C.1
Dikmen, Z.G.2
Wright, W.E.3
Gryaznov, S.4
Shay, J.W.5
-
34
-
-
0025145238
-
Replicative senescence: The human fibroblast comes of age
-
Goldstein S (1990). Replicative senescence: the human fibroblast comes of age. Science 249: 1129-1133.
-
(1990)
Science
, vol.249
, pp. 1129-1133
-
-
Goldstein, S.1
-
35
-
-
33845994055
-
Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumour cells
-
Gomez D, Wenner T, Brassart B, Douarre C, O'Donohue MF, El Khoury V et al. (2006). Telomestatin-induced telomere uncapping is modulated by POT1 through G-overhang extension in HT1080 human tumour cells. J Biol Chem 281: 38721-38729.
-
(2006)
J Biol Chem
, vol.281
, pp. 38721-38729
-
-
Gomez, D.1
Wenner, T.2
Brassart, B.3
Douarre, C.4
O'Donohue, M.F.5
El Khoury, V.6
-
36
-
-
0343228751
-
Telomerase deficient mice with short telomeres are resistant to skin tumourigenesis
-
Gonzalez-Suarez E, Samper E, Flores JM, Blasco MA (2000). Telomerase deficient mice with short telomeres are resistant to skin tumourigenesis. Nat Genet 26: 114-117.
-
(2000)
Nat Genet
, vol.26
, pp. 114-117
-
-
Gonzalez-Suarez, E.1
Samper, E.2
Flores, J.M.3
Blasco, M.A.4
-
37
-
-
0034760505
-
Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes
-
Gowan S, Heald R, Stevens MFG, Kelland LR (2001). Potent inhibition of telomerase by small-molecule pentacyclic acridines capable of interacting with G-quadruplexes. Mol Pharmacol 60: 981-988.
-
(2001)
Mol Pharmacol
, vol.60
, pp. 981-988
-
-
Gowan, S.1
Heald, R.2
Stevens, M.F.G.3
Kelland, L.R.4
-
38
-
-
0025931671
-
Chromosome first aid
-
Greider CW (1991). Chromosome first aid. Cell 67: 645-647.
-
(1991)
Cell
, vol.67
, pp. 645-647
-
-
Greider, C.W.1
-
39
-
-
0033614998
-
Creation of human tumour cells with defined genetic elements
-
Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW, Weinberg RA (1999a). Creation of human tumour cells with defined genetic elements. Nature 400: 464-468.
-
(1999)
Nature
, vol.400
, pp. 464-468
-
-
Hahn, W.C.1
Counter, C.M.2
Lundberg, A.S.3
Beijersbergen, R.L.4
Brooks, M.W.5
Weinberg, R.A.6
-
40
-
-
0032828652
-
Inhibition of telomerase limits the growth of human cancer cells
-
Hahn WC, Stewart SA, Brooks MW, York SG, Eaton E, Kurachi A et al. (1999b). Inhibition of telomerase limits the growth of human cancer cells. Nat Med 5: 1164-1170.
-
(1999)
Nat Med
, vol.5
, pp. 1164-1170
-
-
Hahn, W.C.1
Stewart, S.A.2
Brooks, M.W.3
York, S.G.4
Eaton, E.5
Kurachi, A.6
-
41
-
-
0017785769
-
Primary bioassay of human tumour stem cells
-
Hamburger AW, Salmon SE (1977). Primary bioassay of human tumour stem cells. Science 197: 461-463.
-
(1977)
Science
, vol.197
, pp. 461-463
-
-
Hamburger, A.W.1
Salmon, S.E.2
-
42
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA (2000). The hallmarks of cancer. Cell 100: 50-70.
-
(2000)
Cell
, vol.100
, pp. 50-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
43
-
-
28944455294
-
Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
-
Hao LY, Armanios M, Strong MA, Karim B, Feldser DM, Huso D et al. (2005). Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123: 1121-1131.
-
(2005)
Cell
, vol.123
, pp. 1121-1131
-
-
Hao, L.Y.1
Armanios, M.2
Strong, M.A.3
Karim, B.4
Feldser, D.M.5
Huso, D.6
-
44
-
-
0025279931
-
Telomeres shorten during ageing of human fibroblasts
-
Harley CB, Fuchter BA, Greider CW (1990). Telomeres shorten during ageing of human fibroblasts. Nature 345: 458-460.
