Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

EMBO Journal

Volumn 20, Issue 23, 2001, Pages 6783-6792

  Friant, Sylvie ^a,b   Lombardi, Ruben ^a   Schmelzle, Tobias ^a   Hall, Michael N ^a   Riezman, Howard ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

Endocytosis; PKH, PKC1 and PDK1 kinases; Signaling pathway; Sphingoid base

Indexed keywords

ACTIN; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTRANSFERASE; SPHINGOLIPID;

ARTICLE; CYTOSKELETON; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME DEFECT; ENZYME PHOSPHORYLATION; INTERNALIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; YEAST;

ACTINS; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; GENOTYPE; MICROSCOPY, FLUORESCENCE; MUTATION; PHALLOIDINE; PHOSPHORYLATION; PLASMIDS; PRECIPITIN TESTS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; RHODAMINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; SPHINGOSINE; TIME FACTORS;

EID: 0035803482     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.23.6783     Document Type: Article

References (44)

1. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
2. Protein kinase C in yeast. Characteristics of the Saccharomyces cerevisiae PKC1 gene product
3. The END3 gene encodes a protein that is required for the internalization step of endocytosis and for actin cytoskeleton organization in yeast
4. A GTPase-independent mechanism of p21-activated kinase activation. Regulation by sphingosine and other biologically active lipids
5. Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast
6. Role of phosphatidylinositol 3, 4, 5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1
7. Phosphoinositides as regulators in membrane traffic
8. Protein and lipid requirements for endocytosis
9. Yeast endocytosis assays
10. Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis
11. Phosphoinositide binding domains: Embracing 3-phosphate
12. Endocytic internalization in yeast and animal cells: Similar and different
13. Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro, in human platelets
14. Analysis of inositol metabolites produced by saccharomyces cerevisiae in response to glucose stimulation
15. The Rho1 effector Pkc1 and but not Bni1 and mediates signalling from Tor2 to the actin cytoskeleton
16. DMSO-enhanced whole cell yeast transformation
17. Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast
18. PDK1 homologs activate the Pkc1-mitogen-activated protein kinase pathway in yeast
19. Sphingosine is a novel activator of 3-phosphoinositide- dependent kinase-1
20. Actin and fimbrin are required for the internalization step of endocytosis in yeast
21. Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1
22. Endocytosis in Saccharomyces cerevisiae: Involvement of actin and actin-associated protein complexes and lipids in the internalization step
23. Activation of casein kinase II by sphingosine
24. PKC ζ is a molecular switch in signal transduction of TNF-α and bifunctionally regulated by ceramide and arachidonic acid
25. Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: Identification of six new END genes
26. end5, end6 and end7: Mutations that cause actin delocalization and block the internalization step of endocytosis in Saccharomyces cerevisiae
27. Specific sterols required for the internalization step of endocytosis in yeast
28. The LCB2 gene of Saccharomyces and the related LCBI gene encode subunits of serine palmitoyltransferase and the initial enzyme in sphingolipid synthesis
29. Phosphorylation and activation of p70s6k by PDK1
30. Sphingosine activation of protein kinases in Jurkat T cells. In vitro phosphorylation of endogenous protein substrates and specificity of action
31. Regulation of sphingosine-activated protein kinases: Selectivity of activation by sphingoid bases and inhibition by non-esterified fatty acids
32. end3 and end4: Two mutants defective in receptor-mediated and fluid-phase endocytosis in Saccharomyces cerevisiae
33. Actin- and myosin- and ubiquitin-dependent endocytosis
34. Yeast casein kinase I homologues: An essential gene pair
35. Extraction of cholesterol with methyl-β-cyclodextrin perturbs formation of clathrin-coated endocytic vesicles
36. High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier
37. Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae
38. Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
39. Acute cholesterol depletion inhibits clathrincoated pit budding
40. Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast
41. Specific requirements for the ER to Golgi transport of GPI-anchored proteins in yeast
42. Regulation of lipid biosynthesis in Saccharomyces cerevisiae by fumonisin B1
43. Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae