Life in the midst of scarcity: Adaptations to nutrient availability in Saccharomyces cerevisiae

Current Genetics

Volumn 56, Issue 1, 2010, Pages 1-32

  Smets, Bart ^a   Ghillebert, Ruben ^a   De Snijder, Pepijn ^a   Binda, Matteo ^b   Swinnen, Erwin ^a   De Virgilio, Claudio ^b   Winderickx, Joris ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Nutrient sensing; PKA; Sch9; Signal transduction; TOR; Yeast

Indexed keywords

ADENOSINE TRIPHOSPHATASE (CALCIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENYLATE CYCLASE; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIN DEPENDENT KINASE 1; DNA DIRECTED RNA POLYMERASE; DNA DIRECTED RNA POLYMERASE III; FK 506 BINDING PROTEIN; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INOSITOL PHOSPHATE; PHOSPHATE; PHOSPHODIESTERASE I; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHORIBOSYLAMINOIMIDAZOLECARBOXAMIDE FORMYLTRANSFERASE; PROTEIN 14 3 3; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; RAPAMYCIN; RAS PROTEIN; RNA POLYMERASE II; SPLEEN EXONUCLEASE; TARGET OF RAPAMYCIN KINASE; TRANSCRIPTION FACTOR GCN4;

CALCIUM SIGNALING; DRUG TARGETING; ENZYME REGULATION; ENZYME STRUCTURE; FUNGAL GENETICS; FUNGAL METABOLISM; FUNGUS GROWTH; GENE EXPRESSION REGULATION; NONHUMAN; PHOSPHATE METABOLISM; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; REVIEW; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

NUTRITIONAL PHYSIOLOGICAL PHENOMENA; PROTEIN KINASES; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 73249152807     PISSN: 01728083     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00294-009-0287-1     Document Type: Review

References (402)

1. D Ahuatzi P Herrero T de la Cera F Moreno 2004 The glucose-regulated nuclear localization of hexokinase 2 in Saccharomyces cerevisiae is Mig1-dependent J Biol Chem 279 14440 14446 1:CAS:528:DC%2BD2cXis1eksr8%3D 14715653
2. D Ahuatzi A Riera R Pelaez P Herrero F Moreno 2007 Hxk2 regulates the phosphorylation state of Mig1 and therefore its nucleocytoplasmic distribution J Biol Chem 282 4485 4493 1:CAS:528:DC%2BD2sXhsFKgsro%3D 17178716
3. C Almaguer D Mantella E Perez J Patton-Vogt 2003 Inositol and phosphate regulate GIT1 transcription and glycerophosphoinositol incorporation in Saccharomyces cerevisiae Eukaryot Cell 2 729 736 1:CAS:528:DC%2BD3sXmsFymsLc%3D 12912892
4. T Araki Y Uesono T Oguchi EA Toh 2005 LAS24/KOG1, a component of the TOR complex 1 (TORC1), is needed for resistance to local anesthetic tetracaine and normal distribution of actin cytoskeleton in yeast Genes Genet Syst 80 325 343 1:CAS:528:DC%2BD28Xhs1Kgur0%3D 16394584
5. JC Arguelles K Mbonyi L Van Aelst M Vanhalewyn AW Jans JM Thevelein 1990 Absence of glucose-induced cAMP signaling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins Arch Microbiol 154 199 205 1:STN:280:DyaK3czos1CltA%3D%3D 2169717
6. KT Arndt CA Styles GR Fink 1989 A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases Cell 56 527 537 1:CAS:528:DyaL1MXls1ygt7s%3D 2537149
7. S Aronova K Wedaman S Anderson J Yates 3rd T Powers 2007 Probing the membrane environment of the TOR kinases reveals functional interactions between TORC1, actin, and membrane trafficking in Saccharomyces cerevisiae Mol Biol Cell 18 2779 2794 1:CAS:528:DC%2BD2sXovFaltbY%3D 17507646
8. S Aronova K Wedaman PA Aronov K Fontes K Ramos BD Hammock T Powers 2008 Regulation of ceramide biosynthesis by TOR complex 2 Cell Metab 7 148 158 1:CAS:528:DC%2BD1cXitVWhtLk%3D 18249174
9. A Audhya R Loewith AB Parsons L Gao M Tabuchi H Zhou C Boone MN Hall SD Emr 2004 Genome-wide lethality screen identifies new PI4, 5P2 effectors that regulate the actin cytoskeleton EMBO J 23 3747 3757 1:CAS:528: DC%2BD2cXnvFCgtrc%3D 15372071
10. C Auesukaree T Homma Y Kaneko S Harashima 2003 Transcriptional regulation of phosphate-responsive genes in low-affinity phosphate-transporter-defective mutants in Saccharomyces cerevisiae Biochem Biophys Res Commun 306 843 850 1:CAS:528:DC%2BD3sXkvVChtbY%3D 12821119
11. C Auesukaree T Homma H Tochio M Shirakawa Y Kaneko S Harashima 2004 Intracellular phosphate serves as a signal for the regulation of the PHO pathway in Saccharomyces cerevisiae J Biol Chem 279 17289 17294 1:CAS:528: DC%2BD2cXjt1Gns70%3D 14966138
12. C Auesukaree H Tochio M Shirakawa Y Kaneko S Harashima 2005 Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae J Biol Chem 280 25127 25133 1:CAS:528: DC%2BD2MXlsFyqt7o%3D 15866881
13. G Badis ET Chan H van Bakel L Pena-Castillo D Tillo K Tsui CD Carlson AJ Gossett MJ Hasinoff CL Warren M Gebbia S Talukder A Yang S Mnaimneh D Terterov D Coburn A Li Yeo ZX Yeo ND Clarke JD Lieb AZ Ansari C Nislow TR Hughes 2008 A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters Mol Cell 32 878 887 1:CAS:528:DC%2BD1MXjtFGltQ%3D%3D 19111667
14. NC Barbet U Schneider SB Helliwell I Stansfield MF Tuite MN Hall 1996 TOR controls translation initiation and early G1 progression in yeast Mol Biol Cell 7 25 42 1:CAS:528:DyaK28XnvVyitQ%3D%3D 8741837
15. M Batlle A Lu DA Green Y Xue JP Hirsch 2003 Krh1p and Krh2p act downstream of the Gpa2p G(alpha) subunit to negatively regulate haploid invasive growth J Cell Sci 116 701 710 1:CAS:528:DC%2BD3sXhvVOkurw%3D 12538771
16. T Beck MN Hall 1999 The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors Nature 402 689 692 1:CAS:528:DC%2BD3cXjvVSh 10604478
17. T Beck A Schmidt MN Hall 1999 Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast J Cell Biol 146 1227 1238 1:CAS:528:DyaK1MXmt1Gnsrs%3D 10491387
18. D Berchtold TC Walther 2009 TORC2 plasma membrane localization is essential for cell viability and restricted to a distinct domain Mol Biol Cell 20 1565 1575 1:CAS:528:DC%2BD1MXlsFyisLs%3D 19144819
19. AB Berger L Decourty G Badis U Nehrbass A Jacquier O Gadal 2007 Hmo1 is required for TOR-dependent regulation of ribosomal protein gene transcription Mol Cell Biol 27 8015 8026 1:CAS:528:DC%2BD2sXhtlWmsrnP 17875934
20. C Berset H Trachsel M Altmann 1998 The TOR (target of rapamycin) signal transduction pathway regulates the stability of translation initiation factor eIF4G in the yeast Saccharomyces cerevisiae Proc Natl Acad Sci USA 95 4264 4269 1:CAS:528:DyaK1cXis1OhtLc%3D 9539725
21. PG Bertram JH Choi J Carvalho TF Chan W Ai XF Zheng 2002 Convergence of TOR-nitrogen and Snf1-glucose signaling pathways onto Gln3 Mol Cell Biol 22 1246 1252 1:CAS:528:DC%2BD38XovVajsg%3D%3D 11809814
22. M Beullens K Mbonyi L Geerts D Gladines K Detremerie AW Jans JM Thevelein 1988 Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae Eur J Biochem 172 227 231 1:CAS:528:DyaL1cXht1yhu70%3D 2831059
23. N Bharucha J Ma CJ Dobry SK Lawson Z Yang A Kumar 2008 Analysis of the yeast kinome reveals a network of regulated protein localization during filamentous growth Mol Biol Cell 19 2708 2717 1:CAS:528:DC%2BD1cXoslWitrs%3D 18417610
24. LT Bhoite DJ Stillman 1998 Residues in the Swi5 zinc finger protein that mediate cooperative DNA binding with the Pho2 homeodomain protein Mol Cell Biol 18 6436 6446 1:CAS:528:DyaK1cXmvF2gu7k%3D 9774660
25. LT Bhoite JM Allen E Garcia LR Thomas ID Gregory WP Voth K Whelihan RJ Rolfes DJ Stillman 2002 Mutations in the pho2 (bas2) transcription factor that differentially affect activation with its partner proteins bas1, pho4, and swi5 J Biol Chem 277 37612 37618 1:CAS:528:DC%2BD38XnsVejsb4%3D 12145299
26. M Bickle PA Delley A Schmidt MN Hall 1998 Cell wall integrity modulates RHO1 activity via the exchange factor ROM2 EMBO J 17 2235 2245 1:CAS:528:DyaK1cXivFOmsb0%3D 9545237
27. M Binda MP Peli-Gulli G Bonfils N Panchaud J Urban TW Sturgill R Loewith C De Virgilio 2009 The Vam6 GEF controls TORC1 by activating the EGO complex Mol Cell 35 563 573 1:CAS:528:DC%2BD1MXhsVChsr3P 19748353
28. LM Boustany MS Cyert 2002 Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site Genes Dev 16 608 619 1:CAS:528:DC%2BD38XitVWltbs%3D 11877380
29. E Boy-Marcotte M Perrot F Bussereau H Boucherie M Jacquet 1998 Msn2p and Msn4p control a large number of genes induced at the diauxic transition which are repressed by cyclic AMP in Saccharomyces cerevisiae J Bacteriol 180 1044 1052 1:CAS:528:DyaK1cXhsFyjuro%3D 9495741
30. D Broek T Toda T Michaeli L Levin C Birchmeier M Zoller S Powers M Wigler 1987 The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway Cell 48 789 799 1:CAS:528:DyaL1cXhs1agsrY%3D 3545497
31. AW Bruun I Svendsen SO Sorensen MC Kielland-Brandt JR Winther 1998 A high-affinity inhibitor of yeast carboxypeptidase Y is encoded by TFS1 and shows homology to a family of lipid binding proteins Biochemistry 37 3351 3357 1:CAS:528:DyaK1cXhtFejsro%3D 9521655
32. YV Budovskaya JS Stephan F Reggiori DJ Klionsky PK Herman 2004 The Ras/cAMP-dependent protein kinase signaling pathway regulates an early step of the autophagy process in Saccharomyces cerevisiae J Biol Chem 279 20663 20671 1:CAS:528:DC%2BD2cXjvV2nsrw%3D 15016820
33. YV Budovskaya JS Stephan SJ Deminoff PK Herman 2005 An evolutionary proteomics approach identifies substrates of the cAMP-dependent protein kinase Proc Natl Acad Sci USA 102 13933 13938 1:CAS:528:DC%2BD2MXhtVOqsbjI 16172400
34. RA Butow NG Avadhani 2004 Mitochondrial signaling: the retrograde response Mol Cell 14 1 15 1:CAS:528:DC%2BD2cXjvVaqsbs%3D 15068799
35. R Caesar A Blomberg 2004 The stress-induced Tfs1p requires NatB-mediated acetylation to inhibit carboxypeptidase Y and to regulate the protein kinase A pathway J Biol Chem 279 38532 38543 1:CAS:528:DC%2BD2cXnt1Oqtbs%3D 15229224
36. R Cafferkey PR Young MM McLaughlin DJ Bergsma Y Koltin GM Sathe L Faucette WK Eng RK Johnson GP Livi 1993 Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity Mol Cell Biol 13 6012 6023 1:CAS:528: DyaK2cXksFCgsQ%3D%3D 8413204
37. E Cameroni N Hulo J Roosen J Winderickx C De Virgilio 2004 The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms Cell Cycle 3 462 468 1:CAS:528:DC%2BD2cXhtVSis77L 15300954
38. JH Camonis M Jacquet 1988 A new RAS mutation that suppresses the CDC25 gene requirement for growth of Saccharomyces cerevisiae Mol Cell Biol 8 2980 2983 1:CAS:528:DyaL1cXks1yjurk%3D 3043203
39. C Camus E Boy-Marcotte M Jacquet 1994 Two subclasses of guanine exchange factor (GEF) domains revealed by comparison of activities of chimeric genes constructed from CDC25, SDC25 and BUD5 in Saccharomyces cerevisiae Mol Gen Genet 245 167 176 1:CAS:528:DyaK2MXjvFGlsLk%3D 7816024
40. ME Cardenas J Heitman 1995 FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity EMBO J 14 5892 5907 1:CAS:528:DyaK2MXhtVSmurrN 8846782
41. ME Cardenas NS Cutler MC Lorenz CJ Di Como J Heitman 1999 The TOR signaling cascade regulates gene expression in response to nutrients Genes Dev 13 3271 3279 1:CAS:528:DC%2BD3cXktFChug%3D%3D 10617575
42. A Casamayor PD Torrance T Kobayashi J Thorner DR Alessi 1999 Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast Curr Biol 9 186 197 1:CAS:528:DyaK1MXhsFyrsb8%3D 10074427
