The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway

Microbiology

Volumn 143, Issue 8, 1997, Pages 2627-2637

  Crauwels, Marion ^a   Donaton, Monica C V ^a   Pernambuco, Maria Beatriz ^a   Winderickx, Joris ^a   De Winde, Johannes H ^a   Thevelein, Johan M ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Nutrient signalling; Ribosomal protein genes; Trehalase; Yeast

Indexed keywords

ADENYLATE CYCLASE; CARBON; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLUCOSE; KEMPTIDE; NITROGEN; PROTEIN KINASE; RAS PROTEIN; TREHALASE; TREHALOSE;

ARTICLE; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME SUBUNIT; FERMENTATION; FUNGUS CULTURE; FUNGUS GROWTH; GENE DELETION; GROWTH RATE; METABOLIC ACTIVATION; METABOLIC INHIBITION; METABOLIC REGULATION; METABOLISM; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

FUNGI; SACCHAROMYCES CEREVISIAE; TRIXIS;

EID: 0030850943     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-8-2627     Document Type: Article

References (48)

1. Arguelles, J. C., Mbonyi, K., Van Aelst, L., Vanhalewyn, M., Jans, A. W. H. & Thevelein, J. M. (1990). Absence of glucose-induced cAMP signalling in the Saccharomyces cerevisiae mutants cat1 and cat3 which are deficient in derepression of glucose-repressible proteins. Arch Microbiol 154, 199-205.
2. Belazzi, T., Wagner, A., Wieser, R., Schanz, M., Adam, G., Hartig, A. & Ruis, H. (1991). Negative regulation of transcription of the Saccharomyces cerevisiae catalase-T (CTT1) gene by cAMP is mediated by a positive control element. EMBO J 10, 585-592.
3. Beullens, M., Mbonyi, K., Geerts, L., Gladines, D., Detremerie, K., Jans, A. W. H. & Thevelein, J. M. (1988). Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae. Eur J Biochem 172, 227-231.
4. Bissinger, P. H., Wieser, R., Hamilton, B. & Ruis, H. (1989). Control of Saccharomyces cerevisiae catalase T gene (CTT1) expression by nutrient supply via the Ras-cyclic AMP pathway. Mol Cell Biol 9, 1309-1315.
5. Boy-Marcotte, E., Tadi, D., Perrot, M., Boucherie, H. & Jacquet, M. (1996). High cAMP levels antagonize the reprogramming of gene expression that occurs at the diauxic shift in Saccharomyces cerevisiae. Microbiology 142, 459-467.
6. Broek, D., Samiy, N., Fasano, O., Fujiyama, A., Tamanoi, F., Northup, J. & Wigler, M. (1985). Differential activation of yeast adenylate cyclase by wild type and mutant Ras proteins. Cell 41, 763-769.
7. Broek, D., Toda, T., Michaeli, T., Levin, L., Birchmeier, C., Zoller, M., Powers, S. & Wigler, M. (1987). The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell 48, 789-799.
8. Cameron, S., Levin, L., Zoller, M. & Wigler, M. (1988). cAMP-independent control of sporulation, glycogen metabolism and heat shock resistance in S. cerevisiae. Cell 53, 555-566.
9. Camonis, J. H., Kalékine, M., Gondré, B., Garreau, H., Boy-Marcotte, E. & Jacquet, M, (1986). Characterization, cloning and sequence analysis of the CDC25 gene which controls the cylic AMP level of Saccharomyces cerevisiae. EMBO J. 5, 375-380.
10. Denis, C. L. & Audino, D. C. (1991). The Ccr1 (Snf1) and Sch9 protein kinases act independently of cAMP-dependent protein kinase and the transcriptional activator Adr1 in controlling yeast ADH2 expression. Mol Gen Genet 229, 395-399.
11. Dumortier, F., Arguelles, J. C. & Thevelein, J. M. (1995). Constitutive glucose-induced activation of the Ras-cAMP pathway and aberrant stationary-phase entry on a glucose-containing medium in the Saccharomyces cerevisiae glucose-repression mutant hex2. Microbiology 141, 1559-1566.
