메뉴 건너뛰기




Volumn 18, Issue 20, 1999, Pages 5577-5591

A novel regulator of G protein signalling in yeast, Rgs2, downregulates glucose-activation of the cAMP pathway through direct inhibition of Gpa2

Author keywords

cAMP; G ; Protein kinase A; RGS; Yeast

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; GLYCOGEN; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; REGULATOR PROTEIN; TREHALOSE;

EID: 0033569790     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.20.5577     Document Type: Article
Times cited : (116)

References (70)
  • 2
    • 0032492722 scopus 로고    scopus 로고
    • Sst2 is a GTPase-activating protein for Gpa1: Purification and characterization of a cognate RGS-G a protein pair in yeast
    • Apanovitch, D.M., Slep, K.C., Sigler, P.B. and Dohlman, H.G. (1998) Sst2 is a GTPase-activating protein for Gpa1: purification and characterization of a cognate RGS-G a protein pair in yeast. Biochemistry, 37, 4815-4822.
    • (1998) Biochemistry , vol.37 , pp. 4815-4822
    • Apanovitch, D.M.1    Slep, K.C.2    Sigler, P.B.3    Dohlman, H.G.4
  • 3
    • 0025850305 scopus 로고
    • The YDp plasmids: A uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae
    • Berben, G., Dumont, J., Gilliquet, V., Bolle, P.-A. and Hilger, F. (1991) The YDp plasmids: a uniform set of vectors bearing versatile gene disruption cassettes for Saccharomyces cerevisiae. Yeast, 7, 475-477.
    • (1991) Yeast , vol.7 , pp. 475-477
    • Berben, G.1    Dumont, J.2    Gilliquet, V.3    Bolle, P.-A.4    Hilger, F.5
  • 4
    • 0030576518 scopus 로고    scopus 로고
    • GAIP and RGS4 are GTPase-activating proteins for the G (i) subfamily of G protein a subunits
    • Berman, D.M., Wilkie, T.M. and Gilman, A.G. (1996a) GAIP and RGS4 are GTPase-activating proteins for the G (i) subfamily of G protein a subunits. Cell, 86, 445-452.
    • (1996) Cell , vol.86 , pp. 445-452
    • Berman, D.M.1    Wilkie, T.M.2    Gilman, A.G.3
  • 5
    • 0029861417 scopus 로고    scopus 로고
    • The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis
    • Berman, D.M., Kozasa, J. and Gilman, A.G. (1996b) The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J. Biol. Chem., 271, 27209-27212.
    • (1996) J. Biol. Chem. , vol.271 , pp. 27209-27212
    • Berman, D.M.1    Kozasa, J.2    Gilman, A.G.3
  • 6
    • 0024286760 scopus 로고
    • Studies on the mechanism of the glucose-induced cAMP-signal in glycolysis- and glucose repression-mutants of the yeast Saccharomyces cerevisiae
    • Beullens, M., Mbonyi, K., Geerts, L., Gladines, D., Detremerie, K., Jans, A.W.H. and Thevelein, J.M. (1988) Studies on the mechanism of the glucose-induced cAMP-signal in glycolysis- and glucose repression-mutants of the yeast Saccharomyces cerevisiae. Eur. J. Biochem., 172, 227-231.
    • (1988) Eur. J. Biochem. , vol.172 , pp. 227-231
    • Beullens, M.1    Mbonyi, K.2    Geerts, L.3    Gladines, D.4    Detremerie, K.5    Jans, A.W.H.6    Thevelein, J.M.7
  • 7
    • 0025785410 scopus 로고
    • A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/ E.coli shuttle vectors
    • Bonneaud, N., Ozier-Kalogeropoulos, O., Li, G.Y., Labouesse, M., Minvielle-Sebastia, L. and Lacroute, F.A. (1991) A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/ E.coli shuttle vectors. Yeast, 7, 609-615.
    • (1991) Yeast , vol.7 , pp. 609-615
    • Bonneaud, N.1    Ozier-Kalogeropoulos, O.2    Li, G.Y.3    Labouesse, M.4    Minvielle-Sebastia, L.5    Lacroute, F.A.6
  • 8
    • 0026051160 scopus 로고
    • RAS genes in Saccharomyces cerevisiae - Signal transduction in search of a pathway
    • Broach, J.R. (1991) RAS genes in Saccharomyces cerevisiae - signal transduction in search of a pathway. Trends Genet., 7, 28-33.
