메뉴 건너뛰기




Volumn , Issue , 2008, Pages 241-299

New Developments in the Pathogenesis and Management of Neonatal Pulmonary Hypertension

Author keywords

[No Author keywords available]

Indexed keywords


EID: 70349825388     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-141603166-6.10012-9     Document Type: Chapter
Times cited : (10)

References (450)
  • 1
    • 0022381509 scopus 로고
    • Distribution and regulation of blood flow in the fetal and neonatal lamb
    • AM Rudolph (1985) Distribution and regulation of blood flow in the fetal and neonatal lamb. Circ Res 57 811
    • (1985) Circ Res , vol.57 , pp. 811
    • Rudolph, A.M.1
  • 2
    • 0014749911 scopus 로고
    • Circulatory changes during growth in the fetal lamb
    • AM Rudolph and MA Heymann (1970) Circulatory changes during growth in the fetal lamb. Circ Res 26 289
    • (1970) Circ Res , vol.26 , pp. 289
    • Rudolph, A.M.1    Heymann, M.A.2
  • 3
    • 0018144461 scopus 로고
    • Models of congenital heart disease in fetal lambs
    • NH Fishman, RB Hof, AM Rudolph, et al. (1978) Models of congenital heart disease in fetal lambs. Circulation 58 354
    • (1978) Circulation , vol.58 , pp. 354
    • Fishman, N.H.1    Hof, R.B.2    Rudolph, A.M.3
  • 4
    • 0017722989 scopus 로고
    • Fetal and neonatal pulmonary circulation
    • AM Rudolph (1977) Fetal and neonatal pulmonary circulation. Am Rev Respir Dis 115 11
    • (1977) Am Rev Respir Dis , vol.115 , pp. 11
    • Rudolph, A.M.1
  • 5
    • 0022446313 scopus 로고
    • Blood gases and acid-base status of the human second-trimester fetus
    • PW Soothill, KH Nicolaides, CH Rodeck, et al. (1986) Blood gases and acid-base status of the human second-trimester fetus. Obstet Gynecol 68 173
    • (1986) Obstet Gynecol , vol.68 , pp. 173
    • Soothill, P.W.1    Nicolaides, K.H.2    Rodeck, C.H.3
  • 6
    • 0025356380 scopus 로고
    • Changes in the pulmonary circulation during birth-related events
    • DF Teitel, HS Iwamoto and AM Rudolph (1990) Changes in the pulmonary circulation during birth-related events. Pediatr Res 27 372
    • (1990) Pediatr Res , vol.27 , pp. 372
    • Teitel, D.F.1    Iwamoto, H.S.2    Rudolph, A.M.3
  • 7
    • 0018408032 scopus 로고
    • Augmentation of pulmonary surfactant secretion by lung expansion at birth
    • EE Lawson, RL Birdwell, PS Huang, et al. (1979) Augmentation of pulmonary surfactant secretion by lung expansion at birth. Pediatr Res 13 611
    • (1979) Pediatr Res , vol.13 , pp. 611
    • Lawson, E.E.1    Birdwell, R.L.2    Huang, P.S.3
  • 8
    • 0021507344 scopus 로고
    • Surface active material: influence of lung distension and mechanical ventilation on secretion
    • WE Truog (1984) Surface active material: influence of lung distension and mechanical ventilation on secretion. Semin Perinatol 8 300
    • (1984) Semin Perinatol , vol.8 , pp. 300
    • Truog, W.E.1
  • 9
    • 0017372862 scopus 로고
    • The role of airway receptors in the control of respiration in infants: a review
    • RB Haddad Grellins (1977) The role of airway receptors in the control of respiration in infants: a review. J Pediatr 91 281
    • (1977) J Pediatr , vol.91 , pp. 281
    • Haddad Grellins, R.B.1
  • 10
    • 0023485806 scopus 로고
    • Effects of birth-related events on central blood flow patterns
    • DF Teitel, HS Iwamoto and AM Rudolph (1987) Effects of birth-related events on central blood flow patterns. Pediatr Res 22 557
    • (1987) Pediatr Res , vol.22 , pp. 557
    • Teitel, D.F.1    Iwamoto, H.S.2    Rudolph, A.M.3
  • 11
    • 0023574671 scopus 로고
    • Effects of birth-related events on blood flow distribution
    • HS Iwamoto, D Teitel and AM Rudolph (1987) Effects of birth-related events on blood flow distribution. Pediatr Res 22 634
    • (1987) Pediatr Res , vol.22 , pp. 634
    • Iwamoto, H.S.1    Teitel, D.2    Rudolph, A.M.3
  • 12
    • 0016870166 scopus 로고
    • Morphological development of the pulmonary vascular bed in fetal lambs
    • DL Levin, AM Rudolph, MA Heymann, et al. (1976) Morphological development of the pulmonary vascular bed in fetal lambs. Circulation 53 144
    • (1976) Circulation , vol.53 , pp. 144
    • Levin, D.L.1    Rudolph, A.M.2    Heymann, M.A.3
  • 13
    • 0014737156 scopus 로고
    • The changes in the circulation after birth. Their importance in congenital heart disease
    • AM Rudolph (1970) The changes in the circulation after birth. Their importance in congenital heart disease. Circulation 41 343
    • (1970) Circulation , vol.41 , pp. 343
    • Rudolph, A.M.1
  • 14
    • 0018337016 scopus 로고
    • Fetal and neonatal pulmonary circulation
    • AM Rudolph (1979) Fetal and neonatal pulmonary circulation. Annu Rev Physiol 41 383
    • (1979) Annu Rev Physiol , vol.41 , pp. 383
    • Rudolph, A.M.1
  • 15
    • 0028045680 scopus 로고
    • Ontogeny of NO activity and response to inhaled NO in the developing ovine pulmonary circulation
    • JP Kinsella, DD Ivy and SH Abman (1994) Ontogeny of NO activity and response to inhaled NO in the developing ovine pulmonary circulation. Am J Physiol 267 H1955
    • (1994) Am J Physiol , vol.267 , pp. H1955
    • Kinsella, J.P.1    Ivy, D.D.2    Abman, S.H.3
  • 16
    • 0026741888 scopus 로고
    • Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension
    • FC Morin III and EA Egan (1992) Pulmonary hemodynamics in fetal lambs during development at normal and increased oxygen tension. J Appl Physiol 73 213
    • (1992) J Appl Physiol , vol.73 , pp. 213
    • Morin, F.C.1    Egan, E.A.2
  • 17
    • 0006568964 scopus 로고
    • Arterial changes during the perinatal period
    • RL Naeye (1961) Arterial changes during the perinatal period. Arch Pathol 71 121
    • (1961) Arch Pathol , vol.71 , pp. 121
    • Naeye, R.L.1
  • 18
    • 0015408602 scopus 로고
    • Intra-pulmonary arterial development during fetal life-branching pattern and structure
    • A Hislop and L Reid (1972) Intra-pulmonary arterial development during fetal life-branching pattern and structure. J Anat 113 35
    • (1972) J Anat , vol.113 , pp. 35
    • Hislop, A.1    Reid, L.2
  • 19
    • 0025870473 scopus 로고
    • Pulmonary vascular smooth muscle: biochemical and mechanical developmental changes
    • J Belik, A Halayko, K Rao, et al. (1991) Pulmonary vascular smooth muscle: biochemical and mechanical developmental changes. J Appl Physiol 71 1129
    • (1991) J Appl Physiol , vol.71 , pp. 1129
    • Belik, J.1    Halayko, A.2    Rao, K.3
  • 20
    • 0023425986 scopus 로고
    • Fetal expression of muscle-specific isoactins in multiple organs of the Wistar-Kyoto rat
    • R Ariel Gomez, BC Sturgill, RL Chevalier, et al. (1987) Fetal expression of muscle-specific isoactins in multiple organs of the Wistar-Kyoto rat. Cell Tissue Res 250 7
    • (1987) Cell Tissue Res , vol.250 , pp. 7
    • Ariel Gomez, R.1    Sturgill, B.C.2    Chevalier, R.L.3
  • 21
    • 0004246915 scopus 로고
    • The nervous control of the circulation in the foetal and newly expanded lungs of the lamb
    • HJ Colebatch, GS Dawes, JW Goodwin, et al. (1965) The nervous control of the circulation in the foetal and newly expanded lungs of the lamb. J Physiol 178 544
    • (1965) J Physiol , vol.178 , pp. 544
    • Colebatch, H.J.1    Dawes, G.S.2    Goodwin, J.W.3
  • 22
    • 0017201860 scopus 로고
    • Gestational changes in pulmonary vascular responses in fetal lambs in utero
    • AB Lewis, MA Heymann and AM Rudolph (1976) Gestational changes in pulmonary vascular responses in fetal lambs in utero. Circ Res 39 536
    • (1976) Circ Res , vol.39 , pp. 536
    • Lewis, A.B.1    Heymann, M.A.2    Rudolph, A.M.3
  • 23
    • 0023926028 scopus 로고
    • Effect of changing lung liquid volume on the pulmonary circulation of fetal lambs
    • AM Walker, BC Ritchie, TM Adamson, et al. (1988) Effect of changing lung liquid volume on the pulmonary circulation of fetal lambs. J Appl Physiol 64 61
    • (1988) J Appl Physiol , vol.64 , pp. 61
    • Walker, A.M.1    Ritchie, B.C.2    Adamson, T.M.3
  • 24
    • 0001529359 scopus 로고
    • Changes in the lungs of the new-born lamb
    • GS Dawes, JC Mott, JG Widdicombe, et al. (1953) Changes in the lungs of the new-born lamb. J Physiol 121 141
    • (1953) J Physiol , vol.121 , pp. 141
    • Dawes, G.S.1    Mott, J.C.2    Widdicombe, J.G.3
  • 25
    • 0024418107 scopus 로고
    • Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation
    • SH Abman and FJ Accurso (1989) Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation. Am J Physiol 257 H626
    • (1989) Am J Physiol , vol.257 , pp. H626
    • Abman, S.H.1    Accurso, F.J.2
  • 26
    • 0022654649 scopus 로고
    • Time-dependent response of fetal pulmonary blood flow to an increase in fetal oxygen tension
    • FJ Accurso, B Alpert, RB Wilkening, et al. (1986) Time-dependent response of fetal pulmonary blood flow to an increase in fetal oxygen tension. Respir Physiol 63 43
    • (1986) Respir Physiol , vol.63 , pp. 43
    • Accurso, F.J.1    Alpert, B.2    Wilkening, R.B.3
  • 27
    • 0032953090 scopus 로고    scopus 로고
    • In vivo evidence for a myogenic response in the fetal pulmonary circulation
    • L Storme, RL Rairigh, TA Parker, et al. (1999) In vivo evidence for a myogenic response in the fetal pulmonary circulation. Pediatr Res 45 425
    • (1999) Pediatr Res , vol.45 , pp. 425
    • Storme, L.1    Rairigh, R.L.2    Parker, T.A.3
  • 28
    • 22444445227 scopus 로고    scopus 로고
    • Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation
    • TA Parker, TR Grover, JP Kinsella, et al. (2005) Inhibition of 20-HETE abolishes the myogenic response during NOS antagonism in the ovine fetal pulmonary circulation. Am J Physiol Lung Cell Mol Physiol 289 L261
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289 , pp. L261
    • Parker, T.A.1    Grover, T.R.2    Kinsella, J.P.3
  • 29
    • 0032899216 scopus 로고    scopus 로고
    • Signaling mechanisms underlying the vascular myogenic response
    • MJ Davis and MA Hill (1999) Signaling mechanisms underlying the vascular myogenic response. Physiol Rev 79 387
    • (1999) Physiol Rev , vol.79 , pp. 387
    • Davis, M.J.1    Hill, M.A.2
  • 30
    • 0028235346 scopus 로고
    • Myogenic response in large pulmonary arteries and its ontogenesis
    • J Belik (1994) Myogenic response in large pulmonary arteries and its ontogenesis. Pediatr Res 36 34
    • (1994) Pediatr Res , vol.36 , pp. 34
    • Belik, J.1
  • 31
    • 0024259798 scopus 로고
    • Stretch-induced contraction in pulmonary arteries
    • TJ Kulik, JN Evans and WJ Gamble (1988) Stretch-induced contraction in pulmonary arteries. Am J Physiol 255 H1391
    • (1988) Am J Physiol , vol.255 , pp. H1391
    • Kulik, T.J.1    Evans, J.N.2    Gamble, W.J.3
  • 32
    • 0022471077 scopus 로고
    • Pulmonary arterial distension does not cause pulmonary vasoconstriction
    • TC Lloyd Jr (1986) Pulmonary arterial distension does not cause pulmonary vasoconstriction. J Appl Physiol 61 741
    • (1986) J Appl Physiol , vol.61 , pp. 741
    • Lloyd, T.C.1
  • 33
    • 0023836383 scopus 로고
    • Temporal response of the fetal pulmonary circulation to pharmacologic vasodilators
    • FJ Accurso and RB Wilkening (1988) Temporal response of the fetal pulmonary circulation to pharmacologic vasodilators. Proc Soc Exp Biol Med 187 89
    • (1988) Proc Soc Exp Biol Med , vol.187 , pp. 89
    • Accurso, F.J.1    Wilkening, R.B.2
  • 34
    • 0023890250 scopus 로고
    • Development of pulmonary vascular response to oxygen
    • FC Morin III, EA Egan, W Ferguson, et al. (1988) Development of pulmonary vascular response to oxygen. Am J Physiol 254 H542
    • (1988) Am J Physiol , vol.254 , pp. H542
    • Morin, F.C.1    Egan, E.A.2    Ferguson, W.3
  • 35
    • 0021712595 scopus 로고
    • Perinatal pulmonary responses to arachidonic acid during normoxia and hypoxia
    • ML Tod and S Cassin (1984) Perinatal pulmonary responses to arachidonic acid during normoxia and hypoxia. J Appl Physiol 57 977
    • (1984) J Appl Physiol , vol.57 , pp. 977
    • Tod, M.L.1    Cassin, S.2
  • 36
    • 0016663759 scopus 로고
    • The effects of indomethacin on the pulmonary vascular response to hypoxia in the premature and mature newborn goat
    • T Tyler, R Wallis, C Leffler, et al. (1975) The effects of indomethacin on the pulmonary vascular response to hypoxia in the premature and mature newborn goat. Proc Soc Exp Biol Med 150 695
    • (1975) Proc Soc Exp Biol Med , vol.150 , pp. 695
    • Tyler, T.1    Wallis, R.2    Leffler, C.3
  • 37
    • 0018108872 scopus 로고
    • Circulatory responses of perinatal goats to prostaglandin precursors
    • TL Tyler, CW Leffler and S Cassin (1978) Circulatory responses of perinatal goats to prostaglandin precursors. Prostaglandins Med 1 213
    • (1978) Prostaglandins Med , vol.1 , pp. 213
    • Tyler, T.L.1    Leffler, C.W.2    Cassin, S.3
  • 38
    • 0021796530 scopus 로고
    • Thromboxane synthase inhibition and perinatal pulmonary response to arachidonic acid
    • ML Tod and S Cassin (1985) Thromboxane synthase inhibition and perinatal pulmonary response to arachidonic acid. J Appl Physiol 58 710
    • (1985) J Appl Physiol , vol.58 , pp. 710
    • Tod, M.L.1    Cassin, S.2
  • 39
    • 0022394739 scopus 로고
    • Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs
    • M Clozel, RI Clyman, SJ Soifer, et al. (1985) Thromboxane is not responsible for the high pulmonary vascular resistance in fetal lambs. Pediatr Res 19 1254
    • (1985) Pediatr Res , vol.19 , pp. 1254
    • Clozel, M.1    Clyman, R.I.2    Soifer, S.J.3
  • 40
    • 0023617388 scopus 로고
    • Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs
    • J Lebidois, SJ Soifer, RI Clyman, et al. (1987) Piriprost: a putative leukotriene synthesis inhibitor increases pulmonary blood flow in fetal lambs. Pediatr Res 22 350
    • (1987) Pediatr Res , vol.22 , pp. 350
    • Lebidois, J.1    Soifer, S.J.2    Clyman, R.I.3
  • 41
    • 0022115721 scopus 로고
    • Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs
    • SJ Soifer, RD Loitz, C Roman, et al. (1985) Leukotriene end organ antagonists increase pulmonary blood flow in fetal lambs. Am J Physiol 249 H570
    • (1985) Am J Physiol , vol.249 , pp. H570
    • Soifer, S.J.1    Loitz, R.D.2    Roman, C.3
  • 42
    • 0023071703 scopus 로고
    • Role of prostaglandins, thromboxanes, and leukotrienes in the control of the pulmonary circulation in the fetus and newborn
    • S Cassin (1987) Role of prostaglandins, thromboxanes, and leukotrienes in the control of the pulmonary circulation in the fetus and newborn. Semin Perinatol 11 53
    • (1987) Semin Perinatol , vol.11 , pp. 53
    • Cassin, S.1
  • 43
    • 0026604163 scopus 로고
    • Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs
    • SH Abman and KR Stenmark (1992) Changes in lung eicosanoid content during normal and abnormal transition in perinatal lambs. Am J Physiol 262 L214
    • (1992) Am J Physiol , vol.262 , pp. L214
    • Abman, S.H.1    Stenmark, K.R.2
  • 44
    • 0028904786 scopus 로고
    • Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone
    • DR Harder, WB Campbell and RJ Roman (1995) Role of cytochrome P-450 enzymes and metabolites of arachidonic acid in the control of vascular tone. J Vasc Res 32 79
    • (1995) J Vasc Res , vol.32 , pp. 79
    • Harder, D.R.1    Campbell, W.B.2    Roman, R.J.3
  • 45
    • 0036073380 scopus 로고    scopus 로고
    • Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone
    • M Fuloria, TK Smith and JL Aschner (2002) Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone. Am J Physiol Lung Cell Mol Physiol 283 L383
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , pp. L383
    • Fuloria, M.1    Smith, T.K.2    Aschner, J.L.3
  • 46
    • 3242693445 scopus 로고    scopus 로고
    • 20-hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation
    • M Fuloria, DM Eckman, DA Leach, et al. (2004) 20-hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation. Am J Physiol Lung Cell Mol Physiol 287 L360
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. L360
    • Fuloria, M.1    Eckman, D.M.2    Leach, D.A.3
  • 47
    • 0037115255 scopus 로고    scopus 로고
    • The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease
    • JD Morrow and LJ Roberts (2002) The isoprostanes: their role as an index of oxidant stress status in human pulmonary disease. Am J Respir Crit Care Med 166 S25
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. S25
    • Morrow, J.D.1    Roberts, L.J.2
  • 48
    • 0142211397 scopus 로고    scopus 로고
    • Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium
    • J Belik, RP Jankov, J Pan, et al. (2003) Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium. J Appl Physiol 95 1979
    • (2003) J Appl Physiol , vol.95 , pp. 1979
    • Belik, J.1    Jankov, R.P.2    Pan, J.3
  • 49
    • 19444369274 scopus 로고    scopus 로고
    • Age-related differences in vasoconstrictor responses to isoprostanes in piglet pulmonary and mesenteric vascular smooth muscle
    • G Gonzalez-Luis, F Perez-Vizcaino, F Garcia-Munoz, et al. (2005) Age-related differences in vasoconstrictor responses to isoprostanes in piglet pulmonary and mesenteric vascular smooth muscle. Pediatr Res 57 845
    • (2005) Pediatr Res , vol.57 , pp. 845
    • Gonzalez-Luis, G.1    Perez-Vizcaino, F.2    Garcia-Munoz, F.3
  • 51
    • 0031823130 scopus 로고    scopus 로고
    • Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries
    • C Docherty and MR MacLean (1998) Development of endothelin receptors in perinatal rabbit pulmonary resistance arteries. Br J Pharmacol 124 1165
    • (1998) Br J Pharmacol , vol.124 , pp. 1165
    • Docherty, C.1    MacLean, M.R.2
  • 52
    • 0026653621 scopus 로고
    • In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1
    • H Toga, BO Ibe and JU Raj (1992) In vitro responses of ovine intrapulmonary arteries and veins to endothelin-1. Am J Physiol 263 L15
    • (1992) Am J Physiol , vol.263 , pp. L15
    • Toga, H.1    Ibe, B.O.2    Raj, J.U.3
  • 53
    • 0026664067 scopus 로고
    • Isolated pulmonary resistance vessels from fetal lambs. Contractile behavior and responses to indomethacin and endothelin-1
    • Y Wang and F Coceani (1992) Isolated pulmonary resistance vessels from fetal lambs. Contractile behavior and responses to indomethacin and endothelin-1. Circ Res 71 320
    • (1992) Circ Res , vol.71 , pp. 320
    • Wang, Y.1    Coceani, F.2
  • 54
    • 0026089590 scopus 로고
    • Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ
    • S Cassin, V Kristova, T Davis, et al. (1991) Tone-dependent responses to endothelin in the isolated perfused fetal sheep pulmonary circulation in situ. J Appl Physiol 70 1228
    • (1991) J Appl Physiol , vol.70 , pp. 1228
    • Cassin, S.1    Kristova, V.2    Davis, T.3
  • 55
    • 0025830319 scopus 로고
    • Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation
    • BA Chatfield, IF McMurtry, SL Hall, et al. (1991) Hemodynamic effects of endothelin-1 on ovine fetal pulmonary circulation. Am J Physiol 261 R182
    • (1991) Am J Physiol , vol.261 , pp. R182
    • Chatfield, B.A.1    McMurtry, I.F.2    Hall, S.L.3
  • 56
    • 0036710036 scopus 로고    scopus 로고
    • Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology
    • P D'Orleans-Juste, J Labonte, G Bkaily, et al. (2002) Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol Ther 95 221
    • (2002) Pharmacol Ther , vol.95 , pp. 221
    • D'Orleans-Juste, P.1    Labonte, J.2    Bkaily, G.3
  • 57
    • 23444436906 scopus 로고
    • Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation
    • DD Ivy, JP Kinsella and SH Abman (1994) Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest 93 2141
    • (1994) J Clin Invest , vol.93 , pp. 2141
    • Ivy, D.D.1    Kinsella, J.P.2    Abman, S.H.3
  • 58
    • 0026764549 scopus 로고
    • Endothelin-1-induced pulmonary arterial dilatation is reduced by N omega-nitro-L-arginine in fetal lambs
    • ML Tod and S Cassin (1992) Endothelin-1-induced pulmonary arterial dilatation is reduced by N omega-nitro- L-arginine in fetal lambs. J Appl Physiol 72 1730
    • (1992) J Appl Physiol , vol.72 , pp. 1730
    • Tod, M.L.1    Cassin, S.2