43. GF Casperson N Walker AR Brasier HR Bourne 1983 A guanine nucleotide-sensitive adenylate cyclase in the yeast Saccharomyces cerevisiae J Biol Chem 258 7911 7914 1:CAS:528:DyaL3sXksV2nu7c%3D 6345532
44. GF Casperson N Walker HR Bourne 1985 Isolation of the gene encoding adenylate cyclase in Saccharomyces cerevisiae Proc Natl Acad Sci USA 82 5060 5063 1:CAS:528:DyaL2MXltlKgtbY%3D 2991907
45. P Cazzaniga D Pescini D Besozzi G Mauri S Colombo E Martegani 2008 Modeling and stochastic simulation of the Ras/cAMP/PKA pathway in the yeast Saccharomyces cerevisiae evidences a key regulatory function for intracellular guanine nucleotides pools J Biotechnol 133 377 385 1:CAS:528: DC%2BD1cXhtlensw%3D%3D 18023904
46. JL Celenza M Carlson 1989 Mutational analysis of the Saccharomyces cerevisiae SNF1 protein kinase and evidence for functional interaction with the SNF4 protein Mol Cell Biol 9 5034 5044 1:CAS:528:DyaK3cXhvVal 2557546 (Pubitemid 19275974)
47. JL Celenza FJ Eng M Carlson 1989 Molecular analysis of the SNF4 gene of Saccharomyces cerevisiae: evidence for physical association of the SNF4 protein with the SNF1 protein kinase Mol Cell Biol 9 5045 5054 1:CAS:528: DyaK3cXhtFehu7g%3D 2481228 (Pubitemid 19275975)
48. YY Chang G Juhasz P Goraksha-Hicks AM Arsham DR Mallin LK Muller TP Neufeld 2009 Nutrient-dependent regulation of autophagy through the target of rapamycin pathway Biochem Soc Trans 37 232 236 1:CAS:528:DC%2BD1MXotVWlsQ%3D%3D 19143638
49. H Chautard M Jacquet F Schoentgen N Bureaud H Benedetti 2004 Tfs1p, a member of the PEBP family, inhibits the Ira2p but not the Ira1p Ras GTPase-activating protein in Saccharomyces cerevisiae Eukaryot Cell 3 459 470 1:CAS:528:DC%2BD2cXjtlKqsrc%3D 15075275
50. EJ Chen CA Kaiser 2002 Amino acids regulate the intracellular trafficking of the general amino acid permease of Saccharomyces cerevisiae Proc Natl Acad Sci USA 99 14837 14842 1:CAS:528:DC%2BD38Xpt1yrt74%3D 12417748
51. EJ Chen CA Kaiser 2003 LST8 negatively regulates amino acid biosynthesis as a component of the TOR pathway J Cell Biol 161 333 347 1:CAS:528: DC%2BD3sXjtl2isbs%3D 12719473
52. VA Cherkasova AG Hinnebusch 2003 Translational control by TOR and TAP42 through dephosphorylation of eIF2alpha kinase GCN2 Genes Dev 17 859 872 1:CAS:528:DC%2BD3sXislOltrw%3D 12654728
53. C Chevtzoff J Vallortigara N Averet M Rigoulet A Devin 2005 The yeast cAMP protein kinase Tpk3p is involved in the regulation of mitochondrial enzymatic content during growth Biochim Biophys Acta 1706 117 125 1:CAS:528:DC%2BD2cXhtFGht7%2FI 15620372
54. JA Claypool SL French K Johzuka K Eliason L Vu JA Dodd AL Beyer M Nomura 2004 Tor pathway regulates Rrn3p-dependent recruitment of yeast RNA polymerase I to the promoter but does not participate in alteration of the number of active genes Mol Biol Cell 15 946 956 1:CAS:528:DC%2BD2cXhtlGlsrc%3D 14595104
55. JA Coffman R Rai TG Cooper 1995 Genetic evidence for Gln3p-independent, nitrogen catabolite repression-sensitive gene expression in Saccharomyces cerevisiae J Bacteriol 177 6910 6918 1:CAS:528:DyaK2MXpsFKrtbY%3D 7592485
56. JA Coffman R Rai T Cunningham V Svetlov TG Cooper 1996 Gat1p, a GATA family protein whose production is sensitive to nitrogen catabolite repression, participates in transcriptional activation of nitrogen-catabolic genes in Saccharomyces cerevisiae Mol Cell Biol 16 847 858 1:CAS:528:DyaK28XhtFOmurY%3D 8622686
57. JA Coffman R Rai DM Loprete T Cunningham V Svetlov TG Cooper 1997 Cross regulation of four GATA factors that control nitrogen catabolic gene expression in Saccharomyces cerevisiae J Bacteriol 179 3416 3429 1:CAS:528: DyaK2sXjsF2jtb0%3D 9171383
58. A Cohen N Perzov H Nelson N Nelson 1999 A novel family of yeast chaperons involved in the distribution of V-ATPase and other membrane proteins J Biol Chem 274 26885 26893 1:CAS:528:DyaK1MXmt1aksLs%3D 10480897
59. S Colombo P Ma L Cauwenberg J Winderickx M Crauwels A Teunissen D Nauwelaers JH de Winde MF Gorwa D Colavizza JM Thevelein 1998 Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae EMBO J 17 3326 3341 1:CAS:528:DyaK1cXksFClt7c%3D 9628870
60. S Colombo D Ronchetti JM Thevelein J Winderickx E Martegani 2004 Activation state of the Ras2 protein and glucose-induced signaling in Saccharomyces cerevisiae J Biol Chem 279 46715 46722 1:CAS:528: DC%2BD2cXptFaqurg%3D 15339905
61. TG Cooper 2002 Transmitting the signal of excess nitrogen in Saccharomyces cerevisiae from the Tor proteins to the GATA factors: connecting the dots FEMS Microbiol Rev 26 223 238 1:CAS:528:DC%2BD38XmtVamsr8%3D 12165425
62. MN Corradetti KL Guan 2006 Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 25 6347 6360 1:CAS:528: DC%2BD28XhtVOlsrrM 17041621
63. M Crauwels MC Donaton MB Pernambuco J Winderickx JH de Winde JM Thevelein 1997 The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway Microbiology 143 Pt 8 2627 2637 1:CAS:528:DyaK2sXls1yjtLw%3D 9274016
64. M Crauwels J Winderickx JH de Winde JM Thevelein 1997 Identification of genes with nutrient-controlled expression by PCR-mapping in the yeast Saccharomyces cerevisiae Yeast 13 973 984 1:CAS:528:DyaK2sXltlGmsb8%3D 9271111
65. JL Crespo T Powers B Fowler MN Hall 2002 The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine Proc Natl Acad Sci USA 99 6784 6789 1:CAS:528: DC%2BD38XjvFCrt7g%3D 11997479
66. M Cytrynska M Frajnt T Jakubowicz 2001 Saccharomyces cerevisiae pyruvate kinase Pyk1 is PKA phosphorylation substrate in vitro FEMS Microbiol Lett 203 223 227 1:CAS:528:DC%2BD3MXnt1Shsbs%3D 11583852
67. B Daignan-Fornier GR Fink 1992 Coregulation of purine and histidine biosynthesis by the transcriptional activators BAS1 and BAS2 Proc Natl Acad Sci USA 89 6746 6750 1:CAS:528:DyaK38XmtVKhsL0%3D 1495962
68. P Danaie M Altmann MN Hall H Trachsel SB Helliwell 1999 CLN3 expression is sufficient to restore G1-to-S-phase progression in Saccharomyces cerevisiae mutants defective in translation initiation factor eIF4E Biochem J 340 Pt 1 135 141 1:CAS:528:DyaK1MXjs12ksrw%3D 10229668
69. JO De Craene O Soetens B Andre 2001 The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease J Biol Chem 276 43939 43948 11500493 (Pubitemid 37383963)
70. C De Virgilio R Loewith 2006 Cell growth control: little eukaryotes make big contributions Oncogene 25 6392 6415 17041625
71. C De Virgilio R Loewith 2006 The TOR signalling network from yeast to man Int J Biochem Cell Biol 38 1476 1481 16647875
72. MJ De Vit M Johnston 1999 The nuclear exportin Msn5 is required for nuclear export of the Mig1 glucose repressor of Saccharomyces cerevisiae Curr Biol 9 1231 1241
73. MJ De Vit JA Waddle M Johnston 1997 Regulated nuclear translocation of the Mig1 glucose repressor Mol Biol Cell 8 1603 1618 9285828
74. JH De Winde M Crauwels S Hohmann JM Thevelein J Winderickx 1996 Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state Eur J Biochem 241 633 643 8917466
75. G Devasahayam D Ritz SB Helliwell DJ Burke TW Sturgill 2006 Pmr1, a Golgi Ca2+/Mn2+-ATPase, is a regulator of the target of rapamycin (TOR) signaling pathway in yeast Proc Natl Acad Sci USA 103 17840 17845 1:CAS:528: DC%2BD28Xht1Knu77P 17095607
76. G Devasahayam DJ Burke TW Sturgill 2007 Golgi manganese transport is required for rapamycin signaling in Saccharomyces cerevisiae Genetics 177 231 238 1:CAS:528:DC%2BD2sXhtlaksLvE 17603109
77. TE Dever L Feng RC Wek AM Cigan TF Donahue AG Hinnebusch 1992 Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast Cell 68 585 596 1:CAS:528:DyaK38XhsVOrtrw%3D 1739968
78. CJ Di Como KT Arndt 1996 Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases Genes Dev 10 1904 1916 8756348
79. H Dihazi R Kessler K Eschrich 2003 Glucose-induced stimulation of the Ras-cAMP pathway in yeast leads to multiple phosphorylations and activation of 6-phosphofructo-2-kinase Biochemistry 42 6275 6282 1:CAS:528: DC%2BD3sXjsVSgs7k%3D 12755632
80. I Dilova CY Chen T Powers 2002 Mks1 in concert with TOR signaling negatively regulates RTG target gene expression in S. cerevisiae Curr Biol 12 389 395 1:CAS:528:DC%2BD38XhvVCns7c%3D 11882290
81. I Dilova S Aronova JC Chen T Powers 2004 Tor signaling and nutrient-based signals converge on Mks1p phosphorylation to regulate expression of Rtg1.Rtg3p-dependent target genes J Biol Chem 279 46527 46535 1:CAS:528:DC%2BD2cXptFaqtL8%3D 15326168
82. F Dubouloz O Deloche V Wanke E Cameroni C De Virgilio 2005 The TOR and EGO protein complexes orchestrate microautophagy in yeast Mol Cell 19 15 26 1:CAS:528:DC%2BD2MXmsVejsbY%3D 15989961
83. K Duvel JR Broach 2004 The role of phosphatases in TOR signaling in yeast Curr Top Microbiol Immunol 279 19 38 1:STN:280:DC%2BD3svot1Cksw%3D%3D 14560949
84. K Duvel A Santhanam S Garrett L Schneper JR Broach 2003 Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast Mol Cell 11 1467 1478 12820961
85. KD Entian 1980 Genetic and biochemical evidence for hexokinase PII as a key enzyme involved in carbon catabolite repression in yeast Mol Gen Genet 178 633 637 1:CAS:528:DyaL3cXkvFWlu7g%3D 6993859
86. KD Entian FK Zimmermann 1980 Glycolytic enzymes and intermediates in carbon catabolite repression mutants of Saccharomyces cerevisiae Mol Gen Genet 177 345 350 1:CAS:528:DyaL3cXhs1ShtrY%3D 6988675
87. F Estruch M Carlson 1993 Two homologous zinc finger genes identified by multicopy suppression in a SNF1 protein kinase mutant of Saccharomyces cerevisiae Mol Cell Biol 13 3872 3881 1:CAS:528:DyaK3sXmsVagtLg%3D 8321194
88. F Estruch MA Treitel X Yang M Carlson 1992 N-terminal mutations modulate yeast SNF1 protein kinase function Genetics 132 639 650 1:CAS:528: DyaK3sXhs1eqsL0%3D 1468623
89. M Fadri A Daquinag S Wang T Xue J Kunz 2005 The pleckstrin homology domain proteins Slm1 and Slm2 are required for actin cytoskeleton organization in yeast and bind phosphatidylinositol-4,5-bisphosphate and TORC2 Mol Biol Cell 16 1883 1900 1:CAS:528:DC%2BD2MXjt1Kqtb4%3D 15689497
90. E Fayard LA Tintignac A Baudry BA Hemmings 2005 Protein kinase B/Akt at a glance J Cell Sci 118 5675 5678 1:CAS:528:DC%2BD28XosFemsw%3D%3D 16339964
91. SB Ferguson ES Anderson RB Harshaw T Thate NL Craig HC Nelson 2005 Protein kinase A regulates constitutive expression of small heat-shock genes in an Msn2/4p-independent and Hsf1p-dependent manner in Saccharomyces cerevisiae Genetics 169 1203 1214 1:CAS:528:DC%2BD2MXktFCqurs%3D 15545649
92. J Field J Nikawa D Broek B MacDonald L Rodgers IA Wilson RA Lerner M Wigler 1988 Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method Mol Cell Biol 8 2159 2165 1:CAS:528:DyaL1cXktVart7s%3D 2455217
93. JS Flick J Thorner 1998 An essential function of a phosphoinositide- specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae Genetics 148 33 47 1:CAS:528:DyaK1cXovFyqtw%3D%3D 9475719
