메뉴 건너뛰기




Volumn 24, Issue 7, 2004, Pages 2779-2788

Mdt1, a Novel Rad53 FHA1 Domain-Interacting Protein, Modulates DNA Damage Tolerance and G2/M Cell Cycle Progression in Saccharomyces cerevisiae

Author keywords

[No Author keywords available]

Indexed keywords

CELL DNA; CELL PROTEIN; CHECKPOINT KINASE 2; PHOSPHOTHREONINE; PROTEIN MDT1; PROTEIN MEC1; THREONINE; UNCLASSIFIED DRUG;

EID: 1642411849     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.24.7.2779-2788.2004     Document Type: Article
Times cited : (36)

References (53)
  • 1
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham, R. T. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev. 15:2177-2196.
    • (2001) Genes Dev. , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 6
    • 0032076248 scopus 로고    scopus 로고
    • The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
    • Carney, J. P., R. S. Maser, H. Olivares, E. M. Davis, M. Le Beau, J. R. Yates III, L. Hays, W. F. Morgan, and J. H. Petrini. 1998. The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response. Cell 93:477-486.
    • (1998) Cell , vol.93 , pp. 477-486
    • Carney, J.P.1    Maser, R.S.2    Olivares, H.3    Davis, E.M.4    Le Beau, M.5    Yates III, J.R.6    Hays, L.7    Morgan, W.F.8    Petrini, J.H.9
  • 7
    • 0035890267 scopus 로고    scopus 로고
    • Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression
    • Clerici, M., V. Paciotti, V. Baldo, M. Romano, G. Lucchini, and M. P. Longhese. 2001. Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression. EMBO J. 20:6485-6498.
    • (2001) EMBO J. , vol.20 , pp. 6485-6498
    • Clerici, M.1    Paciotti, V.2    Baldo, V.3    Romano, M.4    Lucchini, G.5    Longhese, M.P.6
  • 8
    • 0035941021 scopus 로고    scopus 로고
    • ATR and ATRIP: Partners in checkpoint signaling
    • Cortez, D., S. Guntuku, J. Qin, and S. J. Elledge. 2001. ATR and ATRIP: partners in checkpoint signaling. Science 294:1713-1716.
    • (2001) Science , vol.294 , pp. 1713-1716
    • Cortez, D.1    Guntuku, S.2    Qin, J.3    Elledge, S.J.4
  • 9
    • 0032079366 scopus 로고    scopus 로고
    • RAD9 and RAD24 define two additive, interacting branches of the DNA damage check-point pathway in budding yeast normally required for Rad53 modification and activation
    • de la Torre-Ruiz, M. A., C. M. Green, and N. F. Lowndes. 1998. RAD9 and RAD24 define two additive, interacting branches of the DNA damage check-point pathway in budding yeast normally required for Rad53 modification and activation. EMBO J. 17:2687-2698.
    • (1998) EMBO J. , vol.17 , pp. 2687-2698
    • De La Torre-Ruiz, M.A.1    Green, C.M.2    Lowndes, N.F.3
  • 10
    • 0035958585 scopus 로고    scopus 로고
    • Prions affect the appearance of other prions: The story of [PIN+]
    • Derkatch, I. L., M. E. Bradley, J. Y. Hong, and S. W. Liebman. 2001. Prions affect the appearance of other prions: the story of [PIN+]. Cell 106:171-182.
    • (2001) Cell , vol.106 , pp. 171-182
    • Derkatch, I.L.1    Bradley, M.E.2    Hong, J.Y.3    Liebman, S.W.4
  • 11
    • 0037059064 scopus 로고    scopus 로고
    • An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing
    • Duncker, B. P., K. Shimada, M. Tsai-Pflugfelder, P. Pasero, and S. M. Gasser. 2002. An N-terminal domain of Dbf4p mediates interaction with both origin recognition complex (ORC) and Rad53p and can deregulate late origin firing. Proc. Natl. Acad. Sci. USA 99:16087-16092.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16087-16092
    • Duncker, B.P.1    Shimada, K.2    Tsai-Pflugfelder, M.3    Pasero, P.4    Gasser, S.M.5
  • 13
    • 0033638454 scopus 로고    scopus 로고
    • The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms
    • Durocher, D., I. A. Taylor, D. Sarbassova, L. F. Haire, S. L. Westcott, S. P. Jackson, S. J. Smerdon, and M. B. Yaffe. 2000. The molecular basis of FHA domain:phosphopeptide binding specificity and implications for phospho-dependent signaling mechanisms. Mol. Cell 6:1169-1182.