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Fuchter, B.A.2
Greider, C.W.3
-
45
-
-
0025143252
-
Telomere reduction in human colorectal carcinoma and with ageing
-
Hastie ND, Dempster M, Dunlop MC, Thompson AM, Green DK, Allshire RC (1990). Telomere reduction in human colorectal carcinoma and with ageing. Nature 346: 866-868.
-
(1990)
Nature
, vol.346
, pp. 866-868
-
-
Hastie, N.D.1
Dempster, M.2
Dunlop, M.C.3
Thompson, A.M.4
Green, D.K.5
Allshire, R.C.6
-
46
-
-
0026776241
-
Aging, longevity, and immortality in vitro
-
Hayflick L (1992). Aging, longevity, and immortality in vitro. Exper Gerontol 27: 363-368.
-
(1992)
Exper Gerontol
, vol.27
, pp. 363-368
-
-
Hayflick, L.1
-
47
-
-
0033455559
-
Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
-
Herbert B, Pitts AE, Baker SI, Hamilton WE,Wright WE, Shay JW et al. (1999). Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci USA 96: 14276-14281.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14276-14281
-
-
Herbert, B.1
Pitts, A.E.2
Baker, S.I.3
Hamilton, W.E.4
Wright, W.E.5
Shay, J.W.6
-
48
-
-
0033118355
-
Functional requirement of p23 and Hsp90 in telomerase complexes
-
Holt SE, Aisner DL, Baur J, Tesmer VM, Dy M, Ouellette M et al. (1999). Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev 13: 817-826.
-
(1999)
Genes Dev
, vol.13
, pp. 817-826
-
-
Holt, S.E.1
Aisner, D.L.2
Baur, J.3
Tesmer, V.M.4
Dy, M.5
Ouellette, M.6
-
49
-
-
0029895383
-
Refining the telomere-telomerase hypothesis of aging and cancer
-
Holt SE, Shay JW, Wright WE (1996). Refining the telomere-telomerase hypothesis of aging and cancer. Nat Biotechnol 14: 1734-1741.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 1734-1741
-
-
Holt, S.E.1
Shay, J.W.2
Wright, W.E.3
-
50
-
-
0032515974
-
Telomere loss in cells treated with cisplatin
-
Ishibashi T, Lippard SJ (1998). Telomere loss in cells treated with cisplatin. Proc Natl Acad Sci USA 95: 4219-4223.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 4219-4223
-
-
Ishibashi, T.1
Lippard, S.J.2
-
51
-
-
33847071293
-
Antiadhesive effects of GRN163L - an oligonucleotide N3′->P5′ thio-phosphoramidate targeting telomerase
-
Jackson SR, Zhu CH, Paulson V,Watkins L, Dikmen ZG, Gryaznov SM et al. (2007). Antiadhesive effects of GRN163L - an oligonucleotide N3′->P5′ thio-phosphoramidate targeting telomerase. Cancer Res 67: 1121-1129.
-
(2007)
Cancer Res
, vol.67
, pp. 1121-1129
-
-
Jackson, S.R.1
Zhu, C.H.2
Paulson, V.3
Watkins, L.4
Dikmen, Z.G.5
Gryaznov, S.M.6
-
52
-
-
33744535197
-
Telomeres and telomerase in cancer stem cells
-
Ju Z, Rudolph KL (2006). Telomeres and telomerase in cancer stem cells. Eur J Cancer 42: 1197-1203.
-
(2006)
Eur J Cancer
, vol.42
, pp. 1197-1203
-
-
Ju, Z.1
Rudolph, K.L.2
-
53
-
-
0033605145
-
P53 and ATM-dependent apoptosis induced by telomeres lacking TRF2
-
Karlseder J, Broccoli D, Dai Y, Hardy S, de Lange T (1999). P53 and ATM-dependent apoptosis induced by telomeres lacking TRF2. Science 283: 1321-1325.