94. H Forsberg PO Ljungdahl 2001 Sensors of extracellular nutrients in Saccharomyces cerevisiae Curr Genet 40 91 109 1:CAS:528:DC%2BD3MXmvVehtbs%3D 11680826
95. S Friant R Lombardi T Schmelzle MN Hall H Riezman 2001 Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast EMBO J 20 6783 6792 1:CAS:528:DC%2BD3MXptVaqtb0%3D 11726514
96. T Funakoshi A Matsuura T Noda Y Ohsumi 1997 Analyses of APG13 gene involved in autophagy in yeast, Saccharomyces cerevisiae Gene 192 207 213 1:CAS:528:DyaK2sXjsVersrc%3D 9224892
97. JM Gancedo 1998 Yeast carbon catabolite repression Microbiol Mol Biol Rev 62 334 361 1:CAS:528:DyaK1cXkt1OitLY%3D 9618445
98. JM Gancedo 2008 The early steps of glucose signalling in yeast FEMS Microbiol Rev 32 673 704 1:CAS:528:DC%2BD1cXotVyhtL0%3D 18559076
99. JM Gancedo MJ Mazon C Gancedo 1983 Fructose 2,6-bisphosphate activates the cAMP-dependent phosphorylation of yeast fructose-1,6-bisphosphatase in vitro J Biol Chem 258 5998 5999 1:CAS:528:DyaL3sXktFyltrc%3D 6304022
100. S Gander D Bonenfant P Altermatt DE Martin S Hauri S Moes MN Hall P Jenoe 2008 Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase Rapid Commun Mass Spectrom 22 3743 3753 1:CAS:528:DC%2BD1cXhsV2qtb7P 18980262
101. M Gao CA Kaiser 2006 A conserved GTPase-containing complex is required for intracellular sorting of the general amino-acid permease in yeast Nat Cell Biol 8 657 667 1:CAS:528:DC%2BD28XmsVentLY%3D 16732272
102. H Garreau RN Hasan G Renault F Estruch E Boy-Marcotte M Jacquet 2000 Hyperphosphorylation of Msn2p and Msn4p in response to heat shock and the diauxic shift is inhibited by cAMP in Saccharomyces cerevisiae Microbiology 146 Pt 9 2113 2120 1:CAS:528:DC%2BD3cXmslGksbY%3D 10974099
103. S Garrett J Broach 1989 Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAKI, whose product may act downstream of the cAMP-dependent protein kinase Genes Dev 3 1336 1348 1:CAS:528:DyaK3cXhtFehtbg%3D 2558053
104. S Garrett MM Menold JR Broach 1991 The Saccharomyces cerevisiae YAK1 gene encodes a protein kinase that is induced by arrest early in the cell cycle Mol Cell Biol 11 4045 4052 1:CAS:528:DyaK3MXlsFahtL8%3D 2072907
105. AP Gasch PT Spellman CM Kao O Carmel-Harel MB Eisen G Storz D Botstein PO Brown 2000 Genomic expression programs in the response of yeast cells to environmental changes Mol Biol Cell 11 4241 4257 1:CAS:528:DC%2BD3cXovFansbw%3D 11102521
106. S Gauthier F Coulpier L Jourdren M Merle S Beck M Konrad B Daignan-Fornier B Pinson 2008 Co-regulation of yeast purine and phosphate pathways in response to adenylic nucleotide variations Mol Microbiol 68 1583 1594 1:CAS:528:DC%2BD1cXntlWjt7Y%3D 18433446
107. I Georis JJ Tate TG Cooper E Dubois 2008 Tor pathway control of the nitrogen-responsive DAL5 gene bifurcates at the level of Gln3 and Gat1 regulation in Saccharomyces cerevisiae J Biol Chem 283 8919 8929 1:CAS:528:DC%2BD1cXjslyrtLs%3D 18245087
108. I Geyskens SHMC Kumara MCV Donaton JCT Bergsma JM Thevelein S Wera 2001 Expression of mammalian PKB complements deletion of the yeast protein kinase Sch9 Nato Sci Ser A 316 117 126
109. V Gilliquet G Berben 1993 Positive and negative regulators of the Saccharomyces cerevisiae 'PHO system' participate in several cell functions FEMS Microbiol Lett 108 333 339 1:CAS:528:DyaK3sXktVCktLk%3D 8099891
110. P Godard A Urrestarazu S Vissers K Kontos G Bontempi J van Helden B Andre 2007 Effect of 21 different nitrogen sources on global gene expression in the yeast Saccharomyces cerevisiae Mol Cell Biol 27 3065 3086 1:CAS:528: DC%2BD2sXkt1Ogtb4%3D 17308034
111. W Gorner E Durchschlag MT Martinez-Pastor F Estruch G Ammerer B Hamilton H Ruis C Schuller 1998 Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity Genes Dev 12 586 597 1:CAS:528:DyaK1cXhtlSnt7g%3D 9472026
112. W Gorner E Durchschlag J Wolf EL Brown G Ammerer H Ruis C Schuller 2002 Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor EMBO J 21 135 144 1:CAS:528:DC%2BD38XpsFCisQ%3D%3D 11782433
113. G Griffioen WH Mager RJ Planta 1994 Nutritional upshift response of ribosomal protein gene transcription in Saccharomyces cerevisiae FEMS Microbiol Lett 123 137 144 1:CAS:528:DyaK2cXmslKmsrk%3D 7988881
114. G Griffioen P Anghileri E Imre MD Baroni H Ruis 2000 Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae J Biol Chem 275 1449 1456 1:CAS:528:DC%2BD3cXntleksQ%3D%3D 10625697
115. G Griffioen P Branduardi A Ballarini P Anghileri J Norbeck MD Baroni H Ruis 2001 Nucleocytoplasmic distribution of budding yeast protein kinase A regulatory subunit Bcy1 requires Zds1 and is regulated by Yak1-dependent phosphorylation of its targeting domain Mol Cell Biol 21 511 523 1:CAS:528:DC%2BD3MXhsFyhtLY%3D 11134339
116. JS Hahn DJ Thiele 2004 Activation of the Saccharomyces cerevisiae heat shock transcription factor under glucose starvation conditions by Snf1 protein kinase J Biol Chem 279 5169 5176 1:CAS:528:DC%2BD2cXhtFeqsbw%3D 14612437
117. JS Hahn Z Hu DJ Thiele VR Iyer 2004 Genome-wide analysis of the biology of stress responses through heat shock transcription factor Mol Cell Biol 24 5249 5256 1:CAS:528:DC%2BD2cXkvFOqt78%3D 15169889
118. DB Hall JT Wade K Struhl 2006 An HMG protein, Hmo1, associates with promoters of many ribosomal protein genes and throughout the rRNA gene locus in Saccharomyces cerevisiae Mol Cell Biol 26 3672 3679 1:CAS:528: DC%2BD28XksVKksbk%3D 16612005
119. T Harashima J Heitman 2002 The Galpha protein Gpa2 controls yeast differentiation by interacting with kelch repeat proteins that mimic Gbeta subunits Mol Cell 10 163 173 1:CAS:528:DC%2BD38XmtFaktbk%3D 12150916
120. T Harashima J Heitman 2005 Galpha subunit Gpa2 recruits kelch repeat subunits that inhibit receptor-G protein coupling during cAMP-induced dimorphic transitions in Saccharomyces cerevisiae Mol Biol Cell 16 4557 4571 1:CAS:528:DC%2BD2MXhtVygtL7E 16030250
121. T Harashima S Anderson JR Yates 3rd J Heitman 2006 The kelch proteins Gpb1 and Gpb2 inhibit Ras activity via association with the yeast RasGAP neurofibromin homologs Ira1 and Ira2 Mol Cell 22 819 830 1:CAS:528: DC%2BD28XmvVCitLc%3D 16793550
122. DG Hardie 2007 AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy Nat Rev Mol Cell Biol 8 774 785 1:CAS:528:DC%2BD2sXhtVKmt7vP 17712357
123. JS Hardwick FG Kuruvilla JK Tong AF Shamji SL Schreiber 1999 Rapamycin-modulated transcription defines the subset of nutrient-sensitive signaling pathways directly controlled by the Tor proteins Proc Natl Acad Sci USA 96 14866 14870 1:CAS:528:DC%2BD3cXhtFantg%3D%3D 10611304
124. TA Hardy PJ Roach 1993 Control of yeast glycogen synthase-2 by COOH-terminal phosphorylation J Biol Chem 268 23799 23805 1:CAS:528: DyaK3sXlvFygsbs%3D 8226915
125. AD Hartley MP Ward S Garrett 1994 The Yak1 protein kinase of Saccharomyces cerevisiae moderates thermotolerance and inhibits growth by an Sch9 protein kinase-independent mechanism Genetics 136 465 474 1:CAS:528:DyaK2cXmt1KjsL0%3D 8150276
126. AM Healy S Zolnierowicz AE Stapleton M Goebl AA DePaoli-Roach JR Pringle 1991 CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase Mol Cell Biol 11 5767 5780 1:CAS:528: DyaK38XmsVKgsr8%3D 1656238
127. K Hedbacker M Carlson 2006 Regulation of the nucleocytoplasmic distribution of Snf1-Gal83 protein kinase Eukaryot Cell 5 1950 1956 1:CAS:528:DC%2BD28XhtlGrurzP 17071825
128. K Hedbacker M Carlson 2008 SNF1/AMPK pathways in yeast Front Biosci 13 2408 2420 1:CAS:528:DC%2BD1cXhs1Cgu78%3D 17981722
129. K Hedbacker SP Hong M Carlson 2004 Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase Mol Cell Biol 24 8255 8263 1:CAS:528:DC%2BD2cXnslCrtro%3D 15340085 (Pubitemid 39167473)
130. D Hedges M Proft KD Entian 1995 CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae Mol Cell Biol 15 1915 1922 1:CAS:528:DyaK2MXksFWjsbg%3D 7891685
131. J Heitman NR Movva MN Hall 1991 Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast Science 253 905 909 1:CAS:528: DyaK3MXlsl2hsr8%3D 1715094
132. SB Helliwell P Wagner J Kunz M Deuter-Reinhard R Henriquez MN Hall 1994 TOR1 and TOR2 are structurally and functionally similar but not identical phosphatidylinositol kinase homologues in yeast Mol Biol Cell 5 105 118 1:CAS:528:DyaK2cXlslWltbw%3D 8186460
133. SB Helliwell A Schmidt Y Ohya MN Hall 1998 The Rho1 effector Pkc1, but not Bni1, mediates signalling from Tor2 to the actin cytoskeleton Curr Biol 8 1211 1214 1:CAS:528:DyaK1cXnt1Grsrk%3D 9811607
134. SB Helliwell S Losko CA Kaiser 2001 Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease J Cell Biol 153 649 662 1:CAS:528:DC%2BD3MXjs1WgsL4%3D 11352928
135. P Herrero C Martinez-Campa F Moreno 1998 The hexokinase 2 protein participates in regulatory DNA-protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiae FEBS Lett 434 71 76 1:CAS:528:DyaK1cXlsl2msrc%3D 9738454
136. MH Herruer WH Mager LP Woudt RT Nieuwint GM Wassenaar P Groeneveld RJ Planta 1987 Transcriptional control of yeast ribosomal protein synthesis during carbon-source upshift Nucleic Acids Res 15 10133 10144 1:CAS:528: DyaL1cXhtV2gurY%3D 3320961
137. M Hiesinger S Roth E Meissner HJ Schuller 2001 Contribution of Cat8 and Sip4 to the transcriptional activation of yeast gluconeogenic genes by carbon source-responsive elements Curr Genet 39 68 76 1:CAS:528:DC%2BD3MXivFaisrg%3D 11405098
138. AG Hinnebusch 2005 Translational regulation of GCN4 and the general amino acid control of yeast Annu Rev Microbiol 59 407 450 1:CAS:528: DC%2BD2MXht1ShsL7N 16153175
139. HL Ho HY Lee HC Liao MY Chen 2008 Involvement of Saccharomyces cerevisiae Avo3p/Tsc11p in maintaining TOR complex 2 integrity and coupling to downstream signaling Eukaryot Cell 7 1328 1343 1:CAS:528:DC%2BD1cXhtVWrsb%2FO 18552287
140. S Hohmann J Winderickx JH de Winde D Valckx P Cobbaert K Luyten C de Meirsman J Ramos JM Thevelein 1999 Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2 Microbiology 145 Pt 3 703 714 1:CAS:528:DyaK1MXitFegtLg%3D 10217505
141. S Hohmann M Krantz B Nordlander 2007 Yeast osmoregulation Methods Enzymol 428 29 45 1:CAS:528:DC%2BD1cXhtlCju7k%3D 17875410
142. I Holsbeeks O Lagatie A Van Nuland S Van de Velde JM Thevelein 2004 The eukaryotic plasma membrane as a nutrient-sensing device Trends Biochem Sci 29 556 564 1:CAS:528:DC%2BD2cXnvVOhs7g%3D 15450611
143. SP Hong M Momcilovic M Carlson 2005 Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast J Biol Chem 280 21804 21809 1:CAS:528:DC%2BD2MXksl2iu7g%3D 15831494
144. S Huang EK O'Shea 2005 A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation Genetics 169 1859 1871 1:CAS:528:DC%2BD2MXlt12qtLw%3D 15695358
145. D Huang KT Chun MG Goebl PJ Roach 1996 Genetic interactions between REG1/HEX2 and GLC7, the gene encoding the protein phosphatase type 1 catalytic subunit in Saccharomyces cerevisiae Genetics 143 119 127 1:CAS:528: DyaK28XjtVGqurY%3D 8722767
