TOR and PKA Signaling Pathways Converge on the Protein Kinase Rim15 to Control Entry into G0

Molecular Cell

Volumn 12, Issue 6, 2003, Pages 1607-1613

  Pedruzzi, Ivo ^a   Dubouloz, Frédérique ^a   Cameroni, Elisabetta ^a   Wanke, Valeria ^a   Roosen, Johnny ^b   Winderickx, Joris ^b   De Virgilio, Claudio ^a  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN DERIVATIVE; PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE RIM15; PROTEIN SCH9; PROTEIN SIT4; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G0 PHASE; CELL MATURATION; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INDUCTION; EUKARYOTE; NONHUMAN; NUTRIENT; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION;

EUKARYOTA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE; TOR;

EID: 0348047591     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(03)00485-4     Document Type: Article

References (28)

1. Beck T., Hall M.N. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature. 402:1999;689-692.
2. Broek D., Toda T., Michaeli T., Levin L., Birchmeier C., Zoller M., Powers S., Wigler M. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell. 48:1987;789-799.
3. Burke D., Dawson D., Stearns T. Methods in Yeast Genetics; 2000 Edition. 2000;Cold Spring Harbor Laboratory Press, Cold Spring Harbor New York.
4. Cherkasova V.A., Hinnebusch A.G. Translational control by TOR and TAP42 through dephosphorylation of eIF2α kinase GCN2. Genes Dev. 17:2003;859-872.
5. Colomina N., Liu Y., Aldea M., Garí E. TOR regulates the subcellular localization of Ime1, a transcriptional activator of meiotic development in budding yeast. Mol. Cell. Biol. 23:2003;7415-7424.
6. Crauwels M., Donaton M.C.V., Pernambuco M.B., Winderickx J., de Winde J.H., Thevelein J.M. The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiol. 143:1997;2627-2637.
7. Crespo J.L., Powers T., Fowler B., Hall M.N. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc. Natl. Acad. Sci. USA. 99:2002;6784-6789.
8. Di Como C.J., Arndt K.T. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases. Genes Dev. 10:1996;1904-1916.
9. Düvel K., Santhanam A., Garrett S., Schneper L., Broach J.R. Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast. Mol. Cell. 11:2003;1467-1478.
10. Fabrizio P., Pozza F., Pletcher S.D., Gendron C.M., Longo V.D. Regulation of longevity and stress resistance by Sch9 in yeast. Science. 292:2001;288-290.
11. Garrett S., Broach J. Loss of Ras activity in Saccharomyces cerevisiae is suppressed by disruptions of a new kinase gene, YAK1, whose product may act downstream of the cAMP-dependent protein kinase. Genes Dev. 3:1989;1336-1348.
12. 2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev. 12:1998;586-597.
13. Görner W., Durchschlag E., Wolf J., Brown E.L., Ammerer G., Ruis H., Schüller C. Acute glucose starvation activates the nuclear localization signal of a stress-specific yeast transcription factor. EMBO J. 21:2002;135-144.
14. Griffioen G., Anghileri P., Imre E., Baroni M.D., Ruis H. Nutritional control of nucleocytoplasmic localization of cAMP-dependent protein kinase catalytic and regulatory subunits in Saccharomyces cerevisiae. J. Biol. Chem. 275:2000;1449-1456.
15. Helliwell S.B., Wagner P., Kunz J., Deuter-Reinhard M., Henriquez R., Hall M.N. TOR1 and TOR2 are structurally related and functionally similar but not identical phophatidylinositol kinase homologues in yeast. Mol. Biol. Cell. 5:1994;105-118.
16. Jacinto E., Hall M.N. TOR signalling in bugs, brain and brawn. Nat. Rev. Mol. Cell Biol. 4:2003;117-126.
17. Jiang Y., Broach J.R. Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast. EMBO J. 18:1999;2782-2792.
18. Komeili A., Wedaman K.P., O'Shea E.K., Powers T. Mechanism of metabolic control. target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors J. Cell Biol. 151:2000;863-878.
19. Liu Z., Sekito T., Spírek M., Thornton J., Butow R.A. Retrograde signaling is regulated by the dynamic interaction between Rtg2p and Mks1p. Mol. Cell. 12:2003;401-411.
20. Longtine M.S., McKenzie A. 3rd, DeMarini D.J., Shah N.G., Wach A., Brachat A., Philippsen P., Pringle J.R. Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast. 14:1998;953-961.
21. Lorenz M.C., Pan X., Harashima T., Cardenas M.E., Xue Y., Hirsch J.P., Heitman J. The G protein-coupled receptor Gpr1 is a nutrient sensor that regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Genetics. 154:2000;609-622.
22. Pedruzzi I., Bürckert N., Egger P., De Virgilio C. Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J. 19:2000;2569-2579.
23. Reinders A., Bürckert N., Boller T., Wiemken A., De Virgilio C. Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes Dev. 12:1998;2943-2955.
24. Sakumoto N., Matsuoka I., Mukai Y., Ogawa N., Kaneko Y., Harashima S. A series of double disruptants for protein phosphatase genes in Saccharomyces cerevisiae and their phenotypic analysis. Yeast. 19:2002;587-599.
25. Saxena D., Kannan K.B., Brandriss M.C. Rapamycin treatment results in GATA factor-independent hyperphosphorylation of the proline utilization pathway activator in Saccharomyces cerevisiae. Eukaryot. Cell. 2:2003;552-559.
26. Schmidt A., Beck T., Koller A., Kunz J., Hall M.N. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 17:1998;6924-6931.
27. Stuart J.S., Frederick D.L., Varner C.M., Tatchell K. The mutant type 1 protein phosphatase encoded by glc7-1 from Saccharomyces cerevisiae fails to interact productively with the GAC1-encoded regulatory subunit. Mol. Cell. Biol. 14:1994;896-905.
28. Werner-Washburne M., Braun E., Johnston G.C., Singer R.A. Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol. Rev. 57:1993;383-401.