12. Durnez, P., Oris, E., Argüelles, J. C., Mergelsberg, H. & Thevelein, J. M. (1994). Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of cAMP-dependent protein kinase. Yeast 10, 1049-1064.
13. Griffioen, G., Mager, W. H. & Planta, R. J. (1994). Nutritional upshift reponse of ribosomal protein gene transcription in Saccharomyces cerevisiae. FEMS Microbiol Lett 123, 137-144.
14. Griffioen, G., Laan, R. J., Mager, W. H. & Planta, R. J. (1996). Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes. Microbiology 142, 2279-2287.
15. Hirimburegama, K., Durnez, P., Keleman, J., Oris, E., Vergauwen, R., Mergelsberg, H. & Thevelein, J. M. (1992). Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger. J Gen Microbiol 138, 2035-2043.
16. Jin, M., Fujita, M., Culley, B. M., Apolinario, E., Yamamoto, M., Maundrell, K. & Hoffman, C. S. (1995). sck1, a high copy number suppressor of defects in the cAMP-dependent protein kinase pathway in fission yeast, encodes a protein homologous to the Saccharomyces cerevisiae SCH9 kinase. Genetics 140, 457-467.
17. Jones, S., Vignais, M.-L. & Broach, J. R. (1991). The CDC25 protein of Saccharomyces cerevisiae promotes exchange of guanine nucleotides bound to RAS. Mol Cell Biol 11, 2641-2646.
18. Kataoka, T., Broek, D. & Wigler, M. (1985). DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell 43, 493-505.
19. Klein, C. & Struhl, K. (1994). Protein kinase A mediates growth-related expression of ribosomal protein genes by modulating RAP1 transcriptional activity. Mol Cell Biol 14, 1920-1928.
20. Kraakman, L. S., Griffioen, G., Zerp, S., Groeneveld, P., Thevelein, J. M., Mager, W. H. & Planta, R. J. (1993). Growth-related expression of ribosomal protein genes in Saccharomyces cerevisiae. Mol Gen Genet 239, 196-204.
21. Levin, L. R., Kuret, J., Johnston, K. E., Powers, S., Cameron, S., Michaeli, T., Wigler, M. & Zoller, M. J. (1988). A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation. Science 240, 68-70.
22. Lillie, S. H. & Pringle, J. R. (1980). Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation. J Bacteriol 143, 1384-1394.
23. Maeda, T., Watanabe, Y., Kunitomo, H. & Yamamoto, M. (1994). Cloning of the pka1 gene encoding the catalytic subunit of the cAMP-dependent protein kinase in Schizosaccharomyces pombe. J Biol Chem 269, 9632-9637.
24. Mager, W. H. & Planta, R. J. (1991). Coordinate expression of ribosomal protein genes in yeast as a function of cellular growth rate. Mol Cell Biochem 104, 181-187.
25. Mbonyi, K, Beullens, M., Detremerie, K., Geerts, L. & Thevelein, J. M. (1988). Requirement of one functional RAS gene and inability of a Ras-variant to mediate the glucose-induced cAMP signal in the yeast Saccharomyces cerevisiae. Mol Cell Biol 8, 3051-3057.
26. Mbonyi, K., Van Aelst, L., Arguelles, J. C., Jans, A. W. H. & Thevelein, J. M. (1990). Glucose-induced hyperaccumulation of cvclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase. Mol Cell Biol 10, 4518-4523.
27. Neuman-Silberberg, F. S., Bhattacharya, S. & Broach, J. R. (1995). Nutrient availability and the RAS/cyclic AMP pathway both induce expression of ribosomal protein genes in Saccharomyces cerevisiae but by different mechanisms. Mol Cell Biol 15, 3187-3196.
28. Nikawa, J., Cameron, S., Toda, T., Ferguson, K. W. & Wigler, M. (1987a). Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev 1, 931-937.
29. Nikawa, J., Sass, P. & Wigler, M. (1987b). Cloning and characterization of the low-affinity cyclic phosphodiesterase gene of Saccharomyces cerevisiae. Mol Cell Biol 7, 3629-3636.