146. S Huang DA Jeffery MD Anthony EK O'Shea 2001 Functional analysis of the cyclin-dependent kinase inhibitor Pho81 identifies a novel inhibitory domain Mol Cell Biol 21 6695 6705 1:CAS:528:DC%2BD3MXmvFGhtrs%3D 11533256
147. D Huang J Moffat B Andrews 2002 Dissection of a complex phenotype by functional genomics reveals roles for the yeast cyclin-dependent protein kinase Pho85 in stress adaptation and cell integrity Mol Cell Biol 22 5076 5088 1:CAS:528:DC%2BD38XltVOqtr0%3D 12077337
148. D Huang H Friesen B Andrews 2007 Pho85, a multifunctional cyclin-dependent protein kinase in budding yeast Mol Microbiol 66 303 314 1:CAS:528:DC%2BD2sXht1Wks7jM 17850263 (Pubitemid 47482378)
149. K Huang I Ferrin-O'Connell W Zhang GA Leonard EK O'Shea FA Quiocho 2007 Structure of the Pho85-Pho80 CDK-cyclin complex of the phosphate-responsive signal transduction pathway Mol Cell 28 614 623 1:CAS:528:DC%2BD2sXhsVGmurvJ 18042456
150. A Huber B Bodenmiller A Uotila M Stahl S Wanka B Gerrits R Aebersold R Loewith 2009 Characterization of the rapamycin-sensitive phosphoproteome reveals that Sch9 is a central coordinator of protein synthesis Genes Dev 23 1929 1943 1:CAS:528:DC%2BD1MXhtVegurbI 19684113
151. HC Hurlimann M Stadler-Waibel TP Werner FM Freimoser 2007 Pho91 Is a vacuolar phosphate transporter that regulates phosphate and polyphosphate metabolism in Saccharomyces cerevisiae Mol Biol Cell 18 4438 4445 1:CAS:528:DC%2BD2sXht12js73F 17804816
152. HC Hurlimann B Pinson M Stadler-Waibel SC Zeeman FM Freimoser 2009 The SPX domain of the yeast low-affinity phosphate transporter Pho90 regulates transport activity EMBO Rep 10 1003 1008 1:CAS:528:DC%2BD1MXotlegtrs%3D 19590579
153. R Iyengar 1996 Gating by cyclic AMP: expanded role for an old signaling pathway Science 271 461 463 1:CAS:528:DyaK28XmvFyksw%3D%3D 8560257
154. E Jacinto B Guo KT Arndt T Schmelzle MN Hall 2001 TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway Mol Cell 8 1017 1026 1:CAS:528:DC%2BD3MXovFOit7s%3D 11741537
155. Y Jiang JR Broach 1999 Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast EMBO J 18 2782 2792 1:CAS:528:DyaK1MXjslemsbY%3D 10329624
156. R Jiang M Carlson 1996 Glucose regulates protein interactions within the yeast SNF1 protein kinase complex Genes Dev 10 3105 3115 1:CAS:528: DyaK2sXjsV2isA%3D%3D 8985180
157. R Jiang M Carlson 1997 The Snf1 protein kinase and its activating subunit, Snf4, interact with distinct domains of the Sip1/Sip2/Gal83 component in the kinase complex Mol Cell Biol 17 2099 2106 1:CAS:528:DyaK2sXhvFOhsr8%3D 9121458
158. S Jones ML Vignais JR Broach 1991 The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to ras Mol Cell Biol 11 2641 2646 1:CAS:528:DyaK3MXktVentL8%3D 2017169
159. JD Jordan R Iyengar 1998 Modes of interactions between signaling pathways Biochem Pharmacol 55 1347 1352 1:CAS:528:DyaK1cXislemsLg%3D 10076524
160. P Jorgensen JL Nishikawa BJ Breitkreutz M Tyers 2002 Systematic identification of pathways that couple cell growth and division in yeast Science 297 395 400 1:CAS:528:DC%2BD38Xls1Cju7k%3D 12089449
161. P Jorgensen I Rupes JR Sharom L Schneper JR Broach M Tyers 2004 A dynamic transcriptional network communicates growth potential to ribosome synthesis and critical cell size Genes Dev 18 2491 2505 1:CAS:528:DC%2BD2cXovVynsrw%3D 15466158
162. KA Kafadar MS Cyert 2004 Integration of stress responses: modulation of calcineurin signaling in Saccharomyces cerevisiae by protein kinase A Eukaryot Cell 3 1147 1153 1:CAS:528:DC%2BD2cXptFaisrg%3D 15470242
163. KA Kafadar H Zhu M Snyder MS Cyert 2003 Negative regulation of calcineurin signaling by Hrr25p, a yeast homolog of casein kinase I Genes Dev 17 2698 2708 1:CAS:528:DC%2BD3sXovVahtLw%3D 14597664
164. A Kaffman NM Rank EM O'Neill LS Huang EK O'Shea 1998 The receptor Msn5 exports the phosphorylated transcription factor Pho4 out of the nucleus Nature 396 482 486 1:CAS:528:DyaK1cXotVSitbk%3D 9853758
165. A Kaffman NM Rank EK O'Shea 1998 Phosphorylation regulates association of the transcription factor Pho4 with its import receptor Pse1/Kap121 Genes Dev 12 2673 2683 1:CAS:528:DyaK1cXlvFKqtb4%3D 9732266
166. Y Kamada T Funakoshi T Shintani K Nagano M Ohsumi Y Ohsumi 2000 Tor-mediated induction of autophagy via an Apg1 protein kinase complex J Cell Biol 150 1507 1513 1:CAS:528:DC%2BD3cXmslGlsr4%3D 10995454
167. Y Kamada Y Fujioka NN Suzuki F Inagaki S Wullschleger R Loewith MN Hall Y Ohsumi 2005 Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization Mol Cell Biol 25 7239 7248 1:CAS:528:DC%2BD2MXhtVejs7%2FN 16055732
168. T Kataoka D Broek M Wigler 1985 DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase Cell 43 493 505 1:CAS:528:DyaL28Xmtlamsg%3D%3D 2934138
169. CT Keith SL Schreiber 1995 PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints Science 270 50 51 1:CAS:528: DyaK2MXosFOms7g%3D 7569949
170. CA Keleher MJ Redd J Schultz M Carlson AD Johnson 1992 Ssn6-Tup1 is a general repressor of transcription in yeast Cell 68 709 719 1:CAS:528: DyaK38Xhs1Oktbc%3D 1739976
171. EM Kim YK Jang SD Park 2002 Phosphorylation of Rph1, a damage-responsive repressor of PHR1 in Saccharomyces cerevisiae, is dependent upon Rad53 kinase Nucleic Acids Res 30 643 648 1:CAS:528:DC%2BD38XhsVyhsbw%3D 11809875
172. MD Kim SP Hong M Carlson 2005 Role of Tos3, a Snf1 protein kinase kinase, during growth of Saccharomyces cerevisiae on nonfermentable carbon sources Eukaryot Cell 4 861 866 1:CAS:528:DC%2BD2MXksFalsbk%3D 15879520
173. E Kim P Goraksha-Hicks L Li TP Neufeld KL Guan 2008 Regulation of TORC1 by Rag GTPases in nutrient response Nat Cell Biol 10 935 945 1:CAS:528:DC%2BD1cXpt1SmtLc%3D 18604198
174. DJ Klionsky SD Emr 1989 Membrane protein sorting: biosynthesis, transport and processing of yeast vacuolar alkaline phosphatase EMBO J 8 2241 2250 1:CAS:528:DyaL1MXkvFeksbY%3D 2676517
175. JP Knight TM Daly LW Bergman 2004 Regulation by phosphorylation of Pho81p, a cyclin-dependent kinase inhibitor in Saccharomyces cerevisiae Curr Genet 46 10 19 1:CAS:528:DC%2BD2cXltVGls7k%3D 15127225
176. A Komeili KP Wedaman EK O'Shea T Powers 2000 Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors J Cell Biol 151 863 878 1:CAS:528:DC%2BD3cXotFens7c%3D 11076970
177. M Konrad 1988 Analysis and in vivo disruption of the gene coding for adenylate kinase (ADK1) in the yeast Saccharomyces cerevisiae J Biol Chem 263 19468 19474 1:CAS:528:DyaL1cXmt1ekuro%3D 2848829
178. LS Kraakman G Griffioen S Zerp P Groeneveld JM Thevelein WH Mager RJ Planta 1993 Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae Mol Gen Genet 239 196 204 1:CAS:528:DyaK3sXltlarsbY%3D 8389977
179. L Kraakman K Lemaire P Ma AW Teunissen MC Donaton P Van Dijck J Winderickx JH de Winde JM Thevelein 1999 A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose Mol Microbiol 32 1002 1012 1:CAS:528:DyaK1MXjvVSmsL4%3D 10361302
180. LS Kraakman J Winderickx JM Thevelein JH De Winde 1999 Structure-function analysis of yeast hexokinase: structural requirements for triggering cAMP signalling and catabolite repression Biochem J 343 159 168 1:CAS:528: DyaK1MXmvVyju74%3D 10493925
181. E Kubler HU Mosch S Rupp MP Lisanti 1997 Gpa2p, a G-protein alpha-subunit, regulates growth and pseudohyphal development in Saccharomyces cerevisiae via a cAMP-dependent mechanism J Biol Chem 272 20321 20323 1:CAS:528:DyaK2sXlsFKhsbo%3D 9252333
182. H Kubota T Obata K Ota T Sasaki T Ito 2003 Rapamycin-induced translational derepression of GCN4 mRNA involves a novel mechanism for activation of the eIF2 alpha kinase GCN2 J Biol Chem 278 20457 20460 1:CAS:528:DC%2BD3sXkt1Wjtb0%3D 12676950
183. L Kuepfer M Peter U Sauer J Stelling 2007 Ensemble modeling for analysis of cell signaling dynamics Nat Biotechnol 25 1001 1006 1:CAS:528: DC%2BD2sXhtVWksLjM 17846631
184. J Kunz R Henriquez U Schneider M Deuter-Reinhard NR Movva MN Hall 1993 Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression Cell 73 585 596 1:CAS:528:DyaK3sXks1OqtrY%3D 8387896
185. J Kunz U Schneider I Howald A Schmidt MN Hall 2000 HEAT repeats mediate plasma membrane localization of Tor2p in yeast J Biol Chem 275 37011 37020 1:CAS:528:DC%2BD3cXoslWlsbs%3D 10973982
186. J Kuret KE Johnson C Nicolette MJ Zoller 1988 Mutagenesis of the regulatory subunit of yeast cAMP-dependent protein kinase. Isolation of site-directed mutants with altered binding affinity for catalytic subunit J Biol Chem 263 9149 9154 1:CAS:528:DyaL1cXks1yjt7k%3D 3288630
187. FG Kuruvilla AF Shamji SL Schreiber 2001 Carbon- and nitrogen-quality signaling to translation are mediated by distinct GATA-type transcription factors Proc Natl Acad Sci USA 98 7283 7288 1:CAS:528:DC%2BD3MXkslWmtb8%3D 11416207
188. K Lecoq I Belloc C Desgranges B Daignan-Fornier 2001 Role of adenosine kinase in Saccharomyces cerevisiae: identification of the ADO1 gene and study of the mutant phenotypes Yeast 18 335 342 1:CAS:528:DC%2BD3MXitFGqtbs%3D 11223943
189. M Lee S O'Regan JL Moreau AL Johnson LH Johnston CR Goding 2000 Regulation of the Pcl7-Pho85 cyclin-cdk complex by Pho81 Mol Microbiol 38 411 422 1:CAS:528:DC%2BD3cXotVGqtLc%3D 11069666
190. TI Lee NJ Rinaldi F Robert DT Odom Z Bar-Joseph GK Gerber NM Hannett CT Harbison CM Thompson I Simon J Zeitlinger EG Jennings HL Murray DB Gordon B Ren JJ Wyrick JB Tagne TL Volkert E Fraenkel DK Gifford RA Young 2002 Transcriptional regulatory networks in Saccharomyces cerevisiae Science 298 799 804 1:CAS:528:DC%2BD38XotFSntL0%3D 12399584
191. YS Lee S Mulugu JD York EK O'Shea 2007 Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates Science 316 109 112 1:CAS:528:DC%2BD2sXjvVarsLg%3D 17412959
192. P Lee BR Cho HS Joo JS Hahn 2008 Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4 Mol Microbiol 70 882 895 1:CAS:528:DC%2BD1cXhsVarur3F 18793336
193. YS Lee K Huang FA Quiocho EK O'Shea 2008 Molecular basis of cyclin-CDK-CKI regulation by reversible binding of an inositol pyrophosphate Nat Chem Biol 4 25 32 1:CAS:528:DC%2BD2sXhsVegtbbN 18059263
194. J Lee RD Moir IM Willis 2009 Regulation of RNA polymerase III transcription involves SCH9-dependent and -independent branches of the TOR pathway J Biol Chem 284 12604 12608 1:CAS:528:DC%2BD1MXltlentbY%3D 19299514
195. K Lemaire S Van de Velde P Van Dijck JM Thevelein 2004 Glucose and sucrose act as agonist and mannose as antagonist ligands of the G protein-coupled receptor Gpr1 in the yeast Saccharomyces cerevisiae Mol Cell 16 293 299 1:CAS:528:DC%2BD2cXhtVWit7rM 15494315
196. MA Lemmon 2008 Membrane recognition by phospholipid-binding domains Nat Rev Mol Cell Biol 9 99 111 1:CAS:528:DC%2BD1cXovFOntQ%3D%3D 18216767
197. H Lempiainen A Uotila J Urban I Dohnal G Ammerer R Loewith D Shore 2009 Sfp1 interaction with TORC1 and Mrs6 reveals feedback regulation on TOR signaling Mol Cell 33 704 716 1:CAS:528:DC%2BD1MXltFSms7c%3D 19328065
198. ME Lenburg EK O'Shea 1996 Signaling phosphate starvation Trends Biochem Sci 21 383 387 1:CAS:528:DyaK28XmsleitLg%3D 8918192
