Cellular and molecular mechanisms of endothelial cell dysfunction

Journal of Clinical Investigation

Volumn 100, Issue 9, 1997, Pages 2153-2157

  Harrison, David G ^a,b  

^a EMORY UNIVERSITY   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANTICOAGULATION; ATHEROGENESIS; CELL METABOLISM; CELL PROLIFERATION; ENDOTHELIUM CELL; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0030711684     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119751     Document Type: Review

References (62)

1. Harrison, D.G. 1996. Endothelial control of vasomotion and nitric oxide production. Cardiol. Clin. 14:1-15.
2. Venema, R., H. Sayegh, J. Kent, and D. Harrison. 1996. Identification, characterization, and comparison of the calmodulin-binding domains of the endothelial cell and inducible nitric oxide synthases. J. Biol. Chem. 271:6435-6440.
3. Boger, R.H., S.M. Bode-Boger, W. Thiele, W. Junker, K. Alexander, and J.C. Frolich. 1447. Biochemical evidence for impaired nitric oxide synthesis in patients with peripheral arterial occlussive disease. Circulation. 45:2068-2074.
4. Arnal, J.-F., T. Münzel, R.C. Venema, N.L. James, C.-L. Bai, W.E. Mitch, and D.G. Harrison. 1995. Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase substrate availability. J. Clin. Invest. 95:2565-2572.
5. Hecker, M., W.C. Sessa, H.J. Harris, E.E. Ånggard, and J.R. Vane. 1990. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: cultured endothelial cells recycle L-citrulline to L-arginine. Proc. Natl. Acad. Sci. USA. 87:8612-8616.
6. Bogle, R.G., A.R. Baydoun, J.D. Pearson, and G.E. Mann. 1996. Regulation of L-arginine transport and nitric oxide release in superfused porcine aortic endothelial cells. J. Physiol. 490:229-241.
7. Cendan, J.C., W.W. Souba, E.M.R. Copeland, and D.S. Lind. 1995. Cytokines regulate endotoxin stimulation of endothelial cell arginine transport. Surgery (St. Louis). 117:213-219.
8. Durante, W., L. Liao, K. Cheng, and A.I. Schafer. 1996. Selective induction of a cationic amino acid transporter by tumor necrosis factor-alpha in vascular endothelium. Proc. Assoc. Am. Phys. 108:356-361.
9. Sobrevia, L., A. Nadal, D.L. Yudilevich, and G.E. Mann. 1996. Activation of L-arginine transport (system y+) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. J. Physiol. 490:775-781.
10. Mügge, A., and D.G. Harrison. 1991. L-arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels. 28:354-357.
11. Cooke, J.P., N.A. Andon, X.J. Girerd, A.T. Hirsch, and M.A. Creager. 1991. Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta. Circulation. 83:1057-1062.
12. Creager, M.A., S.J. Gallagher, X.J. Girerd, S.M. Coleman, V.J. Dzau, and J.P. Cooke. 1992. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J. Clin. Invest. 90:1248-1253.
13. Drexler, H., A.M. Zeiher, K. Meinzer, and H. Just. 1991. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolaemic patients by L-arginine. Lancet. 338:1546-1550.
14. Girerd, X.J., A.T. Hirsch, J.P. Cooke, V.J. Dzau, and M.A. Creager. 1990. L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ. Res. 67:1301-1308.
15. Pieper, G.M., and B.A. Peltier. 1995. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J. Cardiovasc. Pharmacol. 25:397-403.
16. Chen, P.Y., and P.W. Sanders. 1993. Role of nitric oxide synthesis in salt-sensitive hypertension in Dahl/Rapp rats. Hypertension (Dallas). 22:812-818.
17. Cooke, J.P., A.H. Singer, P. Tsao, P. Zera, R.A. Rowan, and M.E. Billingham. 1992. Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. J. Clin. Invest. 90:1168-1172.
