Glucose-induced cAMP signalling in yeast requires both a G-protein coupled receptor system for extracellular glucose detection and a separable hexose kinase-dependent sensing process

Molecular Microbiology

Volumn 38, Issue 2, 2000, Pages 348-358

  Rolland, Filip ^a   De Winde, Johannes H ^a   Lemaire, Katleen ^a,b   Boles, Eckhard ^c   Thevelein, Johan M ^a   Winderickx, Joris ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP; FRUCTOSE; G PROTEIN COUPLED RECEPTOR; GALACTOSE; GLUCOSE; GLUCOSE TRANSPORTER; HEXOKINASE; MALTOSE; MANNOSE; PERMEASE; SUCROSE;

ARTICLE; BINDING KINETICS; CONTROLLED STUDY; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HYDROLYSIS; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RECEPTOR AFFINITY; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; YEAST;

AMINO ACID SUBSTITUTION; BIOLOGICAL TRANSPORT; CARBOHYDRATE METABOLISM; CYCLIC AMP; EXTRACELLULAR SPACE; FRUCTOSE; FUNGAL PROTEINS; GLUCOSE; GLUCOSE-6-PHOSPHATE; GTP-BINDING PROTEIN ALPHA SUBUNITS; HETEROTRIMERIC GTP-BINDING PROTEINS; HEXOKINASE; HEXOSES; MONOSACCHARIDE TRANSPORT PROTEINS; PHOSPHORYLATION; RECEPTORS, CELL SURFACE; RECEPTORS, G-PROTEIN-COUPLED; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION;

SACCHAROMYCES CEREVISIAE;

EID: 0033745888     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2000.02125.x     Document Type: Article

References (50)

1. An overview of membrane transport proteins in Saccharomyces cerevisiae
2. Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae
3. Yeast sugar transporters
4. The molecular genetics of hexose transport in yeasts
5. High cAMP levels antagonize the reprogramming of gene expression that occurs at the diauxic shift in Saccharomyces cerevisiae
6. The function of RAS genes in Saccharomyces cerevisiae
7. Glucose-stimulated cAMP increase may be mediated by intracellular acidification in Saccharomyces cerevisiae
8. Involvement of distinct G-proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae
9. Efficient transition to growth on fermentable carbon sources in Saccharomyces cerevisiae requires signaling through the Ras pathway
10. Regulation of carbon and phosphate utilization
11. Multiple mechanisms provide rapid and stringent glucose repression of GAL gene expression in Saccharomyces cerevisiae
12. DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase
13. A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH
14. A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose
15. The hexose transporter family of Saccharomyces cerevisiae
16. A novel signal transduction pathway in Saccharomyces cerevisiae defined by Snf3-regulated expression of HXT6
17. Genetics of yeast hexokinase
18. Protein measurement with the Folin phenol reagent
19. Genetics of yeast glucokinase
20. Identification of the structural gene and nonsense alleles for adenylate cyclase in Saccharomyces cerevisiae
21. Control of maltase synthesis
22. Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms
23. Two glucose transporters in S. cerevisiae are glucose sensors that generate a signal for induction of gene expression
24. Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae
25. Glucose-triggered signalling in Saccharomyces cerevisiae: Different requirements for sugar phosphorylation between cells grown on glucose and those grown an non-fermentable carbon sources
26. Cyclic 3',5'-adenosine monophosphate stimulates trehalose degradation in baker's yeast
27. Cyclic AMP-dependent phosphorylation of fructose 1,6-bisphosphatase in yeast
28. Mechanism of control of adenylate cyclase activity in yeast by fermentable sugars and carbonyl cyanide m-chlorophenylhydrazone
29. The roles of multiple hexose transporters in S. cerevisiae
30. Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on glycolytic flux
31. Kinetic characterization of individual hexose transporters of Saccharomyces cerevisiae and their relation to the triggering mechanisms of glucose repression
32. Glucose repression in fungi
33. Stress signaling in yeast
34. RAS genes in the budding yeast Saccharomyces cerevisiae
35. Cyclic-AMP content and trehalase activation in vegetative cells and ascospores of yeast
36. Fermentable sugars and intracellular acidification as specific activators of the Ras-adenylate cyclase signalling pathway in yeast: The relationship to nutrient-induced cell cycle control
37. The RAS-adenylate cyclase pathway and cell cycle control in Saccharomyces cerevisiae
38. Signal transduction in yeast
39. Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
40. Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: The glucose-induced cAMP signal is not mediated by a transient drop in the intracellular pH
41. Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: Intracellular pH and the effect of membrane depolarizing compounds
42. In yeast, Ras proteins are controlling elements of adenylate cyclase
43. Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae
44. Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase
45. Effect of caffeine on glucose-induced inactivation of gluconeogenetic enzymes in Saccharomyces cerevisiae. A possible role of cyclic AMP
46. Structure and regulation of the multigene family controlling maltose fermentation in budding yeast
47. Differential requirement of the yeast sugar kinases for sugar sensing in establishing the catabolite-repressed state
48. From feast to famine: Adaptation to nutrient depletion in yeast
49. GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G subunit and functions in a Ras-independent pathway
50. G-protein coupled receptor from yeast Saccharomyces cerevisiae