The Saccharomyces cerevisiae phosphotyrosyl phosphatase activator proteins are required for a subset of the functions disrupted by protein phosphatase 2A mutations

Experimental Cell Research

Volumn 264, Issue 2, 2001, Pages 372-387

  Van Hoof, Christine ^a   Janssens, Veerle ^a   De Baere, Ivo ^a   Stark, Michael J R ^b   De Winde, Johannes H ^a   Winderickx, Joris ^a   Thevelein, Johan M ^a   Merlevede, Wilfried ^a   Goris, Jozef ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Actin cytoskeleton; Bud morphology; Cell cycle; Mitotic spindle; Phosphotyrosyl phosphatase activator; PP2A; Protein phosphatase 2A; PTPA

Indexed keywords

NOCODAZOLE; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOTYROSYL PHOSPHATASE ACTIVATOR PROTEIN; PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE; ENZYME ANALYSIS; GENE DELETION; GENE MUTATION; GENOTYPE; MITOSIS SPINDLE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 0035298134     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2000.5144     Document Type: Article

References (67)

1. Protein serine/threonine phosphatases: Structure, regulation and functions in cell growth
2. Protein phosphatase 2A - A 'ménage à trois'
3. Serine/threonine phosphatases
4. Protein phosphatases
5. Structure of the 55-kDa regulatory subunit of protein phosphatase 2A: Evidence for a neuronal-specific isoform
6. Structure and expression of a 72 kDa regulatory subunit of protein phosphatase 2A
7. Diversity of regulatory B subunits of protein phosphatase 2A: Identification of a novel isoform highly expressed in brain
8. Identification of a new family of protein phosphatase 2A regulatory subunits
9. 0 defines a novel multimember family of regulatory subunits
10. 0
11. Molecular cloning of a 74-kDa regulatory subunit (B or) of human protein phosphatase 2A
12. Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein
13. PR48, a novel regulatory subunit of protein phosphatase 2A, interacts with Cdc 6 and modulates DNA replication in human cells
14. Separation of PP2A core enzyme and holoenzyme with monoclonal antibodies against the regulatory A subunit: Abundant expression of both forms in cells
15. PTPA adjusts the phosphotyrosyl phosphatase activity of PP2A
16. Regulation of protein kinase cascades by protein phosphatase 2A
17. Protein phosphatase 2A: Who shall regulate the regulator?
18. Eukaryotic translation termination factor 1 associates with protein phosphatase 2A and targets it to ribosomes
19. Protein phosphatase 2A: A panoply of enzymes
20. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A
21. Raf-1-associated protein phosphatase 2A as a positive regulator of kinase activation
22. Autophosphorylation-activated protein kinase phosphorylates and inactivates protein phosphatase 2A
23. Tyrosine phosphorylation of protein phosphatase 2A in response to growth stimulation and v-src transformation of fibroblasts
24. Protein phosphatase 2A catalytic subunit is methyl-esterified at its carboxyl terminus by a novel methyltransferase
25. Protein phosphatase 2A is reversibly modified by methyl esterification at its C-terminal leucine residue in bovine brain
26. The catalytic subunit of protein phosphatase 2A is carboxymethylated in vivo
27. A specific carboxyl methylesterase that demethylates phosphoprotein phosphatase 2A in bovine brain
28. Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue
29. A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of protein phosphatase 2A
30. Isolation and characterization of a tyrosyl phosphatase activator from rabbit skeletal muscle and Xenopus laevis oocytes
31. Molecular cloning, expression and characterization of PTPA, a protein that activates the tyrosyl phosphatase activity of protein phosphatase 2A
32. The phosphotyrosyl phosphatase activator (PTPA) of protein phosphatase 2A: A novel purification method, immunological and enzymic characterization
33. Functional analysis of conserved domains in the phosphotyrosyl phosphatase activator: Molecular cloning of the homologues from Drosophila melanogaster and Saccharomyces cerevisiae
34. A yeast homologue of the human phosphotyrosyl phosphatase activator PTPA is implicated in protection against oxidative DNA damage induced by the model carcinogen 4-nitroquinoline 1-Oxide
35. The phosphotyrosyl phosphatase activator of protein phosphatase 2A, YPA functions in the G1 phase of the cell cycle in Saccharomyces cerevisiae
36. Functional analysis of RRD1 (YIL153w) and RRD2 (YPL152w), which encode two putative activators of the tyrosyl phosphatase activity of PP2A in Saccharomyces cerevisiae
37. Yeast protein serine/threonine phosphatases: Multiple roles and diverse regulation
38. Saccaromyces cerevisiae protein phosphatase 2A performs an essential cellular function and is encoded by two genes
39. Protein phosphatase 2A in Saccaromyces cerevisiae: Effects on cell growth and bud morphogenesis
40. Mutations in the Saccharomyces cerevisiae type 2A protein phosphatase catalytic subunit reveal roles in cell wall integrity, actin cytoskeleton organization and mitosis
41. The role of Saccharomyces cerevisiae type 2A phosphatase in the actin cytoskeleton and in entry into mitosis
42. Role of protein phosphatase 2A in the control of glycogen metabolism in yeast
43. CDC55, a Saccharomyces cerevisiae gene involved in cellular morphogenesis: Identification, characterization, and homology to the B subunit of mammalian type 2A protein phosphatase
44. Protein phosphatase 2A regulates MPF activity and sister chromatid cohesion in budding yeast
45. Cdc55, the B-type regulatory subunit of protein phosphatase 2A, has multiple functions in mitosis and is required for the kinetochore/spindle checkpoint in Saccharomyces cerevisiae
46. Inactivation of the protein phosphatase 2A regulatory subunit A results in morphological and transcriptional defects in Saccharomyces cerevisiae
47. Rox3p and Rts1 function in the global stress response pathway in baker's yeast
48. Molecular genetic analysis of Rts1, a B′ regulatory subunit of Saccharomyces cerevisiae protein phosphatase 2A
49. Saccharomyces cerevisiae homologs of mammalian B and B′ subunits of protein phosphatase 2A direct the enzyme to distinct cellular fucntions
50. The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway
51. Characterization and physiological importance of a novel cell cycle regulated protein kinase in Xenopus laevis oocytes that phosphorylates cyclin B2
52. Analysis of the response of Saccharomyces cerevisiae cells to Kluyveromyces lactis toxin
53. Synthetic peptides as model substrates for the study of the specificity of the polycation-stimulated phosphatases
54. cdc2 kinase
55. Assay of inorganic and organic phosphorus in the 0.1-5 nanomole range
56. PTPA regulating PP2A as a dual specificity phosphatase
57. Cell cycle control of morphogenesis in budding yeast
58. Mechanisms that help the yeast cell cycle clock tick: G2 cyclins transcriptionally activate G2 cyclins and repress G1 cyclins
59. Cell cycle arrest in cdc20 mutants of Saccharomyces cerevisiae is independent of Ndc10p and kinetochore function but requires a subset of spindle checkpoint genes
60. 2 from rabbit skeletal muscle
61. Purification and properties of the polycation-stimulated phosphorylase phosphatases from rabbit skeletal muscle
62. Role of astral microtubules and actin in the spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae
63. Loss of a protein phosphatase 2A regulatory subunit (Cdc55p) elicits improper regulation of Swe1p degradation
64. In vivo activation of a microtubule-associated protein kinase during the meiotic maturation of the Xenopus oocyte
65. Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo
66. Nutrients, via the Tor proteins, stimulate the association of Tap42 with type 2A phosphatases