Regulation of a cyclin-CDK-CDK inhibitor complex by inositol pyrophosphates

Science

Volumn 316, Issue 5821, 2007, Pages 109-112

  Lee, Young Sam ^a   Mulugu, Sashidhar ^b   York, John D ^b   O'Shea, Erin K ^a  

^a HARVARD UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR; INOSITOL DERIVATIVE; INOSITOL PYROPHOSPHATE; MYOINOSITOL HEPTAKISPHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG;

ENZYME ACTIVITY; GENE EXPRESSION; INHIBITION; METABOLITE; ORGANIC PHOSPHORUS; SIGNALING;

ARTICLE; CELL LEVEL; ENZYME INHIBITION; ENZYME REGULATION; ENZYME SYNTHESIS; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STARVATION; YEAST;

CELL NUCLEUS; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA-BINDING PROTEINS; INOSITOL PHOSPHATES; PHOSPHOTRANSFERASES (PHOSPHATE GROUP ACCEPTOR); RECOMBINANT PROTEINS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS;

SACCHAROMYCETALES;

EID: 34147092063     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1139080     Document Type: Article

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27. We thank Y. Liu for preparation of strains; P. Fridy for reagents; B. Stern, H. Kim, C. Leimkuhler, and D. Schwarz for comments on the manuscript members of the J.D.Y. laboratory for unpublished data, helpful discussions, and comments on the manuscript and D. Kahne and his laboratory members for access to equipment. This work was supported by NIH R01 GM051377 (E.K.O.), DK070272 (J.D.Y.), and HL055672 (J.D.Y.); the David and Lucile Packard Foundation (E.K.O.); and the Howard Hughes Medical Institute (E.K.O. and J.D.Y.). The authors have no conflicting financial interest.