Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-β1 and bone morphogenetic proteins

Circulation

Volumn 104, Issue 7, 2001, Pages 790-795

  Morrell, Nicholas W ^a,c   Yang, Xudong ^a   Upton, Paul D ^a   Jourdan, Karen B ^a   Morgan, Neal ^a   Sheares, Karen K ^a   Trembath, Richard C ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Growth substances; Hypertension, pulmonary; Muscle, smooth; Proteins

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; MESSENGER RNA; OSTEOGENIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTERY MUSCLE; ARTICLE; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; FEMALE; GENE MUTATION; GROWTH REGULATION; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RECEPTOR BINDING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0035859940     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc3201.094152     Document Type: Article

References (29)

1. Primary pulmonary hypertension
2. Histopathology of primary pulmonary hypertension
3. Three-dimensional reconstruction of pulmonary arteries in plexiform pulmonary hypertension using cell-specific markers
4. Fine mapping of PPH1, a gene for familial primary pulmonary hypertension, to a 3-cM region on chromosome 2q33
5. Localization of the gene for familial primary pulmonary hypertension to chromosome 2q31-32
6. Heterozygous germ-line mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension
7. Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene
8. Sporadic primary pulmonary hypertension is associated with germline mutations of the gene encoding BMPR-II, a receptor member of the TGF-β family
9. Transforming growth factor-beta: Vasculogenesis, angiogenesis, and vessel wall integrity
10. TGF-βs, and TGF-β receptors in atherosclerosis
11. Cellular and molecular mechanisms of pulmonary vascular remodeling
12. Genomic instability in the type II TGF-β1 receptor gene in atherosclerotic and restenotic vascular cells
13. Positive- and negative-acting Kruppel-like transcription factors bind a transforming growth factor beta control element required for expression of the smooth muscle cell differentiation marker SM22alpha in vivo
14. Bone morphogenetic protein-7 (OP-1) inhibits smooth muscle cell proliferation and stimulates the expression of markers that are characteristic of SMC phenotype in vitro
15. Inhibition of rat vascular smooth muscle proliferation in vitro and in vivo by bone morphogenetic protein-2
16. 1 receptors
17. Transforming growth factor β (TGF-β) expression in isolated and cultured rat hepatocytes
18. Decreased type I/type II TGF-β receptor ratio in cells derived from human atherosclerotic lesions
19. The activin receptor-like kinase 1 gene: Genomic structure and mutations in hereditary hemorrhagic telangiectasia type 2
20. Molecular mechanisms of inactivation of TGF-b receptors during carcinogenesis
21. Vascular smooth muscle cells express multiple type I receptors for TGF-b, activin, and bone morphogenetic proteins
22. Distribution and characterization of specific cellular binding proteins for bone morphogenetic protein-2
23. TGFβ signaling in growth control, cancer, and heritable disorders
24. Role of transforming growth factor β in human disease
25. BMP-2 gene expression and effects on human vascular smooth muscle cells
26. BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension
27. Mutation of the type II transforming growth factor-beta receptor is coincident with the transformation of human colon adenomas to malignant carcinomas
28. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members