    • (1991) Trends Genet. , vol.7 , pp. 28-33
    • Broach, J.R.1
  • 9
    • 0025191377 scopus 로고
    • Aluminofluoride and beryllofluoride complexes: A new phosphate analogs in enzymology
    • Chabre, M. (1990) Aluminofluoride and beryllofluoride complexes: a new phosphate analogs in enzymology. Trends Biochem. Sci., 15, 6-10.
    • (1990) Trends Biochem. Sci. , vol.15 , pp. 6-10
    • Chabre, M.1
  • 10
    • 0030933718 scopus 로고    scopus 로고
    • Characterization of a novel mammalian RGS-protein that binds to G a proteins and inhibits pheromone signaling in yeast
    • Chen, C.H., Zheng, B., Han, J.H. and Lin, S.C. (1997) Characterization of a novel mammalian RGS-protein that binds to G a proteins and inhibits pheromone signaling in yeast. J. Biol. Chem., 272, 8679-8685.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8679-8685
    • Chen, C.H.1    Zheng, B.2    Han, J.H.3    Lin, S.C.4
  • 11
    • 0029843409 scopus 로고    scopus 로고
    • RGS-r, a retinal specific RGS-protein, binds an intermediate conformation of transducin and enhances recycling
    • Chen, C.K., Wieland, T. and Simon, M.I. (1996) RGS-r, a retinal specific RGS-protein, binds an intermediate conformation of transducin and enhances recycling. Proc. Natl Acad. Sci. USA, 93, 12885-12889.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 12885-12889
    • Chen, C.K.1    Wieland, T.2    Simon, M.I.3
  • 12
    • 0032526715 scopus 로고    scopus 로고
    • Involvement of distinct G proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae
    • Colombo, S. et al. (1998) Involvement of distinct G proteins, Gpa2 and Ras, in glucose- and intracellular acidification-induced cAMP signalling in the yeast Saccharomyces cerevisiae. EMBO J., 17, 3326-3341.
    • (1998) EMBO J. , vol.17 , pp. 3326-3341
    • Colombo, S.1
  • 13
    • 0030850943 scopus 로고    scopus 로고
    • The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway
    • Crauwels, M., Donaton, M.C.V., Pernambuco, M.B., Winderickx, J., de Winde, J.H. and Thevelein, J.M. (1997) The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway. Microbiology, 143, 2627-2637.
    • (1997) Microbiology , vol.143 , pp. 2627-2637
    • Crauwels, M.1    Donaton, M.C.V.2    Pernambuco, M.B.3    Winderickx, J.4    De Winde, J.H.5    Thevelein, J.M.6
  • 14
    • 0030807624 scopus 로고    scopus 로고
    • A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole
    • Darsow, T., Rieder, S.E. and Emr, S.D. (1997) A multispecificity syntaxin homologue, Vam3p, essential for autophagic and biosynthetic protein transport to the vacuole. J. Cell Biol, 138, 517-529.
    • (1997) J. Cell Biol , vol.138 , pp. 517-529
    • Darsow, T.1    Rieder, S.E.2    Emr, S.D.3
  • 15
    • 0026715777 scopus 로고
    • A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH
    • de Koning, W. and van Dam, K. (1992) A method for the determination of changes of glycolytic metabolites in yeast on a subsecond time scale using extraction at neutral pH. Anal. Biochem., 204, 118-123.
    • (1992) Anal. Biochem. , vol.204 , pp. 118-123
    • De Koning, W.1    Van Dam, K.2
  • 16
    • 0344528755 scopus 로고    scopus 로고
    • RGS-proteins: More than just GAPs for heterotrimeric G proteins
    • De Vries, L. and Farquhar, M.G. (1999) RGS-proteins: more than just GAPs for heterotrimeric G proteins. Trends. Cell Biol., 9, 138-144.