    • (2000) Mol. Cell , vol.6 , pp. 1169-1182
    • Durocher, D.1    Taylor, I.A.2    Sarbassova, D.3    Haire, L.F.4    Westcott, S.L.5    Jackson, S.P.6    Smerdon, S.J.7    Yaffe, M.B.8
  • 14
    • 0032133216 scopus 로고    scopus 로고
    • MEC1-dependent phosphorylation of Rad9p in response to DNA damage
    • Emili, A. 1998. MEC1-dependent phosphorylation of Rad9p in response to DNA damage. Mol. Cell 2:183-189.
    • (1998) Mol. Cell , vol.2 , pp. 183-189
    • Emili, A.1
  • 15
    • 0035101733 scopus 로고    scopus 로고
    • Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1
    • Emili, A., D. M. Schieltz, J. R. Yates III, and L. H. Hartwell. 2001. Dynamic interaction of DNA damage checkpoint protein Rad53 with chromatin assembly factor Asf1. Mol. Cell 7:13-20.
    • (2001) Mol. Cell , vol.7 , pp. 13-20
    • Emili, A.1    Schieltz, D.M.2    Yates III, J.R.3    Hartwell, L.H.4
  • 16
    • 0024406857 scopus 로고
    • A novel genetic system to detect protein-protein interactions
    • Fields, S., and O. Song. 1989. A novel genetic system to detect protein-protein interactions. Nature 340:245-247.
    • (1989) Nature , vol.340 , pp. 245-247
    • Fields, S.1    Song, O.2
  • 17
    • 0037151028 scopus 로고    scopus 로고
    • Posttranscriptional regulation of the RAD5 DNA repair gene by the Dunl kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks
    • Hammet, A., B. L. Pike, and J. Heierhorst. 2002. Posttranscriptional regulation of the RAD5 DNA repair gene by the Dunl kinase and the Pan2-Pan3 poly(A)-nuclease complex contributes to survival of replication blocks. J. Biol. Chem. 277:22469-22474.
    • (2002) J. Biol. Chem. , vol.277 , pp. 22469-22474
    • Hammet, A.1    Pike, B.L.2    Heierhorst, J.3
  • 21
    • 0032483576 scopus 로고    scopus 로고
    • The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor
    • Huang, M., Z. Zhou, and S. J. Elledge. 1998. The DNA replication and damage checkpoint pathways induce transcription by inhibition of the Crt1 repressor. Cell 94:595-605.
    • (1998) Cell , vol.94 , pp. 595-605
    • Huang, M.1    Zhou, Z.2    Elledge, S.J.3
  • 22
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James, P., J. Hailaday, and E. A. Craig. 1996. Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144:1425-1436.
    • (1996) Genetics , vol.144 , pp. 1425-1436
    • James, P.1    Hailaday, J.2    Craig, E.A.3
  • 23
    • 0037135134 scopus 로고    scopus 로고
    • Systematic identification of pathways that couple cell growth and division in yeast
    • Jorgensen, P., J. L. Nishikawa, B.-J. Breitkreutz, and M. Tyers. 2002. Systematic identification of pathways that couple cell growth and division in yeast. Science 297:395-400.