-
(1999)
Science
, vol.283
, pp. 1321-1325
-
-
Karlseder, J.1
Broccoli, D.2
Dai, Y.3
Hardy, S.4
de Lange, T.5
-
54
-
-
0035171612
-
Telomerase and Cancer: Time to move from a promising target to a clinical trial
-
Keith NW, Evans JTR, Glasspool RM (2001). Telomerase and Cancer: time to move from a promising target to a clinical trial. J Pathol 195: 404-414.
-
(2001)
J Pathol
, vol.195
, pp. 404-414
-
-
Keith, N.W.1
Evans, J.T.R.2
Glasspool, R.M.3
-
56
-
-
0035262502
-
Telomerase: Biology and phase I trials
-
Kelland LR (2001). Telomerase: biology and phase I trials. Lancet Oncol 2: 95-102.
-
(2001)
Lancet Oncol
, vol.2
, pp. 95-102
-
-
Kelland, L.R.1
-
57
-
-
18044391665
-
Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospectus
-
Kelland LR (2005). Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-current status and future prospectus. Eur J Cancer 41: 971-979.
-
(2005)
Eur J Cancer
, vol.41
, pp. 971-979
-
-
Kelland, L.R.1
-
58
-
-
0037070575
-
Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex
-
Kim MY, Vankayalapati H, Shin-Ya K, Wierzba K, Hurley LH (2002). Telomestatin, a potent telomerase inhibitor that interacts quite specifically with the human telomeric intramolecular G-quadruplex. J Am Chem Soc 124: 2098-2099.
-
(2002)
J Am Chem Soc
, vol.124
, pp. 2098-2099
-
-
Kim, M.Y.1
Vankayalapati, H.2
Shin-Ya, K.3
Wierzba, K.4
Hurley, L.H.5
-
59
-
-
0028564951
-
Specific association of human telomerase activity with immortal cells and cancer
-
Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL et al. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266: 2011-2015.
-
(1994)
Science
, vol.266
, pp. 2011-2015
-
-
Kim, N.W.1
Piatyszek, M.A.2
Prowse, K.R.3
Harley, C.B.4
West, M.D.5
Ho, P.L.6
-
60
-
-
0035024256
-
Treatment of bladder cancer cells in vitro and in vivo with 2-5 A anti telomerase RNA
-
Koga S, Kondo Y, Komata T, Kondo S (2001). Treatment of bladder cancer cells in vitro and in vivo with 2-5 A anti telomerase RNA. Gene Therapy 8: 654-658.
-
(2001)
Gene Therapy
, vol.8
, pp. 654-658
-
-
Koga, S.1
Kondo, Y.2
Komata, T.3
Kondo, S.4
-
61
-
-
0032566005
-
Targeted therapy of humanmalignant glioma in amousemodel by 2-5A antisense directed against telomerase RNA
-
Kondo S, Kondo Y, Li G, Silverman RH, Cowel JK (1998). Targeted therapy of humanmalignant glioma in amousemodel by 2-5A antisense directed against telomerase RNA. Oncogene 16: 3323-3330.
-
(1998)
Oncogene
, vol.16
, pp. 3323-3330
-
-
Kondo, S.1
Kondo, Y.2
Li, G.3
Silverman, R.H.4
Cowel, J.K.5
-
62
-
-
0033980773
-
2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells
-
Kushner DM, Paranjape JM, Bandyopadhyay B, Cramer H, Leaman DW, Kennedy AW et al. (2000). 2-5A antisense directed against telomerase RNA produces apoptosis in ovarian cancer cells. Gynecol Oncol 76: 183-192.
-
(2000)
Gynecol Oncol
, vol.76
, pp. 183-192
-
-
Kushner, D.M.1
Paranjape, J.M.2
Bandyopadhyay, B.3
Cramer, H.4
Leaman, D.W.5
Kennedy, A.W.6
-
63
-
-
0027266758
-
An alternative pathway for yeast telomere maintenance rescues est-1 senescence
-
Lundblad V, Blackburn EH (1993). An alternative pathway for yeast telomere maintenance rescues est-1 senescence. Cell 73: 347-360.