    • (1999) Trends. Cell Biol. , vol.9 , pp. 138-144
    • De Vries, L.1    Farquhar, M.G.2
  • 17
    • 0029559788 scopus 로고
    • GAIP, a protein that specifically interacts with the trimeric G protein G α i3, is a member of a protein family with a highly conserved core domain
    • De Vries, L., Mousli, M., Wurmser, A. and Farquhar, M.G. (1995) GAIP, a protein that specifically interacts with the trimeric G protein G α i3, is a member of a protein family with a highly conserved core domain. Proc. Natl Acad. Sci. USA, 92, 11916-11920.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 11916-11920
    • De Vries, L.1    Mousli, M.2    Wurmser, A.3    Farquhar, M.G.4
  • 18
    • 0030448762 scopus 로고    scopus 로고
    • GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G α i subunits
    • De Vries, L., Elenko, E., Hubler, L., Jones, T.L. and Farquhar, M.G. (1996) GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G α i subunits. Proc. Natl Acad. Sci. USA, 93, 15203-15208.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 15203-15208
    • De Vries, L.1    Elenko, E.2    Hubler, L.3    Jones, T.L.4    Farquhar, M.G.5
  • 19
    • 0002403263 scopus 로고    scopus 로고
    • From feast to famine: Adaptation to nutrient depletion in yeast
    • Hohmann, S. and Mager, W.H. (eds), Landes, Austin, TX
    • de Winde, J.H., Thevelein, J.M. and Winderickx, J. (1997) From feast to famine: adaptation to nutrient depletion in yeast. In Hohmann, S. and Mager, W.H. (eds), Yeast stress responses. Landes, Austin, TX, pp. 7-52.
    • (1997) Yeast Stress Responses , pp. 7-52
    • De Winde, J.H.1    Thevelein, J.M.2    Winderickx, J.3
  • 20
    • 0023460928 scopus 로고
    • Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: A model for desensitization to pheromone
    • Dietzel, C. and Kurjan, J. (1987) Pheromonal regulation and sequence of the Saccharomyces cerevisiae SST2 gene: a model for desensitization to pheromone. Mol. Cell. Biol., 7, 4169-4177.
    • (1987) Mol. Cell. Biol. , vol.7 , pp. 4169-4177
    • Dietzel, C.1    Kurjan, J.2
  • 21
    • 0029058433 scopus 로고
    • Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae
    • Dohlman, H.G., Apaniesk, D., Chen, Y., Song, J.P. and Nusskern, D. (1995) Inhibition of G-protein signaling by dominant gain-of-function mutations in Sst2p, a pheromone desensitization factor in Saccharomyces cerevisiae. Mol. Cell. Biol., 15, 3635-3643.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3635-3643
    • Dohlman, H.G.1    Apaniesk, D.2    Chen, Y.3    Song, J.P.4    Nusskern, D.5
  • 22
    • 0029767982 scopus 로고    scopus 로고
    • Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: Expression, localization and genetic interaction and physical association with Gpa1 (the G-protein a subunit)
    • Dohlman, H.G., Song, J.P., Ma, D.R., Courchesne, W.E. and Thorner, J. (1996) Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization and genetic interaction and physical association with Gpa1 (the G-protein a subunit). Mol. Cell. Biol., 16, 5194-5209.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 5194-5209
    • Dohlman, H.G.1    Song, J.P.2    Ma, D.R.3    Courchesne, W.E.4    Thorner, J.5
  • 24
    • 0030725498 scopus 로고    scopus 로고
    • Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins
    • Druey, K.M. and Kehrl, J.H. (1997) Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins. Proc. Natl Acad. Sci. USA, 94, 12851-12856.
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 12851-12856
    • Druey, K.M.1    Kehrl, J.H.2
  • 25
    • 0030029727 scopus 로고    scopus 로고
    • Inhibition of C-protein-mediated MAP kinase activation by a new mammalian gene family
    • Druey, K.M., Blumer, K.J., Kang, V.H. and Kehrl, J.H. (1996) Inhibition of C-protein-mediated MAP kinase activation by a new mammalian gene family. Nature, 379, 742-746.
    • (1996) Nature , vol.379 , pp. 742-746
    • Druey, K.M.1    Blumer, K.J.2    Kang, V.H.3    Kehrl, J.H.4
  • 26
    • 0033603315 scopus 로고    scopus 로고
    • Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling
    • Druey, K.M., Ugur, O., Caron, J.M., Chen, C.K., Backlund, P.S. and Jones T.L. (1999) Amino-terminal cysteine residues of RGS16 are required for palmitoylation and modulation of Gi- and Gq-mediated signaling. J. Biol. Chem., 274, 18836-18842.