    • (2002) Science , vol.297 , pp. 395-400
    • Jorgensen, P.1    Nishikawa, J.L.2    Breitkreutz, B.-J.3    Tyers, M.4
  • 24
    • 0032962928 scopus 로고    scopus 로고
    • Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway
    • Kondo, T., K. Matsumoto, and K. Sugimoto. 1999. Role of a complex containing Rad17, Mec3, and Ddc1 in the yeast DNA damage checkpoint pathway. Mol. Cell. Biol. 19:1136-1143.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1136-1143
    • Kondo, T.1    Matsumoto, K.2    Sugimoto, K.3
  • 25
    • 0343442520 scopus 로고    scopus 로고
    • Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase
    • Kumar, R., D. M. Reynolds, A. Shevchenko, S. D. Goldstone, and S. Dalton. 2000. Forkhead transcription factors, Fkh1p and Fkh2p, collaborate with Mcm1p to control transcription required for M-phase. Curr. Biol. 10:896-906.
    • (2000) Curr. Biol. , vol.10 , pp. 896-906
    • Kumar, R.1    Reynolds, D.M.2    Shevchenko, A.3    Goldstone, S.D.4    Dalton, S.5
  • 26
    • 0042470439 scopus 로고    scopus 로고
    • Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling
    • Lee, S. J., M. F. Schwartz, J. K. Duong, and D. F. Stern. 2003. Rad53 phosphorylation site clusters are important for Rad53 regulation and signaling. Mol. Cell. Biol. 23:6300-6314.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6300-6314
    • Lee, S.J.1    Schwartz, M.F.2    Duong, J.K.3    Stern, D.F.4
  • 27
    • 0344643062 scopus 로고    scopus 로고
    • PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break
    • Leroy, C., S. E. Lee, M. B. Vaze, F. Ochsenbien, R. Guerois, J. E. Haber, and M. C. Marsolier-Kergoat. 2003. PP2C phosphatases Ptc2 and Ptc3 are required for DNA checkpoint inactivation after a double-strand break. Mol. Cell 11:827-835.
    • (2003) Mol. Cell , vol.11 , pp. 827-835
    • Leroy, C.1    Lee, S.E.2    Vaze, M.B.3    Ochsenbien, F.4    Guerois, R.5    Haber, J.E.6    Marsolier-Kergoat, M.C.7
  • 28
    • 0034531364 scopus 로고    scopus 로고
    • The FHA domain mediates phosphoprotein interactions
    • Li, J., G. Lee, S. R. Van Doren, and J. C. Walker. 2000. The FHA domain mediates phosphoprotein interactions. J. Cell Sci. 113:4143-4149.
    • (2000) J. Cell Sci. , vol.113 , pp. 4143-4149
    • Li, J.1    Lee, G.2    Van Doren, S.R.3    Walker, J.C.4
  • 29
    • 0028574241 scopus 로고
    • Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro
    • Lin, J. J., and V. A. Zakian. 1994. Isolation and characterization of two Saccharomyces cerevisiae genes that encode proteins that bind to (TG1-3)n single strand telomeric DNA in vitro. Nucleic Acids Res. 22:4906-4913.
    • (1994) Nucleic Acids Res. , vol.22 , pp. 4906-4913
    • Lin, J.J.1    Zakian, V.A.2
  • 30
    • 0034610290 scopus 로고    scopus 로고
    • Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase
    • Mallory, J. C., and T. D. Petes. 2000. Protein kinase activity of Tel1p and Mec1p, two Saccharomyces cerevisiae proteins related to the human ATM protein kinase. Proc. Natl. Acad. Sci. USA 97:13749-13754.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 13749-13754
    • Mallory, J.C.1    Petes, T.D.2
  • 31
    • 0033612287 scopus 로고    scopus 로고
    • Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast
    • Martin, S. G., T. Laroche, N. Suka, M. Grunstein, and S. M. Gasser. 1999. Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast. Cell 97:621-633.
    • (1999) Cell , vol.97 , pp. 621-633
    • Martin, S.G.1    Laroche, T.2    Suka, N.3    Grunstein, M.4    Gasser, S.M.5
  • 32
    • 0032484084 scopus 로고    scopus 로고
    • Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
    • Matsuoka, S., M. Huang, and S. J. Elledge. 1998. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 282:1893-1897.