  • 59
    • 0030482452 scopus 로고    scopus 로고
    • Endothelin blockade augments pulmonary vasodilatation in the ovine fetus
    • DD Ivy, JP Kinsella and SH Abman (1996) Endothelin blockade augments pulmonary vasodilatation in the ovine fetus. J Appl Physiol 81 2481
    • (1996) J Appl Physiol , vol.81 , pp. 2481
    • Ivy, D.D.1    Kinsella, J.P.2    Abman, S.H.3
  • 60
    • 0028261631 scopus 로고
    • Systemic and pulmonary hemodynamic effects of big endothelin-1 and phosphoramidon in the ovine fetus
    • OW Jones III and SH Abman (1994) Systemic and pulmonary hemodynamic effects of big endothelin-1 and phosphoramidon in the ovine fetus. Am J Physiol 266 R929
    • (1994) Am J Physiol , vol.266 , pp. R929
    • Jones, O.W.1    Abman, S.H.2
  • 61
    • 0028302221 scopus 로고
    • The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone
    • J Wong, JR Fineman and MA Heymann (1994) The role of endothelin and endothelin receptor subtypes in regulation of fetal pulmonary vascular tone. Pediatr Res 35 664
    • (1994) Pediatr Res , vol.35 , pp. 664
    • Wong, J.1    Fineman, J.R.2    Heymann, M.A.3
  • 62
    • 12944272079 scopus 로고    scopus 로고
    • Developmental changes in endothelin expression and activity in the ovine fetal lung
    • DD Ivy, TD Le Cras, TA Parker, et al. (2000) Developmental changes in endothelin expression and activity in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 278 L785
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L785
    • Ivy, D.D.1    Le Cras, T.D.2    Parker, T.A.3
  • 63
    • 33751108266 scopus 로고    scopus 로고
    • Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung
    • TA Parker, G Roe, TR Grover, et al. (2006) Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 291 L976
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291 , pp. L976
    • Parker, T.A.1    Roe, G.2    Grover, T.R.3
  • 64
    • 0842313242 scopus 로고    scopus 로고
    • Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension
    • IF McMurtry, NR Bauer, KA Fagan, et al. (2003) Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. Adv Exp Med Biol 543 127
    • (2003) Adv Exp Med Biol , vol.543 , pp. 127
    • McMurtry, I.F.1    Bauer, N.R.2    Fagan, K.A.3
  • 65
    • 0021362279 scopus 로고
    • Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age
    • MP Printz, RA Skidgel and WF Friedman (1984) Studies of pulmonary prostaglandin biosynthetic and catabolic enzymes as factors in ductus arteriosus patency and closure. Evidence for a shift in products with gestational age. Pediatr Res 18 19
    • (1984) Pediatr Res , vol.18 , pp. 19
    • Printz, M.P.1    Skidgel, R.A.2    Friedman, W.F.3
  • 66
    • 0017337915 scopus 로고
    • Prostaglandin biosynthesis and catabolism in the developing fetal sheep lung
    • CR Pace-Asciak (1977) Prostaglandin biosynthesis and catabolism in the developing fetal sheep lung. Prostaglandins 13 649
    • (1977) Prostaglandins , vol.13 , pp. 649
    • Pace-Asciak, C.R.1
  • 67
    • 0019152490 scopus 로고
    • Role of prostaglandins and thromboxanes in the control of the pulmonary circulation in the fetus and newborn
    • S Cassin (1980) Role of prostaglandins and thromboxanes in the control of the pulmonary circulation in the fetus and newborn. Semin Perinatol 4 101
    • (1980) Semin Perinatol , vol.4 , pp. 101
    • Cassin, S.1
  • 68
    • 0019830863 scopus 로고
    • Effects of prostacyclin on the fetal pulmonary circulation
    • S Cassin, I Winikor, M Tod, et al. (1981) Effects of prostacyclin on the fetal pulmonary circulation. Pediatr Pharmacol (New York) 1 197
    • (1981) Pediatr Pharmacol (New York) , vol.1 , pp. 197
    • Cassin, S.1    Winikor, I.2    Tod, M.3
  • 69
    • 0018378893 scopus 로고
    • Pulmonary and systemic vascular effects of exogenous prostaglandin I2 in fetal lambs
    • CW Leffler and JR Hessler (1979) Pulmonary and systemic vascular effects of exogenous prostaglandin I2 in fetal lambs. Eur J Pharmacol 54 37
    • (1979) Eur J Pharmacol , vol.54 , pp. 37
    • Leffler, C.W.1    Hessler, J.R.2
  • 70
    • 0019640478 scopus 로고
    • Perinatal pulmonary prostaglandin production
    • CW Leffler and JR Hessler (1981) Perinatal pulmonary prostaglandin production. Am J Physiol 241 H756
    • (1981) Am J Physiol , vol.241 , pp. H756
    • Leffler, C.W.1    Hessler, J.R.2
  • 71
    • 84936613628 scopus 로고
    • Effect of indomethacin on pulmonary vascular response to ventilation of fetal goats
    • CW Leffler, TL Tyler and S Cassin (1978) Effect of indomethacin on pulmonary vascular response to ventilation of fetal goats. Am J Physiol 234 H346
    • (1978) Am J Physiol , vol.234 , pp. H346
    • Leffler, C.W.1    Tyler, T.L.2    Cassin, S.3
  • 72
    • 0028092344 scopus 로고
    • Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung
    • AJ North, RA Star, TS Brannon, et al. (1994) Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung. Am J Physiol 266 L635
    • (1994) Am J Physiol , vol.266 , pp. L635
    • North, A.J.1    Star, R.A.2    Brannon, T.S.3
  • 73
    • 0027997570 scopus 로고
    • Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung
    • AC Halbower, RM Tuder, WA Franklin, et al. (1994) Maturation-related changes in endothelial nitric oxide synthase immunolocalization in developing ovine lung. Am J Physiol 267 L585
    • (1994) Am J Physiol , vol.267 , pp. L585
    • Halbower, A.C.1    Tuder, R.M.2    Franklin, W.A.3
  • 74
    • 0037154751 scopus 로고    scopus 로고
    • Birth upregulates nitric oxide synthase activity in the porcine lung
    • FI Arrigoni, AA Hislop, JS Pollock, et al. (2002) Birth upregulates nitric oxide synthase activity in the porcine lung. Life Sci 70 1609
    • (2002) Life Sci , vol.70 , pp. 1609
    • Arrigoni, F.I.1    Hislop, A.A.2    Pollock, J.S.3
  • 75
    • 0036891874 scopus 로고    scopus 로고
    • Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung
    • PW Shaul, S Afshar, LL Gibson, et al. (2002) Developmental changes in nitric oxide synthase isoform expression and nitric oxide production in fetal baboon lung. Am J Physiol Lung Cell Mol Physiol 283 L1192
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , pp. L1192
    • Shaul, P.W.1    Afshar, S.2    Gibson, L.L.3
  • 76
    • 12844255701 scopus 로고    scopus 로고
    • Developmental changes in endothelial vasoactive and angiogenic growth factors in the human perinatal lung
    • M Levy, C Maurey, B Chailley-Heu, et al. (2005) Developmental changes in endothelial vasoactive and angiogenic growth factors in the human perinatal lung. Pediatr Res 57 248
    • (2005) Pediatr Res , vol.57 , pp. 248
    • Levy, M.1    Maurey, C.2    Chailley-Heu, B.3
  • 77
    • 0033953824 scopus 로고    scopus 로고
    • Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung
    • TA Parker, TD Le Cras, JP Kinsella, et al. (2000) Developmental changes in endothelial nitric oxide synthase expression and activity in ovine fetal lung. Am J Physiol Lung Cell Mol Physiol 278 L202
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L202
    • Parker, T.A.1    Le Cras, T.D.2    Kinsella, J.P.3
  • 78
    • 0033962099 scopus 로고    scopus 로고
    • Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus
    • RL Rairigh, L Storme, TA Parker, et al. (2000) Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 278 L105
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.278 , pp. L105
    • Rairigh, R.L.1    Storme, L.2    Parker, T.A.3
  • 79
    • 0025696993 scopus 로고
    • Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth
    • SH Abman, BA Chatfield, SL Hall, et al. (1990) Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol 259 H1921
    • (1990) Am J Physiol , vol.259 , pp. H1921
    • Abman, S.H.1    Chatfield, B.A.2    Hall, S.L.3
  • 80
    • 0028842356 scopus 로고
    • The effects of nitric oxide inhalation on the pulmonary circulation of preterm lambs
    • JW Skimming, VG DeMarco and S Cassin (1995) The effects of nitric oxide inhalation on the pulmonary circulation of preterm lambs. Pediatr Res 37 35
    • (1995) Pediatr Res , vol.37 , pp. 35
    • Skimming, J.W.1    DeMarco, V.G.2    Cassin, S.3
  • 81
    • 0037090743 scopus 로고    scopus 로고
    • Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension
    • LS Shekerdemian, HB Ravn and DJ Penny (2002) Intravenous sildenafil lowers pulmonary vascular resistance in a model of neonatal pulmonary hypertension. Am J Respir Crit Care Med 165 1098
    • (2002) Am J Respir Crit Care Med , vol.165 , pp. 1098
    • Shekerdemian, L.S.1    Ravn, H.B.2    Penny, D.J.3
  • 82
    • 0034047308 scopus 로고    scopus 로고
    • Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension
    • J Weimann, R Ullrich, J Hromi, et al. (2000) Sildenafil is a pulmonary vasodilator in awake lambs with acute pulmonary hypertension. Anesthesiology 92 1702
    • (2000) Anesthesiology , vol.92 , pp. 1702
    • Weimann, J.1    Ullrich, R.2    Hromi, J.3
  • 83
    • 0031725551 scopus 로고    scopus 로고
    • Pulmonary and systemic effects of the phosphodiesterase inhibitor dipyridamole in newborn lambs with persistent pulmonary hypertension
    • RC Dukarm, FC Morin III, JA Russell, et al. (1998) Pulmonary and systemic effects of the phosphodiesterase inhibitor dipyridamole in newborn lambs with persistent pulmonary hypertension. Pediatr Res 44 831
    • (1998) Pediatr Res , vol.44 , pp. 831
    • Dukarm, R.C.1    Morin, F.C.2    Russell, J.A.3
  • 84
    • 0033024361 scopus 로고    scopus 로고
    • Dypiridamole, a cGMP phosphodiesterase inhibitor, transiently improves the response to inhaled nitric oxide in two newborns with congenital diaphragmatic hernia
    • B Thebaud, C Saizou, C Farnoux, et al. (1999) Dypiridamole, a cGMP phosphodiesterase inhibitor, transiently improves the response to inhaled nitric oxide in two newborns with congenital diaphragmatic hernia. Intensive Care Med 25 300
    • (1999) Intensive Care Med , vol.25 , pp. 300
    • Thebaud, B.1    Saizou, C.2    Farnoux, C.3
  • 85
    • 0031767180 scopus 로고    scopus 로고
    • Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity
    • KA Hanson, JW Ziegler, SD Rybalkin, et al. (1998) Chronic pulmonary hypertension increases fetal lung cGMP phosphodiesterase activity. Am J Physiol 275 L931
    • (1998) Am J Physiol , vol.275 , pp. L931
    • Hanson, K.A.1    Ziegler, J.W.2    Rybalkin, S.D.3
  • 86
    • 0035983252 scopus 로고    scopus 로고
    • Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia
    • B Thebaud, T Petit, P De Lagausie, et al. (2002) Altered guanylyl-cyclase activity in vitro of pulmonary arteries from fetal lambs with congenital diaphragmatic hernia. Am J Respir Cell Mol Biol 27 42
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 42
    • Thebaud, B.1    Petit, T.2    De Lagausie, P.3
  • 87
    • 0034005668 scopus 로고    scopus 로고
    • Site-specific effect of guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs
    • RH Steinhorn, JB Gordon and ML Tod (2000) Site-specific effect of guanosine 3′,5′-cyclic monophosphate phosphodiesterase inhibition in isolated lamb lungs. Crit Care Med 28 490
    • (2000) Crit Care Med , vol.28 , pp. 490
    • Steinhorn, R.H.1    Gordon, J.B.2    Tod, M.L.3
  • 88
    • 0028808770 scopus 로고
    • The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide
    • KG Thusu, FC Morin III, JA Russell, et al. (1995) The cGMP phosphodiesterase inhibitor zaprinast enhances the effect of nitric oxide. Am J Respir Crit Care Med 152 1605
    • (1995) Am J Respir Crit Care Med , vol.152 , pp. 1605
    • Thusu, K.G.1    Morin, F.C.2    Russell, J.A.3
  • 89
    • 78651166541 scopus 로고
    • The vascular resistance of the foetal and newly ventilated lung of the lamb
    • S Cassin, GS Dawes, JC Mott, et al. (1964) The vascular resistance of the foetal and newly ventilated lung of the lamb. J Physiol 171 61
    • (1964) J Physiol , vol.171 , pp. 61
    • Cassin, S.1    Dawes, G.S.2    Mott, J.C.3
  • 90
    • 0027310668 scopus 로고
    • Effects of lung distension and spontaneous fetal breathing on hemodynamics in sheep
    • HS Iwamoto, DF Teitel and AM Rudolph (1993) Effects of lung distension and spontaneous fetal breathing on hemodynamics in sheep. Pediatr Res 33 639
    • (1993) Pediatr Res , vol.33 , pp. 639
    • Iwamoto, H.S.1    Teitel, D.F.2    Rudolph, A.M.3
  • 91
    • 0025646683 scopus 로고
    • Pulmonary pressure-flow relationships in the fetal lamb during in utero ventilation
    • DL Reid and KL Thornburg (1990) Pulmonary pressure-flow relationships in the fetal lamb during in utero ventilation. J Appl Physiol 69 1630
    • (1990) J Appl Physiol , vol.69 , pp. 1630
    • Reid, D.L.1    Thornburg, K.L.2
  • 92
    • 0024267586 scopus 로고
    • Human postnatal pulmonary arterial remodeling. Ultrastructural studies of smooth muscle cell and connective tissue maturation
    • K Allen and SG Haworth (1988) Human postnatal pulmonary arterial remodeling. Ultrastructural studies of smooth muscle cell and connective tissue maturation. Lab Invest 59 702
    • (1988) Lab Invest , vol.59 , pp. 702
    • Allen, K.1    Haworth, S.G.2
  • 93
    • 0023235487 scopus 로고
    • Thinning of fetal pulmonary arterial wall and postnatal remodelling: ultrastructural studies on the respiratory unit arteries of the pig
    • SG Haworth, SM Hall, M Chew, et al. (1987) Thinning of fetal pulmonary arterial wall and postnatal remodelling: ultrastructural studies on the respiratory unit arteries of the pig. Virchows Arch A Pathol Anat Histopathol 411 161
    • (1987) Virchows Arch A Pathol Anat Histopathol , vol.411 , pp. 161
    • Haworth, S.G.1    Hall, S.M.2    Chew, M.3
  • 94
    • 0033228503 scopus 로고    scopus 로고
    • Abnormal vasoreactivity in the pathophysiology of persistent pulmonary hypertension of the newborn
    • SH Abman (1999) Abnormal vasoreactivity in the pathophysiology of persistent pulmonary hypertension of the newborn. Pediatr Rev 20 e103
    • (1999) Pediatr Rev , vol.20 , pp. e103
    • Abman, S.H.1
  • 95
    • 0036174861 scopus 로고    scopus 로고
    • Correlation of pulmonary arterial smooth muscle structure and reactivity during adaptation to extrauterine life
    • DA Kelly, AA Hislop, SM Hall, et al. (2002) Correlation of pulmonary arterial smooth muscle structure and reactivity during adaptation to extrauterine life. J Vasc Res 39 30
    • (2002) J Vasc Res , vol.39 , pp. 30
    • Kelly, D.A.1    Hislop, A.A.2    Hall, S.M.3
  • 96
    • 0021244673 scopus 로고
    • Indomethacin and the cardiopulmonary adaptations of transition
    • C Hammerman and EM Scarpelli (1984) Indomethacin and the cardiopulmonary adaptations of transition. Pediatr Res 18 842
    • (1984) Pediatr Res , vol.18 , pp. 842
    • Hammerman, C.1    Scarpelli, E.M.2
  • 97
    • 0023946395 scopus 로고
    • Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs
    • D Davidson (1988) Pulmonary hemodynamics at birth: effect of acute cyclooxygenase inhibition in lambs. J Appl Physiol 64 1676
    • (1988) J Appl Physiol , vol.64 , pp. 1676
    • Davidson, D.1
  • 98
    • 0026717373 scopus 로고
    • Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus
    • DN Cornfield, BA Chatfield, JA McQueston, et al. (1992) Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol 262 H1474
    • (1992) Am J Physiol , vol.262 , pp. H1474
    • Cornfield, D.N.1    Chatfield, B.A.2    McQueston, J.A.3
  • 99
    • 0025813311 scopus 로고
    • Prostaglandin inhibition prevents the fall in pulmonary vascular resistance as a result of rhythmic distension of the lungs in fetal lambs
    • H Velvis, P Moore and MA Heymann (1991) Prostaglandin inhibition prevents the fall in pulmonary vascular resistance as a result of rhythmic distension of the lungs in fetal lambs. Pediatr Res 30 62
    • (1991) Pediatr Res , vol.30 , pp. 62
    • Velvis, H.1    Moore, P.2    Heymann, M.A.3
  • 100
    • 0021676022 scopus 로고
    • Mechanism of stimulation of pulmonary prostacyclin synthesis at birth
    • CW Leffler, JR Hessler and RS Green (1984) Mechanism of stimulation of pulmonary prostacyclin synthesis at birth. Prostaglandins 28 877
    • (1984) Prostaglandins , vol.28 , pp. 877
    • Leffler, C.W.1    Hessler, J.R.2    Green, R.S.3
  • 101
    • 0028218504 scopus 로고
    • Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression
    • TS Brannon, AJ North, LB Wells, et al. (1994) Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression. J Clin Invest 93 2230
    • (1994) J Clin Invest , vol.93 , pp. 2230
    • Brannon, T.S.1    North, A.J.2    Wells, L.B.3
  • 102
    • 0018866924 scopus 로고
    • Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation
    • DL Levin (1980) Effects of inhibition of prostaglandin synthesis on fetal development, oxygenation, and the fetal circulation. Semin Perinatol 4 35
    • (1980) Semin Perinatol , vol.4 , pp. 35
    • Levin, D.L.1
  • 103
    • 0022788288 scopus 로고
    • Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects
    • FR Witter and JR Niebyl (1986) Inhibition of arachidonic acid metabolism in the perinatal period: pharmacology, clinical application, and potential adverse effects. Semin Perinatol 10 316
    • (1986) Semin Perinatol , vol.10 , pp. 316
    • Witter, F.R.1    Niebyl, J.R.2
  • 104
    • 0028935069 scopus 로고
    • Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development
    • N Kawai, DB Bloch, G Filippov, et al. (1995) Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. Am J Physiol 268 L589
    • (1995) Am J Physiol , vol.268 , pp. L589
    • Kawai, N.1    Bloch, D.B.2    Filippov, G.3
  • 105
    • 0030979142 scopus 로고    scopus 로고
    • Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus
    • E Villamor, TD Le Cras, MP Horan, et al. (1997) Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am J Physiol 272 L1013
    • (1997) Am J Physiol , vol.272 , pp. L1013
    • Villamor, E.1    Le Cras, T.D.2    Horan, M.P.3
  • 106
    • 33749076070 scopus 로고    scopus 로고
    • Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity
    • M Sheffield, S Mabry, DW Thibeault, et al. (2006) Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity. Pediatrics 118 1056
    • (2006) Pediatrics , vol.118 , pp. 1056
    • Sheffield, M.1    Mabry, S.2    Thibeault, D.W.3
  • 107
    • 0025763020 scopus 로고
    • Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro
    • SH Abman, BA Chatfield, DM Rodman, et al. (1991) Maturational changes in endothelium-derived relaxing factor activity of ovine pulmonary arteries in vitro. Am J Physiol 260 L280
    • (1991) Am J Physiol , vol.260 , pp. L280
    • Abman, S.H.1    Chatfield, B.A.2    Rodman, D.M.3
  • 108
    • 0027133839 scopus 로고
    • Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn
    • PW Shaul, MA Farrar and RR Magness (1993) Pulmonary endothelial nitric oxide production is developmentally regulated in the fetus and newborn. Am J Physiol 265 H1056
    • (1993) Am J Physiol , vol.265 , pp. H1056
    • Shaul, P.W.1    Farrar, M.A.2    Magness, R.R.3
  • 109
    • 0028290543 scopus 로고
    • Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs
    • JR Fineman, J Wong, FC Morin III, et al. (1994) Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs. J Clin Invest 93 2675
    • (1994) J Clin Invest , vol.93 , pp. 2675
    • Fineman, J.R.1    Wong, J.2    Morin, F.C.3
  • 110
    • 22444445619 scopus 로고    scopus 로고
    • Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice
    • AA Miller, AA Hislop, PJ Vallance, et al. (2005) Deletion of the eNOS gene has a greater impact on the pulmonary circulation of male than female mice. Am J Physiol Lung Cell Mol Physiol 289 L299
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.289 , pp. L299
    • Miller, A.A.1    Hislop, A.A.2    Vallance, P.J.3
  • 111
    • 0030954154 scopus 로고    scopus 로고
    • Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension
    • PW Shaul, IS Yuhanna, Z German, et al. (1997) Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension. Am J Physiol 272 L1005
    • (1997) Am J Physiol , vol.272 , pp. L1005
    • Shaul, P.W.1    Yuhanna, I.S.2    German, Z.3
  • 112
    • 0031724886 scopus 로고    scopus 로고
    • Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension
    • SM Black, JR Fineman, RH Steinhorn, et al. (1998) Increased endothelial NOS in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol 275 H1643
    • (1998) Am J Physiol , vol.275 , pp. H1643
    • Black, S.M.1    Fineman, J.R.2    Steinhorn, R.H.3
  • 113
    • 0031965759 scopus 로고    scopus 로고
    • Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension
    • DD Ivy, TD Le Cras, MP Horan, et al. (1998) Increased lung preproET-1 and decreased ETB-receptor gene expression in fetal pulmonary hypertension. Am J Physiol 274 L535
    • (1998) Am J Physiol , vol.274 , pp. L535
    • Ivy, D.D.1    Le Cras, T.D.2    Horan, M.P.3
  • 114
    • 0033971183 scopus 로고    scopus 로고
    • Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension
    • SM Black, JM Bekker, MJ Johengen, et al. (2000) Altered regulation of the ET-1 cascade in lambs with increased pulmonary blood flow and pulmonary hypertension. Pediatr Res 47 97
    • (2000) Pediatr Res , vol.47 , pp. 97
    • Black, S.M.1    Bekker, J.M.2    Johengen, M.J.3
  • 115
    • 0029820551 scopus 로고    scopus 로고
    • Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn
    • P Kumar, NJ Kazzi and S Shankaran (1996) Plasma immunoreactive endothelin-1 concentrations in infants with persistent pulmonary hypertension of the newborn. Am J Perinatol 13 335
    • (1996) Am J Perinatol , vol.13 , pp. 335
    • Kumar, P.1    Kazzi, N.J.2    Shankaran, S.3
  • 116
    • 0027168628 scopus 로고
    • Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension
    • AA Rosenberg, J Kennaugh, SL Koppenhafer, et al. (1993) Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension. J Pediatr 123 109
    • (1993) J Pediatr , vol.123 , pp. 109
    • Rosenberg, A.A.1    Kennaugh, J.2    Koppenhafer, S.L.3
  • 117
    • 0029950993 scopus 로고    scopus 로고
    • Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs
    • JW Winters, J Wong, DD Van, et al. (1996) Endothelin receptor blockade does not alter the increase in pulmonary blood flow due to oxygen ventilation in fetal lambs. Pediatr Res 40 152
    • (1996) Pediatr Res , vol.40 , pp. 152
    • Winters, J.W.1    Wong, J.2    Van, D.D.3
  • 118
    • 0028297762 scopus 로고
    • Eicosanoids decrease with successful extracorporeal membrane oxygenation therapy in neonatal pulmonary hypertension
    • EL Dobyns, JY Wescott, JM Kennaugh, et al. (1994) Eicosanoids decrease with successful extracorporeal membrane oxygenation therapy in neonatal pulmonary hypertension. Am J Respir Crit Care Med 149 873
    • (1994) Am J Respir Crit Care Med , vol.149 , pp. 873
    • Dobyns, E.L.1    Wescott, J.Y.2    Kennaugh, J.M.3
  • 119
    • 0021340307 scopus 로고
    • Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations
    • WD Ford, MJ James and JA Walsh (1984) Congenital diaphragmatic hernia: association between pulmonary vascular resistance and plasma thromboxane concentrations. Arch Dis Child 59 143
    • (1984) Arch Dis Child , vol.59 , pp. 143
    • Ford, W.D.1    James, M.J.2    Walsh, J.A.3
  • 120
    • 0020645349 scopus 로고
    • Leukotriene C4 and D4 in neonates with hypoxemia and pulmonary hypertension
    • KR Stenmark, SL James, NF Voelkel, et al. (1983) Leukotriene C4 and D4 in neonates with hypoxemia and pulmonary hypertension. N Engl J Med 309 77
    • (1983) N Engl J Med , vol.309 , pp. 77
    • Stenmark, K.R.1    James, S.L.2    Voelkel, N.F.3
  • 121
    • 0023191894 scopus 로고
    • Hypoxic vasoconstriction increases with postnatal age in lungs from newborn rabbits
    • CD Fike and TN Hansen (1987) Hypoxic vasoconstriction increases with postnatal age in lungs from newborn rabbits. Circ Res 60 297
    • (1987) Circ Res , vol.60 , pp. 297
    • Fike, C.D.1    Hansen, T.N.2
  • 122
    • 0024461946 scopus 로고
    • Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs
    • JB Gordon, J Hortop and TS Hakim (1989) Developmental effects of hypoxia and indomethacin on distribution of vascular resistances in lamb lungs. Pediatr Res 26 325
    • (1989) Pediatr Res , vol.26 , pp. 325
    • Gordon, J.B.1    Hortop, J.2    Hakim, T.S.3
  • 123
    • 0014508546 scopus 로고
    • Hypoxia and pulmonary arterial pressure in the rabbit
    • JB Owen-Thomas and JT Reeves (1969) Hypoxia and pulmonary arterial pressure in the rabbit. J Physiol 201 665
    • (1969) J Physiol , vol.201 , pp. 665
    • Owen-Thomas, J.B.1    Reeves, J.T.2
  • 124
    • 0019962657 scopus 로고
    • Response of the pulmonary circulation to acute hypoxia in the growing pig
    • A Rendas, M Branthwaite, S Lennox, et al. (1982) Response of the pulmonary circulation to acute hypoxia in the growing pig. J Appl Physiol 52 811
    • (1982) J Appl Physiol , vol.52 , pp. 811
    • Rendas, A.1    Branthwaite, M.2    Lennox, S.3
  • 125
    • 0013888921 scopus 로고
    • Response of the pulmonary vasculature to hypoxia and H+ ion concentration changes
    • AM Rudolph and S Yuan (1966) Response of the pulmonary vasculature to hypoxia and H+ ion concentration changes. J Clin Invest 45 399
    • (1966) J Clin Invest , vol.45 , pp. 399
    • Rudolph, A.M.1    Yuan, S.2
  • 126
    • 0022389328 scopus 로고
    • Alkalosis attenuates hypoxic pulmonary vasoconstriction in neonatal lambs
    • RK Lyrene, KA Welch, G Godoy, et al. (1985) Alkalosis attenuates hypoxic pulmonary vasoconstriction in neonatal lambs. Pediatr Res 19 1268
    • (1985) Pediatr Res , vol.19 , pp. 1268
    • Lyrene, R.K.1    Welch, K.A.2    Godoy, G.3
  • 127
    • 0022901686 scopus 로고
    • Hyperventilation, alkalosis, prostaglandins, and pulmonary circulation of the newborn
    • FC Morin III (1986) Hyperventilation, alkalosis, prostaglandins, and pulmonary circulation of the newborn. J Appl Physiol 61 2088
    • (1986) J Appl Physiol , vol.61 , pp. 2088
    • Morin, F.C.1
  • 128
    • 0024515730 scopus 로고
    • The effect of alkalosis on hypoxia-induced pulmonary vasoconstriction in lungs of newborn rabbits
    • CD Fike and TN Hansen (1989) The effect of alkalosis on hypoxia-induced pulmonary vasoconstriction in lungs of newborn rabbits. Pediatr Res 25 383
    • (1989) Pediatr Res , vol.25 , pp. 383
    • Fike, C.D.1    Hansen, T.N.2
  • 129
    • 0024352206 scopus 로고
    • Effect of pH on pulmonary vascular tone, reactivity, and arachidonate metabolism
    • IS Farrukh, GH Gurtner, PB Terry, et al. (1989) Effect of pH on pulmonary vascular tone, reactivity, and arachidonate metabolism. J Appl Physiol 67 445
    • (1989) J Appl Physiol , vol.67 , pp. 445
    • Farrukh, I.S.1    Gurtner, G.H.2    Terry, P.B.3
  • 130
    • 0027731582 scopus 로고
    • Differing effects of acute and prolonged alkalosis on hypoxic pulmonary vasoconstriction
    • JB Gordon, FR Martinez, PA Keller, et al. (1993) Differing effects of acute and prolonged alkalosis on hypoxic pulmonary vasoconstriction. Am Rev Respir Dis 148 1651
    • (1993) Am Rev Respir Dis , vol.148 , pp. 1651
    • Gordon, J.B.1    Martinez, F.R.2    Keller, P.A.3
  • 131
    • 0023743906 scopus 로고
    • Effects of respiratory alkalosis on thromboxane-induced pulmonary hypertension in piglets
    • GJ Redding, RL Gibson, CB Davis, et al. (1988) Effects of respiratory alkalosis on thromboxane-induced pulmonary hypertension in piglets. Pediatr Res 24 558
    • (1988) Pediatr Res , vol.24 , pp. 558
    • Redding, G.J.1    Gibson, R.L.2    Davis, C.B.3
  • 132
    • 0025962922 scopus 로고
    • Effects of hyperventilation on prostacyclin formation and on pulmonary vasodilation after group B beta-hemolytic streptococci-induced pulmonary hypertension
    • C Hammerman and MJ Aramburo (1991) Effects of hyperventilation on prostacyclin formation and on pulmonary vasodilation after group B beta-hemolytic streptococci-induced pulmonary hypertension. Pediatr Res 29 282
    • (1991) Pediatr Res , vol.29 , pp. 282
    • Hammerman, C.1    Aramburo, M.J.2
  • 133
    • 0022639962 scopus 로고
    • 2, attenuates hypoxia-induced pulmonary vasoconstriction in newborn lambs
    • MD Schreiber, MA Heymann and SJ Soifer (1986) Increased arterial pH, not decreased PaCO 2, attenuates hypoxia-induced pulmonary vasoconstriction in newborn lambs. Pediatr Res 20 113
    • (1986) Pediatr Res , vol.20 , pp. 113
    • Schreiber, M.D.1    Heymann, M.A.2    Soifer, S.J.3
  • 134
    • 0021204617 scopus 로고
    • Neonatal pulmonary hypertension: pathophysiology, classification, and etiology
    • WM Gersony (1984) Neonatal pulmonary hypertension: pathophysiology, classification, and etiology. Clin Perinatol 11 517
    • (1984) Clin Perinatol , vol.11 , pp. 517
    • Gersony, W.M.1
  • 135
    • 0033936418 scopus 로고    scopus 로고
    • Chronic lung injury in preterm lambs: abnormalities of the pulmonary circulation and lung fluid balance
    • RD Bland, KH Albertine, DP Carlton, et al. (2000) Chronic lung injury in preterm lambs: abnormalities of the pulmonary circulation and lung fluid balance. Pediatr Res 48 64
    • (2000) Pediatr Res , vol.48 , pp. 64
    • Bland, R.D.1    Albertine, K.H.2    Carlton, D.P.3
  • 136
    • 15944381917 scopus 로고    scopus 로고
    • Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure
    • N Mulrooney, Z Champion, TJ Moss, et al. (2005) Surfactant and physiologic responses of preterm lambs to continuous positive airway pressure. Am J Respir Crit Care Med 171 488
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 488
    • Mulrooney, N.1    Champion, Z.2    Moss, T.J.3
  • 137
    • 0019430964 scopus 로고
    • The structural basis of persistent pulmonary hypertension of the newborn infant
    • JD Murphy, M Rabinovitch, JD Goldstein, et al. (1981) The structural basis of persistent pulmonary hypertension of the newborn infant. J Pediatr 98 962
    • (1981) J Pediatr , vol.98 , pp. 962
    • Murphy, J.D.1    Rabinovitch, M.2    Goldstein, J.D.3
  • 138
    • 0021277307 scopus 로고
    • Pulmonary vascular disease in fatal meconium aspiration
    • JD Murphy, GF Vawter and LM Reid (1984) Pulmonary vascular disease in fatal meconium aspiration. J Pediatr 104 758
    • (1984) J Pediatr , vol.104 , pp. 758
    • Murphy, J.D.1    Vawter, G.F.2    Reid, L.M.3
  • 139
    • 0024402650 scopus 로고
    • Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs
    • SH Abman, PF Shanley and FJ Accurso (1989) Failure of postnatal adaptation of the pulmonary circulation after chronic intrauterine pulmonary hypertension in fetal lambs. J Clin Invest 83 1849
    • (1989) J Clin Invest , vol.83 , pp. 1849
    • Abman, S.H.1    Shanley, P.F.2    Accurso, F.J.3
  • 140
    • 0028337810 scopus 로고
    • Pulmonary hypertension and vascular remodeling in fetal sheep
    • J Belik, FW Keeley, F Baldwin, et al. (1994) Pulmonary hypertension and vascular remodeling in fetal sheep. Am J Physiol 266 H2303
    • (1994) Am J Physiol , vol.266 , pp. H2303
    • Belik, J.1    Keeley, F.W.2    Baldwin, F.3
  • 141
    • 0024498792 scopus 로고
    • Ligating the ductus arteriosus before birth remodels the pulmonary vasculature of the lamb
    • LM Wild, PA Nickerson and FC Morin III (1989) Ligating the ductus arteriosus before birth remodels the pulmonary vasculature of the lamb. Pediatr Res 25 251
    • (1989) Pediatr Res , vol.25 , pp. 251
    • Wild, L.M.1    Nickerson, P.A.2    Morin, F.C.3
  • 142
    • 0029160781 scopus 로고
    • In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs
    • VM Reddy, B Meyrick, J Wong, et al. (1995) In utero placement of aortopulmonary shunts. A model of postnatal pulmonary hypertension with increased pulmonary blood flow in lambs. Circulation 92 606
    • (1995) Circulation , vol.92 , pp. 606
    • Reddy, V.M.1    Meyrick, B.2    Wong, J.3
  • 143
    • 0041508798 scopus 로고    scopus 로고
    • Systemic arteriovenous fistula leads to pulmonary artery remodeling and abnormal vasoreactivity in the fetal lamb
    • JM Jouannic, R Roussin, AA Hislop, et al. (2003) Systemic arteriovenous fistula leads to pulmonary artery remodeling and abnormal vasoreactivity in the fetal lamb. Am J Physiol Lung Cell Mol Physiol 285 L701
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , pp. L701
    • Jouannic, J.M.1    Roussin, R.2    Hislop, A.A.3
  • 144
    • 15244360516 scopus 로고    scopus 로고
    • Effect of lung hypoplasia on birth-related changes in the pulmonary circulation in sheep
    • K Suzuki, SB Hooper, ML Cock, et al. (2005) Effect of lung hypoplasia on birth-related changes in the pulmonary circulation in sheep. Pediatr Res 57 530
    • (2005) Pediatr Res , vol.57 , pp. 530
    • Suzuki, K.1    Hooper, S.B.2    Cock, M.L.3
  • 145
    • 0017890148 scopus 로고
    • Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic hernia
    • DL Levin (1978) Morphologic analysis of the pulmonary vascular bed in congenital left-sided diaphragmatic hernia. J Pediatr 92 805
    • (1978) J Pediatr , vol.92 , pp. 805
    • Levin, D.L.1
  • 146
    • 0027530107 scopus 로고
    • Fetal ductus arteriosus ligation. Pulmonary vascular smooth muscle biochemical and mechanical changes
    • J Belik, AJ Halayko, K Rao, et al. (1993) Fetal ductus arteriosus ligation. Pulmonary vascular smooth muscle biochemical and mechanical changes. Circ Res 72 588
    • (1993) Circ Res , vol.72 , pp. 588
    • Belik, J.1    Halayko, A.J.2    Rao, K.3
  • 147
    • 24344456014 scopus 로고    scopus 로고
    • Relationship between structural remodeling and reactivity in pulmonary resistance arteries from hypertensive piglets
    • DA Kelly, AA Hislop, SM Hall, et al. (2005) Relationship between structural remodeling and reactivity in pulmonary resistance arteries from hypertensive piglets. Pediatr Res 58 525
    • (2005) Pediatr Res , vol.58 , pp. 525
    • Kelly, D.A.1    Hislop, A.A.2    Hall, S.M.3
  • 148
    • 0031891501 scopus 로고    scopus 로고
    • Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension
    • J Belik, R Majumdar, VE Fabris, et al. (1998) Myosin light chain phosphatase and kinase abnormalities in fetal sheep pulmonary hypertension. Pediatr Res 43 57
    • (1998) Pediatr Res , vol.43 , pp. 57
    • Belik, J.1    Majumdar, R.2    Fabris, V.E.3
  • 149
    • 0028873122 scopus 로고
    • Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation
    • JA McQueston, JP Kinsella, DD Ivy, et al. (1995) Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol 268 H288
    • (1995) Am J Physiol , vol.268 , pp. H288
    • McQueston, J.A.1    Kinsella, J.P.2    Ivy, D.D.3
  • 150
    • 33750725158 scopus 로고    scopus 로고
    • Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow
    • VM Reddy, J Wong, JR Liddicoat, et al. (1996) Altered endothelium-dependent responses in lambs with pulmonary hypertension and increased pulmonary blood flow. Am J Physiol 271 H562
    • (1996) Am J Physiol , vol.271 , pp. H562
    • Reddy, V.M.1    Wong, J.2    Liddicoat, J.R.3
  • 151
    • 28444488311 scopus 로고    scopus 로고
    • Perinatal changes in pulmonary vascular endothelial function
    • B Wojciak-Stothard and SG Haworth (2006) Perinatal changes in pulmonary vascular endothelial function. Pharmacol Ther 109 78
    • (2006) Pharmacol Ther , vol.109 , pp. 78
    • Wojciak-Stothard, B.1    Haworth, S.G.2
  • 152
    • 0035009871 scopus 로고    scopus 로고
    • Perinatal development influences mechanisms of bradykinin-induced relaxations in pulmonary resistance and conduit arteries differently
    • PJ Boels, J Deutsch, B Gao, et al. (2001) Perinatal development influences mechanisms of bradykinin-induced relaxations in pulmonary resistance and conduit arteries differently. Cardiovasc Res 51 140
    • (2001) Cardiovasc Res , vol.51 , pp. 140
    • Boels, P.J.1    Deutsch, J.2    Gao, B.3
  • 153
    • 85047686462 scopus 로고    scopus 로고
    • Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow
    • SM Black, JM Bekker, DM McMullan, et al. (2002) Alterations in nitric oxide production in 8-week-old lambs with increased pulmonary blood flow. Pediatr Res 52 233
    • (2002) Pediatr Res , vol.52 , pp. 233
    • Black, S.M.1    Bekker, J.M.2    McMullan, D.M.3
  • 154
    • 0028603561 scopus 로고
    • Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs
    • CD Fike and MR Kaplowitz (1994) Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs. J Appl Physiol 77 2853
    • (1994) J Appl Physiol , vol.77 , pp. 2853
    • Fike, C.D.1    Kaplowitz, M.R.2
  • 155
  • 156
    • 2442661628 scopus 로고    scopus 로고
    • Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn piglets
    • CD Fike, JL Aschner, Y Zhang, et al. (2004) Impaired NO signaling in small pulmonary arteries of chronically hypoxic newborn piglets. Am J Physiol Lung Cell Mol Physiol 286 L1244
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.286 , pp. L1244
    • Fike, C.D.1    Aschner, J.L.2    Zhang, Y.3
  • 157
    • 0028276159 scopus 로고
    • Severe respiratory failure in neonates: mortality and morbidity rates and neurodevelopmental outcomes
    • MC Walsh-Sukys, RE Bauer, DJ Cornell, et al. (1994) Severe respiratory failure in neonates: mortality and morbidity rates and neurodevelopmental outcomes. J Pediatr 125 104
    • (1994) J Pediatr , vol.125 , pp. 104
    • Walsh-Sukys, M.C.1    Bauer, R.E.2    Cornell, D.J.3
  • 158
    • 0035481997 scopus 로고    scopus 로고
    • Epidemiology of neonatal respiratory failure in the United States: projections from California and New York
    • DC Angus, WT Linde-Zwirble, G Clermont, et al. (2001) Epidemiology of neonatal respiratory failure in the United States: projections from California and New York. Am J Respir Crit Care Med 164 1154
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1154
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Clermont, G.3
  • 159
    • 0035859237 scopus 로고    scopus 로고
    • Neonatal pulmonary hypertension–urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function
    • DL Pearson, S Dawling, WF Walsh, et al. (2001) Neonatal pulmonary hypertension–urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. N Engl J Med 344 1832
    • (2001) N Engl J Med , vol.344 , pp. 1832
    • Pearson, D.L.1    Dawling, S.2    Walsh, W.F.3
  • 160
    • 19244377972 scopus 로고    scopus 로고
    • Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes
    • MC Walsh-Sukys, JE Tyson, LL Wright, et al. (2000) Persistent pulmonary hypertension of the newborn in the era before nitric oxide: practice variation and outcomes. Pediatrics 105 14
    • (2000) Pediatrics , vol.105 , pp. 14
    • Walsh-Sukys, M.C.1    Tyson, J.E.2    Wright, L.L.3
  • 161
    • 0017350601 scopus 로고
    • Pulmonary hypertension in the perinatal aspiration syndromes
    • WW Fox, MH Gewitz, R Dinwiddie, et al. (1977) Pulmonary hypertension in the perinatal aspiration syndromes. Pediatrics 59 205
    • (1977) Pediatrics , vol.59 , pp. 205
    • Fox, W.W.1    Gewitz, M.H.2    Dinwiddie, R.3
  • 162
    • 4344620649 scopus 로고    scopus 로고
    • New approaches for persistent pulmonary hypertension of newborn
    • GG Konduri (2004) New approaches for persistent pulmonary hypertension of newborn. Clin Perinatol 31 591
    • (2004) Clin Perinatol , vol.31 , pp. 591
    • Konduri, G.G.1
  • 163
    • 0032727159 scopus 로고    scopus 로고
    • The pathophysiology of pulmonary hypertension in congenital heart disease
    • RH Steinhorn and JR Fineman (1999) The pathophysiology of pulmonary hypertension in congenital heart disease. Artif Organs 23 970
    • (1999) Artif Organs , vol.23 , pp. 970
    • Steinhorn, R.H.1    Fineman, J.R.2
  • 164
    • 0037244611 scopus 로고    scopus 로고
    • Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery
    • FE Barr, H Beverley, K VanHook, et al. (2003) Effect of cardiopulmonary bypass on urea cycle intermediates and nitric oxide levels after congenital heart surgery. J Pediatr 142 26
    • (2003) J Pediatr , vol.142 , pp. 26
    • Barr, F.E.1    Beverley, H.2    VanHook, K.3
  • 165
    • 0035120389 scopus 로고    scopus 로고
    • Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn
    • MA Alano, E Ngougmna, EM Ostrea Jr., et al. (2001) Analysis of nonsteroidal antiinflammatory drugs in meconium and its relation to persistent pulmonary hypertension of the newborn. Pediatrics 107 519
    • (2001) Pediatrics , vol.107 , pp. 519