    • (1999) J. Biol. Chem. , vol.274 , pp. 18836-18842
    • Druey, K.M.1    Ugur, O.2    Caron, J.M.3    Chen, C.K.4    Backlund, P.S.5    Jones, T.L.6
  • 27
    • 0032940102 scopus 로고    scopus 로고
    • RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to G-a11
    • Dulin, N.O., Sorokin, A., Reed, E., Elliott, S., Kehrl, J.H. and Dunn, M.J. (1999) RGS3 inhibits G protein-mediated signaling via translocation to the membrane and binding to G-a11. Mol. Cell. Biol., 19, 714-723.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 714-723
    • Dulin, N.O.1    Sorokin, A.2    Reed, E.3    Elliott, S.4    Kehrl, J.H.5    Dunn, M.J.6
  • 28
    • 0029861940 scopus 로고    scopus 로고
    • Synergy between trehalose and Hsp104 for thermotolerance in Saccharomyces cerevisiae
    • Elliott, B., Haltiwanger, R.S. and Futcher, B. (1996) Synergy between trehalose and Hsp104 for thermotolerance in Saccharomyces cerevisiae. Genetics, 144, 923-933.
    • (1996) Genetics , vol.144 , pp. 923-933
    • Elliott, B.1    Haltiwanger, R.S.2    Futcher, B.3
  • 29
    • 0024406857 scopus 로고
    • A novel genetic system to detect protein-protein interactions
    • Fields, S. and Song, O. (1989) A novel genetic system to detect protein-protein interactions. Nature, 340, 245-246.
    • (1989) Nature , vol.340 , pp. 245-246
    • Fields, S.1    Song, O.2
  • 30
    • 0024266139 scopus 로고
    • New-yeast Escherichia coli shuttle vectors constructed with in vitro mutagenized genes lacking six-base pair restriction sites
    • Gietz, R.D. and Sugino, A. (1988) New-yeast Escherichia coli shuttle vectors constructed with in vitro mutagenized genes lacking six-base pair restriction sites. Gene, 74, 527-534.
    • (1988) Gene , vol.74 , pp. 527-534
    • Gietz, R.D.1    Sugino, A.2
  • 31
    • 0029994841 scopus 로고    scopus 로고
    • A new efficient gene disruption cassette for repeated use in budding yeast
    • Guldener, U., Heck, S., Fiedler, T., Beinhauer, J. and Hegemann, J.H. (1996) A new efficient gene disruption cassette for repeated use in budding yeast. Nucleic Acids Res., 24, 2519-2524.
    • (1996) Nucleic Acids Res. , vol.24 , pp. 2519-2524
    • Guldener, U.1    Heck, S.2    Fiedler, T.3    Beinhauer, J.4    Hegemann, J.H.5
  • 32
    • 0027534678 scopus 로고
    • The growth and signalling defects of the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII
    • Hohmann, S., Neves, M.J., de Koning, W., Alijo, R., Ramos, J. and Thevelein, J.M. (1993) The growth and signalling defects of the ggs1 (fdp1/byp1) deletion mutant on glucose are suppressed by a deletion of the gene encoding hexokinase PII. Curr. Genet., 23, 281-289.
    • (1993) Curr. Genet. , vol.23 , pp. 281-289
    • Hohmann, S.1    Neves, M.J.2    De Koning, W.3    Alijo, R.4    Ramos, J.5    Thevelein, J.M.6
  • 33
    • 0023649963 scopus 로고
    • Rapid changes of heat and desiccation tolerance correlated with changes of trehalose content in Saccharomyces cerevisiae cells subjected to temperature shifts
    • Hottiger, T., Boller, T. and Wiemken, A. (1987) Rapid changes of heat and desiccation tolerance correlated with changes of trehalose content in Saccharomyces cerevisiae cells subjected to temperature shifts. FEBS Lett., 220, 113-115.
    • (1987) FEBS Lett. , vol.220 , pp. 113-115
    • Hottiger, T.1    Boller, T.2    Wiemken, A.3
  • 34
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James, P., Halladay, J. and Craig, E.A. (1996) Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics, 144, 1425-1436.