199. E Lenssen U Oberholzer J Labarre C De Virgilio MA Collart 2002 Saccharomyces cerevisiae Ccr4-not complex contributes to the control of Msn2p-dependent transcription by the Ras/cAMP pathway Mol Microbiol 43 1023 1037 1:CAS:528:DC%2BD38Xit1GnsLg%3D 11929548
200. E Lenssen N James I Pedruzzi F Dubouloz E Cameroni R Bisig L Maillet M Werner J Roosen K Petrovic J Winderickx MA Collart C De Virgilio 2005 The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation-via a newly identified Glc7/Bud14 type I protein phosphatase module-and TFIID promoter distribution Mol Cell Biol 25 488 498 1:CAS:528:DC%2BD2MXis1Gguw%3D%3D 15601868
201. P Lesage X Yang M Carlson 1996 Yeast SNF1 protein kinase interacts with SIP4, a C6 zinc cluster transcriptional activator: a new role for SNF1 in the glucose response Mol Cell Biol 16 1921 1928 1:CAS:528:DyaK28XisFeksrc%3D 8628258
202. DE Levin 2005 Cell wall integrity signaling in Saccharomyces cerevisiae Microbiol Mol Biol Rev 69 262 291 1:CAS:528:DC%2BD2MXmtFartr8%3D 15944456
203. H Li CK Tsang M Watkins PG Bertram XF Zheng 2006 Nutrient regulates Tor1 nuclear localization and association with rDNA promoter Nature 442 1058 1061 1:CAS:528:DC%2BD28XovVyhtb0%3D 16900101
204. D Liko MG Slattery W Heideman 2007 Stb3 binds to ribosomal RNA processing element motifs that control transcriptional responses to growth in Saccharomyces cerevisiae J Biol Chem 282 26623 26628 1:CAS:528: DC%2BD2sXpslGjtbY%3D 17616518
205. Z Liu RA Butow 2006 Mitochondrial retrograde signaling Annu Rev Genet 40 159 185 1:CAS:528:DC%2BD2sXnslKm 16771627
206. C Liu Z Yang J Yang Z Xia S Ao 2000 Regulation of the yeast transcriptional factor PHO2 activity by phosphorylation J Biol Chem 275 31972 31978 1:CAS:528:DC%2BD3cXnsFejsLY%3D 10884387
207. Z Liu T Sekito M Spirek J Thornton RA Butow 2003 Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p Mol Cell 12 401 411 1:CAS:528:DC%2BD3sXnt12qtLs%3D 14536080
208. K Liu X Zhang RL Lester RC Dickson 2005 The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9 J Biol Chem 280 22679 22687 1:CAS:528: DC%2BD2MXltVyhsbw%3D 15840588
209. K Liu X Zhang C Sumanasekera RL Lester RC Dickson 2005 Signalling functions for sphingolipid long-chain bases in Saccharomyces cerevisiae Biochem Soc Trans 33 1170 1173 1:CAS:528:DC%2BD2MXhtFCqs7fJ 16246074
210. WS Lo L Duggan NC Emre R Belotserkovskya WS Lane R Shiekhattar SL Berger 2001 Snf1-a histone kinase that works in concert with the histone acetyltransferase Gcn5 to regulate transcription Science 293 1142 1146 1:CAS:528:DC%2BD3MXmtVWqt7s%3D 11498592
211. R Loewith E Jacinto S Wullschleger A Lorberg JL Crespo D Bonenfant W Oppliger P Jenoe MN Hall 2002 Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control Mol Cell 10 457 468 1:CAS:528:DC%2BD38XnvFSlt74%3D 12408816
212. MC Lorenz J Heitman 1997 Yeast pseudohyphal growth is regulated by GPA2, a G protein alpha homolog EMBO J 16 7008 7018 1:CAS:528:DyaK1cXisVChtA%3D%3D 9384580
213. MC Lorenz X Pan T Harashima ME Cardenas Y Xue JP Hirsch J Heitman 2000 The G protein-coupled receptor gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae Genetics 154 609 622 1:CAS:528:DC%2BD3cXht1yqt7g%3D 10655215
214. A Lu JP Hirsch 2005 Cyclic AMP-independent regulation of protein kinase A substrate phosphorylation by Kelch repeat proteins Eukaryot Cell 4 1794 1800 1:CAS:528:DC%2BD2MXht1CgtbfP 16278446
215. K Ludin R Jiang M Carlson 1998 Glucose-regulated interaction of a regulatory subunit of protein phosphatase 1 with the Snf1 protein kinase in Saccharomyces cerevisiae Proc Natl Acad Sci USA 95 6245 6250 1:CAS:528:DyaK1cXjtlKnsrY%3D 9600950
216. MM Luke F Della Seta CJ Di Como H Sugimoto R Kobayashi KT Arndt 1996 The SAP, a new family of proteins, associate and function positively with the SIT4 phosphatase Mol Cell Biol 16 2744 2755 1:CAS:528:DyaK28XjtFCqs78%3D 8649382
217. M Lundin JO Nehlin H Ronne 1994 Importance of a flanking AT-rich region in target site recognition by the GC box-binding zinc finger protein MIG1 Mol Cell Biol 14 1979 1985 1:CAS:528:DyaK2cXis1aru70%3D 8114729
218. H Ma LM Bloom CT Walsh D Botstein 1989 The residual enzymatic phosphorylation activity of hexokinase II mutants is correlated with glucose repression in Saccharomyces cerevisiae Mol Cell Biol 9 5643 5649 1:CAS:528:DyaK3cXltF2rsA%3D%3D 2685572
219. B Magasanik CA Kaiser 2002 Nitrogen regulation in Saccharomyces cerevisiae Gene 290 1 18 1:CAS:528:DC%2BD38Xktlart7Y%3D 12062797
220. JP Magbanua N Ogawa S Harashima Y Oshima 1997 The transcriptional activators of the PHO regulon, Pho4p and Pho2p, interact directly with each other and with components of the basal transcription machinery in Saccharomyces cerevisiae J Biochem 121 1182 1189 1:CAS:528:DyaK2sXktlKlsbc%3D 9354395
221. B Mai L Breeden 1997 Xbp1, a stress-induced transcriptional repressor of the Saccharomyces cerevisiae Swi4/Mbp1 family Mol Cell Biol 17 6491 6501 1:CAS:528:DyaK2sXntVSgtr0%3D 9343412
222. RM Marion A Regev E Segal Y Barash D Koller N Friedman EK O'Shea 2004 Sfp1 is a stress- and nutrient-sensitive regulator of ribosomal protein gene expression Proc Natl Acad Sci USA 101 14315 14322 1:CAS:528:DC%2BD2cXovVert7k%3D 15353587
223. DE Martin A Soulard MN Hall 2004 TOR regulates ribosomal protein gene expression via PKA and the Forkhead transcription factor FHL1 Cell 119 969 979 1:CAS:528:DC%2BD2MXltlSitA%3D%3D 15620355
224. MT Martinez-Pastor G Marchler C Schuller A Marchler-Bauer H Ruis F Estruch 1996 The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress response element (STRE) EMBO J 15 2227 2235 1:CAS:528:DyaK28XjtFyjt74%3D 8641288
225. DP Matheos TJ Kingsbury US Ahsan KW Cunningham 1997 Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae Genes Dev 11 3445 3458 1:CAS:528:DyaK1cXivFOktQ%3D%3D 9407036
226. K Matsumoto I Uno T Ishikawa 1983 Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase Cell 32 417 423 1:CAS:528:DyaL3sXhsVSgt70%3D 6297794
227. K Matsumoto I Uno T Ishikawa 1984 Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae J Bacteriol 157 277 282 1:CAS:528:DyaL2cXmsVOrtA%3D%3D 6360999
228. I Mayordomo P Sanz 2001 Hexokinase PII: structural analysis and glucose signalling in the yeast Saccharomyces cerevisiae Yeast 18 923 930 1:CAS:528:DC%2BD3MXlsVenu7Y%3D 11447598
229. I Mayordomo F Estruch P Sanz 2002 Convergence of the target of rapamycin and the Snf1 protein kinase pathways in the regulation of the subcellular localization of Msn2, a transcriptional activator of STRE (Stress Response Element)-regulated genes J Biol Chem 277 35650 35656 1:CAS:528: DC%2BD38Xnt1Wlt74%3D 12093809
230. K Mbonyi M Beullens K Detremerie L Geerts JM Thevelein 1988 Requirement of one functional RAS gene and inability of an oncogenic ras variant to mediate the glucose-induced cyclic AMP signal in the yeast Saccharomyces cerevisiae Mol Cell Biol 8 3051 3057 1:CAS:528:DyaL1cXlt1emur8%3D 2850478
231. K Mbonyi L van Aelst JC Arguelles AW Jans JM Thevelein 1990 Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase Mol Cell Biol 10 4518 4523 1:CAS:528:DyaK3cXlsVyltrY%3D 2201893
232. RR McCartney MC Schmidt 2001 Regulation of Snf1 kinase. Activation requires phosphorylation of threonine 210 by an upstream kinase as well as a distinct step mediated by the Snf4 subunit J Biol Chem 276 36460 36466 1:CAS:528:DC%2BD3MXnt1yrtrY%3D 11486005
233. RR McCartney EM Rubenstein MC Schmidt 2005 Snf1 kinase complexes with different beta subunits display stress-dependent preferences for the three Snf1-activating kinases Curr Genet 47 335 344 1:CAS:528:DC%2BD2MXltFWrt7k%3D 15824893
234. V Measday L Moore R Retnakaran J Lee M Donoviel AM Neiman B Andrews 1997 A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase Mol Cell Biol 17 1212 1223 1:CAS:528:DyaK2sXhtlGitb4%3D 9032248
235. PL Minehart B Magasanik 1991 Sequence and expression of GLN3, a positive nitrogen regulatory gene of Saccharomyces cerevisiae encoding a protein with a putative zinc finger DNA-binding domain Mol Cell Biol 11 6216 6228 1:CAS:528:DyaK3sXjtlOhsA%3D%3D 1682800
236. KI Mitchelhill D Stapleton G Gao C House B Michell F Katsis LA Witters BE Kemp 1994 Mammalian AMP-activated protein kinase shares structural and functional homology with the catalytic domain of yeast Snf1 protein kinase J Biol Chem 269 2361 2364 1:CAS:528:DyaK2cXhvVKjsL0%3D 7905477
237. RD Moir J Lee RA Haeusler N Desai DR Engelke IM Willis 2006 Protein kinase A regulates RNA polymerase III transcription through the nuclear localization of Maf1 Proc Natl Acad Sci USA 103 15044 15049 1:CAS:528: DC%2BD28XhtFais7zK 17005718
238. M Momcilovic SH Iram Y Liu M Carlson 2008 Roles of the glycogen-binding domain and Snf4 in glucose inhibition of SNF1 protein kinase J Biol Chem 283 19521 19529 1:CAS:528:DC%2BD1cXotF2ksbs%3D 18474591
239. H Moriya Y Shimizu-Yoshida A Omori S Iwashita M Katoh A Sakai 2001 Yak1p, a DYRK family kinase, translocates to the nucleus and phosphorylates yeast Pop2p in response to a glucose signal Genes Dev 15 1217 1228 1:CAS:528:DC%2BD3MXktVans70%3D 11358866
240. E Moskvina C Schuller CT Maurer WH Mager H Ruis 1998 A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements Yeast 14 1041 1050 1:CAS:528:DyaK1cXlsF2msbw%3D 9730283
241. M Nakafuku T Obara K Kaibuchi I Miyajima A Miyajima H Itoh S Nakamura K Arai K Matsumoto Y Kaziro 1988 Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions Proc Natl Acad Sci USA 85 1374 1378 1:CAS:528:DyaL1cXkvVOhsLk%3D 2830616
242. K Natarajan MR Meyer BM Jackson D Slade C Roberts AG Hinnebusch MJ Marton 2001 Transcriptional profiling shows that Gcn4p is a master regulator of gene expression during amino acid starvation in yeast Mol Cell Biol 21 4347 4368 1:CAS:528:DC%2BD3MXksVOrtL0%3D 11390663
243. JO Nehlin H Ronne 1990 Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins EMBO J 9 2891 2898 1:CAS:528:DyaK3MXhvVGhuw%3D%3D 2167835
244. D Niederacher KD Entian 1991 Characterization of Hex2 protein, a negative regulatory element necessary for glucose repression in yeast Eur J Biochem 200 311 319 1:CAS:528:DyaK38XhsVOqs70%3D 1889400
245. J Nikawa S Cameron T Toda KM Ferguson M Wigler 1987 Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae Genes Dev 1 931 937 1:CAS:528:DyaL1cXjsVKhtA%3D%3D 2828175
246. J Nikawa P Sass M Wigler 1987 Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae Mol Cell Biol 7 3629 3636 1:CAS:528:DyaL1cXovVOhtA%3D%3D 2824992
247. M Nishizawa Y Kanaya EA Toh 1999 Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, pho85 kinase J Biol Chem 274 33859 33862 1:CAS:528:DyaK1MXnslOltLY%3D 10567344
248. M Nishizawa Y Katou K Shirahige A Toh-e 2004 Yeast Pho85 kinase is required for proper gene expression during the diauxic shift Yeast 21 903 918 1:CAS:528:DC%2BD2cXnsVKmurc%3D 15334555