    • Alano, M.A.1    Ngougmna, E.2    Ostrea, E.M.3
  • 166
    • 32144436098 scopus 로고    scopus 로고
    • Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn
    • CD Chambers, S Hernandez-Diaz, LJ Van Marter, et al. (2006) Selective serotonin-reuptake inhibitors and risk of persistent pulmonary hypertension of the newborn. N Engl J Med 354 579
    • (2006) N Engl J Med , vol.354 , pp. 579
    • Chambers, C.D.1    Hernandez-Diaz, S.2    Van Marter, L.J.3
  • 167
    • 0037181646 scopus 로고    scopus 로고
    • Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants
    • V Gournay, C Savagner, G Thiriez, et al. (2002) Pulmonary hypertension after ibuprofen prophylaxis in very preterm infants. Lancet 359 1486
    • (2002) Lancet , vol.359 , pp. 1486
    • Gournay, V.1    Savagner, C.2    Thiriez, G.3
  • 168
    • 33644820808 scopus 로고    scopus 로고
    • Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    • S Lakshminrusimha, JA Russell, RH Steinhorn, et al. (2006) Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation. Pediatr Res 59 137
    • (2006) Pediatr Res , vol.59 , pp. 137
    • Lakshminrusimha, S.1    Russell, J.A.2    Steinhorn, R.H.3
  • 169
    • 33845478939 scopus 로고    scopus 로고
    • Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    • S Lakshminrusimha, JA Russell, S Wedgwood, et al. (2006) Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension. Am J Respir Crit Care Med 174 1370
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1370
    • Lakshminrusimha, S.1    Russell, J.A.2    Wedgwood, S.3
  • 170
    • 0035071603 scopus 로고    scopus 로고
    • Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates
    • M Vento, M Asensi, J Sastre, et al. (2001) Resuscitation with room air instead of 100% oxygen prevents oxidative stress in moderately asphyxiated term neonates. Pediatrics 107 642
    • (2001) Pediatrics , vol.107 , pp. 642
    • Vento, M.1    Asensi, M.2    Sastre, J.3
  • 171
    • 7044232096 scopus 로고    scopus 로고
    • Pulmonary vascular effects of inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia
    • PM Mourani, DD Ivy, D Gao, et al. (2004) Pulmonary vascular effects of inhaled nitric oxide and oxygen tension in bronchopulmonary dysplasia. Am J Respir Crit Care Med 170 1006
    • (2004) Am J Respir Crit Care Med , vol.170 , pp. 1006
    • Mourani, P.M.1    Ivy, D.D.2    Gao, D.3
  • 172
    • 0021850407 scopus 로고
    • Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation
    • JT Wung, LS James, E Kilchevsky, et al. (1985) Management of infants with severe respiratory failure and persistence of the fetal circulation, without hyperventilation. Pediatrics 76 488
    • (1985) Pediatrics , vol.76 , pp. 488
    • Wung, J.T.1    James, L.S.2    Kilchevsky, E.3
  • 173
    • 0018183786 scopus 로고
    • Physiologic factors affecting pulmonary artery pressure in infants with persistent pulmonary hypertension
    • GJ Peckham and WW Fox (1978) Physiologic factors affecting pulmonary artery pressure in infants with persistent pulmonary hypertension. J Pediatr 93 1005
    • (1978) J Pediatr , vol.93 , pp. 1005
    • Peckham, G.J.1    Fox, W.W.2
  • 174
    • 0019468342 scopus 로고
    • The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension
    • WH Drummond, GA Gregory, MA Heymann, et al. (1981) The independent effects of hyperventilation, tolazoline, and dopamine on infants with persistent pulmonary hypertension. J Pediatr 98 603
    • (1981) J Pediatr , vol.98 , pp. 603
    • Drummond, W.H.1    Gregory, G.A.2    Heymann, M.A.3
  • 175
    • 0021153670 scopus 로고
    • Control of the pulmonary circulation in the perinatal period
    • MA Heymann (1984) Control of the pulmonary circulation in the perinatal period. J Dev Physiol 6 281
    • (1984) J Dev Physiol , vol.6 , pp. 281
    • Heymann, M.A.1
  • 176
    • 0023820789 scopus 로고
    • 2 on pulmonary and systemic hemodynamics after surgery in children with congenital heart disease and pulmonary hypertension
    • JP Morray, AM Lynn and PB Mansfield (1988) Effect of pH and PCO 2 on pulmonary and systemic hemodynamics after surgery in children with congenital heart disease and pulmonary hypertension. J Pediatr 113 474
    • (1988) J Pediatr , vol.113 , pp. 474
    • Morray, J.P.1    Lynn, A.M.2    Mansfield, P.B.3
  • 177
    • 0024402493 scopus 로고
    • Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation
    • AR Dworetz, FR Moya, B Sabo, et al. (1989) Survival of infants with persistent pulmonary hypertension without extracorporeal membrane oxygenation. Pediatrics 84 1
    • (1989) Pediatrics , vol.84 , pp. 1
    • Dworetz, A.R.1    Moya, F.R.2    Sabo, B.3
  • 178
    • 0023891848 scopus 로고
    • Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension
    • EM Bifano and A Pfannenstiel (1988) Duration of hyperventilation and outcome in infants with persistent pulmonary hypertension. Pediatrics 81 657
    • (1988) Pediatrics , vol.81 , pp. 657
    • Bifano, E.M.1    Pfannenstiel, A.2
  • 179
    • 0023891847 scopus 로고
    • Hearing loss in infants with persistent fetal circulation
    • KD Hendricks-Munoz and JP Walton (1988) Hearing loss in infants with persistent fetal circulation. Pediatrics 81 650
    • (1988) Pediatrics , vol.81 , pp. 650
    • Hendricks-Munoz, K.D.1    Walton, J.P.2
  • 180
    • 0018294304 scopus 로고
    • Refractory hypoxemia associated with neonatal pulmonary disease: the use and limitations of tolazoline
    • DK Stevenson, DS Kasting, RA Darnall Jr., et al. (1979) Refractory hypoxemia associated with neonatal pulmonary disease: the use and limitations of tolazoline. J Pediatr 95 595
    • (1979) J Pediatr , vol.95 , pp. 595
    • Stevenson, D.K.1    Kasting, D.S.2    Darnall, R.A.3
  • 181
    • 0031264039 scopus 로고    scopus 로고
    • Endotracheal tolazoline administration in neonates with persistent pulmonary hypertension
    • SK Parida, S Baker, R Kuhn, et al. (1997) Endotracheal tolazoline administration in neonates with persistent pulmonary hypertension. J Perinatol 17 461
    • (1997) J Perinatol , vol.17 , pp. 461
    • Parida, S.K.1    Baker, S.2    Kuhn, R.3
  • 182
    • 0029114165 scopus 로고
    • Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates
    • TJ Wu, RJ Teng and KI Tsou (1995) Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates. Pediatrics 96 472
    • (1995) Pediatrics , vol.96 , pp. 472
    • Wu, T.J.1    Teng, R.J.2    Tsou, K.I.3
  • 183
    • 0035063930 scopus 로고    scopus 로고
    • Pharmacologic therapy of persistent pulmonary hypertension of the newborn
    • B Weinberger, K Weiss, DE Heck, et al. (2001) Pharmacologic therapy of persistent pulmonary hypertension of the newborn. Pharmacol Ther 89 67
    • (2001) Pharmacol Ther , vol.89 , pp. 67
    • Weinberger, B.1    Weiss, K.2    Heck, D.E.3
  • 184
    • 0026593089 scopus 로고
    • Treatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphate
    • YK Abu-Osba, O Galal, K Manasra, et al. (1992) Treatment of severe persistent pulmonary hypertension of the newborn with magnesium sulphate. Arch Dis Child 67 31
    • (1992) Arch Dis Child , vol.67 , pp. 31
    • Abu-Osba, Y.K.1    Galal, O.2    Manasra, K.3
  • 185
    • 0029422195 scopus 로고
    • Experimental and clinical effects of magnesium infusion in the treatment of neonatal pulmonary hypertension
    • SK Patole and NN Finer (1995) Experimental and clinical effects of magnesium infusion in the treatment of neonatal pulmonary hypertension. Magnes Res 8 373
    • (1995) Magnes Res , vol.8 , pp. 373
    • Patole, S.K.1    Finer, N.N.2
  • 186
    • 85136299323 scopus 로고    scopus 로고
    • The Neonatal Inhaled Nitric Oxide Study Group (NINOS)
    • Inhaled nitric oxide and hypoxic respiratory failure in infants with congenital diaphragmatic hernia (1997) The Neonatal Inhaled Nitric Oxide Study Group (NINOS). Pediatrics 99 838
    • (1997) Pediatrics , vol.99 , pp. 838
  • 187
    • 0034030710 scopus 로고    scopus 로고
    • neurodevelopmental follow-up of the neonatal inhaled nitric oxide study group (NINOS)
    • Inhaled nitric oxide in term and near-term infants (2000) neurodevelopmental follow-up of the neonatal inhaled nitric oxide study group (NINOS). J Pediatr 136 611
    • (2000) J Pediatr , vol.136 , pp. 611
  • 188
    • 0034677445 scopus 로고    scopus 로고
    • Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group
    • RH Clark, TJ Kueser, MW Walker, et al. (2000) Low-dose nitric oxide therapy for persistent pulmonary hypertension of the newborn. Clinical Inhaled Nitric Oxide Research Group. N Engl J Med 342 469
    • (2000) N Engl J Med , vol.342 , pp. 469
    • Clark, R.H.1    Kueser, T.J.2    Walker, M.W.3
  • 189
    • 0031267468 scopus 로고    scopus 로고
    • Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn
    • DL Wessel, I Adatia, LJ Van Marter, et al. (1997) Improved oxygenation in a randomized trial of inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 100 E7
    • (1997) Pediatrics , vol.100 , pp. E7
    • Wessel, D.L.1    Adatia, I.2    Van Marter, L.J.3
  • 190
    • 0031910578 scopus 로고    scopus 로고
    • Inhaled nitric oxide and high frequency oscillatory ventilation in persistent pulmonary hypertension of the newborn
    • JP Kinsella and SH Abman (1998) Inhaled nitric oxide and high frequency oscillatory ventilation in persistent pulmonary hypertension of the newborn. Eur J Pediatr 157(Suppl 1), S28
    • (1998) Eur J Pediatr , vol.157 , pp. S28
    • Kinsella, J.P.1    Abman, S.H.2
  • 191
    • 0013655172 scopus 로고    scopus 로고
    • Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group
    • JD Roberts Jr., JR Fineman, FC Morin III, et al. (1997) Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. The Inhaled Nitric Oxide Study Group. N Engl J Med 336 605
    • (1997) N Engl J Med , vol.336 , pp. 605
    • Roberts, J.D.1    Fineman, J.R.2    Morin, F.C.3
  • 192
    • 0030411572 scopus 로고    scopus 로고
    • Inhaled nitric oxide in term infants with hypoxemic respiratory failure
    • ES Barefield, VA Karle, JB Phillips III, et al. (1996) Inhaled nitric oxide in term infants with hypoxemic respiratory failure. J Pediatr 129 279
    • (1996) J Pediatr , vol.129 , pp. 279
    • Barefield, E.S.1    Karle, V.A.2    Phillips, J.B.3
  • 193
    • 0033678609 scopus 로고    scopus 로고
    • Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn
    • H Christou, LJ Van Marter, DL Wessel, et al. (2000) Inhaled nitric oxide reduces the need for extracorporeal membrane oxygenation in infants with persistent pulmonary hypertension of the newborn. Crit Care Med 28 3722
    • (2000) Crit Care Med , vol.28 , pp. 3722
    • Christou, H.1    Van Marter, L.J.2    Wessel, D.L.3
  • 194
    • 0031929875 scopus 로고    scopus 로고
    • Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group
    • D Davidson, ES Barefield, J Kattwinkel, et al. (1998) Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response, multicenter study. The I-NO/PPHN Study Group. Pediatrics 101 325
    • (1998) Pediatrics , vol.101 , pp. 325
    • Davidson, D.1    Barefield, E.S.2    Kattwinkel, J.3
  • 195
    • 84921429696 scopus 로고    scopus 로고
    • Nitric oxide for respiratory failure in infants born at or near term
    • CD000399
    • NN Finer and KJ Barrington (2006) Nitric oxide for respiratory failure in infants born at or near term. Cochrane Database Syst Rev CD000399
    • (2006) Cochrane Database Syst , vol.Rev
    • Finer, N.N.1    Barrington, K.J.2
  • 196
    • 0036213582 scopus 로고    scopus 로고
    • Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide
    • PH Lipkin, D Davidson, L Spivak, et al. (2002) Neurodevelopmental and medical outcomes of persistent pulmonary hypertension in term newborns treated with nitric oxide. J Pediatr 140 306
    • (2002) J Pediatr , vol.140 , pp. 306
    • Lipkin, P.H.1    Davidson, D.2    Spivak, L.3
  • 197
    • 0344943241 scopus 로고    scopus 로고
    • Inhaled nitric oxide in premature infants with the respiratory distress syndrome
    • MD Schreiber, K Gin-Mestan, JD Marks, et al. (2003) Inhaled nitric oxide in premature infants with the respiratory distress syndrome. N Engl J Med 349 2099
    • (2003) N Engl J Med , vol.349 , pp. 2099
    • Schreiber, M.D.1    Gin-Mestan, K.2    Marks, J.D.3
  • 198
    • 21444459262 scopus 로고    scopus 로고
    • Inhaled nitric oxide for premature infants with severe respiratory failure
    • KP Van Meurs, LL Wright, RA Ehrenkranz, et al. (2005) Inhaled nitric oxide for premature infants with severe respiratory failure. N Engl J Med 353 13
    • (2005) N Engl J Med , vol.353 , pp. 13
    • Van Meurs, K.P.1    Wright, L.L.2    Ehrenkranz, R.A.3
  • 199
    • 33746430578 scopus 로고    scopus 로고
    • Early inhaled nitric oxide therapy in premature newborns with respiratory failure
    • JP Kinsella, GR Cutter, WF Walsh, et al. (2006) Early inhaled nitric oxide therapy in premature newborns with respiratory failure. N Engl J Med 355 354
    • (2006) N Engl J Med , vol.355 , pp. 354
    • Kinsella, J.P.1    Cutter, G.R.2    Walsh, W.F.3
  • 200
    • 33746452905 scopus 로고    scopus 로고
    • Inhaled nitric oxide in preterm infants undergoing mechanical ventilation
    • RA Ballard, WE Truog, A Cnaan, et al. (2006) Inhaled nitric oxide in preterm infants undergoing mechanical ventilation. N Engl J Med 355 343
    • (2006) N Engl J Med , vol.355 , pp. 343
    • Ballard, R.A.1    Truog, W.E.2    Cnaan, A.3
  • 201
    • 0037396819 scopus 로고    scopus 로고
    • Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia
    • JP Kinsella, TA Parker, DD Ivy, et al. (2003) Noninvasive delivery of inhaled nitric oxide therapy for late pulmonary hypertension in newborn infants with congenital diaphragmatic hernia. J Pediatr 142 397
    • (2003) J Pediatr , vol.142 , pp. 397
    • Kinsella, J.P.1    Parker, T.A.2    Ivy, D.D.3
  • 202
    • 0033059098 scopus 로고    scopus 로고
    • Changes in oxygenation with inhaled nitric oxide in severe bronchopulmonary dysplasia
    • BA Banks, I Seri, H Ischiropoulos, et al. (1999) Changes in oxygenation with inhaled nitric oxide in severe bronchopulmonary dysplasia. Pediatrics 103 610
    • (1999) Pediatrics , vol.103 , pp. 610
    • Banks, B.A.1    Seri, I.2    Ischiropoulos, H.3
  • 203
    • 0029896789 scopus 로고    scopus 로고
    • Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests
    • RN Channick, JW Newhart, FW Johnson, et al. (1996) Pulsed delivery of inhaled nitric oxide to patients with primary pulmonary hypertension: an ambulatory delivery system and initial clinical tests. Chest 109 1545
    • (1996) Chest , vol.109 , pp. 1545
    • Channick, R.N.1    Newhart, J.W.2    Johnson, F.W.3
  • 204
    • 0033948098 scopus 로고    scopus 로고
    • Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease
    • RW Day, JA Hawkins, EC McGough, et al. (2000) Randomized controlled study of inhaled nitric oxide after operation for congenital heart disease. Ann Thorac Surg 69 1907
    • (2000) Ann Thorac Surg , vol.69 , pp. 1907
    • Day, R.W.1    Hawkins, J.A.2    McGough, E.C.3
  • 205
    • 0033504799 scopus 로고    scopus 로고
    • Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure
    • EL Dobyns, DN Cornfield, NG Anas, et al. (1999) Multicenter randomized controlled trial of the effects of inhaled nitric oxide therapy on gas exchange in children with acute hypoxemic respiratory failure. J Pediatr 134 406
    • (1999) J Pediatr , vol.134 , pp. 406
    • Dobyns, E.L.1    Cornfield, D.N.2    Anas, N.G.3
  • 206
  • 207
    • 0034727386 scopus 로고    scopus 로고
    • Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: a randomised double-blind study
    • OI Miller, SF Tang, A Keech, et al. (2000) Inhaled nitric oxide and prevention of pulmonary hypertension after congenital heart surgery: a randomised double-blind study. Lancet 356 1464
    • (2000) Lancet , vol.356 , pp. 1464
    • Miller, O.I.1    Tang, S.F.2    Keech, A.3
  • 208
    • 0037420269 scopus 로고    scopus 로고
    • Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease
    • DL Weiner, PL Hibberd, P Betit, et al. (2003) Preliminary assessment of inhaled nitric oxide for acute vaso-occlusive crisis in pediatric patients with sickle cell disease. JAMA 289 1136
    • (2003) JAMA , vol.289 , pp. 1136
    • Weiner, D.L.1    Hibberd, P.L.2    Betit, P.3
  • 209
    • 10744231522 scopus 로고    scopus 로고
    • A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failure
    • GG Konduri, A Solimano, GM Sokol, et al. (2004) A randomized trial of early versus standard inhaled nitric oxide therapy in term and near-term newborn infants with hypoxic respiratory failure. Pediatrics 113 559
    • (2004) Pediatrics , vol.113 , pp. 559
    • Konduri, G.G.1    Solimano, A.2    Sokol, G.M.3
  • 210
    • 85161825027 scopus 로고    scopus 로고
    • The Franco-Belgium Collaborative NO Trial Group
    • Early compared with delayed inhaled nitric oxide in moderately hypoxaemic neonates with respiratory failure: a randomised controlled trial (1999) The Franco-Belgium Collaborative NO Trial Group. Lancet 354 1066
    • (1999) Lancet , vol.354 , pp. 1066
  • 211
    • 0027389250 scopus 로고
    • Inhaled nitric oxide for the adult respiratory distress syndrome
    • R Rossaint, KJ Falke, F Lopez, et al. (1993) Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 328 399
    • (1993) N Engl J Med , vol.328 , pp. 399
    • Rossaint, R.1    Falke, K.J.2    Lopez, F.3
  • 212
    • 0001121834 scopus 로고    scopus 로고
    • The Neonatal Inhaled Nitric Oxide Study Group
    • Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure (1997) The Neonatal Inhaled Nitric Oxide Study Group. N Engl J Med 336 597
    • (1997) N Engl J Med , vol.336 , pp. 597
  • 213
    • 0030715652 scopus 로고    scopus 로고
    • Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn
    • JP Kinsella, WE Truog, WF Walsh, et al. (1997) Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr 131 55
    • (1997) J Pediatr , vol.131 , pp. 55
    • Kinsella, J.P.1    Truog, W.E.2    Walsh, W.F.3
  • 214
    • 0028134996 scopus 로고
    • Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios
    • HL Karamanoukian, PL Glick, M Zayek, et al. (1994) Inhaled nitric oxide in congenital hypoplasia of the lungs due to diaphragmatic hernia or oligohydramnios. Pediatrics 94 715
    • (1994) Pediatrics , vol.94 , pp. 715
    • Karamanoukian, H.L.1    Glick, P.L.2    Zayek, M.3
  • 215
    • 0027976855 scopus 로고
    • Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response
    • NN Finer, PC Etches, B Kamstra, et al. (1994) Inhaled nitric oxide in infants referred for extracorporeal membrane oxygenation: dose response. J Pediatr 124 302
    • (1994) J Pediatr , vol.124 , pp. 302
    • Finer, N.N.1    Etches, P.C.2    Kamstra, B.3
  • 216
    • 0028798482 scopus 로고
    • Combined effects of nitric oxide and hyperoxia on surfactant function and pulmonary inflammation
    • CG Robbins, JM Davis, TA Merritt, et al. (1995) Combined effects of nitric oxide and hyperoxia on surfactant function and pulmonary inflammation. Am J Physiol 269 L545
    • (1995) Am J Physiol , vol.269 , pp. L545
    • Robbins, C.G.1    Davis, J.M.2    Merritt, T.A.3
  • 217
    • 0025189864 scopus 로고
    • Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide
    • JS Beckman, TW Beckman, J Chen, et al. (1990) Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci USA 87 1620
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1620
    • Beckman, J.S.1    Beckman, T.W.2    Chen, J.3
  • 218
    • 2542506336 scopus 로고    scopus 로고
    • Initial dosing of inhaled nitric oxide in infants with hypoxic respiratory failure
    • SO Guthrie, WF Walsh, K Auten, et al. (2004) Initial dosing of inhaled nitric oxide in infants with hypoxic respiratory failure. J Perinatol 24 290
    • (2004) J Perinatol , vol.24 , pp. 290
    • Guthrie, S.O.1    Walsh, W.F.2    Auten, K.3
  • 219
    • 0029819053 scopus 로고    scopus 로고
    • Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn
    • AP Goldman, RC Tasker, SG Haworth, et al. (1996) Four patterns of response to inhaled nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 98 706
    • (1996) Pediatrics , vol.98 , pp. 706