    • (1996) Genetics , vol.144 , pp. 1425-1436
    • James, P.1    Halladay, J.2    Craig, E.A.3
  • 35
    • 0025483120 scopus 로고
    • Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers
    • Jones, J.S. and Prakash, L. (1990) Yeast Saccharomyces cerevisiae selectable markers in pUC18 polylinkers. Yeast, 6, 363-366.
    • (1990) Yeast , vol.6 , pp. 363-366
    • Jones, J.S.1    Prakash, L.2
  • 36
    • 0030907376 scopus 로고    scopus 로고
    • A new family of G-protein regulators- the RGS-proteins
    • Koelle, M.R. (1997) A new family of G-protein regulators- the RGS-proteins. Curr. Opin. Cell Biol., 9, 143-147.
    • (1997) Curr. Opin. Cell Biol. , vol.9 , pp. 143-147
    • Koelle, M.R.1
  • 37
    • 0032986914 scopus 로고    scopus 로고
    • A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose
    • Kraakman, L., Lemaire, K., Ma, P., Teunissen, A.W., Donaton, M.C., Van Dijck, P., Winderickx J., de Winde, J.H. and Thevelein, J.M. (1999) A Saccharomyces cerevisiae G-protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose. Mol. Microbiol., 32, 1002-1012.
    • (1999) Mol. Microbiol. , vol.32 , pp. 1002-1012
    • Kraakman, L.1    Lemaire, K.2    Ma, P.3    Teunissen, A.W.4    Donaton, M.C.5    Van Dijck, P.6    Winderickx, J.7    De Winde, J.H.8    Thevelein, J.M.9
  • 38
    • 0037829786 scopus 로고    scopus 로고
    • Gpa2p, a G-protein a subunit, regulates growth and pseudohyphal development in Saccharomvces cerevisiae via a cAMP-dependent mechanism
    • Kubler, E., Mosch, H.U., Rupp, S. and Lisanti, M.P. (1997) Gpa2p, a G-protein a subunit, regulates growth and pseudohyphal development in Saccharomvces cerevisiae via a cAMP-dependent mechanism. J. Biol. Chem., 272, 20321-20323.
    • (1997) J. Biol. Chem. , vol.272 , pp. 20321-20323
    • Kubler, E.1    Mosch, H.U.2    Rupp, S.3    Lisanti, M.P.4
  • 39
    • 0030703189 scopus 로고    scopus 로고
    • Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog
    • Lorenz, M.C. and Heitman, J. (1997) Yeast pseudohyphal growth is regulated by GPA2, a G protein a homolog. EMBO J., 16, 7008-7018.
    • (1997) EMBO J. , vol.16 , pp. 7008-7018
    • Lorenz, M.C.1    Heitman, J.2
  • 40
    • 0032896365 scopus 로고    scopus 로고
    • The PDE1 encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalling
    • Ma, P., Wera, S., Van Dijck, P. and Thevelein, J.M. (1999) The PDE1 encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalling. Mol. Biol. Cell, 10, 91-104.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 91-104
    • Ma, P.1    Wera, S.2    Van Dijck, P.3    Thevelein, J.M.4
  • 41
    • 0024988790 scopus 로고
    • Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase
    • Mbonyi, K., Van Aelst, L., Argüelles, J.C., Jans, A.W.H. and Thevelein, J.M. (1990) Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase. Mol. Cell. Biol., 10, 4518-4523.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 4518-4523
    • Mbonyi, K.1    Van Aelst, L.2    Argüelles, J.C.3    Jans, A.W.H.4    Thevelein, J.M.5
  • 42
    • 0030036699 scopus 로고    scopus 로고
    • Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate and GTPase-activating proteins
    • Mittal, R., Ahmadian, M.R., Goody, R.S. and Wittinghofer, A. (1996) Formation of a transition-state analog of the Ras GTPase reaction by Ras-GDP, tetrafluoroaluminate and GTPase-activating proteins. Science, 273, 115-117.
    • (1996) Science , vol.273 , pp. 115-117
    • Mittal, R.1    Ahmadian, M.R.2    Goody, R.S.3    Wittinghofer, A.4
  • 43
    • 0029861894 scopus 로고    scopus 로고
    • Multiple DNA and protein sequence alignment based on segment-to-segment comparison
    • Morgenstern, B., Dress, A. and Werner, T. (1996) Multiple DNA and protein sequence alignment based on segment-to-segment comparison. Proc. Natl Acad. Sci. USA, 93, 12098-12103.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 12098-12103
    • Morgenstern, B.1    Dress, A.2    Werner, T.3
  • 44
    • 0023972484 scopus 로고
    • Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: Studies on its structure and possible functions
    • Nakafuku, M. et al. (1988) Isolation of a second yeast Saccharomyces cerevisiae gene (GPA2) coding for guanine nucleotide-binding regulatory protein: studies on its structure and possible functions. Proc. Natl Acad. Sci. USA, 85, 1374-1378.