249. M Nishizawa T Komai Y Katou K Shirahige T Ito EA Toh 2008 Nutrient-regulated antisense and intragenic RNAs modulate a signal transduction pathway in yeast PLoS Biol 6 2817 2830 1:CAS:528:DC%2BD1MXlsFGhsw%3D%3D 19108609
250. M Nishizawa T Komai N Morohashi M Shimizu A Toh-e 2008 Transcriptional repression by the Pho4 transcription factor controls the timing of SNZ1 expression Eukaryot Cell 7 949 957 1:CAS:528:DC%2BD1cXnvVaktbY%3D 18408055
251. EM O'Neill A Kaffman ER Jolly EK O'Shea 1996 Regulation of PHO4 nuclear localization by the PHO80-PHO85 cyclin-CDK complex Science 271 209 212 8539622
252. D Oficjalska-Pham O Harismendy WJ Smagowicz A Gonzalez de Peredo M Boguta A Sentenac O Lefebvre 2006 General repression of RNA polymerase III transcription is triggered by protein phosphatase type 2A-mediated dephosphorylation of Maf1 Mol Cell 22 623 632 1:CAS:528:DC%2BD28XmtFSrurc%3D 16762835
253. N Ogawa J DeRisi PO Brown 2000 New components of a system for phosphate accumulation and polyphosphate metabolism in Saccharomyces cerevisiae revealed by genomic expression analysis Mol Biol Cell 11 4309 4321 1:CAS:528: DC%2BD3cXovFansbg%3D 11102525
254. X Pan J Heitman 1999 Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae Mol Cell Biol 19 4874 4887 1:CAS:528:DyaK1MXktVCgtr0%3D 10373537
255. AC Panek PS de Araujo V Moura Neto AD Panek 1987 Regulation of the trehalose-6-phosphate synthase complex in Saccharomyces. I. Interconversion of forms by phosphorylation Curr Genet 11 459 465 1:CAS:528:DyaL2sXhvFamsrw%3D 2967122
256. M Papamichos-Chronakis T Gligoris D Tzamarias 2004 The Snf1 kinase controls glucose repression in yeast by modulating interactions between the Mig1 repressor and the Cyc8-Tup1 co-repressor EMBO Rep 5 368 372 1:CAS:528:DC%2BD2cXis1Krtr0%3D 15031717
257. JI Park CM Grant IW Dawes 2005 The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses Biochem Biophys Res Commun 327 311 319 1:CAS:528:DC%2BD2MXksFKm 15629464
258. A Pascual-Ahuir M Proft 2007 The Sch9 kinase is a chromatin-associated transcriptional activator of osmostress-responsive genes EMBO J 26 3098 3108 1:CAS:528:DC%2BD2sXnsFejt7s%3D 17568771
259. I Pedruzzi N Burckert P Egger C De Virgilio 2000 Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1 EMBO J 19 2569 2579 1:CAS:528: DC%2BD3cXkslantr4%3D 10835355
260. I Pedruzzi F Dubouloz E Cameroni V Wanke J Roosen J Winderickx C De Virgilio 2003 TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0 Mol Cell 12 1607 1613 1:CAS:528: DC%2BD2cXhsVOktQ%3D%3D 14690612
261. T Peeters W Louwet R Gelade D Nauwelaers JM Thevelein M Versele 2006 Kelch-repeat proteins interacting with the Galpha protein Gpa2 bypass adenylate cyclase for direct regulation of protein kinase A in yeast Proc Natl Acad Sci USA 103 13034 13039 1:CAS:528:DC%2BD28XptlWju7c%3D 16924114
262. BL Persson JO Lagerstedt JR Pratt J Pattison-Granberg K Lundh S Shokrollahzadeh F Lundh 2003 Regulation of phosphate acquisition in Saccharomyces cerevisiae Curr Genet 43 225 244 1:CAS:528:DC%2BD3sXlsVaku7o%3D 12740714
263. BL Pike S Yongkiettrakul MD Tsai J Heierhorst 2004 Mdt1, a novel Rad53 FHA1 domain-interacting protein, modulates DNA damage tolerance and G(2)/M cell cycle progression in Saccharomyces cerevisiae Mol Cell Biol 24 2779 2788 1:CAS:528:DC%2BD2cXis1emsb8%3D 15024067
264. B Pinson S Vaur I Sagot F Coulpier S Lemoine B Daignan-Fornier 2009 Metabolic intermediates selectively stimulate transcription factor interaction and modulate phosphate and purine pathways Genes Dev 23 1399 1407 1:CAS:528:DC%2BD1MXnslGms70%3D 19528318
265. RC Piper 2006 Successful transporter gets an EGO boost Dev Cell 11 6 7 1:CAS:528:DC%2BD28XnsVWntrk%3D 16824948
266. RJ Planta 1997 Regulation of ribosome synthesis in yeast Yeast 13 1505 1518 1:CAS:528:DyaK1cXht1Ontr0%3D 9509571
267. RS Polizotto MS Cyert 2001 Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p J Cell Biol 154 951 960 1:CAS:528:DC%2BD3MXms1Slurc%3D 11535618
268. G Popova Iu MV Padkina EV Sambuk 2000 Effect of mutations in PHO85 and PHO4 genes on utilization of proline in Saccharomyces cerevisiae yeasts Genetika 36 1622 1628 1:STN:280:DC%2BD3M7hs12gug%3D%3D 11190469
269. P Portela S Moreno 2006 Glucose-dependent activation of protein kinase A activity in Saccharomyces cerevisiae and phosphorylation of its TPK1 catalytic subunit Cell Signal 18 1072 1086 1:CAS:528:DC%2BD28XivVaktbw%3D 16226873
270. P Portela S Howell S Moreno S Rossi 2002 In vivo and in vitro phosphorylation of two isoforms of yeast pyruvate kinase by protein kinase A J Biol Chem 277 30477 30487 1:CAS:528:DC%2BD38XmsFyqsbk%3D 12063246
271. D Pruyne A Bretscher 2000 Polarization of cell growth in yeast J Cell Sci 113 Pt 4 571 585 1:CAS:528:DC%2BD3cXhvFSgsbc%3D 10652251
272. D Pruyne A Bretscher 2000 Polarization of cell growth in yeast. I. Establishment and maintenance of polarity states J Cell Sci 113 Pt 3 365 375 1:CAS:528:DC%2BD3cXhsFCqsL8%3D 10639324 (Pubitemid 30116643)
273. J Ptacek G Devgan G Michaud H Zhu X Zhu J Fasolo H Guo G Jona A Breitkreutz R Sopko RR McCartney MC Schmidt N Rachidi SJ Lee AS Mah L Meng MJ Stark DF Stern C De Virgilio M Tyers B Andrews M Gerstein B Schweitzer PF Predki M Snyder 2005 Global analysis of protein phosphorylation in yeast Nature 438 679 684 1:CAS:528:DC%2BD2MXht1Gqs7%2FJ 16319894 (Pubitemid 41740579)
274. A Rahner A Scholer E Martens B Gollwitzer HJ Schuller 1996 Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8 Nucleic Acids Res 24 2331 2337 1:CAS:528:DyaK28XktVagtLc%3D 8710504
275. F Randez-Gil N Bojunga M Proft KD Entian 1997 Glucose derepression of gluconeogenic enzymes in Saccharomyces cerevisiae correlates with phosphorylation of the gene activator Cat8p Mol Cell Biol 17 2502 2510 1:CAS:528:DyaK2sXislCjtb8%3D 9111319
276. F Randez-Gil P Herrero P Sanz JA Prieto F Moreno 1998 Hexokinase PII has a double cytosolic-nuclear localisation in Saccharomyces cerevisiae FEBS Lett 425 475 478 1:CAS:528:DyaK1cXitVKhsL0%3D 9563516
277. K Rebora C Desmoucelles F Borne B Pinson B Daignan-Fornier 2001 Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate Mol Cell Biol 21 7901 7912 1:CAS:528:DC%2BD3MXotl2gt7o%3D 11689683
278. K Rebora B Laloo B Daignan-Fornier 2005 Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule Genetics 170 61 70 1:CAS:528:DC%2BD2MXlslKktb8%3D 15744050
279. A Reinders N Burckert T Boller A Wiemken C De Virgilio 1998 Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase Genes Dev 12 2943 2955 1:CAS:528: DyaK1cXmtFGitL0%3D 9744870
280. A Reinke S Anderson JM McCaffery J Yates 3rd S Aronova S Chu S Fairclough C Iverson KP Wedaman T Powers 2004 TOR complex 1 includes a novel component, Tco89p (YPL180w), and cooperates with Ssd1p to maintain cellular integrity in Saccharomyces cerevisiae J Biol Chem 279 14752 14762 1:CAS:528: DC%2BD2cXivVKhtLs%3D 14736892
281. J Rittenhouse L Moberly F Marcus 1987 Phosphorylation in vivo of yeast (Saccharomyces cerevisiae) fructose-1,6-bisphosphatase at the cyclic AMP-dependent site J Biol Chem 262 10114 10119 1:CAS:528:DyaL2sXkvFehu7k%3D 3038868
282. KJ Roberg N Rowley CA Kaiser 1997 Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae J Cell Biol 137 1469 1482 1:CAS:528:DyaK2sXkt1yisr8%3D 9199164 (Pubitemid 27282230)
283. DN Roberts B Wilson JT Huff AJ Stewart BR Cairns 2006 Dephosphorylation and genome-wide association of Maf1 with Pol III-transcribed genes during repression Mol Cell 22 633 644 1:CAS:528:DC%2BD28XmtFSru74%3D 16762836
284. LS Robertson GR Fink 1998 The three yeast A kinases have specific
285. LS Robertson HC Causton RA Young GR Fink 2000 The yeast A kinases differentially regulate iron uptake and respiratory function Proc Natl Acad Sci USA 97 5984 5988 1:CAS:528:DC%2BD3cXjvFarsrc%3D 10811893
286. LC Robinson K Tatchell 1991 TFS1: a suppressor of cdc25 mutations in Saccharomyces cerevisiae Mol Gen Genet 230 241 250 1:CAS:528:DyaK3sXhs1ajurk%3D 1745232
287. FM Roelants PD Torrance J Thorner 2004 Differential roles of PDK1- and PDK2-phosphorylation sites in the yeast AGC kinases Ypk1, Pkc1 and Sch9 Microbiology 150 3289 3304 1:CAS:528:DC%2BD2cXptVyjt70%3D 15470109
288. JR Rohde S Campbell SA Zurita-Martinez NS Cutler M Ashe ME Cardenas 2004 TOR controls transcriptional and translational programs via Sap-Sit4 protein phosphatase signaling effectors Mol Cell Biol 24 8332 8341 1:CAS:528: DC%2BD2cXnvVaktr0%3D 15367655
289. JR Rohde R Bastidas R Puria ME Cardenas 2008 Nutritional control via Tor signaling in Saccharomyces cerevisiae Curr Opin Microbiol 11 153 160 1:CAS:528:DC%2BD1cXkvFaiu7w%3D 18396450
290. F Rolland JH De Winde K Lemaire E Boles JM Thevelein J Winderickx 2000 Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process Mol Microbiol 38 348 358 1:CAS:528: DC%2BD3cXotVGqtL0%3D 11069660
291. H Ronne 1995 Glucose repression in fungi Trends Genet 11 12 17 1:CAS:528:DyaK2MXjtFGjtbo%3D 7900189
292. H Ronne M Carlberg GZ Hu JO Nehlin 1991 Protein phosphatase 2A in Saccharomyces cerevisiae: effects on cell growth and bud morphogenesis Mol Cell Biol 11 4876 4884 1:CAS:528:DyaK38Xls1Ontrw%3D 1656215
293. Roosen J, Oesterhelt C, Pardons K, Swinnen E, Winderickx J (2004) Integration of nutrient signalling pathways in the yeast Saccharomyces cerevisiae. In: Winderickx J, Taylor PM (eds) Topics in current genetics. Nutrient-induced responses in eukaryotic cells, vol 7. Springer, Heidelberg, pp 277-318
294. J Roosen K Engelen K Marchal J Mathys G Griffioen E Cameroni JM Thevelein C De Virgilio B De Moor J Winderickx 2005 PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability Mol Microbiol 55 862 880 1:CAS:528:DC%2BD2MXhtlanu78%3D 15661010
295. M Rose W Albig KD Entian 1991 Glucose repression in Saccharomyces cerevisiae is directly associated with hexose phosphorylation by hexokinases PI and PII Eur J Biochem 199 511 518 1:CAS:528:DyaK3MXkvVyqt78%3D 1868842
296. EM Rubenstein RR McCartney C Zhang KM Shokat MK Shirra KM Arndt MC Schmidt 2008 Access denied: Snf1 activation loop phosphorylation is controlled by availability of the phosphorylated threonine 210 to the PP1 phosphatase J Biol Chem 283 222 230 1:CAS:528:DC%2BD1cXhtVOltg%3D%3D 17991748
297. S Rudoni S Colombo P Coccetti E Martegani 2001 Role of guanine nucleotides in the regulation of the Ras/cAMP pathway in Saccharomyces cerevisiae Biochim Biophys Acta 1538 181 189 1:CAS:528:DC%2BD3MXivFehtrw%3D 11336789
298. D Rudra Y Zhao JR Warner 2005 Central role of Ifh1p-Fhl1p interaction in the synthesis of yeast ribosomal proteins EMBO J 24 533 542 1:CAS:528: DC%2BD2MXhtFaru74%3D 15692568
299. Y Sancak TR Peterson YD Shaul RA Lindquist CC Thoreen L Bar-Peled DM Sabatini 2008 The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1 Science 320 1496 1501 1:CAS:528:DC%2BD1cXntVWqsr4%3D 18497260