    • Goldman, A.P.1    Tasker, R.C.2    Haworth, S.G.3
  • 220
    • 6844236992 scopus 로고    scopus 로고
    • Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group
    • A Lotze, BR Mitchell, DI Bulas, et al. (1998) Multicenter study of surfactant (beractant) use in the treatment of term infants with severe respiratory failure. Survanta in Term Infants Study Group. J Pediatr 132 40
    • (1998) J Pediatr , vol.132 , pp. 40
    • Lotze, A.1    Mitchell, B.R.2    Bulas, D.I.3
  • 221
    • 0031428207 scopus 로고    scopus 로고
    • Weaning strategy with inhaled nitric oxide treatment in persistent pulmonary hypertension of the newborn
    • H Aly, R Sahni and JT Wung (1997) Weaning strategy with inhaled nitric oxide treatment in persistent pulmonary hypertension of the newborn. Arch Dis Child Fetal Neonatal Ed 76 F118
    • (1997) Arch Dis Child Fetal Neonatal Ed , vol.76 , pp. F118
    • Aly, H.1    Sahni, R.2    Wung, J.T.3
  • 222
    • 0031460678 scopus 로고    scopus 로고
    • Life-threatening effects of discontinuing inhaled nitric oxide in children
    • E Cueto, J Lopez-Herce, A Sanchez, et al. (1997) Life-threatening effects of discontinuing inhaled nitric oxide in children. Acta Paediatr 86 1337
    • (1997) Acta Paediatr , vol.86 , pp. 1337
    • Cueto, E.1    Lopez-Herce, J.2    Sanchez, A.3
  • 223
    • 0032780775 scopus 로고    scopus 로고
    • Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn
    • D Davidson, ES Barefield, J Kattwinkel, et al. (1999) Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn. Pediatrics 104 231
    • (1999) Pediatrics , vol.104 , pp. 231
    • Davidson, D.1    Barefield, E.S.2    Kattwinkel, J.3
  • 224
    • 0031965802 scopus 로고    scopus 로고
    • Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease
    • DD Ivy, JP Kinsella, JW Ziegler, et al. (1998) Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease. J Thorac Cardiovasc Surg 115 875
    • (1998) J Thorac Cardiovasc Surg , vol.115 , pp. 875
    • Ivy, D.D.1    Kinsella, J.P.2    Ziegler, J.W.3
  • 225
    • 0029069107 scopus 로고
    • Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn
    • JP Kinsella and SH Abman (1995) Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn. J Pediatr 126 853
    • (1995) J Pediatr , vol.126 , pp. 853
    • Kinsella, J.P.1    Abman, S.H.2
  • 226
    • 0032735160 scopus 로고    scopus 로고
    • Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension
    • SM Black, RS Heidersbach, DM McMullan, et al. (1999) Inhaled nitric oxide inhibits NOS activity in lambs: potential mechanism for rebound pulmonary hypertension. Am J Physiol 277 H1849
    • (1999) Am J Physiol , vol.277 , pp. H1849
    • Black, S.M.1    Heidersbach, R.S.2    McMullan, D.M.3
  • 227
    • 0027436619 scopus 로고
    • Negative feedback regulation of endothelial cell function by nitric oxide
    • GM Buga, JM Griscavage, NE Rogers, et al. (1993) Negative feedback regulation of endothelial cell function by nitric oxide. Circ Res 73 808
    • (1993) Circ Res , vol.73 , pp. 808
    • Buga, G.M.1    Griscavage, J.M.2    Rogers, N.E.3
  • 228
    • 0034996074 scopus 로고    scopus 로고
    • Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1
    • DM McMullan, JM Bekker, MJ Johengen, et al. (2001) Inhaled nitric oxide-induced rebound pulmonary hypertension: role for endothelin-1. Am J Physiol Heart Circ Physiol 280 H777
    • (2001) Am J Physiol Heart Circ Physiol , vol.280 , pp. H777
    • McMullan, D.M.1    Bekker, J.M.2    Johengen, M.J.3
  • 229
    • 0035903240 scopus 로고    scopus 로고
    • Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy
    • S Wedgwood, DM McMullan, JM Bekker, et al. (2001) Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy. Circ Res 89 357
    • (2001) Circ Res , vol.89 , pp. 357
    • Wedgwood, S.1    McMullan, D.M.2    Bekker, J.M.3
  • 230
    • 0034960038 scopus 로고    scopus 로고
    • Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide
    • GM Sokol, NS Fineberg, LL Wright, et al. (2001) Changes in arterial oxygen tension when weaning neonates from inhaled nitric oxide. Pediatr Pulmonol 32 14
    • (2001) Pediatr Pulmonol , vol.32 , pp. 14
    • Sokol, G.M.1    Fineberg, N.S.2    Wright, L.L.3
  • 231
    • 0036998022 scopus 로고    scopus 로고
    • Inhaled nitric oxide: more than a selective pulmonary vasodilator
    • J Gianetti, S Bevilacqua and CR De (2002) Inhaled nitric oxide: more than a selective pulmonary vasodilator. Eur J Clin Invest 32 628
    • (2002) Eur J Clin Invest , vol.32 , pp. 628
    • Gianetti, J.1    Bevilacqua, S.2    De, C.R.3
  • 232
    • 0028816452 scopus 로고
    • Inhaled nitric oxide prevents neutrophil-mediated, oxygen radical-dependent leak in isolated rat lungs
    • DM Guidot, MJ Repine, BM Hybertson, et al. (1995) Inhaled nitric oxide prevents neutrophil-mediated, oxygen radical-dependent leak in isolated rat lungs. Am J Physiol 269 L2
    • (1995) Am J Physiol , vol.269 , pp. L2
    • Guidot, D.M.1    Repine, M.J.2    Hybertson, B.M.3
  • 233
    • 0030928473 scopus 로고    scopus 로고
    • Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease
    • JP Kinsella, TA Parker, H Galan, et al. (1997) Effects of inhaled nitric oxide on pulmonary edema and lung neutrophil accumulation in severe experimental hyaline membrane disease. Pediatr Res 41 457
    • (1997) Pediatr Res , vol.41 , pp. 457
    • Kinsella, J.P.1    Parker, T.A.2    Galan, H.3
  • 234
    • 2142705354 scopus 로고    scopus 로고
    • Inhaled nitric oxide therapy in the near-term or term neonate with hypoxic respiratory failure
    • LJ Williams, TH Shaffer and JS Greenspan (2004) Inhaled nitric oxide therapy in the near-term or term neonate with hypoxic respiratory failure. Neonatal Netw 23 5
    • (2004) Neonatal Netw , vol.23 , pp. 5
    • Williams, L.J.1    Shaffer, T.H.2    Greenspan, J.S.3
  • 235
    • 0022006689 scopus 로고
    • Pulmonary vascular response to oxygen in infants with severe bronchopulmonary dysplasia
    • SH Abman, RR Wolfe, FJ Accurso, et al. (1985) Pulmonary vascular response to oxygen in infants with severe bronchopulmonary dysplasia. Pediatrics 75 80
    • (1985) Pediatrics , vol.75 , pp. 80
    • Abman, S.H.1    Wolfe, R.R.2    Accurso, F.J.3
  • 236
    • 0033869797 scopus 로고    scopus 로고
    • Use of inhaled nitric oxide
    • American Academy of Pediatrics. Committee on Fetus and Newborn (2000) Use of inhaled nitric oxide. Pediatrics 106 344
    • (2000) Pediatrics , vol.106 , pp. 344
  • 237
    • 0035005362 scopus 로고    scopus 로고
    • Child health status, neurodevelopmental outcome, and parental satisfaction in a randomized, controlled trial of nitric oxide for persistent pulmonary hypertension of the newborn
    • M Ellington Jr., D O'Reilly, EN Allred, et al. (2001) Child health status, neurodevelopmental outcome, and parental satisfaction in a randomized, controlled trial of nitric oxide for persistent pulmonary hypertension of the newborn. Pediatrics 107 1351
    • (2001) Pediatrics , vol.107 , pp. 1351
    • Ellington, M.1    O'Reilly, D.2    Allred, E.N.3
  • 238
    • 0030702855 scopus 로고    scopus 로고
    • Longitudinal follow-up of a cohort of newborn infants treated with inhaled nitric oxide for persistent pulmonary hypertension
    • AA Rosenberg, JM Kennaugh, SG Moreland, et al. (1997) Longitudinal follow-up of a cohort of newborn infants treated with inhaled nitric oxide for persistent pulmonary hypertension. J Pediatr 131 70
    • (1997) J Pediatr , vol.131 , pp. 70
    • Rosenberg, A.A.1    Kennaugh, J.M.2    Moreland, S.G.3
  • 239
    • 0036213491 scopus 로고    scopus 로고
    • Outcome in term infants treated with inhaled nitric oxide
    • AA Rosenberg (2002) Outcome in term infants treated with inhaled nitric oxide. J Pediatr 140 284
    • (2002) J Pediatr , vol.140 , pp. 284
    • Rosenberg, A.A.1
  • 240
    • 0018940239 scopus 로고
    • Evidence of surfactant deficiency in persistence of the fetal circulation
    • M Hallman and K Kankaanpaa (1980) Evidence of surfactant deficiency in persistence of the fetal circulation. Eur J Pediatr 134 129
    • (1980) Eur J Pediatr , vol.134 , pp. 129
    • Hallman, M.1    Kankaanpaa, K.2
  • 241
    • 0025304946 scopus 로고
    • Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation
    • A Lotze, JA Whitsett, LA Kammerman, et al. (1990) Surfactant protein A concentrations in tracheal aspirate fluid from infants requiring extracorporeal membrane oxygenation. J Pediatr 116 435
    • (1990) J Pediatr , vol.116 , pp. 435
    • Lotze, A.1    Whitsett, J.A.2    Kammerman, L.A.3
  • 242
    • 0026088058 scopus 로고
    • Surfactant treatment of full-term newborns with respiratory failure
    • RL Auten, RH Notter, JW Kendig, et al. (1991) Surfactant treatment of full-term newborns with respiratory failure. Pediatrics 87 101
    • (1991) Pediatrics , vol.87 , pp. 101
    • Auten, R.L.1    Notter, R.H.2    Kendig, J.W.3
  • 243
    • 0027393888 scopus 로고
    • Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation
    • A Lotze, GR Knight, GR Martin, et al. (1993) Improved pulmonary outcome after exogenous surfactant therapy for respiratory failure in term infants requiring extracorporeal membrane oxygenation. J Pediatr 122 261
    • (1993) J Pediatr , vol.122 , pp. 261
    • Lotze, A.1    Knight, G.R.2    Martin, G.R.3
  • 244
    • 0037072098 scopus 로고    scopus 로고
    • Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn
    • MP Moya, AJ Gow, RM Califf, et al. (2002) Inhaled ethyl nitrite gas for persistent pulmonary hypertension of the newborn. Lancet 360 141
    • (2002) Lancet , vol.360 , pp. 141
    • Moya, M.P.1    Gow, A.J.2    Califf, R.M.3
  • 245
    • 0033521110 scopus 로고    scopus 로고
    • Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5)
    • TL Fink, SH Francis, A Beasley, et al. (1999) Expression of an active, monomeric catalytic domain of the cGMP-binding cGMP-specific phosphodiesterase (PDE5). J Biol Chem 274 34613
    • (1999) J Biol Chem , vol.274 , pp. 34613
    • Fink, T.L.1    Francis, S.H.2    Beasley, A.3
  • 246
    • 21544444144 scopus 로고    scopus 로고
    • Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells
    • J Wharton, JW Strange, GM Moller, et al. (2005) Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am J Respir Crit Care Med 172 105
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 105
    • Wharton, J.1    Strange, J.W.2    Moller, G.M.3
  • 247
    • 0035198893 scopus 로고    scopus 로고
    • sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension
    • SM Black, LS Sanchez, E Mata-Greenwood, et al. (2001) sGC and PDE5 are elevated in lambs with increased pulmonary blood flow and pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 281 L1051
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.281 , pp. L1051
    • Black, S.M.1    Sanchez, L.S.2    Mata-Greenwood, E.3
  • 248
    • 0035212699 scopus 로고    scopus 로고
    • The use of dipyridamole to wean from inhaled nitric oxide in congenital diaphragmatic hernia
    • C Buysse, C Fonteyne, H Dessy, et al. (2001) The use of dipyridamole to wean from inhaled nitric oxide in congenital diaphragmatic hernia. J Pediatr Surg 36 1864
    • (2001) J Pediatr Surg , vol.36 , pp. 1864
    • Buysse, C.1    Fonteyne, C.2    Dessy, H.3
  • 249
    • 0029128510 scopus 로고
    • Dipyridamole augmentation of response to nitric oxide
    • JP Kinsella, F Torielli, JW Ziegler, et al. (1995) Dipyridamole augmentation of response to nitric oxide. Lancet 346 647
    • (1995) Lancet , vol.346 , pp. 647
    • Kinsella, J.P.1    Torielli, F.2    Ziegler, J.W.3
  • 250
    • 21444456940 scopus 로고    scopus 로고
    • Sildenafil and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets
    • KM Binns-Loveman, MR Kaplowitz and CD Fike (2005) Sildenafil and an early stage of chronic hypoxia-induced pulmonary hypertension in newborn piglets. Pediatr Pulmonol 40 72
    • (2005) Pediatr Pulmonol , vol.40 , pp. 72
    • Binns-Loveman, K.M.1    Kaplowitz, M.R.2    Fike, C.D.3
  • 251
    • 1842530387 scopus 로고    scopus 로고
    • Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study
    • BK Sastry, C Narasimhan, NK Reddy, et al. (2004) Clinical efficacy of sildenafil in primary pulmonary hypertension: a randomized, placebo-controlled, double-blind, crossover study. J Am Coll Cardiol 43 1149
    • (2004) J Am Coll Cardiol , vol.43 , pp. 1149
    • Sastry, B.K.1    Narasimhan, C.2    Reddy, N.K.3
  • 252
    • 0037150158 scopus 로고    scopus 로고
    • Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide
    • E Michelakis, W Tymchak, D Lien, et al. (2002) Oral sildenafil is an effective and specific pulmonary vasodilator in patients with pulmonary arterial hypertension: comparison with inhaled nitric oxide. Circulation 105 2398
    • (2002) Circulation , vol.105 , pp. 2398
    • Michelakis, E.1    Tymchak, W.2    Lien, D.3
  • 253
    • 0037106989 scopus 로고    scopus 로고
    • Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension
    • JJ Lepore, A Maroo, NL Pereira, et al. (2002) Effect of sildenafil on the acute pulmonary vasodilator response to inhaled nitric oxide in adults with primary pulmonary hypertension. Am J Cardiol 90 677
    • (2002) Am J Cardiol , vol.90 , pp. 677
    • Lepore, J.J.1    Maroo, A.2    Pereira, N.L.3
  • 254
    • 0037152092 scopus 로고    scopus 로고
    • Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial
    • HA Ghofrani, R Wiedemann, F Rose, et al. (2002) Sildenafil for treatment of lung fibrosis and pulmonary hypertension: a randomised controlled trial. Lancet 360 895
    • (2002) Lancet , vol.360 , pp. 895
    • Ghofrani, H.A.1    Wiedemann, R.2    Rose, F.3
  • 255
    • 26444534291 scopus 로고    scopus 로고
    • Sildenafil citrate therapy for pulmonary arterial hypertension
    • N Galie, HA Ghofrani, A Torbicki, et al. (2005) Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 353 2148
    • (2005) N Engl J Med , vol.353 , pp. 2148
    • Galie, N.1    Ghofrani, H.A.2    Torbicki, A.3
  • 256
    • 0344258463 scopus 로고    scopus 로고
    • Sildenafil ameliorates effects of inhaled nitric oxide withdrawal
    • AM Atz and DL Wessel (1999) Sildenafil ameliorates effects of inhaled nitric oxide withdrawal. Anesthesiology 91 307
    • (1999) Anesthesiology , vol.91 , pp. 307
    • Atz, A.M.1    Wessel, D.L.2
  • 257
    • 26444485467 scopus 로고    scopus 로고
    • Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil
    • AE Juliana and FC Abbad (2005) Severe persistent pulmonary hypertension of the newborn in a setting where limited resources exclude the use of inhaled nitric oxide: successful treatment with sildenafil. Eur J Pediatr 164 626
    • (2005) Eur J Pediatr , vol.164 , pp. 626
    • Juliana, A.E.1    Abbad, F.C.2
  • 258
    • 33646343464 scopus 로고    scopus 로고
    • Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study
    • H Baquero, A Soliz, F Neira, et al. (2006) Oral sildenafil in infants with persistent pulmonary hypertension of the newborn: a pilot randomized blinded study. Pediatrics 117 1077
    • (2006) Pediatrics , vol.117 , pp. 1077
    • Baquero, H.1    Soliz, A.2    Neira, F.3
  • 259
    • 0346328361 scopus 로고    scopus 로고
    • Phosphodiesterase inhibitors for persistent pulmonary hypertension of the newborn: a review
    • JN Travadi and SK Patole (2003) Phosphodiesterase inhibitors for persistent pulmonary hypertension of the newborn: a review. Pediatr Pulmonol 36 529
    • (2003) Pediatr Pulmonol , vol.36 , pp. 529
    • Travadi, J.N.1    Patole, S.K.2
  • 260
    • 0942290454 scopus 로고    scopus 로고
    • Severe retinopathy of prematurity (ROP) in a premature baby treated with sildenafil acetate (Viagra) for pulmonary hypertension
    • CS Marsh, B Marden and R Newsom (2004) Severe retinopathy of prematurity (ROP) in a premature baby treated with sildenafil acetate (Viagra) for pulmonary hypertension. Br J Ophthalmol 88 306
    • (2004) Br J Ophthalmol , vol.88 , pp. 306
    • Marsh, C.S.1    Marden, B.2    Newsom, R.3
  • 261
    • 12944304593 scopus 로고    scopus 로고
    • No evidence for severe retinopathy of prematurity following sildenafil
    • CM Pierce, AJ Petros and AR Fielder (2005) No evidence for severe retinopathy of prematurity following sildenafil. Br J Ophthalmol 89 250
    • (2005) Br J Ophthalmol , vol.89 , pp. 250
    • Pierce, C.M.1    Petros, A.J.2    Fielder, A.R.3
  • 262
    • 0344585989 scopus 로고    scopus 로고
    • mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain
    • WC Van Staveren, HW Steinbusch, IM Markerink-Van, et al. (2003) mRNA expression patterns of the cGMP-hydrolyzing phosphodiesterases types 2, 5, and 9 during development of the rat brain. J Comp Neurol 467 566
    • (2003) J Comp Neurol , vol.467 , pp. 566
    • Van Staveren, W.C.1    Steinbusch, H.W.2    Markerink-Van, I.M.3
  • 263
    • 16844372455 scopus 로고    scopus 로고
    • Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor
    • L Zhang, RL Zhang, Y Wang, et al. (2005) Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor. Stroke 36 847
    • (2005) Stroke , vol.36 , pp. 847
    • Zhang, L.1    Zhang, R.L.2    Wang, Y.3
  • 264
    • 33750602910 scopus 로고    scopus 로고
    • Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children
    • P Namachivayam, U Theilen, WW Butt, et al. (2006) Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children. Am J Respir Crit Care Med 174 1042
    • (2006) Am J Respir Crit Care Med , vol.174 , pp. 1042
    • Namachivayam, P.1    Theilen, U.2    Butt, W.W.3
  • 265
    • 0030711684 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of endothelial cell dysfunction
    • DG Harrison (1997) Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 100 2153
    • (1997) J Clin Invest , vol.100 , pp. 2153
    • Harrison, D.G.1
  • 266
    • 0030840893 scopus 로고    scopus 로고
    • Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats
    • Y Mitani, K Maruyama and M Sakurai (1997) Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation 96 689
    • (1997) Circulation , vol.96 , pp. 689
    • Mitani, Y.1    Maruyama, K.2    Sakurai, M.3
  • 267
    • 0034094862 scopus 로고    scopus 로고
    • L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs
    • CD Fike, MR Kaplowitz, LA Rehorst-Paea, et al. (2000) L-Arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs. J Appl Physiol 88 1797
    • (2000) J Appl Physiol , vol.88 , pp. 1797
    • Fike, C.D.1    Kaplowitz, M.R.2    Rehorst-Paea, L.A.3
  • 268
    • 0029083303 scopus 로고
    • Short-term pulmonary vasodilatation with L-arginine in pulmonary hypertension
    • S Mehta, DJ Stewart, D Langleben, et al. (1995) Short-term pulmonary vasodilatation with L-arginine in pulmonary hypertension. Circulation 92 1539
    • (1995) Circulation , vol.92 , pp. 1539
    • Mehta, S.1    Stewart, D.J.2    Langleben, D.3
  • 269
    • 0035060156 scopus 로고    scopus 로고
    • Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension
    • N Nagaya, M Uematsu, H Oya, et al. (2001) Short-term oral administration of L-arginine improves hemodynamics and exercise capacity in patients with precapillary pulmonary hypertension. Am J Respir Crit Care Med 163 887
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 887
    • Nagaya, N.1    Uematsu, M.2    Oya, H.3
  • 270
    • 0033578465 scopus 로고    scopus 로고
    • L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery
    • I Schulze-Neick, DJ Penny, ML Rigby, et al. (1999) L-arginine and substance P reverse the pulmonary endothelial dysfunction caused by congenital heart surgery. Circulation 100 749
    • (1999) Circulation , vol.100 , pp. 749
    • Schulze-Neick, I.1    Penny, D.J.2    Rigby, M.L.3
  • 271
    • 0029015149 scopus 로고
    • Effect of L-arginine infusion on infants with persistent pulmonary hypertension of the newborn
    • MJ McCaffrey, CL Bose, PD Reiter, et al. (1995) Effect of L-arginine infusion on infants with persistent pulmonary hypertension of the newborn. Biol Neonate 67 240
    • (1995) Biol Neonate , vol.67 , pp. 240
    • McCaffrey, M.J.1    Bose, C.L.2    Reiter, P.D.3
  • 272
    • 0043204998 scopus 로고    scopus 로고
    • Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease?