-
(1993)
Cell
, vol.73
, pp. 347-360
-
-
Lundblad, V.1
Blackburn, E.H.2
-
64
-
-
3242656131
-
Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing
-
Mochizuki Y, He J, Kulkarni S, Bessler M, Mason PJ (2004). Mouse dyskerin mutations affect accumulation of telomerase RNA and small nucleolar RNA, telomerase activity, and ribosomal RNA processing. Proc Natl Acad Sci USA 101: 10756-10761.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10756-10761
-
-
Mochizuki, Y.1
He, J.2
Kulkarni, S.3
Bessler, M.4
Mason, P.J.5
-
65
-
-
0029649685
-
Is telomerase a universal cancer target?
-
Morin GB (1995). Is telomerase a universal cancer target? J Natl Cancer Inst 87: 859-861.
-
(1995)
J Natl Cancer Inst
, vol.87
, pp. 859-861
-
-
Morin, G.B.1
-
66
-
-
0033406877
-
Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops
-
Murti KG, Prescott DM (1999). Telomeres of polytene chromosomes in a ciliated protozoan terminate in duplex DNA loops. Proc Natl Acad Sci USA 96: 14436-14439.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 14436-14439
-
-
Murti, K.G.1
Prescott, D.M.2
-
67
-
-
0030819894
-
Telomerase catalytic subunit homologs from fission yeast and human
-
Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J et al. (1997). Telomerase catalytic subunit homologs from fission yeast and human. Science 277: 955-959.
-
(1997)
Science
, vol.277
, pp. 955-959
-
-
Nakamura, T.M.1
Morin, G.B.2
Chapman, K.B.3
Weinrich, S.L.4
Andrews, W.H.5
Lingner, J.6
-
68
-
-
84888741514
-
-
No authors listed. NIH Clinical Research Studies Protocol Number, 06-C-0172 http://clinicalstudies, info.nih.gov/detail/A_, 2006-C-0172, html.
-
No authors listed. NIH Clinical Research Studies Protocol Number, 06-C-0172 http://clinicalstudies, info.nih.gov/detail/A_, 2006-C-0172, html.
-
-
-
-
69
-
-
3242690518
-
Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumours endogenously expressing telomerase
-
Parkhurst MR, Riley JP, Igarashi T, Li Y, Robbins PF, Rosenberg SA (2004). Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumours endogenously expressing telomerase. Clin Cancer Res 10: 4688-4698.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4688-4698
-
-
Parkhurst, M.R.1
Riley, J.P.2
Igarashi, T.3
Li, Y.4
Robbins, P.F.5
Rosenberg, S.A.6
-
70
-
-
0037142071
-
Crystal structure of parallel quadruplexes from human telomeric DNA
-
Parkinson GN, Lee MP, Neidle S (2002). Crystal structure of parallel quadruplexes from human telomeric DNA. Nature 417: 876-880.
-
(2002)
Nature
, vol.417
, pp. 876-880
-
-
Parkinson, G.N.1
Lee, M.P.2
Neidle, S.3
-
71
-
-
20944447769
-
Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands
-
Pennarun G, Granotier C, Gauthier LR, Gomez D, Hoffschir F, Mandine E et al. (2005). Apoptosis related to telomere instability and cell cycle alterations in human glioma cells treated by new highly selective G-quadruplex ligands. Oncogene 24: 2917-2928.
-
(2005)
Oncogene
, vol.24
, pp. 2917-2928
-
-
Pennarun, G.1
Granotier, C.2
Gauthier, L.R.3
Gomez, D.4
Hoffschir, F.5
Mandine, E.6
-
72
-
-
34247208639
-
Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
-
Phatak P, Cookson JC, Dai F, Smith V, Gartenhaus RB, Stevens MF et al. (2007). Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br J Cancer 96: 1223-1233.
-
(2007)
Br J Cancer
, vol.96
, pp. 1223-1233
-
-
Phatak, P.1
Cookson, J.C.2
Dai, F.3
Smith, V.4
Gartenhaus, R.B.5
Stevens, M.F.6
-
73
-
-
0035936001
-
Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954
-
Plumb JA, Bilsland A, Kakani R, Zhao J, Glasspool RM, Knox RJ et al. (2001). Telomerase-specific suicide gene therapy vectors expressing bacterial nitroreductase sensitize human cancer cells to the pro-drug CB1954. Oncogene 20: 7797-7803.