    • (1998) Science , vol.282 , pp. 1893-1897
    • Matsuoka, S.1    Huang, M.2    Elledge, S.J.3
  • 34
    • 0028979332 scopus 로고
    • DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint
    • Navas, T. A., Z. Zhou, and S. J. Elledge. 1995. DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint. Cell 80:29-39.
    • (1995) Cell , vol.80 , pp. 29-39
    • Navas, T.A.1    Zhou, Z.2    Elledge, S.J.3
  • 35
    • 0033570894 scopus 로고    scopus 로고
    • Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase
    • Pellicioli, A., C. Lucca, G. Liberi, F. Marini, M. Lopes, P. Plevani, A. Romano, P. P. Di Fiore, and M. Foiani. 1999. Activation of Rad53 kinase in response to DNA damage and its effect in modulating phosphorylation of the lagging strand DNA polymerase. EMBO J. 18:6561-6572.
    • (1999) EMBO J. , vol.18 , pp. 6561-6572
    • Pellicioli, A.1    Lucca, C.2    Liberi, G.3    Marini, F.4    Lopes, M.5    Plevani, P.6    Romano, A.7    Di Fiore, P.P.8    Foiani, M.9
  • 36
    • 0035957965 scopus 로고    scopus 로고
    • Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase
    • Pike, B. L., A. Hammet, and J. Heierhorst. 2001. Role of the N-terminal forkhead-associated domain in the cell cycle checkpoint function of the Rad53 kinase. J. Biol. Chem. 276:14019-14026.
    • (2001) J. Biol. Chem. , vol.276 , pp. 14019-14026
    • Pike, B.L.1    Hammet, A.2    Heierhorst, J.3
  • 37
    • 0042734418 scopus 로고    scopus 로고
    • Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation
    • Pike, B. L., S. Yongkiettrakul, M. D. Tsai, and J. Heierhorst. 2003. Diverse but overlapping functions of the two forkhead-associated (FHA) domains in Rad53 checkpoint kinase activation. J. Biol. Chem. 278:30421-30424.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30421-30424
    • Pike, B.L.1    Yongkiettrakul, S.2    Tsai, M.D.3    Heierhorst, J.4
  • 38
    • 0036241880 scopus 로고    scopus 로고
    • Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo
    • Rouse, J., and S. P. Jackson. 2002. Lcd1p recruits Mec1p to DNA lesions in vitro and in vivo. Mol. Cell 9:857-869.
    • (2002) Mol. Cell , vol.9 , pp. 857-869
    • Rouse, J.1    Jackson, S.P.2
  • 39
    • 0033527787 scopus 로고    scopus 로고
    • Control of the DNA damage checkpoint by chkl and rad53 protein kinases through distinct mechanisms
    • Sanchez, Y., J. Bachant, H. Wang, F. Hu, D. Liu, M. Tetzlaff, and S. J. Elledge. 1999. Control of the DNA damage checkpoint by chkl and rad53 protein kinases through distinct mechanisms. Science 286:1166-1171.
    • (1999) Science , vol.286 , pp. 1166-1171
    • Sanchez, Y.1    Bachant, J.2    Wang, H.3    Hu, F.4    Liu, D.5    Tetzlaff, M.6    Elledge, S.J.7
  • 40
    • 0030593033 scopus 로고    scopus 로고
    • Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways
    • Sanchez, Y., B. A. Desany, W. J. Jones, Q. Liu, B. Wang, and S. J. Elledge. 1996. Regulation of RAD53 by the ATM-like kinases MEC1 and TEL1 in yeast cell cycle checkpoint pathways. Science 271:357-360.
    • (1996) Science , vol.271 , pp. 357-360
    • Sanchez, Y.1    Desany, B.A.2    Jones, W.J.3    Liu, Q.4    Wang, B.5    Elledge, S.J.6
  • 41
    • 0032497529 scopus 로고    scopus 로고
    • A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication
    • Santocanale, C., and J. F. Diffley. 1998. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature 395:615-618.