300. GM Santangelo 2006 Glucose signaling in Saccharomyces cerevisiae Microbiol Mol Biol Rev 70 253 282 1:CAS:528:DC%2BD28Xjs1Sgs70%3D 16524925
301. A Santhanam A Hartley K Duvel JR Broach S Garrett 2004 PP2A phosphatase activity is required for stress and Tor kinase regulation of yeast stress response factor Msn2p Eukaryot Cell 3 1261 1271 1:CAS:528:DC%2BD2cXptFais7c%3D 15470255
302. P Sanz GR Alms TA Haystead M Carlson 2000 Regulatory interactions between the Reg1-Glc7 protein phosphatase and the Snf1 protein kinase Mol Cell Biol 20 1321 1328 1:CAS:528:DC%2BD3cXos1emuw%3D%3D 10648618 (Pubitemid 30069253)
303. P Sass J Field J Nikawa T Toda M Wigler 1986 Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae Proc Natl Acad Sci USA 83 9303 9307 1:CAS:528:DyaL2sXhtFCnt70%3D 3025832
304. SB Schawalder M Kabani I Howald U Choudhury M Werner D Shore 2004 Growth-regulated recruitment of the essential yeast ribosomal protein gene activator Ifh1 Nature 432 1058 1061 1:CAS:528:DC%2BD2cXhtFeisrfP 15616569
305. T Schmelzle SB Helliwell MN Hall 2002 Yeast protein kinases and the RHO1 exchange factor TUS1 are novel components of the cell integrity pathway in yeast Mol Cell Biol 22 1329 1339 1:CAS:528:DC%2BD38XhtlKgtro%3D 11839800
306. T Schmelzle T Beck DE Martin MN Hall 2004 Activation of the RAS/cyclic AMP pathway suppresses a TOR deficiency in yeast Mol Cell Biol 24 338 351 1:CAS:528:DC%2BD2cXhtVWlsg%3D%3D 14673167
307. A Schmidt J Kunz MN Hall 1996 TOR2 is required for organization of the actin cytoskeleton in yeast Proc Natl Acad Sci USA 93 13780 13785 1:CAS:528:DyaK28Xnt1Gms7s%3D 8943012
308. A Schmidt T Beck A Koller J Kunz MN Hall 1998 The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease EMBO J 17 6924 6931 1:CAS:528:DyaK1MXivFalsQ%3D%3D 9843498
309. AP Schmitt K McEntee 1996 Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae Proc Natl Acad Sci USA 93 5777 5782 1:CAS:528:DyaK28Xjs1Kqu7w%3D 8650168
310. HJ Schuller 2003 Transcriptional control of nonfermentative metabolism in the yeast Saccharomyces cerevisiae Curr Genet 43 139 160 12715202
311. R Serrano A Ruiz D Bernal JR Chambers J Arino 2002 The transcriptional response to alkaline pH in Saccharomyces cerevisiae: evidence for calcium-mediated signalling Mol Microbiol 46 1319 1333 1:CAS:528: DC%2BD38XpsFGisLY%3D 12453218
312. AF Shamji FG Kuruvilla SL Schreiber 2000 Partitioning the transcriptional program induced by rapamycin among the effectors of the Tor proteins Curr Biol 10 1574 1581 1:CAS:528:DC%2BD3cXovFKgtbY%3D 11137008
313. D Shao CL Creasy LW Bergman 1998 A cysteine residue in helixII of the bHLH domain is essential for homodimerization of the yeast transcription factor Pho4p Nucleic Acids Res 26 710 714 1:CAS:528:DyaK1cXhtV2gt78%3D 9443961
314. KK Singh AK Rasmussen LJ Rasmussen 2004 Genome-wide analysis of signal transducers and regulators of mitochondrial dysfunction in Saccharomyces cerevisiae Ann N Y Acad Sci 1011 284 298 1:CAS:528:DC%2BD2cXkvVeitbk%3D 15126304
315. B Smets P De Snijder K Engelen E Joossens R Ghillebert K Thevissen K Marchal J Winderickx 2008 Genome-wide expression analysis reveals TORC1-dependent and -independent functions of Sch9 FEMS Yeast Res 8 1276 1288 1:CAS:528:DC%2BD1cXhsVCjt7vF 18759743
316. A Smith MP Ward S Garrett 1998 Yeast PKA represses Msn2p/Msn4p-dependent gene expression to regulate growth, stress response and glycogen accumulation EMBO J 17 3556 3564 1:CAS:528:DyaK1cXkslSjtrs%3D 9649426
317. FC Smith SP Davies WA Wilson D Carling DG Hardie 1999 The SNF1 kinase complex from Saccharomyces cerevisiae phosphorylates the transcriptional repressor protein Mig1p in vitro at four sites within or near regulatory domain 1 FEBS Lett 453 219 223 1:CAS:528:DyaK1MXkt1Gjs7s%3D 10403407
318. AA Sneddon PT Cohen MJ Stark 1990 Saccharomyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes EMBO J 9 4339 4346 1:CAS:528:DyaK3MXkt1egtbg%3D 2176150
319. O Soetens JO De Craene B Andre 2001 Ubiquitin is required for sorting to the vacuole of the yeast general amino acid permease, Gap1 J Biol Chem 276 43949 43957 1:STN:280:DC%2BD3MnmslKgtQ%3D%3D 11500494
320. R Sopko D Huang N Preston G Chua B Papp K Kafadar M Snyder SG Oliver M Cyert TR Hughes C Boone B Andrews 2006 Mapping pathways and phenotypes by systematic gene overexpression Mol Cell 21 319 330 1:CAS:528: DC%2BD28Xhslehurc%3D 16455487
321. JY Springael B Andre 1998 Nitrogen-regulated ubiquitination of the Gap1 permease of Saccharomyces cerevisiae Mol Biol Cell 9 1253 1263 1:CAS:528:DyaK1cXjvVehsrY%3D 9614172
322. JY Springael E Nikko B Andre AM Marini 2002 Yeast Npi3/Bro1 is involved in ubiquitin-dependent control of permease trafficking FEBS Lett 517 103 109 1:CAS:528:DC%2BD38XjtVamt7s%3D 12062418
323. AM Stathopoulos MS Cyert 1997 Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast Genes Dev 11 3432 3444 1:CAS:528:DyaK1cXivFOltQ%3D%3D 9407035
324. A Stathopoulos-Gerontides JJ Guo MS Cyert 1999 Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation Genes Dev 13 798 803 1:CAS:528:DyaK1MXisF2isrs%3D 10197980
325. DJ Steger ES Haswell AL Miller SR Wente EK O'Shea 2003 Regulation of chromatin remodeling by inositol polyphosphates Science 299 114 116 1:CAS:528:DC%2BD38XpvVensLg%3D 12434012
326. TW Sturgill A Cohen M Diefenbacher M Trautwein DE Martin MN Hall 2008 TOR1 and TOR2 have distinct locations in live cells Eukaryot Cell 7 1819 1830 1:CAS:528:DC%2BD1cXhtlChtbfO 18723607
327. M Subramanian WB Qiao N Khanam O Wilkins SD Der JD Lalich AL Bognar 2005 Transcriptional regulation of the one-carbon metabolism regulon in Saccharomyces cerevisiae by Bas1p Mol Microbiol 57 53 69 1:CAS:528:DC%2BD2MXmtVemsbs%3D 15948949
328. CM Sutherland SA Hawley RR McCartney A Leech MJ Stark MC Schmidt DG Hardie 2003 Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex Curr Biol 13 1299 1305 1:CAS:528:DC%2BD3sXmt1Kitrk%3D 12906789
329. E Swinnen J Rosseels J Winderickx 2005 The minimum domain of Pho81 is not sufficient to control the Pho85-Rim15 effector branch involved in phosphate starvation-induced stress responses Curr Genet 48 18 33 1:CAS:528: DC%2BD2MXmt1ygsrg%3D 15926040
330. E Swinnen V Wanke J Roosen B Smets F Dubouloz I Pedruzzi E Cameroni C De Virgilio J Winderickx 2006 Rim15 and the crossroads of nutrient signalling pathways in Saccharomyces cerevisiae Cell Div 1 3 16759348
331. H Tamaki 2007 Glucose-stimulated cAMP-protein kinase A pathway in yeast Saccharomyces cerevisiae J Biosci Bioeng 104 245 250 1:CAS:528: DC%2BD1cXjtV2msQ%3D%3D 18023794
332. K Tanaka K Matsumoto EA Toh 1989 IRA1, an inhibitory regulator of the RAS-cyclic AMP pathway in Saccharomyces cerevisiae Mol Cell Biol 9 757 768 1:CAS:528:DyaL1MXht12ktr4%3D 2540426 (Pubitemid 19038876)
333. K Tanaka M Nakafuku T Satoh MS Marshall JB Gibbs K Matsumoto Y Kaziro A Toh-e 1990 S. cerevisiae genes IRA1 and IRA2 encode proteins that may be functionally equivalent to mammalian ras GTPase activating protein Cell 60 803 807 1:CAS:528:DyaK3cXhslenur0%3D 2178777
334. K Tanaka M Nakafuku F Tamanoi Y Kaziro K Matsumoto A Toh-e 1990 IRA2, a second gene of Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian ras GTPase-activating protein Mol Cell Biol 10 4303 4313 1:CAS:528:DyaK3cXmt1Gntr8%3D 2164637
335. K Tanaka BK Lin DR Wood F Tamanoi 1991 IRA2, an upstream negative regulator of RAS in yeast, is a RAS GTPase-activating protein Proc Natl Acad Sci USA 88 468 472 1:CAS:528:DyaK3MXhtFKis7w%3D 1988946
336. JJ Tate KH Cox R Rai TG Cooper 2002 Mks1p is required for negative regulation of retrograde gene expression in Saccharomyces cerevisiae but does not affect nitrogen catabolite repression-sensitive gene expression J Biol Chem 277 20477 20482 1:CAS:528:DC%2BD38XkslWgtLs%3D 11923302
337. JJ Tate I Georis A Feller E Dubois TG Cooper 2009 Rapamycin-induced Gln3 dephosphorylation is insufficient for nuclear localization: Sit4 and PP2A phosphatases are regulated and function differently J Biol Chem 284 2522 2534 1:CAS:528:DC%2BD1MXlvFehtw%3D%3D 19015262
338. CN Tennyson J Lee BJ Andrews 1998 A role for the Pcl9-Pho85 cyclin-cdk complex at the M/G1 boundary in Saccharomyces cerevisiae Mol Microbiol 28 69 79 1:CAS:528:DyaK1cXisV2qtbs%3D 9593297
339. JM Thevelein 1994 Signal transduction in yeast Yeast 10 1753 1790 1:CAS:528:DyaK2MXks1Kqt7k%3D 7747517
340. JM Thevelein L Cauwenberg S Colombo JH De Winde M Donation F Dumortier L Kraakman K Lemaire P Ma D Nauwelaers F Rolland A Teunissen P Van Dijck M Versele S Wera J Winderickx 2000 Nutrient-induced signal transduction through the protein kinase A pathway and its role in the control of metabolism, stress resistance, and growth in yeast Enzyme Microb Technol 26 819 825 1:CAS:528:DC%2BD3cXktFSjur8%3D 10862891
341. BK Timblin K Tatchell LW Bergman 1996 Deletion of the gene encoding the cyclin-dependent protein kinase Pho85 alters glycogen metabolism in Saccharomyces cerevisiae Genetics 143 57 66 1:CAS:528:DyaK28XjtVGqur0%3D 8722762
342. T Toda I Uno T Ishikawa S Powers T Kataoka D Broek S Cameron J Broach K Matsumoto M Wigler 1985 In yeast, RAS proteins are controlling elements of adenylate cyclase Cell 40 27 36 1:CAS:528:DyaL2MXhtV2ls7c%3D 2981630
343. T Toda S Cameron P Sass M Zoller JD Scott B McMullen M Hurwitz EG Krebs M Wigler 1987 Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae Mol Cell Biol 7 1371 1377 1:CAS:528:DyaL2sXksFeitb4%3D 3037314
344. T Toda S Cameron P Sass M Zoller M Wigler 1987 Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase Cell 50 277 287 1:CAS:528:DyaL1cXhvVWit7s%3D 3036373
345. T Toda S Cameron P Sass M Wigler 1988 SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits Genes Dev 2 517 527 1:CAS:528:DyaL1cXltVGks70%3D 3290050
346. MA Treitel M Carlson 1995 Repression by SSN6-TUP1 is directed by MIG1, a repressor/activator protein Proc Natl Acad Sci USA 92 3132 3136 1:CAS:528:DyaK2MXltFSnsbk%3D 7724528
347. MA Treitel S Kuchin M Carlson 1998 Snf1 protein kinase regulates phosphorylation of the Mig1 repressor in Saccharomyces cerevisiae Mol Cell Biol 18 6273 6280 1:CAS:528:DyaK1cXmvF2gur8%3D 9774644
348. J Tu M Carlson 1994 The GLC7 type 1 protein phosphatase is required for glucose repression in Saccharomyces cerevisiae Mol Cell Biol 14 6789 6796 1:CAS:528:DyaK2cXmt1emtb0%3D 7935396
349. J Tu M Carlson 1995 REG1 binds to protein phosphatase type 1 and regulates glucose repression in Saccharomyces cerevisiae EMBO J 14 5939 5946 1:CAS:528:DyaK2MXhtVSmurrJ 8846786
350. KS Tung LL Norbeck SL Nolan NS Atkinson AK Hopper 1992 SRN1, a yeast gene involved in RNA processing, is identical to HEX2/REG1, a negative regulator in glucose repression Mol Cell Biol 12 2673 2680 1:CAS:528:DyaK3sXit1Krtbw%3D 1588964
351. I Uno K Matsumoto K Adachi T Ishikawa 1983 Genetic and biochemical evidence that trehalase is a substrate of cAMP-dependent protein kinase in yeast J Biol Chem 258 10867 10872 1:CAS:528:DyaL3sXlsFCqu7w%3D 6309818