-
(2001)
Oncogene
, vol.20
, pp. 7797-7803
-
-
Plumb, J.A.1
Bilsland, A.2
Kakani, R.3
Zhao, J.4
Glasspool, R.M.5
Knox, R.J.6
-
74
-
-
0035942270
-
Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors
-
Read M, Harrison RJ, Romagnoli B, Tanious FA, Gowan SH, Reszka AP et al. (2001). Structure-based design of selective and potent G quadruplex-mediated telomerase inhibitors. Proc Natl Acad Sci USA 98: 4844-4849.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 4844-4849
-
-
Read, M.1
Harrison, R.J.2
Romagnoli, B.3
Tanious, F.A.4
Gowan, S.H.5
Reszka, A.P.6
-
75
-
-
0037022658
-
Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
-
Riou J-F, Guittat L, Mailliet P, Laoui A, Renou E, Petitgenet O et al. (2002). Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands. Proc Natl Acad Sci USA 99: 2672-2677.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 2672-2677
-
-
Riou, J.-F.1
Guittat, L.2
Mailliet, P.3
Laoui, A.4
Renou, E.5
Petitgenet, O.6
-
76
-
-
36049045013
-
Telomere damage promotes antitumoural activity of the G-quadruplex ligand RHPS4
-
in press
-
Salvati E, Leonetti C, Rizzo A, Scarsella M, Mottolese M, Galati R et al. (2007). Telomere damage promotes antitumoural activity of the G-quadruplex ligand RHPS4. J Clinc Invest (in press).
-
(2007)
J Clinc Invest
-
-
Salvati, E.1
Leonetti, C.2
Rizzo, A.3
Scarsella, M.4
Mottolese, M.5
Galati, R.6
-
77
-
-
0034775290
-
Ribozyme-mediated telomerase inhibition induced immidiate cell loss but not telomere shortening i ovarian cancer cells
-
Saretzki G, Ludwig A, Zglinicki T, Runnebaum IB (2001). Ribozyme-mediated telomerase inhibition induced immidiate cell loss but not telomere shortening i ovarian cancer cells. Cancer Gene Ther 8: 827-834.
-
(2001)
Cancer Gene Ther
, vol.8
, pp. 827-834
-
-
Saretzki, G.1
Ludwig, A.2
Zglinicki, T.3
Runnebaum, I.B.4
-
78
-
-
23944516520
-
Conditional telomerase induction causes proliferation of hair follicle stem cells
-
Sarin KY, Cheung P, Gilison D, Lee E, Tennen RI, Wang E et al. (2005). Conditional telomerase induction causes proliferation of hair follicle stem cells. Nature 436: 1048-1052.
-
(2005)
Nature
, vol.436
, pp. 1048-1052
-
-
Sarin, K.Y.1
Cheung, P.2
Gilison, D.3
Lee, E.4
Tennen, R.I.5
Wang, E.6
-
79
-
-
12344320413
-
Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics
-
Seimiya H, Muramatsu Y, Tomokazu O, Tsuruo T (2005). Tankyrase 1 as a target for telomere-directed molecular cancer therapeutics. Cancer Cell 7: 25-37.
-
(2005)
Cancer Cell
, vol.7
, pp. 25-37
-
-
Seimiya, H.1
Muramatsu, Y.2
Tomokazu, O.3
Tsuruo, T.4
-
80
-
-
0031010342
-
A survey of telomerase activity in human cancer
-
Shay JW, Bacchetti S (1997). A survey of telomerase activity in human cancer. Eur J Cancer 33: 787-791.
-
(1997)
Eur J Cancer
, vol.33
, pp. 787-791
-
-
Shay, J.W.1
Bacchetti, S.2
-
81
-
-
0141456502
-
Telomerase therapeutics: Telomeres recognized as a DNA damage signal
-
Shay JW (2003). Telomerase therapeutics: telomeres recognized as a DNA damage signal. Clin Cancer Res 9: 3521-3525.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 3521-3525
-
-
Shay, J.W.1
-
83
-
-
0345643517
-
Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast
-
Smith CD, Blackburn EH (1999). Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast. J Cell Biol 145: 203-214.