    • (1998) Nature , vol.395 , pp. 615-618
    • Santocanale, C.1    Diffley, J.F.2
  • 42
    • 0036281710 scopus 로고    scopus 로고
    • Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint
    • Schwartz, M. F., J. K. Duong, Z. Sun, J. S. Morrow, D. Pradhan, and D. F. Stern. 2002. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol. Cell 9:1055-1065.
    • (2002) Mol. Cell , vol.9 , pp. 1055-1065
    • Schwartz, M.F.1    Duong, J.K.2    Sun, Z.3    Morrow, J.S.4    Pradhan, D.5    Stern, D.F.6
  • 44
    • 0033919372 scopus 로고    scopus 로고
    • Polarized growth controls cell shape and bipolar bud site selection in Saccharomyces cerevisiae
    • Sheu, Y. J., Y. Barral, and M. Snyder. 2000. Polarized growth controls cell shape and bipolar bud site selection in Saccharomyces cerevisiae. Mol. Cell. Biol. 20:5235-5247.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5235-5247
    • Sheu, Y.J.1    Barral, Y.2    Snyder, M.3
  • 45
    • 0030664297 scopus 로고    scopus 로고
    • Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
    • Sidorova, J. M., and L. L. Breeden. 1997. Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev. 11:3032-3045.
    • (1997) Genes Dev. , vol.11 , pp. 3032-3045
    • Sidorova, J.M.1    Breeden, L.L.2
  • 46
    • 0032504069 scopus 로고    scopus 로고
    • Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint
    • Sun, Z., J. Hsiao, D. S. Fay, and D. F. Stern. 1998. Rad53 FHA domain associated with phosphorylated Rad9 in the DNA damage checkpoint. Science 281:272-274.
    • (1998) Science , vol.281 , pp. 272-274
    • Sun, Z.1    Hsiao, J.2    Fay, D.S.3    Stern, D.F.4
  • 47
  • 49
    • 0032189952 scopus 로고    scopus 로고
    • The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage
    • Vialard, J. E., C. S. Gilbert, C. M. Green, and N. F. Lowndes. 1998. The budding yeast Rad9 checkpoint protein is subjected to Mec1/Tel1-dependent hyperphosphorylation and interacts with Rad53 after DNA damage. EMBO J. 17:5679-5688.
    • (1998) EMBO J. , vol.17 , pp. 5679-5688
    • Vialard, J.E.1    Gilbert, C.S.2    Green, C.M.3    Lowndes, N.F.4
  • 50
    • 0028353634 scopus 로고
    • Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair
    • Weinert, T. A., G. L. Kiser, and L. H. Hartwell. 1994. Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair. Genes Dev. 8:652-665.
    • (1994) Genes Dev. , vol.8 , pp. 652-665
    • Weinert, T.A.1    Kiser, G.L.2    Hartwell, L.H.3
  • 51
    • 0035796505 scopus 로고    scopus 로고
    • The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage
    • Zhao, X., A. Chabes, V. Domkin, L. Thelander, and R. Rothstein. 2001. The ribonucleotide reductase inhibitor Sml1 is a new target of the Mec1/Rad53 kinase cascade during growth and in response to DNA damage. EMBO J. 20:3544-3553.
    • (2001) EMBO J. , vol.20 , pp. 3544-3553
    • Zhao, X.1    Chabes, A.2    Domkin, V.3    Thelander, L.4    Rothstein, R.5
  • 52
    • 0032161269 scopus 로고    scopus 로고
    • A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools
    • Zhao, X., E. G. Muller, and R. Rothstein. 1998. A suppressor of two essential checkpoint genes identifies a novel protein that negatively affects dNTP pools. Mol. Cell 2:329-340.
    • (1998) Mol. Cell , vol.2 , pp. 329-340
    • Zhao, X.1    Muller, E.G.2    Rothstein, R.3
  • 53
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou, B. B., and S. J. Elledge. 2000. The DNA damage response: putting checkpoints in perspective. Nature 48:433-439.
    • (2000) Nature , vol.48 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.