    • (1988) Proc. Natl Acad. Sci. USA , vol.85 , pp. 1374-1378
    • Nakafuku, M.1
  • 45
    • 0032578353 scopus 로고    scopus 로고
    • A single mutation Asp229→Ser confers upon Gs a the ability to interact with regulators of G protein signaling
    • Natochin, M. and Artemyev, N.O. (1998a) A single mutation Asp229→Ser confers upon Gs a the ability to interact with regulators of G protein signaling. Biochemistry, 37, 13776-13780.
    • (1998) Biochemistry , vol.37 , pp. 13776-13780
    • Natochin, M.1    Artemyev, N.O.2
  • 46
    • 0032548499 scopus 로고    scopus 로고
    • Substitution of transducin ser202 by asp abolishes G-protein/RGS interaction
    • Natochin, M. and Artemyev, N.O. (1998b) Substitution of transducin ser202 by asp abolishes G-protein/RGS interaction. J. Biol. Chem., 273, 4300-4303.
    • (1998) J. Biol. Chem. , vol.273 , pp. 4300-4303
    • Natochin, M.1    Artemyev, N.O.2
  • 47
    • 0030859014 scopus 로고    scopus 로고
    • Regulation of transducin GTPase activity by human retinal RGS
    • Natochin, M., Granovsky, A.E. and Artemyev, N.O. (1997) Regulation of transducin GTPase activity by human retinal RGS. J. Biol. Chem., 272, 17444-17449.
    • (1997) J. Biol. Chem. , vol.272 , pp. 17444-17449
    • Natochin, M.1    Granovsky, A.E.2    Artemyev, N.O.3
  • 48
    • 0032549513 scopus 로고    scopus 로고
    • Mutational analysis of the Asn residue essential for RGS-protein binding to G-proteins
    • Natochin, M., McEntaffer, R.L. and Artemyev, N.O. (1998) Mutational analysis of the Asn residue essential for RGS-protein binding to G-proteins. J. Biol. Chem., 273, 6731-6735.
    • (1998) J. Biol. Chem. , vol.273 , pp. 6731-6735
    • Natochin, M.1    McEntaffer, R.L.2    Artemyev, N.O.3
  • 49
    • 0023442858 scopus 로고
    • Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae
    • Nikawa, J., Cameron, S., Toda, T., Ferguson, K.W. and Wigler, M. (1987) Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev., 1, 931-937.
    • (1987) Genes Dev. , vol.1 , pp. 931-937
    • Nikawa, J.1    Cameron, S.2    Toda, T.3    Ferguson, K.W.4    Wigler, M.5
  • 50
    • 0022971952 scopus 로고
    • Amino acid sequences common to rapidly degraded proteins: The PEST hypothesis
    • Rogers, S., Wells, R. and Rechsteiner, M. (1986) Amino acid sequences common to rapidly degraded proteins: the PEST hypothesis. Science, 234, 364-368.
    • (1986) Science , vol.234 , pp. 364-368
    • Rogers, S.1    Wells, R.2    Rechsteiner, M.3
  • 51
    • 0029395010 scopus 로고
    • Stress signaling in yeast
    • Ruis, H. and Schuller, C. (1995) Stress signaling in yeast. BioEssays, 17, 959-965.
    • (1995) BioEssays , vol.17 , pp. 959-965
    • Ruis, H.1    Schuller, C.2
  • 52
    • 0026523626 scopus 로고
    • Hsp104 is required for tolerance to many forms of stress
    • Sanchez, Y., Taulien, J., Borkovich, K.A. and Lindquist, S. (1992) Hsp104 is required for tolerance to many forms of stress. EMBO J., 11, 2357-2364.