-
(1999)
J Cell Biol
, vol.145
, pp. 203-214
-
-
Smith, C.D.1
Blackburn, E.H.2
-
84
-
-
0032553473
-
Tankyrase, a poly(ADP-ribose)polymerase at human telomeres
-
Smith S, Giriat I, Schmitt A, de Lange T (1998). Tankyrase, a poly(ADP-ribose)polymerase at human telomeres. Science 282: 1484-1487.
-
(1998)
Science
, vol.282
, pp. 1484-1487
-
-
Smith, S.1
Giriat, I.2
Schmitt, A.3
de Lange, T.4
-
85
-
-
0029655485
-
Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
-
Strahl C, Blackburn EH (1996). Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol Cell Biol 16: 53-65.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 53-65
-
-
Strahl, C.1
Blackburn, E.H.2
-
86
-
-
34147182310
-
Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial
-
Thomas HD, Calabrese CR, Batey MA, Canan S, Hostomsky Z, Kyle S et al. (2007). Preclinical selection of a novel poly(ADP-ribose) polymerase inhibitor for clinical trial. Mol Cancer Ther 3: 945-956.
-
(2007)
Mol Cancer Ther
, vol.3
, pp. 945-956
-
-
Thomas, H.D.1
Calabrese, C.R.2
Batey, M.A.3
Canan, S.4
Hostomsky, Z.5
Kyle, S.6
-
87
-
-
0031027618
-
Control of telomere length by the human telomeric binding protein TRF1
-
Van Steensel B, de Lange T (1997). Control of telomere length by the human telomeric binding protein TRF1. Nature 385: 740-743.
-
(1997)
Nature
, vol.385
, pp. 740-743
-
-
Van Steensel, B.1
de Lange, T.2
-
88
-
-
0038309566
-
Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells
-
Villa R, Folini M, Porta CD, Valentini A, Pennati M, Daidone MG et al. (2003). Inhibition of telomerase activity by geldanamycin and 17-allylamino, 17-demethoxygeldanamycin in human melanoma cells. Carcinogenesis 24: 851-859.
-
(2003)
Carcinogenesis
, vol.24
, pp. 851-859
-
-
Villa, R.1
Folini, M.2
Porta, C.D.3
Valentini, A.4
Pennati, M.5
Daidone, M.G.6
-
89
-
-
10744221022
-
Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes
-
Vonderheide RH, Domchek SM, Schultze JL, George DJ, Hoar KM, Chen DY et al. (2004). Vaccination of cancer patients against telomerase induces functional antitumor CD8+ T lymphocytes. Clin Cancer Res 10: 828-839.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 828-839
-
-
Vonderheide, R.H.1
Domchek, S.M.2
Schultze, J.L.3
George, D.J.4
Hoar, K.M.5
Chen, D.Y.6
-
90
-
-
0027918585
-
Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex
-
Wang Y, Patel DJ (1993). Solution structure of the human telomeric repeat d[AG3(T2AG3)3] G-tetraplex. Structure 1: 263-282.
-
(1993)
Structure
, vol.1
, pp. 263-282
-
-
Wang, Y.1
Patel, D.J.2
-
91
-
-
12344288452
-
Mechanism-based combination telomerase inhibition therapy
-
Wright WE, Shay JW (2005). Mechanism-based combination telomerase inhibition therapy. Cancer Cell 7: 1-2.
-
(2005)
Cancer Cell
, vol.7
, pp. 1-2
-
-
Wright, W.E.1
Shay, J.W.2
-
92
-
-
0036019380
-
2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells
-
Yatabe N, Kyo S, Kondo S, Kanaya T, Wang Z, Maida Y et al. (2002). 2-5A antisense therapy directed against human telomerase RNA inhibits telomerase activity and induces apoptosis without telomere impairment in cervical cancer cells. Cancer Gene Ther 9: 624-630.
-
(2002)
Cancer Gene Ther
, vol.9
, pp. 624-630
-
-
Yatabe, N.1
Kyo, S.2
Kondo, S.3
Kanaya, T.4
Wang, Z.5
Maida, Y.6
|