    • CR Morris, SM Morris Jr, W Hagar, et al. (2003) Arginine therapy: a new treatment for pulmonary hypertension in sickle cell disease? Am J Respir Crit Care Med 168 63
    • (2003) Am J Respir Crit Care Med , vol.168 , pp. 63
    • Morris, C.R.1    Morris, S.M.2    Hagar, W.3
  • 273
    • 0035085477 scopus 로고    scopus 로고
    • Plasma levels of asymmetrical dimethyl-L-arginine in patients with congenital heart disease and pulmonary hypertension
    • M Gorenflo, C Zheng, E Werle, et al. (2001) Plasma levels of asymmetrical dimethyl- L-arginine in patients with congenital heart disease and pulmonary hypertension. J Cardiovasc Pharmacol 37 489
    • (2001) J Cardiovasc Pharmacol , vol.37 , pp. 489
    • Gorenflo, M.1    Zheng, C.2    Werle, E.3
  • 274
    • 33846219575 scopus 로고    scopus 로고
    • Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA
    • P Bulau, D Zakrzewicz, K Kitowska, et al. (2007) Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA. Am J Physiol Lung Cell Mol Physiol 292 L18
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L18
    • Bulau, P.1    Zakrzewicz, D.2    Kitowska, K.3
  • 275
    • 33846188567 scopus 로고    scopus 로고
    • The lung in the balance: arginine, methylated arginines, and nitric oxide
    • RA Dweik (2007) The lung in the balance: arginine, methylated arginines, and nitric oxide. Am J Physiol Lung Cell Mol Physiol 292 L15
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L15
    • Dweik, R.A.1
  • 276
    • 0037899982 scopus 로고
    • Factors influencing the development of urea-synthesizing enzymes in rat liver
    • NC Raiha and J Suihkonen (1968) Factors influencing the development of urea-synthesizing enzymes in rat liver. Biochem J 107 793
    • (1968) Biochem J , vol.107 , pp. 793
    • Raiha, N.C.1    Suihkonen, J.2
  • 277
    • 0014255415 scopus 로고
    • Development of urea-synthesizing enzymes in human liver
    • NC Raiha and J Suihkonen (1968) Development of urea-synthesizing enzymes in human liver. Acta Paediatr Scand 57 121
    • (1968) Acta Paediatr Scand , vol.57 , pp. 121
    • Raiha, N.C.1    Suihkonen, J.2
  • 278
    • 0026595011 scopus 로고
    • Studies on urea cycle enzyme levels in the human fetal liver at different gestational ages
    • BM Mukarram Ali, CM Habibullah, M Swamy, et al. (1992) Studies on urea cycle enzyme levels in the human fetal liver at different gestational ages. Pediatr Res 31 143
    • (1992) Pediatr Res , vol.31 , pp. 143
    • Mukarram Ali, B.M.1    Habibullah, C.M.2    Swamy, M.3
  • 279
    • 0035859237 scopus 로고    scopus 로고
    • Neonatal pulmonary hypertension–urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function
    • DL Pearson, S Dawling, WF Walsh, et al. (2001) Neonatal pulmonary hypertension–urea-cycle intermediates, nitric oxide production, and carbamoyl-phosphate synthetase function. N Engl J Med 344 1832
    • (2001) N Engl J Med , vol.344 , pp. 1832
    • Pearson, D.L.1    Dawling, S.2    Walsh, W.F.3
  • 280
    • 0035142619 scopus 로고    scopus 로고
    • Current strategies for the management of neonatal urea cycle disorders
    • M Summar (2001) Current strategies for the management of neonatal urea cycle disorders. J Pediatr 138 S30
    • (2001) J Pediatr , vol.138 , pp. S30
    • Summar, M.1
  • 281
    • 33645984975 scopus 로고    scopus 로고
    • Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers
    • KP Kuhn, PA Harris, GR Cunningham, et al. (2002) Oral citrulline effectively elevates plasma arginine levels for 24 hours in normal volunteers. Circulation 106 II-339
    • (2002) Circulation , vol.106 , pp. II-339
    • Kuhn, K.P.1    Harris, P.A.2    Cunningham, G.R.3
  • 282
    • 0028072441 scopus 로고
    • Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline
    • WJ Hartman, PM Torre and RL Prior (1994) Dietary citrulline but not ornithine counteracts dietary arginine deficiency in rats by increasing splanchnic release of citrulline. J Nutr 124 1950
    • (1994) J Nutr , vol.124 , pp. 1950
    • Hartman, W.J.1    Torre, P.M.2    Prior, R.L.3
  • 283
    • 0020057470 scopus 로고
    • Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion
    • ML Batshaw, S Brusilow, L Waber, et al. (1982) Treatment of inborn errors of urea synthesis: activation of alternative pathways of waste nitrogen synthesis and excretion. N Engl J Med 306 1387
    • (1982) N Engl J Med , vol.306 , pp. 1387
    • Batshaw, M.L.1    Brusilow, S.2    Waber, L.3
  • 284
    • 0021252375 scopus 로고
    • Arginine-responsive asymptomatic hyperammonemia in the premature infant
    • ML Batshaw, RC Wachtel, GH Thomas, et al. (1984) Arginine-responsive asymptomatic hyperammonemia in the premature infant. J Pediatr 105 86
    • (1984) J Pediatr , vol.105 , pp. 86
    • Batshaw, M.L.1    Wachtel, R.C.2    Thomas, G.H.3
  • 285
    • 33745196072 scopus 로고    scopus 로고
    • Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline
    • HA Smith, JA Canter, KG Christian, et al. (2006) Nitric oxide precursors and congenital heart surgery: a randomized controlled trial of oral citrulline. J Thorac Cardiovasc Surg 132 58
    • (2006) J Thorac Cardiovasc Surg , vol.132 , pp. 58
    • Smith, H.A.1    Canter, J.A.2    Christian, K.G.3
  • 286
    • 0035883591 scopus 로고    scopus 로고
    • Increased lipid peroxidation in patients with pulmonary hypertension
    • JL Cracowski, C Cracowski, G Bessard, et al. (2001) Increased lipid peroxidation in patients with pulmonary hypertension. Am J Respir Crit Care Med 164 1038
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1038
    • Cracowski, J.L.1    Cracowski, C.2    Bessard, G.3
  • 287
    • 0037418938 scopus 로고    scopus 로고
    • Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase
    • LA Brennan, RH Steinhorn, S Wedgwood, et al. (2003) Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase. Circ Res 92 683
    • (2003) Circ Res , vol.92 , pp. 683
    • Brennan, L.A.1    Steinhorn, R.H.2    Wedgwood, S.3
  • 288
    • 33644846537 scopus 로고    scopus 로고
    • eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    • E Mata-Greenwood, C Jenkins, KN Farrow, et al. (2006) eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally. Am J Physiol Lung Cell Mol Physiol 290 L232
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.290 , pp. L232
    • Mata-Greenwood, E.1    Jenkins, C.2    Farrow, K.N.3
  • 289
    • 0038677171 scopus 로고    scopus 로고
    • Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension
    • GG Konduri, J Ou, Y Shi, et al. (2003) Decreased association of HSP90 impairs endothelial nitric oxide synthase in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol 285 H204
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H204
    • Konduri, G.G.1    Ou, J.2    Shi, Y.3
  • 290
    • 34147118950 scopus 로고    scopus 로고
    • Oxidant stress from uncoupled nitric oxide synthase impairs vasodilatation in fetal lambs with persistent pulmonary hypertension
    • GG Konduri, I Bakhutashvili, A Eis, et al. (2007) Oxidant stress from uncoupled nitric oxide synthase impairs vasodilatation in fetal lambs with persistent pulmonary hypertension. Am J Physiol Heart Circ Physiol 292 H1812
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. H1812
    • Konduri, G.G.1    Bakhutashvili, I.2    Eis, A.3
  • 291
    • 3943073829 scopus 로고    scopus 로고
    • Vascular protection: superoxide dismutase isoforms in the vessel wall
    • FM Faraci and SP Didion (2004) Vascular protection: superoxide dismutase isoforms in the vessel wall. Arterioscler Thromb Vasc Biol 24 1367
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1367
    • Faraci, F.M.1    Didion, S.P.2
  • 292
    • 5444245109 scopus 로고    scopus 로고
    • Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat
    • J Belik, RP Jankov, J Pan, et al. (2004) Peroxynitrite inhibits relaxation and induces pulmonary artery muscle contraction in the newborn rat. Free Radic Biol Med 37 1384
    • (2004) Free Radic Biol Med , vol.37 , pp. 1384
    • Belik, J.1    Jankov, R.P.2    Pan, J.3
  • 293
    • 0027315383 scopus 로고
    • 2-induced contractions of pulmonary arteries
    • DW Sheehan, EC Giese, SF Gugino, et al. (1993) Characterization and mechanisms of H 2O 2-induced contractions of pulmonary arteries. Am J Physiol 264 H1542
    • (1993) Am J Physiol , vol.264 , pp. H1542
    • Sheehan, D.W.1    Giese, E.C.2    Gugino, S.F.3
  • 294
    • 0034990522 scopus 로고    scopus 로고
    • Isoprostanes: an overview and putative roles in pulmonary pathophysiology
    • LJ Janssen (2001) Isoprostanes: an overview and putative roles in pulmonary pathophysiology. Am J Physiol Lung Cell Mol Physiol 280 L1067
    • (2001) Am J Physiol Lung Cell Mol Physiol , vol.280 , pp. L1067
    • Janssen, L.J.1
  • 295
    • 0942287681 scopus 로고    scopus 로고
    • 2 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostane
    • J Belik, RP Jankov, J Pan, et al. (2004) Chronic O 2 exposure in the newborn rat results in decreased pulmonary arterial nitric oxide release and altered smooth muscle response to isoprostane. J Appl Physiol 96 725
    • (2004) J Appl Physiol , vol.96 , pp. 725
    • Belik, J.1    Jankov, R.P.2    Pan, J.3
  • 296
    • 0037215666 scopus 로고    scopus 로고
    • Nitrotyrosine and NO synthases in infants with respiratory failure: influence of inhaled NO
    • O Aikio, K Vuopala, ML Pokela, et al. (2003) Nitrotyrosine and NO synthases in infants with respiratory failure: influence of inhaled NO. Pediatr Pulmonol 35 8
    • (2003) Pediatr Pulmonol , vol.35 , pp. 8
    • Aikio, O.1    Vuopala, K.2    Pokela, M.L.3
  • 297
    • 0031594678 scopus 로고    scopus 로고
    • Eight-epi-PGF2alpha: a possible marker of lipid peroxidation in term infants with severe pulmonary disease
    • S Goil, WE Truog, C Barnes, et al. (1998) Eight-epi-PGF2alpha: a possible marker of lipid peroxidation in term infants with severe pulmonary disease. J Pediatr 132 349
    • (1998) J Pediatr , vol.132 , pp. 349
    • Goil, S.1    Truog, W.E.2    Barnes, C.3
  • 298
    • 0345690185 scopus 로고    scopus 로고
    • Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension
    • S Wedgwood and SM Black (2003) Role of reactive oxygen species in vascular remodeling associated with pulmonary hypertension. Antioxid Redox Signal 5 759
    • (2003) Antioxid Redox Signal , vol.5 , pp. 759
    • Wedgwood, S.1    Black, S.M.2
  • 299
    • 0035447003 scopus 로고    scopus 로고
    • Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension
    • RH Steinhorn, G Albert, DD Swartz, et al. (2001) Recombinant human superoxide dismutase enhances the effect of inhaled nitric oxide in persistent pulmonary hypertension. Am J Respir Crit Care Med 164 834
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 834
    • Steinhorn, R.H.1    Albert, G.2    Swartz, D.D.3
  • 300
    • 0033804544 scopus 로고    scopus 로고
    • Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets
    • E Villamor, F Perez-Vizcaino, AL Cogolludo, et al. (2000) Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets. Pediatr Res 48 546
    • (2000) Pediatr Res , vol.48 , pp. 546
    • Villamor, E.1    Perez-Vizcaino, F.2    Cogolludo, A.L.3
  • 301
    • 0033804544 scopus 로고    scopus 로고
    • Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets
    • E Villamor, F Perez-Vizcaino, AL Cogolludo, et al. (2000) Relaxant effects of carbon monoxide compared with nitric oxide in pulmonary and systemic vessels of newborn piglets. Pediatr Res 48 546
    • (2000) Pediatr Res , vol.48 , pp. 546
    • Villamor, E.1    Perez-Vizcaino, F.2    Cogolludo, A.L.3
  • 302
    • 24944589526 scopus 로고    scopus 로고
    • Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs
    • JP Kinsella, TA Parker, JM Davis, et al. (2005) Superoxide dismutase improves gas exchange and pulmonary hemodynamics in premature lambs. Am J Respir Crit Care Med 172 745
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 745
    • Kinsella, J.P.1    Parker, T.A.2    Davis, J.M.3
  • 303
    • 18544401753 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome
    • JM Davis, WN Rosenfeld, SE Richter, et al. (1997) Safety and pharmacokinetics of multiple doses of recombinant human CuZn superoxide dismutase administered intratracheally to premature neonates with respiratory distress syndrome. Pediatrics 100 24
    • (1997) Pediatrics , vol.100 , pp. 24
    • Davis, J.M.1    Rosenfeld, W.N.2    Richter, S.E.3
  • 304
    • 0344375086 scopus 로고    scopus 로고
    • Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase
    • JM Davis, RB Parad, T Michele, et al. (2003) Pulmonary outcome at 1 year corrected age in premature infants treated at birth with recombinant human CuZn superoxide dismutase. Pediatrics 111 469
    • (2003) Pediatrics , vol.111 , pp. 469
    • Davis, J.M.1    Parad, R.B.2    Michele, T.3
  • 305
    • 0037308240 scopus 로고    scopus 로고
    • Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs
    • CD Fike, MR Kaplowitz and SL Pfister (2003) Arachidonic acid metabolites and an early stage of pulmonary hypertension in chronically hypoxic newborn pigs. Am J Physiol Lung Cell Mol Physiol 284 L316
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284 , pp. L316
    • Fike, C.D.1    Kaplowitz, M.R.2    Pfister, S.L.3
  • 306
    • 0034804704 scopus 로고    scopus 로고
    • Medical therapy of pulmonary hypertension. The prostacyclins
    • N Galie, A Manes and A Branzi (2001) Medical therapy of pulmonary hypertension. The prostacyclins. Clin Chest Med 22 529
    • (2001) Clin Chest Med , vol.22 , pp. 529
    • Galie, N.1    Manes, A.2    Branzi, A.3
  • 307
    • 0037246057 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension in children
    • A Widlitz and RJ Barst (2003) Pulmonary arterial hypertension in children. Eur Respir J 21 155
    • (2003) Eur Respir J , vol.21 , pp. 155
    • Widlitz, A.1    Barst, R.J.2
  • 308
    • 0032729943 scopus 로고    scopus 로고
    • Inhaled prostacyclin in the treatment of pulmonary hypertension
    • M Max and R Rossaint (1999) Inhaled prostacyclin in the treatment of pulmonary hypertension. Eur J Pediatr 158(Suppl 1), S23
    • (1999) Eur J Pediatr , vol.158 , pp. S23
    • Max, M.1    Rossaint, R.2
  • 309
    • 0036907375 scopus 로고    scopus 로고
    • Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide
    • LK Kelly, NF Porta, DM Goodman, et al. (2002) Inhaled prostacyclin for term infants with persistent pulmonary hypertension refractory to inhaled nitric oxide. J Pediatr 141 830
    • (2002) J Pediatr , vol.141 , pp. 830
    • Kelly, L.K.1    Porta, N.F.2    Goodman, D.M.3
  • 310
    • 0026628265 scopus 로고
    • An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension
    • BW Christman, CD McPherson, JH Newman, et al. (1992) An imbalance between the excretion of thromboxane and prostacyclin metabolites in pulmonary hypertension. N Engl J Med 327 70
    • (1992) N Engl J Med , vol.327 , pp. 70
    • Christman, B.W.1    McPherson, C.D.2    Newman, J.H.3
  • 311
    • 23044470391 scopus 로고    scopus 로고
    • Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets
    • CD Fike, Y Zhang and MR Kaplowitz (2005) Thromboxane inhibition reduces an early stage of chronic hypoxia-induced pulmonary hypertension in piglets. J Appl Physiol 99 670
    • (2005) J Appl Physiol , vol.99 , pp. 670
    • Fike, C.D.1    Zhang, Y.2    Kaplowitz, M.R.3
  • 312
    • 20244386797 scopus 로고    scopus 로고
    • Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension
    • D Langleben, BW Christman, RJ Barst, et al. (2002) Effects of the thromboxane synthetase inhibitor and receptor antagonist terbogrel in patients with primary pulmonary hypertension. Am Heart J 143 E4
    • (2002) Am Heart J , vol.143 , pp. E4
    • Langleben, D.1    Christman, B.W.2    Barst, R.J.3
  • 313
    • 30444453849 scopus 로고    scopus 로고
    • A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension
    • M Kataoka, N Nagaya, T Satoh, et al. (2005) A long-acting prostacyclin agonist with thromboxane inhibitory activity for pulmonary hypertension. Am J Respir Crit Care Med 172 1575
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 1575
    • Kataoka, M.1    Nagaya, N.2    Satoh, T.3
  • 314
    • 0035818316 scopus 로고    scopus 로고
    • Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study
    • RN Channick, G Simonneau, O Sitbon, et al. (2001) Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebo-controlled study. Lancet 358 1119
    • (2001) Lancet , vol.358 , pp. 1119
    • Channick, R.N.1    Simonneau, G.2    Sitbon, O.3
  • 315
    • 0036263877 scopus 로고    scopus 로고
    • Complete results of the first randomized placebo-controlled study of bosentan, a dual endothelin receptor antagonist, in pulmonary arterial hypertension
    • DB Badesch, F Bodin, RN Channick, et al. (2002) Complete results of the first randomized placebo-controlled study of bosentan, a dual endothelin receptor antagonist, in pulmonary arterial hypertension. Curr Ther Res 63 227
    • (2002) Curr Ther Res , vol.63 , pp. 227
    • Badesch, D.B.1    Bodin, F.2    Channick, R.N.3
  • 316
    • 0037149718 scopus 로고    scopus 로고
    • Bosentan therapy for pulmonary arterial hypertension
    • LJ Rubin, DB Badesch, RJ Barst, et al. (2002) Bosentan therapy for pulmonary arterial hypertension. N Engl J Med 346 896
    • (2002) N Engl J Med , vol.346 , pp. 896
    • Rubin, L.J.1    Badesch, D.B.2    Barst, R.J.3
  • 317
    • 0344406959 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension
    • RJ Barst, D Ivy, J Dingemanse, et al. (2003) Pharmacokinetics, safety, and efficacy of bosentan in pediatric patients with pulmonary arterial hypertension. Clin Pharmacol Ther 73 372
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 372
    • Barst, R.J.1    Ivy, D.2    Dingemanse, J.3
  • 318
    • 1842476943 scopus 로고    scopus 로고
    • Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan
    • DD Ivy, A Doran, L Claussen, et al. (2004) Weaning and discontinuation of epoprostenol in children with idiopathic pulmonary arterial hypertension receiving concomitant bosentan. Am J Cardiol 93 943
    • (2004) Am J Cardiol , vol.93 , pp. 943
    • Ivy, D.D.1    Doran, A.2    Claussen, L.3
  • 319
    • 24644489695 scopus 로고    scopus 로고
    • Initial experience with bosentan (Tracleer) as treatment for pulmonary arterial hypertension (PAH) due to congenital heart disease in infants and young children
    • N Gilbert, YC Luther, O Miera, et al. (2005) Initial experience with bosentan (Tracleer) as treatment for pulmonary arterial hypertension (PAH) due to congenital heart disease in infants and young children. Z Kardiol 94 570
    • (2005) Z Kardiol , vol.94 , pp. 570
    • Gilbert, N.1    Luther, Y.C.2    Miera, O.3
  • 320
    • 33750629177 scopus 로고    scopus 로고
    • Weaning of epoprostenol in a small infant receiving concomitant bosentan for severe pulmonary arterial hypertension secondary to bronchopulmonary dysplasia
    • S Rugolotto, G Errico, R Beghini, et al. (2006) Weaning of epoprostenol in a small infant receiving concomitant bosentan for severe pulmonary arterial hypertension secondary to bronchopulmonary dysplasia. Minerva Pediatr 58 491
    • (2006) Minerva Pediatr , vol.58 , pp. 491
    • Rugolotto, S.1    Errico, G.2    Beghini, R.3
  • 321
    • 33646255654 scopus 로고    scopus 로고
    • Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan
    • RJ Barst, D Langleben, D Badesch, et al. (2006) Treatment of pulmonary arterial hypertension with the selective endothelin-A receptor antagonist sitaxsentan. J Am Coll Cardiol 47 2049
    • (2006) J Am Coll Cardiol , vol.47 , pp. 2049
    • Barst, R.J.1    Langleben, D.2    Badesch, D.3
  • 322
    • 0037868048 scopus 로고    scopus 로고
    • Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension
    • HA Ghofrani, F Rose, RT Schermuly, et al. (2003) Oral sildenafil as long-term adjunct therapy to inhaled iloprost in severe pulmonary arterial hypertension. J Am Coll Cardiol 42 158
    • (2003) J Am Coll Cardiol , vol.42 , pp. 158
    • Ghofrani, H.A.1    Rose, F.2    Schermuly, R.T.3
  • 323
    • 4544383466 scopus 로고    scopus 로고
    • Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2
    • M Humbert, RJ Barst, IM Robbins, et al. (2004) Combination of bosentan with epoprostenol in pulmonary arterial hypertension: BREATHE-2. Eur Respir J 24 353
    • (2004) Eur Respir J , vol.24 , pp. 353
    • Humbert, M.1    Barst, R.J.2    Robbins, I.M.3
  • 324
    • 33847743922 scopus 로고    scopus 로고
    • Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension
    • SC Mathai, RE Girgis, MR Fisher, et al. (2007) Addition of sildenafil to bosentan monotherapy in pulmonary arterial hypertension. Eur Respir J 29 469
    • (2007) Eur Respir J , vol.29 , pp. 469
    • Mathai, S.C.1    Girgis, R.E.2    Fisher, M.R.3
  • 325
    • 33847368988 scopus 로고    scopus 로고
    • Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension
    • M Hoeper, H Leuchte, M Halank, et al. (2006) Combining inhaled iloprost with bosentan in patients with idiopathic pulmonary arterial hypertension. Eur J Pediatr 28(4), 691
    • (2006) Eur J Pediatr , vol.28 , Issue.4 , pp. 691
    • Hoeper, M.1    Leuchte, H.2    Halank, M.3
  • 326
    • 27744504402 scopus 로고    scopus 로고
    • Goal-oriented treatment and combination therapy for pulmonary arterial hypertension
    • MM Hoeper, I Markevych, E Spiekerkoetter, et al. (2005) Goal-oriented treatment and combination therapy for pulmonary arterial hypertension. Eur Respir J 26 858
    • (2005) Eur Respir J , vol.26 , pp. 858
    • Hoeper, M.M.1    Markevych, I.2    Spiekerkoetter, E.3
  • 327
    • 0037111455 scopus 로고    scopus 로고
    • Therapy of pulmonary hypertension: the evolution from vasodilators to antiproliferative agents
    • LJ Rubin (2002) Therapy of pulmonary hypertension: the evolution from vasodilators to antiproliferative agents. Am J Respir Crit Care Med 166 1308
    • (2002) Am J Respir Crit Care Med , vol.166 , pp. 1308
    • Rubin, L.J.1
  • 328
    • 0031671673 scopus 로고    scopus 로고
    • Elastase and the pathobiology of unexplained pulmonary hypertension
    • M Rabinovitch (1998) Elastase and the pathobiology of unexplained pulmonary hypertension. Chest 114 213S
    • (1998) Chest , vol.114 , pp. 213S
    • Rabinovitch, M.1
  • 329
    • 0030934358 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of pulmonary vascular remodeling
    • KR Stenmark and RP Mecham (1997) Cellular and molecular mechanisms of pulmonary vascular remodeling. Annu Rev Physiol 59 89
    • (1997) Annu Rev Physiol , vol.59 , pp. 89
    • Stenmark, K.R.1    Mecham, R.P.2
  • 330
    • 0028300301 scopus 로고
    • The emerging concept of vascular remodeling
    • GH Gibbons and VJ Dzau (1994) The emerging concept of vascular remodeling. N Engl J Med 330 1431
    • (1994) N Engl J Med , vol.330 , pp. 1431
    • Gibbons, G.H.1    Dzau, V.J.2
  • 331
    • 0031260620 scopus 로고    scopus 로고
    • Cellular and molecular biology of vascular smooth muscle cells in pulmonary hypertension
    • NF Voelkel and RM Tuder (1997) Cellular and molecular biology of vascular smooth muscle cells in pulmonary hypertension. Pulm Pharmacol Ther 10 231
    • (1997) Pulm Pharmacol Ther , vol.10 , pp. 231
    • Voelkel, N.F.1    Tuder, R.M.2
  • 332
    • 0034727717 scopus 로고    scopus 로고
    • Primary pulmonary hypertension: a vascular biology and translational research “Work in progress.”