    • (1992) EMBO J. , vol.11 , pp. 2357-2364
    • Sanchez, Y.1    Taulien, J.2    Borkovich, K.A.3    Lindquist, S.4
  • 53
    • 0030772378 scopus 로고    scopus 로고
    • The Ras-RasGAP complex: Structural basis for GTPase activation and its loss in oncogenic Ras mutants
    • Scheffzek, K., Ahmadian, M.R., Kabsch, W., Wiesmuller, L., Lautwein, A., Schmitz, F., and Wittinghofer, A. (1997) The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants. Science, 277, 333-338.
    • (1997) Science , vol.277 , pp. 333-338
    • Scheffzek, K.1    Ahmadian, M.R.2    Kabsch, W.3    Wiesmuller, L.4    Lautwein, A.5    Schmitz, F.6    Wittinghofer, A.7
  • 54
    • 0032127912 scopus 로고    scopus 로고
    • GTPase-activating proteins: Helping hands to complement an active site
    • Scheffzek, K., Ahmadian, M.R. and Wittinghofer, A. (1998) GTPase-activating proteins: helping hands to complement an active site. Trends Biochem. Sci., 23, 257-262.
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 257-262
    • Scheffzek, K.1    Ahmadian, M.R.2    Wittinghofer, A.3
  • 55
    • 0032568655 scopus 로고    scopus 로고
    • SMART, a simple modular architecture research tool: Identification of signaling domains
    • Schultz, J., Milpetz, F., Bork, P. and Ponting, C.P. (1998) SMART, a simple modular architecture research tool: identification of signaling domains. Proc. Natl Acad. Sci. USA, 95, 5857-5864.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 5857-5864
    • Schultz, J.1    Milpetz, F.2    Bork, P.3    Ponting, C.P.4
  • 56
    • 0032510737 scopus 로고    scopus 로고
    • Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae
    • Srinivasa, S.P., Bernstein, L.S., Blumer, K.J. and Linder, M.E. (1998) Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 95, 5584-5589.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 5584-5589
    • Srinivasa, S.P.1    Bernstein, L.S.2    Blumer, K.J.3    Linder, M.E.4
  • 57
    • 0030982264 scopus 로고    scopus 로고
    • Structure of RGS4 bound to A1F4-activated G (i a1): Stabilization of the transition state for GTP hydrolysis
    • Tesmer, J.J., Berman, D.M., Gilman, A.G. and Sprang, S.R. (1997) Structure of RGS4 bound to A1F4-activated G (i a1): stabilization of the transition state for GTP hydrolysis. Cell, 89, 251-261.
    • (1997) Cell , vol.89 , pp. 251-261
    • Tesmer, J.J.1    Berman, D.M.2    Gilman, A.G.3    Sprang, S.R.4
  • 58
    • 0025879946 scopus 로고
    • Fermentable sugars and intracellular acidification as specific activators of the Ras-adenylate cyclase signalling pathway in yeast: The relationship to nutrient-induced cell cycle control
    • Thevelein, J.M. (1991) Fermentable sugars and intracellular acidification as specific activators of the Ras-adenylate cyclase signalling pathway in yeast: the relationship to nutrient-induced cell cycle control. Mol. Microbiol., 5, 1301-1307.
    • (1991) Mol. Microbiol. , vol.5 , pp. 1301-1307
    • Thevelein, J.M.1
  • 59
    • 0028675642 scopus 로고
    • Signal transduction in yeast
    • Thevelein, J.M. (1994) Signal transduction in yeast. Yeast. 10, 1753-1790.
    • (1994) Yeast , vol.10 , pp. 1753-1790
    • Thevelein, J.M.1
  • 60
    • 0032835137 scopus 로고    scopus 로고
    • Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae
    • Thevelein, J.M. and de Winde, J.H. (1999) Novel sensing mechanisms and targets for the cAMP-protein kinase A pathway in the yeast Saccharomyces cerevisiae. Mol. Microbiol., 33, 904-918.
    • (1999) Mol. Microbiol. , vol.33 , pp. 904-918
    • Thevelein, J.M.1    De Winde, J.H.2
  • 61
    • 0024977417 scopus 로고
    • Elevated recombination rates in transcriptionally active DNA
    • Thomas, B.J. and Rothstein, R.J. (1989) Elevated recombination rates in transcriptionally active DNA. Cell, 56, 619-630.