352. J Urban A Soulard A Huber S Lippman D Mukhopadhyay O Deloche V Wanke D Anrather G Ammerer H Riezman JR Broach C De Virgilio MN Hall R Loewith 2007 Sch9 is a major target of TORC1 in Saccharomyces cerevisiae Mol Cell 26 663 674 1:CAS:528:DC%2BD2sXnt1CqtbY%3D 17560372
353. L Valenzuela C Aranda A Gonzalez 2001 TOR modulates GCN4-dependent expression of genes turned on by nitrogen limitation J Bacteriol 183 2331 2334 1:CAS:528:DC%2BD3MXitFWrsr8%3D 11244074
354. C Van Hoof V Janssens I De Baere MJ Stark JH de Winde J Winderickx JM Thevelein W Merlevede J Goris 2001 The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations Exp Cell Res 264 372 387 11262194
355. CJ van Oevelen HA van Teeffelen FJ van Werven HT Timmers 2006 Snf1p-dependent Spt-Ada-Gcn5-acetyltransferase (SAGA) recruitment and chromatin remodeling activities on the HXT2 and HXT4 promoters J Biol Chem 281 4523 4531 16368692
356. W van Zyl W Huang AA Sneddon M Stark S Camier M Werner C Marck A Sentenac JR Broach 1992 Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae Mol Cell Biol 12 4946 4959 1328868
357. E Vanrobays A Leplus YN Osheim AL Beyer L Wacheul DL Lafontaine 2008 TOR regulates the subcellular distribution of DIM2, a KH domain protein required for cotranscriptional ribosome assembly and pre-40S ribosome export Rna 14 2061 2073 1:CAS:528:DC%2BD1cXht1ektLfN 18755838
358. S Vaseghi F Macherhammer S Zibek M Reuss 2001 Signal transduction dynamics of the protein kinase-A/phosphofructokinase-2 system in Saccharomyces cerevisiae Metab Eng 3 163 172 1:CAS:528:DC%2BD3MXisVKns7g%3D 11289792
359. M Versele JH de Winde JM Thevelein 1999 A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2 EMBO J 18 5577 5591 1:CAS:528: DyaK1MXntFCms7k%3D 10523302
360. S Vidan AP Mitchell 1997 Stimulation of yeast meiotic gene expression by the glucose-repressible protein kinase Rim15p Mol Cell Biol 17 2688 2697 1:CAS:528:DyaK2sXislClt7o%3D 9111339
361. O Vincent M Carlson 1998 Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes EMBO J 17 7002 7008 1:CAS:528:DyaK1MXivFChsg%3D%3D 9843506
362. O Vincent R Townley S Kuchin M Carlson 2001 Subcellular localization of the Snf1 kinase is regulated by specific beta subunits and a novel glucose signaling mechanism Genes Dev 15 1104 1114 1:CAS:528:DC%2BD3MXjsVehtbs%3D 11331606
363. JT Wade DB Hall K Struhl 2004 The transcription factor Ifh1 is a key regulator of yeast ribosomal protein genes Nature 432 1054 1058 1:CAS:528:DC%2BD2cXhtFeisrbF 15616568
364. Z Wang WA Wilson MA Fujino PJ Roach 2001 Antagonistic controls of autophagy and glycogen accumulation by Snf1p, the yeast homolog of AMP-activated protein kinase, and the cyclin-dependent kinase Pho85p Mol Cell Biol 21 5742 5752 1:CAS:528:DC%2BD3MXlvF2htr8%3D 11486014
365. Y Wang M Pierce L Schneper CG Guldal X Zhang S Tavazoie JR Broach 2004 Ras and Gpa2 mediate one branch of a redundant glucose signaling pathway in yeast PLoS Biol 2 E128 15138498
366. V Wanke I Pedruzzi E Cameroni F Dubouloz C De Virgilio 2005 Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex EMBO J 24 4271 4278 1:CAS:528:DC%2BD2MXhtlanu7zP 16308562
367. V Wanke E Cameroni A Uotila M Piccolis J Urban R Loewith C De Virgilio 2008 Caffeine extends yeast lifespan by targeting TORC1 Mol Microbiol 69 277 285 1:CAS:528:DC%2BD1cXotF2hsr8%3D 18513215
368. KP Wedaman A Reinke S Anderson J Yates 3rd JM McCaffery T Powers 2003 Tor kinases are in distinct membrane-associated protein complexes in Saccharomyces cerevisiae Mol Biol Cell 14 1204 1220 1:CAS:528:DC%2BD3sXislOqtb4%3D 12631735
369. Y Wei CK Tsang XF Zheng 2009 Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1 EMBO J 28 2220 2230 1:CAS:528: DC%2BD1MXnslKqsbo%3D 19574957
370. M Werner-Washburne D Brown E Braun 1991 Bcy1, the regulatory subunit of cAMP-dependent protein kinase in yeast, is differentially modified in response to the physiological status of the cell J Biol Chem 266 19704 19709 1:CAS:528:DyaK3MXlsFCktrg%3D 1655793
371. IM Willis RD Moir 2007 Integration of nutritional and stress signaling pathways by Maf1 Trends Biochem Sci 32 51 53 1:CAS:528:DC%2BD2sXhs1Snurk%3D 17174096
372. RB Wilson K Tatchell 1988 SRA5 encodes the low-Km cyclic AMP phosphodiesterase of Saccharomyces cerevisiae Mol Cell Biol 8 505 510 1:CAS:528:DyaL1cXntVSnuw%3D%3D 2827010
373. WA Wilson SA Hawley DG Hardie 1996 Glucose repression/derepression in budding yeast: SNF1 protein kinase is activated by phosphorylation under derepressing conditions, and this correlates with a high AMP:ATP ratio Curr Biol 6 1426 1434 1:CAS:528:DyaK28XntVKiur8%3D 8939604
374. Winderickx J, Holsbeeks I, Lagatie O, Giots F, Thevelein JM, de Winde H (2003) From feast to famine: adaptation to nutrient availability in yeast. In: Hohmann S, Mager PWH (eds) Topics in current genetics. Yeast stress response, vol 1. Springer, Heidelberg, pp 305-386
375. R Wingender-Drissen JU Becker 1983 Regulation of yeast phosphorylase by phosphorylase kinase and cAMP-dependent protein kinase FEBS Lett 163 33 36 1:CAS:528:DyaL2cXhvFOmuw%3D%3D 6354752
376. A Woods MR Munday J Scott X Yang M Carlson D Carling 1994 Yeast SNF1 is functionally related to mammalian AMP-activated protein kinase and regulates acetyl-CoA carboxylase in vivo J Biol Chem 269 19509 19515 1:CAS:528: DyaK2cXltVersbs%3D 7913470
377. S Wullschleger R Loewith W Oppliger MN Hall 2005 Molecular organization of target of rapamycin complex 2 J Biol Chem 280 30697 30704 1:CAS:528:DC%2BD2MXpsVCmsLY%3D 16002396
378. AE Wurmser TK Sato SD Emr 2000 New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion J Cell Biol 151 551 562 1:CAS:528:DC%2BD3cXnsl2lsL0%3D 11062257
379. DD Wykoff AH Rizvi JM Raser B Margolin EK O'Shea 2007 Positive feedback regulates switching of phosphate transporters in S. cerevisiae Mol Cell 27 1005 1013 1:CAS:528:DC%2BD2sXhtFahtrzN 17889672
380. R Wysocki A Javaheri K Kristjansdottir F Sha SJ Kron 2006 CDK Pho85 targets CDK inhibitor Sic1 to relieve yeast G1 checkpoint arrest after DNA damage Nat Struct Mol Biol 13 908 914 1:CAS:528:DC%2BD28XhtVCiurjI 16964260
381. ZX Xia SZ Ao 1999 Analysis of interaction between PHO4 and PHO2 protein by real time BIA Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 31 145 149 1:CAS:528:DyaK1MXitlSqt78%3D
382. Y Xue M Batlle JP Hirsch 1998 GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p Galpha subunit and functions in a Ras-independent pathway EMBO J 17 1996 2007 1:CAS:528:DyaK1cXisV2kuro%3D 9524122
383. G Yan X Shen Y Jiang 2006 Rapamycin activates Tap42-associated phosphatases by abrogating their association with Tor complex 1 EMBO J 25 3546 3555 1:CAS:528:DC%2BD28XnvVGlsL8%3D 16874307
384. X Yang R Jiang M Carlson 1994 A family of proteins containing a conserved domain that mediates interaction with the yeast SNF1 protein kinase complex EMBO J 13 5878 5886 1:STN:280:DyaK2M7ht1Oqug%3D%3D 7813428
385. T Yorimitsu DJ Klionsky 2005 Autophagy: molecular machinery for self-eating Cell Death Differ 12 Suppl 2 1542 1552 1:CAS:528: DC%2BD2MXhtFCjt7%2FJ 16247502
386. T Yorimitsu S Zaman JR Broach DJ Klionsky 2007 Protein kinase A and Sch9 cooperatively regulate induction of autophagy in Saccharomyces cerevisiae Mol Biol Cell 18 4180 4189 1:CAS:528:DC%2BD2sXhtFCnsLfK 17699586
387. T Yorimitsu C He K Wang DJ Klionsky 2007 Tap42-associated protein phosphatase type 2A negatively regulates induction of autophagy Autophagy 5 616 624
388. CW Yun H Tamaki R Nakayama K Yamamoto H Kumagai 1997 G-protein coupled receptor from yeast Saccharomyces cerevisiae Biochem Biophys Res Commun 240 287 292 1:CAS:528:DyaK2sXnsFWnt7k%3D 9388468 (Pubitemid 27523652)
389. P Zabrocki C Van Hoof J Goris JM Thevelein J Winderickx S Wera 2002 Protein phosphatase 2A on track for nutrient-induced signalling in yeast Mol Microbiol 43 835 842 1:CAS:528:DC%2BD38Xit1Gns78%3D 11929536
390. S Zaman SI Lippman X Zhao JR Broach 2008 How Saccharomyces responds to nutrients Annu Rev Genet 42 27 81 1:CAS:528:DC%2BD1cXhsFemtb3O 18303986
391. F Zappacosta MJ Huddleston RL Karcher VI Gelfand SA Carr RS Annan 2002 Improved sensitivity for phosphopeptide mapping using capillary column HPLC and microionspray mass spectrometry: comparative phosphorylation site mapping from gel-derived proteins Anal Chem 74 3221 3231 1:CAS:528:DC%2BD38Xjslegt7o%3D 12141686
392. CE Zeller SC Parnell HG Dohlman 2007 The RACK1 ortholog Asc1 functions as a G-protein beta subunit coupled to glucose responsiveness in yeast J Biol Chem 282 25168 25176 1:CAS:528:DC%2BD2sXpt1Sltbs%3D 17591772
393. F Zhang M Kirouac N Zhu AG Hinnebusch RJ Rolfes 1997 Evidence that complex formation by Bas1p and Bas2p (Pho2p) unmasks the activation function of Bas1p in an adenine-repressible step of ADE gene transcription Mol Cell Biol 17 3272 3283 1:CAS:528:DyaK2sXjtlynt70%3D 9154826
394. N Zhang J Wu SG Oliver 2009 Gis1 is required for transcriptional reprogramming of carbon metabolism and the stress response during transition into stationary phase in yeast Microbiology 155 1690 1698 1:CAS:528: DC%2BD1MXmtV2gtL4%3D 19383711
395. Y Zhao G Boguslawski RS Zitomer AA DePaoli-Roach 1997 Saccharomyces cerevisiae homologs of mammalian B and B' subunits of protein phosphatase 2A direct the enzyme to distinct cellular functions J Biol Chem 272 8256 8262 1:CAS:528:DyaK2sXitF2ls7s%3D 9079645
396. Y Zhao KB McIntosh D Rudra S Schawalder D Shore JR Warner 2006 Fine-structure analysis of ribosomal protein gene transcription Mol Cell Biol 26 4853 4862 1:CAS:528:DC%2BD28XmsVSltbw%3D 16782874
397. Y Zheng Y Jiang 2005 The yeast phosphotyrosyl phosphatase activator is part of the Tap42-phosphatase complexes Mol Biol Cell 16 2119 2127 1:CAS:528:DC%2BD2MXjt1Kqurc%3D 15689491
398. XF Zheng D Florentino J Chen GR Crabtree SL Schreiber 1995 TOR kinase domains are required for two distinct functions, only one of which is inhibited by rapamycin Cell 82 121 130 1:CAS:528:DyaK2MXntVCnsL8%3D 7606777
399. H Zhu JF Klemic S Chang P Bertone A Casamayor KG Klemic D Smith M Gerstein MA Reed M Snyder 2000 Analysis of yeast protein kinases using protein chips Nat Genet 26 283 289 1:CAS:528:DC%2BD3cXotVWhsLg%3D 11062466
400. C Zhu KJ Byers RP McCord Z Shi MF Berger DE Newburger K Saulrieta Z Smith MV Shah M Radhakrishnan AA Philippakis Y Hu F De Masi M Pacek A Rolfs T Murthy J Labaer ML Bulyk 2009 High-resolution DNA-binding specificity analysis of yeast transcription factors Genome Res 19 556 566 1:CAS:528:DC%2BD1MXksVKns70%3D 19158363
401. FK Zimmermann I Scheel 1977 Mutants of Saccharomyces cerevisiae resistant to carbon catabolite repression Mol Gen Genet 154 75 82 1:CAS:528: DyaE2sXltFCns70%3D 197390
402. SA Zurita-Martinez R Puria X Pan JD Boeke ME Cardenas 2007 Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae Genetics 176 2139 2150 1:CAS:528:DC%2BD2sXhtFGnu7fL 17565946