    • S Archer and S Rich (2000) Primary pulmonary hypertension: a vascular biology and translational research “Work in progress.”. Circulation 102 2781
    • (2000) Circulation , vol.102 , pp. 2781
    • Archer, S.1    Rich, S.2
  • 333
    • 33749345684 scopus 로고    scopus 로고
    • Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms
    • KR Stenmark, KA Fagan and MG Frid (2006) Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms. Circ Res 99 675
    • (2006) Circ Res , vol.99 , pp. 675
    • Stenmark, K.R.1    Fagan, K.A.2    Frid, M.G.3
  • 334
    • 0023867659 scopus 로고
    • Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study
    • L Todorovich-Hunter, DJ Johnson, P Ranger, et al. (1988) Altered elastin and collagen synthesis associated with progressive pulmonary hypertension induced by monocrotaline. A biochemical and ultrastructural study. Lab Invest 58 184
    • (1988) Lab Invest , vol.58 , pp. 184
    • Todorovich-Hunter, L.1    Johnson, D.J.2    Ranger, P.3
  • 335
    • 0024851550 scopus 로고
    • Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization
    • IW Prosser, KR Stenmark, M Suthar, et al. (1989) Regional heterogeneity of elastin and collagen gene expression in intralobar arteries in response to hypoxic pulmonary hypertension as demonstrated by in situ hybridization. Am J Pathol 135 1073
    • (1989) Am J Pathol , vol.135 , pp. 1073
    • Prosser, I.W.1    Stenmark, K.R.2    Suthar, M.3
  • 336
    • 0029806822 scopus 로고    scopus 로고
    • Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation
    • PL Jones and M Rabinovitch (1996) Tenascin-C is induced with progressive pulmonary vascular disease in rats and is functionally related to increased smooth muscle cell proliferation. Circ Res 79 1131
    • (1996) Circ Res , vol.79 , pp. 1131
    • Jones, P.L.1    Rabinovitch, M.2
  • 337
    • 0030940521 scopus 로고    scopus 로고
    • Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease
    • PL Jones, KN Cowan and M Rabinovitch (1997) Tenascin-C, proliferation and subendothelial fibronectin in progressive pulmonary vascular disease. Am J Pathol 150 1349
    • (1997) Am J Pathol , vol.150 , pp. 1349
    • Jones, P.L.1    Cowan, K.N.2    Rabinovitch, M.3
  • 338
    • 0035008770 scopus 로고    scopus 로고
    • Alterations in a redox oxygen sensing mechanism in chronic hypoxia
    • HL Reeve, E Michelakis, DP Nelson, et al. (2001) Alterations in a redox oxygen sensing mechanism in chronic hypoxia. J Appl Physiol 90 2249
    • (2001) J Appl Physiol , vol.90 , pp. 2249
    • Reeve, H.L.1    Michelakis, E.2    Nelson, D.P.3
  • 339
    • 0032492407 scopus 로고    scopus 로고
    • Attenuated K+ channel gene transcription in primary pulmonary hypertension
    • XJ Yuan, J Wang, M Juhaszova, et al. (1998) Attenuated K+ channel gene transcription in primary pulmonary hypertension. Lancet 351 726
    • (1998) Lancet , vol.351 , pp. 726
    • Yuan, X.J.1    Wang, J.2    Juhaszova, M.3
  • 340
    • 20444483234 scopus 로고    scopus 로고
    • Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension
    • MS McMurtry, SL Archer, DC Altieri, et al. (2005) Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension. J Clin Invest 115 1479
    • (2005) J Clin Invest , vol.115 , pp. 1479
    • McMurtry, M.S.1    Archer, S.L.2    Altieri, D.C.3
  • 341
    • 20344365090 scopus 로고    scopus 로고
    • Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats
    • C Guignabert, B Raffestin, R Benferhat, et al. (2005) Serotonin transporter inhibition prevents and reverses monocrotaline-induced pulmonary hypertension in rats. Circulation 111 2812
    • (2005) Circulation , vol.111 , pp. 2812
    • Guignabert, C.1    Raffestin, B.2    Benferhat, R.3
  • 342
    • 27744440521 scopus 로고    scopus 로고
    • Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm
    • KN Cowan, WC Leung, C Mar, et al. (2005) Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. FASEB J 19 1848
    • (2005) FASEB J , vol.19 , pp. 1848
    • Cowan, K.N.1    Leung, W.C.2    Mar, C.3
  • 343
    • 0034111839 scopus 로고    scopus 로고
    • Adventitial fibroblasts: defining a role in vessel wall remodeling
    • BH Strauss and M Rabinovitch (2000) Adventitial fibroblasts: defining a role in vessel wall remodeling. Am J Respir Cell Mol Biol 22 1
    • (2000) Am J Respir Cell Mol Biol , vol.22 , pp. 1
    • Strauss, B.H.1    Rabinovitch, M.2
  • 344
    • 33745155785 scopus 로고    scopus 로고
    • An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension
    • S Bonnet, ED Michelakis, CJ Porter, et al. (2006) An abnormal mitochondrial-hypoxia inducible factor-1alpha-Kv channel pathway disrupts oxygen sensing and triggers pulmonary arterial hypertension in fawn hooded rats: similarities to human pulmonary arterial hypertension. Circulation 113 2630
    • (2006) Circulation , vol.113 , pp. 2630
    • Bonnet, S.1    Michelakis, E.D.2    Porter, C.J.3
  • 345
    • 0034126770 scopus 로고    scopus 로고
    • Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor
    • KN Cowan, A Heilbut, T Humpl, et al. (2000) Complete reversal of fatal pulmonary hypertension in rats by a serine elastase inhibitor. Nat Med 6 698
    • (2000) Nat Med , vol.6 , pp. 698
    • Cowan, K.N.1    Heilbut, A.2    Humpl, T.3
  • 346
    • 0029820256 scopus 로고    scopus 로고
    • Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II
    • MJ Pollman, T Yamada, M Horiuchi, et al. (1996) Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin II. Circ Res 79 748
    • (1996) Circ Res , vol.79 , pp. 748
    • Pollman, M.J.1    Yamada, T.2    Horiuchi, M.3
  • 347
    • 0034016144 scopus 로고    scopus 로고
    • Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells
    • M Cattaruzza, C Dimigen, H Ehrenreich, et al. (2000) Stretch-induced endothelin B receptor-mediated apoptosis in vascular smooth muscle cells. FASEB J 14 991
    • (2000) FASEB J , vol.14 , pp. 991
    • Cattaruzza, M.1    Dimigen, C.2    Ehrenreich, H.3
  • 348
    • 0033886373 scopus 로고    scopus 로고
    • Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling
    • K Irani (2000) Oxidant signaling in vascular cell growth, death, and survival: a review of the roles of reactive oxygen species in smooth muscle and endothelial cell mitogenic and apoptotic signaling. Circ Res 87 179
    • (2000) Circ Res , vol.87 , pp. 179
    • Irani, K.1
  • 349
    • 0030860609 scopus 로고    scopus 로고
    • Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth
    • PL Jones, J Crack and M Rabinovitch (1997) Regulation of tenascin-C, a vascular smooth muscle cell survival factor that interacts with the alpha v beta 3 integrin to promote epidermal growth factor receptor phosphorylation and growth. J Cell Biol 139 279
    • (1997) J Cell Biol , vol.139 , pp. 279
    • Jones, P.L.1    Crack, J.2    Rabinovitch, M.3
  • 350
    • 0025946760 scopus 로고
    • Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension
    • CL Ye and M Rabinovitch (1991) Inhibition of elastolysis by SC-37698 reduces development and progression of monocrotaline pulmonary hypertension. Am J Physiol 261 H1255
    • (1991) Am J Physiol , vol.261 , pp. H1255
    • Ye, C.L.1    Rabinovitch, M.2
  • 351
    • 0037192329 scopus 로고    scopus 로고
    • Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension
    • SH Zaidi, XM You, S Ciura, et al. (2002) Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension. Circulation 105 516
    • (2002) Circulation , vol.105 , pp. 516
    • Zaidi, S.H.1    You, X.M.2    Ciura, S.3
  • 352
    • 0026320578 scopus 로고
    • Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity
    • K Maruyama, CL Ye, M Woo, et al. (1991) Chronic hypoxic pulmonary hypertension in rats and increased elastolytic activity. Am J Physiol 261 H1716
    • (1991) Am J Physiol , vol.261 , pp. H1716
    • Maruyama, K.1    Ye, C.L.2    Woo, M.3
  • 353
    • 0033989282 scopus 로고    scopus 로고
    • Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease
    • KN Cowan, PL Jones and M Rabinovitch (2000) Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease. J Clin Invest 105 21
    • (2000) J Clin Invest , vol.105 , pp. 21
    • Cowan, K.N.1    Jones, P.L.2    Rabinovitch, M.3
  • 354
    • 22544484537 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension
    • SL Merklinger, PL Jones, EC Martinez, et al. (2005) Epidermal growth factor receptor blockade mediates smooth muscle cell apoptosis and improves survival in rats with pulmonary hypertension. Circulation 112 423
    • (2005) Circulation , vol.112 , pp. 423
    • Merklinger, S.L.1    Jones, P.L.2    Martinez, E.C.3
  • 355
    • 0027532142 scopus 로고
    • Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes
    • XJ Yuan, WF Goldman, ML Tod, et al. (1993) Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am J Physiol 264 L116
    • (1993) Am J Physiol , vol.264 , pp. L116
    • Yuan, X.J.1    Goldman, W.F.2    Tod, M.L.3
  • 356
    • 0026560976 scopus 로고
    • Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction
    • JM Post, JR Hume, SL Archer, et al. (1992) Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am J Physiol 262 C882
    • (1992) Am J Physiol , vol.262 , pp. C882
    • Post, J.M.1    Hume, J.R.2    Archer, S.L.3
  • 357
    • 33750605037 scopus 로고    scopus 로고
    • The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension
    • R Moudgil, ED Michelakis and SL Archer (2006) The role of k+ channels in determining pulmonary vascular tone, oxygen sensing, cell proliferation, and apoptosis: implications in hypoxic pulmonary vasoconstriction and pulmonary arterial hypertension. Microcirculation 13 615
    • (2006) Microcirculation , vol.13 , pp. 615
    • Moudgil, R.1    Michelakis, E.D.2    Archer, S.L.3
  • 359
    • 0031957686 scopus 로고    scopus 로고
    • Molecular basis and function of voltage-gated K+ channels in pulmonary arterial smooth muscle cells
    • XJ Yuan, J Wang, M Juhaszova, et al. (1998) Molecular basis and function of voltage-gated K+ channels in pulmonary arterial smooth muscle cells. Am J Physiol 274 L621
    • (1998) Am J Physiol , vol.274 , pp. L621
    • Yuan, X.J.1    Wang, J.2    Juhaszova, M.3
  • 360
    • 0037188928 scopus 로고    scopus 로고
    • Diversity in mitochondrial function explains differences in vascular oxygen sensing
    • ED Michelakis, V Hampl, A Nsair, et al. (2002) Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res 90 1307
    • (2002) Circ Res , vol.90 , pp. 1307
    • Michelakis, E.D.1    Hampl, V.2    Nsair, A.3
  • 361
    • 0029157548 scopus 로고
    • Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue
    • HL Reeve, EK Weir, DP Nelson, et al. (1995) Opposing effects of oxidants and antioxidants on K+ channel activity and tone in rat vascular tissue. Exp Physiol 80 825
    • (1995) Exp Physiol , vol.80 , pp. 825
    • Reeve, H.L.1    Weir, E.K.2    Nelson, D.P.3
  • 362
    • 0026018088 scopus 로고
    • Effects of K+ channel blockers on vascular tone in the perfused rat lung
    • K Hasunuma, DM Rodman and IF McMurtry (1991) Effects of K+ channel blockers on vascular tone in the perfused rat lung. Am Rev Respir Dis 144 884
    • (1991) Am Rev Respir Dis , vol.144 , pp. 884
    • Hasunuma, K.1    Rodman, D.M.2    McMurtry, I.F.3
  • 363
    • 0035082449 scopus 로고    scopus 로고
    • Hypoxia induces the release of a pulmonary-selective, Ca(2+)-sensitising, vasoconstrictor from the perfused rat lung
    • TP Robertson, JP Ward and PI Aaronson (2001) Hypoxia induces the release of a pulmonary-selective, Ca(2+)-sensitising, vasoconstrictor from the perfused rat lung. Cardiovasc Res 50 145
    • (2001) Cardiovasc Res , vol.50 , pp. 145
    • Robertson, T.P.1    Ward, J.P.2    Aaronson, P.I.3
  • 364
    • 0024854379 scopus 로고
    • 2 radicals and pulmonary vascular reactivity in rat lung
    • SL Archer, DP Nelson and EK Weir (1989) Simultaneous measurement of O 2 radicals and pulmonary vascular reactivity in rat lung. J Appl Physiol 67 1903
    • (1989) J Appl Physiol , vol.67 , pp. 1903
    • Archer, S.L.1    Nelson, D.P.2    Weir, E.K.3
  • 365
    • 0033529173 scopus 로고    scopus 로고
    • 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase
    • SL Archer, HL Reeve, E Michelakis, et al. (1999) O 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci USA 96 7944
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 7944
    • Archer, S.L.1    Reeve, H.L.2    Michelakis, E.3
  • 366
    • 0027193670 scopus 로고
    • Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors
    • A Paky, JR Michael, TM Burke-Wolin, et al. (1993) Endogenous production of superoxide by rabbit lungs: effects of hypoxia or metabolic inhibitors. J Appl Physiol 74 2868
    • (1993) J Appl Physiol , vol.74 , pp. 2868
    • Paky, A.1    Michael, J.R.2    Burke-Wolin, T.M.3
  • 367
    • 0041343260 scopus 로고    scopus 로고
    • Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries
    • JQ Liu, JS Sham, LA Shimoda, et al. (2003) Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 285 L322
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , pp. L322
    • Liu, J.Q.1    Sham, J.S.2    Shimoda, L.A.3
  • 368
    • 0035933388 scopus 로고    scopus 로고
    • Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing
    • GB Waypa, NS Chandel and PT Schumacker (2001) Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 88 1259
    • (2001) Circ Res , vol.88 , pp. 1259
    • Waypa, G.B.1    Chandel, N.S.2    Schumacker, P.T.3
  • 369
    • 0027340241 scopus 로고
    • 2 sensor in rat pulmonary vasculature
    • SL Archer, J Huang, T Henry, et al. (1993) A redox-based O 2 sensor in rat pulmonary vasculature. Circ Res 73 1100
    • (1993) Circ Res , vol.73 , pp. 1100
    • Archer, S.L.1    Huang, J.2    Henry, T.3
  • 370
    • 0033678986 scopus 로고    scopus 로고
    • The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries
    • RD Jones, JS Thompson and AH Morice (2000) The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries. Physiol Res 49 587
    • (2000) Physiol Res , vol.49 , pp. 587
    • Jones, R.D.1    Thompson, J.S.2    Morice, A.H.3
  • 371
    • 0028829577 scopus 로고
    • 2-elicited responses
    • KM Mohazzab, RP Fayngersh, PM Kaminski, et al. (1995) Potential role of NADH oxidoreductase-derived reactive O 2 species in calf pulmonary arterial PO 2-elicited responses. Am J Physiol 269 L637
    • (1995) Am J Physiol , vol.269 , pp. L637
    • Mohazzab, K.M.1    Fayngersh, R.P.2    Kaminski, P.M.3
  • 372
    • 0028587265 scopus 로고
    • 2 sensor
    • KM Mohazzab and MS Wolin (1994) Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO 2 sensor. Am J Physiol 267 L823
    • (1994) Am J Physiol , vol.267 , pp. L823
    • Mohazzab, K.M.1    Wolin, M.S.2
  • 373
    • 0033679719 scopus 로고    scopus 로고
    • Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)?
    • N Weissmann, A Tadic, J Hanze, et al. (2000) Hypoxic vasoconstriction in intact lungs: a role for NADPH oxidase-derived H(2)O(2)? Am J Physiol Lung Cell Mol Physiol 279 L683
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279 , pp. L683
    • Weissmann, N.1    Tadic, A.2    Hanze, J.3
  • 374
    • 4043123181 scopus 로고    scopus 로고
    • 2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells
    • SL Archer, XC Wu, B Thebaud, et al. (2004) Preferential expression and function of voltage-gated, O 2-sensitive K+ channels in resistance pulmonary arteries explains regional heterogeneity in hypoxic pulmonary vasoconstriction: ionic diversity in smooth muscle cells. Circ Res 95 308
    • (2004) Circ Res , vol.95 , pp. 308
    • Archer, S.L.1    Wu, X.C.2    Thebaud, B.3
  • 375
    • 0037461359 scopus 로고    scopus 로고
    • 2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats
    • ZI Pozeg, ED Michelakis, MS McMurtry, et al. (2003) In vivo gene transfer of the O 2-sensitive potassium channel Kv1.5 reduces pulmonary hypertension and restores hypoxic pulmonary vasoconstriction in chronically hypoxic rats. Circulation 107 2037
    • (2003) Circulation , vol.107 , pp. 2037
    • Pozeg, Z.I.1    Michelakis, E.D.2    McMurtry, M.S.3
  • 376
    • 0035430621 scopus 로고    scopus 로고
    • Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5
    • SL Archer, B London, V Hampl, et al. (2001) Impairment of hypoxic pulmonary vasoconstriction in mice lacking the voltage-gated potassium channel Kv1.5. FASEB J 15 1801
    • (2001) FASEB J , vol.15 , pp. 1801
    • Archer, S.L.1    London, B.2    Hampl, V.3
  • 377
    • 0032104119 scopus 로고    scopus 로고
    • Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes
    • SL Archer, E Souil, AT nh-Xuan, et al. (1998) Molecular identification of the role of voltage-gated K+ channels, Kv1.5 and Kv2.1, in hypoxic pulmonary vasoconstriction and control of resting membrane potential in rat pulmonary artery myocytes. J Clin Invest 101 2319
    • (1998) J Clin Invest , vol.101 , pp. 2319
    • Archer, S.L.1    Souil, E.2    nh-Xuan, A.T.3
  • 378
    • 0034889332 scopus 로고    scopus 로고
    • Effects of anorexinogen agents on cloned voltage-gated K(+) channel hKv1.5
    • L Perchenet, L Hilfiger, J Mizrahi, et al. (2001) Effects of anorexinogen agents on cloned voltage-gated K(+) channel hKv1.5. J Pharmacol Exp Ther 298 1108
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1108
    • Perchenet, L.1    Hilfiger, L.2    Mizrahi, J.3
  • 379
    • 0031720572 scopus 로고    scopus 로고
    • A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension
    • EK Weir, HL Reeve, G Johnson, et al. (1998) A role for potassium channels in smooth muscle cells and platelets in the etiology of primary pulmonary hypertension. Chest 114 200S
    • (1998) Chest , vol.114 , pp. 200S
    • Weir, E.K.1    Reeve, H.L.2    Johnson, G.3
  • 380
    • 0037080541 scopus 로고    scopus 로고
    • Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels
    • ED Michelakis, MS McMurtry, XC Wu, et al. (2002) Dichloroacetate, a metabolic modulator, prevents and reverses chronic hypoxic pulmonary hypertension in rats: role of increased expression and activity of voltage-gated potassium channels. Circulation 105 244
    • (2002) Circulation , vol.105 , pp. 244
    • Michelakis, E.D.1    McMurtry, M.S.2    Wu, X.C.3
  • 381
    • 6344257102 scopus 로고    scopus 로고
    • Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis
    • MS McMurtry, S Bonnet, X Wu, et al. (2004) Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res 95 830
    • (2004) Circ Res , vol.95 , pp. 830
    • McMurtry, M.S.1    Bonnet, S.2    Wu, X.3
  • 382
    • 0026524283 scopus 로고
    • Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat
    • K Sato, S Webb, A Tucker, et al. (1992) Factors influencing the idiopathic development of pulmonary hypertension in the fawn hooded rat. Am Rev Respir Dis 145 793
    • (1992) Am Rev Respir Dis , vol.145 , pp. 793
    • Sato, K.1    Webb, S.2    Tucker, A.3
  • 383
    • 0033839977 scopus 로고    scopus 로고
    • Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude
    • TD Le Cras, DH Kim, NE Markham, et al. (2000) Early abnormalities of pulmonary vascular development in the Fawn-Hooded rat raised at Denver's altitude. Am J Physiol Lung Cell Mol Physiol 279 L283
    • (2000) Am J Physiol Lung Cell Mol Physiol , vol.279 , pp. L283
    • Le Cras, T.D.1    Kim, D.H.2    Markham, N.E.3
  • 384
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
    • LE Huang, Z Arany, DM Livingston, et al. (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit. J Biol Chem 271 32253
    • (1996) J Biol Chem , vol.271 , pp. 32253
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3
  • 386
    • 26444540768 scopus 로고    scopus 로고
    • Reversal of experimental pulmonary hypertension by PDGF inhibition
    • RT Schermuly, E Dony, HA Ghofrani, et al. (2005) Reversal of experimental pulmonary hypertension by PDGF inhibition. J Clin Invest 115 2811
    • (2005) J Clin Invest , vol.115 , pp. 2811
    • Schermuly, R.T.1    Dony, E.2    Ghofrani, H.A.3
  • 387
    • 0344837754 scopus 로고    scopus 로고
    • Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus
    • V Balasubramaniam, TD Le Cras, DD Ivy, et al. (2003) Role of platelet-derived growth factor in vascular remodeling during pulmonary hypertension in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 284 L826
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284 , pp. L826
    • Balasubramaniam, V.1    Le Cras, T.D.2    Ivy, D.D.3
  • 388
    • 25444484658 scopus 로고    scopus 로고
    • Imatinib for the treatment of pulmonary arterial hypertension
    • HA Ghofrani, W Seeger and F Grimminger (2005) Imatinib for the treatment of pulmonary arterial hypertension. N Engl J Med 353 1412
    • (2005) N Engl J Med , vol.353 , pp. 1412
    • Ghofrani, H.A.1    Seeger, W.2    Grimminger, F.3
  • 389
    • 33746745449 scopus 로고    scopus 로고
    • Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension
    • KC Patterson, A Weissmann, T Ahmadi, et al. (2006) Imatinib mesylate in the treatment of refractory idiopathic pulmonary arterial hypertension. Ann Intern Med 145 152
    • (2006) Ann Intern Med , vol.145 , pp. 152
    • Patterson, K.C.1    Weissmann, A.2    Ahmadi, T.3
  • 390
    • 33747041655 scopus 로고    scopus 로고
    • Long term imatinib treatment in pulmonary arterial hypertension
    • R Souza, O Sitbon, F Parent, et al. (2006) Long term imatinib treatment in pulmonary arterial hypertension. Thorax 61 736
    • (2006) Thorax , vol.61 , pp. 736
    • Souza, R.1    Sitbon, O.2    Parent, F.3
  • 391
    • 17944386754 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells
    • S Zhang, I Fantozzi, DD Tigno, et al. (2003) Bone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 285 L740
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.285 , pp. L740
    • Zhang, S.1    Fantozzi, I.2    Tigno, D.D.3
  • 392
    • 0035859940 scopus 로고    scopus 로고
    • Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins
    • NW Morrell, X Yang, PD Upton, et al. (2001) Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins. Circulation 104 790
    • (2001) Circulation , vol.104 , pp. 790
    • Morrell, N.W.1    Yang, X.2    Upton, P.D.3
  • 393
    • 0033817459 scopus 로고    scopus 로고
    • Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium
    • KB Lane, RD Machado, MW Pauciulo, et al. (2000) Heterozygous germline mutations in BMPR2, encoding a TGF-beta receptor, cause familial primary pulmonary hypertension. The International PPH Consortium. Nat Genet 26 81
    • (2000) Nat Genet , vol.26 , pp. 81
    • Lane, K.B.1    Machado, R.D.2    Pauciulo, M.W.3
  • 394
    • 0037267333 scopus 로고    scopus 로고
    • Validating survivin as a cancer therapeutic target
    • DC Altieri (2003) Validating survivin as a cancer therapeutic target. Nat Rev Cancer 3 46
    • (2003) Nat Rev Cancer , vol.3 , pp. 46
    • Altieri, D.C.1
  • 395
    • 0036734095 scopus 로고    scopus 로고
    • Inhibitor of apoptosis protein survivin regulates vascular injury
    • OP Blanc-Brude, J Yu, H Simosa, et al. (2002) Inhibitor of apoptosis protein survivin regulates vascular injury. Nat Med 8 987
    • (2002) Nat Med , vol.8 , pp. 987
    • Blanc-Brude, O.P.1    Yu, J.2    Simosa, H.3
  • 396
    • 3042511852 scopus 로고    scopus 로고
    • Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop
    • JH Newman, BL Fanburg, SL Archer, et al. (2004) Pulmonary arterial hypertension: future directions: report of a National Heart, Lung and Blood Institute/Office of Rare Diseases workshop. Circulation 109 2947
    • (2004) Circulation , vol.109 , pp. 2947
    • Newman, J.H.1    Fanburg, B.L.2    Archer, S.L.3
  • 397
    • 0033618378 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1)
    • U Laufs, D Marra, K Node, et al. (1999) 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1). J Biol Chem 274 21926
    • (1999) J Biol Chem , vol.274 , pp. 21926
    • Laufs, U.1    Marra, D.2    Node, K.3
  • 398
    • 0033972268 scopus 로고    scopus 로고
    • Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury
    • C Indolfi, A Cioppa, E Stabile, et al. (2000) Effects of hydroxymethylglutaryl coenzyme A reductase inhibitor simvastatin on smooth muscle cell proliferation in vitro and neointimal formation in vivo after vascular injury. J Am Coll Cardiol 35 214
    • (2000) J Am Coll Cardiol , vol.35 , pp. 214
    • Indolfi, C.1    Cioppa, A.2    Stabile, E.3
  • 399
    • 0141730236 scopus 로고    scopus 로고
    • Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells
    • T Nishimura, LT Vaszar, JL Faul, et al. (2003) Simvastatin rescues rats from fatal pulmonary hypertension by inducing apoptosis of neointimal smooth muscle cells. Circulation 108 1640
    • (2003) Circulation , vol.108 , pp. 1640
    • Nishimura, T.1    Vaszar, L.T.2    Faul, J.L.3
  • 400
    • 0041859249 scopus 로고    scopus 로고
    • Attenuation of chronic hypoxic pulmonary hypertension by simvastatin
    • RE Girgis, D Li, X Zhan, et al. (2003) Attenuation of chronic hypoxic pulmonary hypertension by simvastatin. Am J Physiol Heart Circ Physiol 285 H938
    • (2003) Am J Physiol Heart Circ Physiol , vol.285 , pp. H938
    • Girgis, R.E.1    Li, D.2    Zhan, X.3
  • 401
    • 0031451344 scopus 로고    scopus 로고
    • Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase
    • U Laufs, VL Fata and JK Liao (1997) Inhibition of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase blocks hypoxia-mediated down-regulation of endothelial nitric oxide synthase. J Biol Chem 272 31725
    • (1997) J Biol Chem , vol.272 , pp. 31725
    • Laufs, U.1    Fata, V.L.2    Liao, J.K.3
  • 402
    • 0034908652 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway
    • S Dimmeler, A Aicher, M Vasa, et al. (2001) HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway. J Clin Invest 108 391
    • (2001) J Clin Invest , vol.108 , pp. 391
    • Dimmeler, S.1    Aicher, A.2    Vasa, M.3
  • 403
    • 0036645303 scopus 로고    scopus 로고
    • Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase
    • M Takemoto, J Sun, J Hiroki, et al. (2002) Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106 57
    • (2002) Circulation , vol.106 , pp. 57
    • Takemoto, M.1    Sun, J.2    Hiroki, J.3
  • 404
    • 33746898591 scopus 로고    scopus 로고
    • The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension
    • E Gurbanov and X Shiliang (2006) The key role of apoptosis in the pathogenesis and treatment of pulmonary hypertension. Eur J Cardiothorac Surg 30 499
    • (2006) Eur J Cardiothorac Surg , vol.30 , pp. 499
    • Gurbanov, E.1    Shiliang, X.2
  • 405
    • 10744222390 scopus 로고    scopus 로고
    • Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats
    • K Abe, H Shimokawa, K Morikawa, et al. (2004) Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 94 385
    • (2004) Circ Res , vol.94 , pp. 385
    • Abe, K.1    Shimokawa, H.2    Morikawa, K.3
  • 406
    • 4544388803 scopus 로고    scopus 로고
    • Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase
    • KA Fagan, M Oka, NR Bauer, et al. (2004) Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho-kinase. Am J Physiol Lung Cell Mol Physiol 287 L656
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. L656
    • Fagan, K.A.1    Oka, M.2    Bauer, N.R.3
  • 407
    • 15944403568 scopus 로고    scopus 로고
    • Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension
    • T Nagaoka, KA Fagan, SA Gebb, et al. (2005) Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171 494
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 494
    • Nagaoka, T.1    Fagan, K.A.2    Gebb, S.A.3
  • 408
    • 0042433541 scopus 로고    scopus 로고
    • Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells
    • N Nagaya, K Kangawa, M Kanda, et al. (2003) Hybrid cell-gene therapy for pulmonary hypertension based on phagocytosing action of endothelial progenitor cells. Circulation 108 889
    • (2003) Circulation , vol.108 , pp. 889
    • Nagaya, N.1    Kangawa, K.2    Kanda, M.3
  • 409
    • 33846980821 scopus 로고    scopus 로고
    • Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction
    • SR Baber, W Deng, RG Master, et al. (2007) Intratracheal mesenchymal stem cell administration attenuates monocrotaline-induced pulmonary hypertension and endothelial dysfunction. Am J Physiol Heart Circ Physiol 292 H1120
    • (2007) Am J Physiol Heart Circ Physiol , vol.292 , pp. H1120
    • Baber, S.R.1    Deng, W.2    Master, R.G.3
  • 410
    • 33747186449 scopus 로고    scopus 로고
    • Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension
    • S Kanki-Horimoto, H Horimoto, S Mieno, et al. (2006) Implantation of mesenchymal stem cells overexpressing endothelial nitric oxide synthase improves right ventricular impairments caused by pulmonary hypertension. Circulation 114 I181
    • (2006) Circulation , vol.114 , pp. I181
    • Kanki-Horimoto, S.1    Horimoto, H.2    Mieno, S.3
  • 411
    • 0031964852 scopus 로고    scopus 로고
    • Effect of prenatal glucocorticoids on pulmonary vascular muscularisation in nitrofen-induced congenital diaphragmatic hernia
    • BO Okoye, PD Losty, DA Lloyd, et al. (1998) Effect of prenatal glucocorticoids on pulmonary vascular muscularisation in nitrofen-induced congenital diaphragmatic hernia. J Pediatr Surg 33 76
    • (1998) J Pediatr Surg , vol.33 , pp. 76
    • Okoye, B.O.1    Losty, P.D.2    Lloyd, D.A.3
  • 412
    • 0030969444 scopus 로고    scopus 로고
    • Active collagen synthesis by pulmonary arteries in pulmonary hypertension complicated by congenital diaphragmatic hernia
    • T Yamataka and P Puri (1997) Active collagen synthesis by pulmonary arteries in pulmonary hypertension complicated by congenital diaphragmatic hernia. J Pediatr Surg 32 682
    • (1997) J Pediatr Surg , vol.32 , pp. 682
    • Yamataka, T.1    Puri, P.2
  • 413
    • 2442614197 scopus 로고    scopus 로고
    • Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscle cells in nitrofen-induced congenital diaphragmatic hernia in rats
    • M Sakai, K Unemoto, V Solari, et al. (2004) Decreased expression of voltage-gated K+ channels in pulmonary artery smooth muscle cells in nitrofen-induced congenital diaphragmatic hernia in rats. Pediatr Surg Int 20 192
    • (2004) Pediatr Surg Int , vol.20 , pp. 192
    • Sakai, M.1    Unemoto, K.2    Solari, V.3
  • 414
    • 0001286311 scopus 로고
    • Incidence of congenital diaphragmatic hernia in the young of rats bred on a diet deficient in Vitamin A
    • DH Anderson (1941) Incidence of congenital diaphragmatic hernia in the young of rats bred on a diet deficient in Vitamin A. Am J Dis Child 62 888
    • (1941) Am J Dis Child , vol.62 , pp. 888
    • Anderson, D.H.1
  • 415
    • 38749102934 scopus 로고
    • Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat
    • DH Anderson (1949) Effect of diet during pregnancy upon the incidence of congenital hereditary diaphragmatic hernia in the rat. Am J Path 25 163
    • (1949) Am J Path , vol.25 , pp. 163
    • Anderson, D.H.1
  • 416
    • 84958699162 scopus 로고
    • An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation
    • JG Wilson, CB Roth and J Warkany (1953) An analysis of the syndrome of malformations induced by maternal vitamin A deficiency. Effects of restoration of vitamin A at various times during gestation. Am J Anat 92 189
    • (1953) Am J Anat , vol.92 , pp. 189
    • Wilson, J.G.1    Roth, C.B.2    Warkany, J.3
  • 417
    • 0028073019 scopus 로고
    • Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants
    • C Mendelsohn, D Lohnes, D Decimo, et al. (1994) Function of the retinoic acid receptors (RARs) during development (II). Multiple abnormalities at various stages of organogenesis in RAR double mutants. Development 120 2749
    • (1994) Development , vol.120 , pp. 2749
    • Mendelsohn, C.1    Lohnes, D.2    Decimo, D.3
  • 420
    • 0019468011 scopus 로고
    • The heart and diaphragm: target organs in the neonatal death induced by nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether)
    • RD Costlow and JM Manson (1981) The heart and diaphragm: target organs in the neonatal death induced by nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether). Toxicology 20 209
    • (1981) Toxicology , vol.20 , pp. 209
    • Costlow, R.D.1    Manson, J.M.2
  • 421
    • 0025111022 scopus 로고
    • Nitrofen-induced diaphragmatic hernias in rats: an animal model
    • D Kluth, R Kangah, P Reich, et al. (1990) Nitrofen-induced diaphragmatic hernias in rats: an animal model. J Pediatr Surg 25 850
    • (1990) J Pediatr Surg , vol.25 , pp. 850
    • Kluth, D.1    Kangah, R.2    Reich, P.3
  • 422
    • 0032752589 scopus 로고    scopus 로고
    • Skeletal malformations associated with congenital diaphragmatic hernia: experimental and human studies
    • L Migliazza, H Xia, JA ez-Pardo, et al. (1999) Skeletal malformations associated with congenital diaphragmatic hernia: experimental and human studies. J Pediatr Surg 34 1624
    • (1999) J Pediatr Surg , vol.34 , pp. 1624
    • Migliazza, L.1    Xia, H.2    ez-Pardo, J.A.3
  • 423
    • 0343098458 scopus 로고    scopus 로고
    • Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats
    • B Thebaud, D Tibboel, C Rambaud, et al. (1999) Vitamin A decreases the incidence and severity of nitrofen-induced congenital diaphragmatic hernia in rats. Am J Physiol 277 L423
    • (1999) Am J Physiol , vol.277 , pp. L423
    • Thebaud, B.1    Tibboel, D.2    Rambaud, C.3
  • 424
    • 0037331717 scopus 로고    scopus 로고
    • Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents
    • J Mey, RP Babiuk, R Clugston, et al. (2003) Retinal dehydrogenase-2 is inhibited by compounds that induce congenital diaphragmatic hernias in rodents. Am J Pathol 162 673
    • (2003) Am J Pathol , vol.162 , pp. 673
    • Mey, J.1    Babiuk, R.P.2    Clugston, R.3
  • 425
    • 0035883697 scopus 로고    scopus 로고
    • Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats
    • B Thebaud, AM Barlier-Mur, B Chailley-Heu, et al. (2001) Restoring effects of vitamin A on surfactant synthesis in nitrofen-induced congenital diaphragmatic hernia in rats. Am J Respir Crit Care Med 164 1083
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1083
    • Thebaud, B.1    Barlier-Mur, A.M.2    Chailley-Heu, B.3
  • 426
    • 0031729095 scopus 로고    scopus 로고
    • Retinol status of newborn infants with congenital diaphragmatic hernia
    • D Major, M Cadenas, L Fournier, et al. (1998) Retinol status of newborn infants with congenital diaphragmatic hernia. Pediatr Surg Int 13 547
    • (1998) Pediatr Surg Int , vol.13 , pp. 547
    • Major, D.1    Cadenas, M.2    Fournier, L.3
  • 427
    • 0037405341 scopus 로고    scopus 로고
    • Etiology of congenital diaphragmatic hernia: the retinoid hypothesis
    • JJ Greer, RP Babiuk and B Thebaud (2003) Etiology of congenital diaphragmatic hernia: the retinoid hypothesis. Pediatr Res 53 726
    • (2003) Pediatr Res , vol.53 , pp. 726
    • Greer, J.J.1    Babiuk, R.P.2    Thebaud, B.3
  • 428
    • 0030944924 scopus 로고    scopus 로고
    • Contributions by individual lungs to the surfactant status in congenital diaphragmatic hernia
    • DT Wilcox, PL Glick, HL Karamanoukian, et al. (1997) Contributions by individual lungs to the surfactant status in congenital diaphragmatic hernia. Pediatr Res 41 686
    • (1997) Pediatr Res , vol.41 , pp. 686
    • Wilcox, D.T.1    Glick, P.L.2    Karamanoukian, H.L.3
  • 429
    • 0031937017 scopus 로고    scopus 로고
    • Surfactant protein A is decreased in a rat model of congenital diaphragmatic hernia
    • MR Mysore, LR Margraf, MA Jaramillo, et al. (1998) Surfactant protein A is decreased in a rat model of congenital diaphragmatic hernia. Am J Respir Crit Care Med 157 654
    • (1998) Am J Respir Crit Care Med , vol.157 , pp. 654
    • Mysore, M.R.1    Margraf, L.R.2    Jaramillo, M.A.3
  • 430
    • 0031006604 scopus 로고    scopus 로고
    • Immunohistochemical distribution of surfactant apoprotein-A in congenital diaphragmatic hernia
    • K Asabe, K Tsuji, N Handa, et al. (1997) Immunohistochemical distribution of surfactant apoprotein-A in congenital diaphragmatic hernia. J Pediatr Surg 32 667
    • (1997) J Pediatr Surg , vol.32 , pp. 667
    • Asabe, K.1    Tsuji, K.2    Handa, N.3
  • 431
    • 0028281460 scopus 로고
    • Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency
    • A Lotze, GR Knight, KD Anderson, et al. (1994) Surfactant (beractant) therapy for infants with congenital diaphragmatic hernia on ECMO: evidence of persistent surfactant deficiency. J Pediatr Surg 29 407
    • (1994) J Pediatr Surg , vol.29 , pp. 407
    • Lotze, A.1    Knight, G.R.2    Anderson, K.D.3
  • 432
    • 0029912388 scopus 로고    scopus 로고
    • Surfactant decreases pulmonary vascular resistance and increases pulmonary blood flow in the fetal lamb model of congenital diaphragmatic hernia
    • SJ O'Toole, HL Karamanoukian, FC Morin III, et al. (1996) Surfactant decreases pulmonary vascular resistance and increases pulmonary blood flow in the fetal lamb model of congenital diaphragmatic hernia. J Pediatr Surg 31 507
    • (1996) J Pediatr Surg , vol.31 , pp. 507
    • O'Toole, S.J.1    Karamanoukian, H.L.2    Morin, F.C.3
  • 433
    • 85056973199 scopus 로고    scopus 로고
    • Pathology of chronic lung disease of early infancy
    • RD Bland, JJ Coalson,(Eds), Informa Healthcare
    • JJ Coalson (1999) Pathology of chronic lung disease of early infancy. RD Bland, JJ Coalson,(Eds) Chronic lung disease in early infancy Informa Healthcare 85-124
    • (1999) Chronic lung disease in early infancy , pp. 85-124
    • Coalson, J.J.1
  • 436
    • 0032706843 scopus 로고    scopus 로고
    • The new BPD: an arrest of lung development
    • AJ Jobe (1999) The new BPD: an arrest of lung development. Pediatr Res 46 641
    • (1999) Pediatr Res , vol.46 , pp. 641
    • Jobe, A.J.1
  • 437
    • 13644268445 scopus 로고    scopus 로고
    • Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease
    • DC McCurnin, RA Pierce, LY Chang, et al. (2005) Inhaled NO improves early pulmonary function and modifies lung growth and elastin deposition in a baboon model of neonatal chronic lung disease. Am J Physiol Lung Cell Mol Physiol 288 L450
    • (2005) Am J Physiol Lung Cell Mol Physiol , vol.288 , pp. L450
    • McCurnin, D.C.1    Pierce, R.A.2    Chang, L.Y.3
  • 438
    • 25444491940 scopus 로고    scopus 로고
    • Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs
    • RD Bland, KH Albertine, DP Carlton, et al. (2005) Inhaled nitric oxide effects on lung structure and function in chronically ventilated preterm lambs. Am J Respir Crit Care Med 172 899
    • (2005) Am J Respir Crit Care Med , vol.172 , pp. 899
    • Bland, R.D.1    Albertine, K.H.2    Carlton, D.P.3
  • 439
    • 22044449026 scopus 로고    scopus 로고
    • Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats
    • YJ Lin, NE Markham, V Balasubramaniam, et al. (2005) Inhaled nitric oxide enhances distal lung growth after exposure to hyperoxia in neonatal rats. Pediatr Res 58 22
    • (2005) Pediatr Res , vol.58 , pp. 22
    • Lin, Y.J.1    Markham, N.E.2    Balasubramaniam, V.3
  • 440
    • 33745686054 scopus 로고    scopus 로고
    • Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia
    • V Balasubramaniam, AM Maxey, DB Morgan, et al. (2006) Inhaled NO restores lung structure in eNOS-deficient mice recovering from neonatal hypoxia. Am J Physiol Lung Cell Mol Physiol 291 L119
    • (2006) Am J Physiol Lung Cell Mol Physiol , vol.291 , pp. L119
    • Balasubramaniam, V.1    Maxey, A.M.2    Morgan, D.B.3
  • 441
    • 3242660994 scopus 로고    scopus 로고
    • Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor
    • JR Tang, NE Markham, YJ Lin, et al. (2004) Inhaled nitric oxide attenuates pulmonary hypertension and improves lung growth in infant rats after neonatal treatment with a VEGF receptor inhibitor. Am J Physiol Lung Cell Mol Physiol 287 L344
    • (2004) Am J Physiol Lung Cell Mol Physiol , vol.287 , pp. L344
    • Tang, J.R.1    Markham, N.E.2    Lin, Y.J.3
  • 442
    • 0029391381 scopus 로고
    • Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury
    • WM Maniscalco, RH Watkins, JN Finkelstein, et al. (1995) Vascular endothelial growth factor mRNA increases in alveolar epithelial cells during recovery from oxygen injury. Am J Respir Cell Mol Biol 13 377
    • (1995) Am J Respir Cell Mol Biol , vol.13 , pp. 377
    • Maniscalco, W.M.1    Watkins, R.H.2    Finkelstein, J.N.3
  • 443
    • 2642597076 scopus 로고    scopus 로고
    • Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells
    • A Papapetropoulos, G Garcia-Cardena, JA Madri, et al. (1997) Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells. J Clin Invest 100 3131
    • (1997) J Clin Invest , vol.100 , pp. 3131
    • Papapetropoulos, A.1    Garcia-Cardena, G.2    Madri, J.A.3
  • 444
    • 0033619780 scopus 로고    scopus 로고
    • A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells
    • J Kroll and J Waltenberger (1999) A novel function of VEGF receptor-2 (KDR): rapid release of nitric oxide in response to VEGF-A stimulation in endothelial cells. Biochem Biophys Res Commun 265 636
    • (1999) Biochem Biophys Res Commun , vol.265 , pp. 636
    • Kroll, J.1    Waltenberger, J.2
  • 445
    • 0036723641 scopus 로고    scopus 로고
    • Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure
    • TD Le Cras, NE Markham, RM Tuder, et al. (2002) Treatment of newborn rats with a VEGF receptor inhibitor causes pulmonary hypertension and abnormal lung structure. Am J Physiol Lung Cell Mol Physiol 283 L555
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , pp. L555
    • Le Cras, T.D.1    Markham, N.E.2    Tuder, R.M.3
  • 446
    • 0035891595 scopus 로고    scopus 로고
    • Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia
    • AJ Bhatt, GS Pryhuber, H Huyck, et al. (2001) Disrupted pulmonary vasculature and decreased vascular endothelial growth factor, Flt-1, and TIE-2 in human infants dying with bronchopulmonary dysplasia. Am J Respir Crit Care Med 164 1971
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1971
    • Bhatt, A.J.1    Pryhuber, G.S.2    Huyck, H.3
  • 447
    • 0036083986 scopus 로고    scopus 로고
    • Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons
    • WM Maniscalco, RH Watkins, GS Pryhuber, et al. (2002) Angiogenic factors and alveolar vasculature: development and alterations by injury in very premature baboons. Am J Physiol Lung Cell Mol Physiol 282 L811
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.282 , pp. L811
    • Maniscalco, W.M.1    Watkins, R.H.2    Pryhuber, G.S.3
  • 448
    • 0018835695 scopus 로고
    • Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn
    • JC Fouron, JC Le Guennec, D Villemant, et al. (1980) Value of echocardiography in assessing the outcome of bronchopulmonary dysplasia of the newborn. Pediatrics 65 529
    • (1980) Pediatrics , vol.65 , pp. 529
    • Fouron, J.C.1    Le Guennec, J.C.2    Villemant, D.3
  • 449
    • 0021168509 scopus 로고
    • Unsuspected cardiopulmonary abnormalities complicating bronchopulmonary dysplasia
    • SH Abman, FJ Accurso and CM Bowman (1984) Unsuspected cardiopulmonary abnormalities complicating bronchopulmonary dysplasia. Arch Dis Child 59 966
    • (1984) Arch Dis Child , vol.59 , pp. 966
    • Abman, S.H.1    Accurso, F.J.2    Bowman, C.M.3
  • 450
    • 0034702908 scopus 로고    scopus 로고
    • Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension
    • N Nagaya, T Nishikimi, M Uematsu, et al. (2000) Plasma brain natriuretic peptide as a prognostic indicator in patients with primary pulmonary hypertension. Circulation 102 865
    • (2000) Circulation , vol.102 , pp. 865
    • Nagaya, N.1    Nishikimi, T.2    Uematsu, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.