    • (1989) Cell , vol.56 , pp. 619-630
    • Thomas, B.J.1    Rothstein, R.J.2
  • 62
    • 0027968068 scopus 로고
    • CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice
    • Thompson, J.D., Higgins, D.G. and Gibson, T.J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, positions-specific gap penalties and weight matrix choice. Nucleic Acids Res., 22, 4673-4680.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4673-4680
    • Thompson, J.D.1    Higgins, D.G.2    Gibson, T.J.3
  • 63
    • 0027178144 scopus 로고
    • Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae
    • Van Aelst, L. et al. (1993) Molecular cloning of a gene involved in glucose sensing in the yeast Saccharomyces cerevisiae. Mol. Microbiol., 8, 927-943.
    • (1993) Mol. Microbiol. , vol.8 , pp. 927-943
    • Van Aelst, L.1
  • 64
    • 0033000062 scopus 로고    scopus 로고
    • A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level
    • Vanhalewyn, M., Dumortier, F., Debast, G., Colombo, S., Ma, P., Winderickx, J., Van Dijck, P. and Thevelein, J.M. (1999) A mutation in Saccharomyces cerevisiae adenylate cyclase, Cyr1K1876M, specifically affects glucose- and acidification-induced cAMP signalling and not the basal cAMP level. Mol. Microbiol., 33, 363-376.
    • (1999) Mol. Microbiol. , vol.33 , pp. 363-376
    • Vanhalewyn, M.1    Dumortier, F.2    Debast, G.3    Colombo, S.4    Ma, P.5    Winderickx, J.6    Van Dijck, P.7    Thevelein, J.M.8
  • 65
    • 0028820129 scopus 로고
    • The Saccharomyces cerevisiae HSP12 gene is activated by the high-osmolarity glycerol pathway and negatively regulated by protein kinase A
    • Varela, J.C.S., Praekelt, U.M., Meacock, P.A., Planta, R.J. and Mager, W.H. (1995) The Saccharomyces cerevisiae HSP12 gene is activated by the high-osmolarity glycerol pathway and negatively regulated by protein kinase A. Mol. Cell. Biol., 15, 6232-6245.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 6232-6245
    • Varela, J.C.S.1    Praekelt, U.M.2    Meacock, P.A.3    Planta, R.J.4    Mager, W.H.5
  • 66
    • 0029808079 scopus 로고    scopus 로고
    • RGS family members: GTPase-activating proteins for heterotrimeric G-protein a-subunits
    • Watson, N., Linder, M.E., Druey, K.M., Kehrl, J.H. and Blumer, K.J. (1996) RGS family members: GTPase-activating proteins for heterotrimeric G-protein a-subunits. Nature, 383, 172-175.
    • (1996) Nature , vol.383 , pp. 172-175
    • Watson, N.1    Linder, M.E.2    Druey, K.M.3    Kehrl, J.H.4    Blumer, K.J.5
  • 67
    • 0024151614 scopus 로고
    • Studies of RAS function in the yeast Saccharomyces cerevisiae
    • Wigler, M. et al. (1988) Studies of RAS function in the yeast Saccharomyces cerevisiae. Cold Spring Harb. Svmp. Quant. Biol., 53, 649-655.
    • (1988) Cold Spring Harb. Svmp. Quant. Biol. , vol.53 , pp. 649-655
    • Wigler, M.1
  • 68
    • 0032055105 scopus 로고    scopus 로고
    • GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G subunit and functions in a Ras-independent pathway
    • Xue, Y., Batlle, M. and Hirsch, J.P. (1998) GPR1 encodes a putative G protein-coupled receptor that associates with the Gpa2p G subunit and functions in a Ras-independent pathway. EMBO J., 17, 1996-2007.
    • (1998) EMBO J. , vol.17 , pp. 1996-2007
    • Xue, Y.1    Batlle, M.2    Hirsch, J.P.3
  • 70
    • 0033613580 scopus 로고    scopus 로고
    • RGS16 attenuates G-αq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor
    • Zhang, Y., Neo, S.Y., Han, J., Yaw, L.P. and Lin, S.C. (1999) RGS16 attenuates G-αq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. J. Biol. Chem., 274, 2851-2857.
    • (1999) J. Biol. Chem. , vol.274 , pp. 2851-2857
    • Zhang, Y.1    Neo, S.Y.2    Han, J.3    Yaw, L.P.4    Lin, S.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.