30. Pernambuco, M. B., Winderickx, J., Crauwels, M., Griffioen, G., Mager, W. H. & Thevelein, J. M. (1996). Differential requirement for sugar phosphorylation in cells of the yeast Saccharomyces cerevisiae grown on glucose or grown on non-fermentable carbon sources for glucose-triggered signalling phenomena. Microbiology 142, 1775-1782.
31. Praekelt, U. M. & Meacock, P. A. (1990). HSP12, a new small heat shock gene of Saccharomyces cerevisiae: analysis of structure, regulation and function. Mol Gen Genet 223, 97-106.
32. Ronne, H. (1995). Glucose repression in fungi. Trends Genet 11, 12-17.
33. Sass, P., Field, J., Nikawa, J., Toda, T. & Wigler, M. (1986). Cloning and characterization of the high-affinity phosphodiesterase of S. cerevisiae. Proc Natl Acad Sci USA 83.
34. Sherman, F., Fink, G. R. & Hicks, J. B. (1986). Methods in Yeast Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory.
35. Soto, T., Fernandez, J., Cansado, J., Vicentesoler, J. & Gacto, M. (1995a). Glucose-induced, cyclic-AMP-independent signalling pathway for activation of neutral trehalase in the fission yeast Schizosaccharomyces pombe. Microbiology 141, 2665-2671.
36. Soto, T., Fernandez, J., Cansado, J., Vicentesoler, J. & Gacto, M. (1995b). Activation of neutral trehalase by glucose and nitrogen-source in Schizosaccharomyces pombe strains deficient in cAMP-dependent protein kinase activity. FEBS Lett 367, 263-266.
37. Tanaka, K., Nakafuku, M., Kaziro, Y., Matsumoto, K. & Toh-e, A. (1990). IRA2, a second gene in Saccharomyces cerevisiae that encodes a protein with a domain homologous to mammalian Ras GTP-ase activating protein. Mol Cell Biol 10, 4303-4313.
38. Thevelein, J. M. (1984). Cyclic-AMP content and trehalase activation in vegetative cells and ascospores of yeast. Arch Microbiol 138, 64-67.
39. Thevelein, J. M. (1991). Fermentable sugars and intracellular acidification as specific activators of the Ras adenylate cyclase signalling pathway in yeast - the relationship to nutrient-induced cell cycle control. Mol Microbiol 5, 1301-1307.
40. Thevelein, J. M. (1994). Signal transduction in yeast. Yeast 10, 1753-1790.
41. Thevelein, J. M. & Beullens, M. (1985). Cyclic AMP and the stimulation of trehalase activity in the yeast Saccharomyces cerevisiae by carbon sources, nitrogen sources and inhibitors of protein synthesis. J Gen Microbiol 131, 3199-3209.
42. Thevelein, J. M. & Hohmann, S. (1995). Trehalose synthase: guard to the gate of glycolysis in yeast? Trends Biochem Sci 20, 3-10.
43. Thevelein, J. M., Beullens, M., Honshoven, F., Hoebeeck, G., Detremerie, K., den Hollander, J. A. & Jans, A. W. H. (1987). Regulation of the cAMP level in the yeast Saccharomyces cerevisiae: intracellular pH and the effect of membrane depolarizing compounds. J Gen Microbiol 133, 2191-2196.
44. Toda, T., Uno, I., Ishikawa, T., Powers, S., Kataoka, T., Broek, D., Cameron, S., Broach, J., Matsumoto, K. & Wigler, M. (1985). In yeast, Ras proteins are controlling elements of adenylate cyclase. Cell 40, 27-36.
45. Toda, T., Cameron, S., Sass, P., Zoller, M., Scott, J. D., McBullen, B., Hurwitz, M., Krebs, E. G. & Wigler, M. (1987a). Cloning and characterisation of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae. Mol Cell Biol 7, 1371-1377.
46. Toda, T., Cameron, S., Sass, P., Zoller, M. & Wigler, M. (1987b). Three different genes in Saccharomyces cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell 50, 277-287.
47. Toda, T., Cameron, S., Sass, P. & Wigler, M. (1988). SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes Dev 2, 517-527.
48. Van der Plaat, J. B. (1974). Cyclic 3′,5′-adenosine monophosphate stimulates trehalose degradation in baker's yeast. Biochem Biophys Res Commun 56, 580-587.