18. Guigliano, D., R. Marfella, G. Verrazzo, R. Acampora, L. Coppola, D. Cozzolino, and F. D'Onofrio. 1997. The vascular effects of L-arginine in humans. The role of endogenous insulin. J. Clin. Invest. 99:433-438.
19. Vallance, P., A. Leone, A. Calver, J. Collier, and S. Moncada. 1992. Accumulation of an endogenous inhibitor of nitric oxide synthesis in chronic renal failure. Lancet. 339:572-575.
20. G-hydroxy-L-arginine during high-output NO production. Am. J. Physiol. 271:H1988-H1998.
21. Nishida, K., D.G. Harrison, J.P. Navas, A.A. Fisher, S.P. Dockery, M. Uematsu, R.M. Nerem, R.W. Alexander, and T.J. Murphy. 1992. Molecular cloning and characterization of the constitutive bovine aortic endothelial cell nitric oxide synthase. J. Clin. Invest. 90:2092-2096.
22. Awolesi, M.A., W.C. Sessa, and B.E. Sumpio. 1995. Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells. J. Clin. Invest. 96:1449-1454.
23. Zembowicz, A., J. Tang, and K.K. Wu. 1995. Transcriptional induction of endothelial nitric oxide synthase type III by lysophosphatidylcholine. J. Biol. Chem. 270:17006-17010.
24. Hirata, K., N. Miki, Y. Kuroda, T. Sakoda, S. Kawashima, and M. Yokoyama. 1995. Low concentration of oxidized low-density lipoprotein and lysophosphatidylcholine upregulate constitutive nitric oxide synthase mRNA expression in bovine aortic endothelial cells. Circ. Res. 76:958-962.
25. Ravichandran, L.V., and R.A. Johns. 1995. Up-regulation of endothelial nitric oxide synthase expression by cyclic guanosine 3′,5′-monophosphate. FEBS Lett. 374:295-298.
26. Sessa, W.C., K. Pritchard, N. Seyedi, J. Wang, and T.H. Hintze. 1994. Chronic exercise in dogs increases coronary vascular nitric oxide production and endothelial cell nitric oxide synthase gene expression. Circ. Res. 74:349-353.
27. Harrison, D.G., R.C. Venema, J.-F. Arnal, N. Inoue, Y. Ohara, H. Sayegh, and T.J. Murphy. 1995. The endothelial cell nitric oxide synthase. Is it really constitutively expressed? Agents Actions. 45:107-117.
28. Wilcox, J.N., R.R. Subramanian, C. Sundell, W.R. Tracey, J.S. Pollock, D.G. Harrison, and P.A. Marsden. 1997. Expression of multiple nitric oxide synthase isoforms in normal and atherosclerotic vessels. Arterioscler. Thromb. Vasc. Biol. In press.
29. Nakayama, T., M. Soma, Y. Takahashi, Y. Izumi, K. Kanmatsuse, and M. Esumi. 1997. Association analysis of CA repeat polymorphism of the endothelial nitric oxide synthase gene with essential hypertension in Japanese. Clin. Genet. 51:26-30.
30. Bonnardeaux, A., S. Nadaud, A. Charru, X. Jeunemaitre, P. Corvol, and F. Soubrier. 1945. Lack of evidence for linkage of the endothelial cell nitric oxide synthase gene to essential hypertension. Circulation. 91:96-102.
31. Bossaller, C., G.B. Habib, H. Yamamoto, C. Williams, S. Wells, and P.D. Henry. 1987. Impaired muscarinic endothelium dependent relaxation and cyclic guanosine 5′ monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J. Clin. Invest. 79:170-174.
32. Shimokawa, H., N. A. Flavahan, and P.M. Vanhoutte, 1991. Loss of endothelial pertussis toxin sensitive G protein function in atherosclerotic porcine coronary arteries. Circulation. 83:652-660.
33. Liao, J.K., and S.L. Clark. 1995. Regulation of G protein alpha(i2) subunit expression by oxidized low-density lipoprotein. J. Clin. Invest. 95:1457-1463.
34. Tsutsui, M., H. Shimokawa, S. Tanaka, I. Kuwaoka, K. Hase, N. Nogami, K. Nakanishi, and S. Okamatsu. 1994. Endothelial Gi protein in human coronary arteries. Eur. Heart J. 15:1261-1266.
35. Corson, M., N. James, S. Latta, R. Nerem, B. Berk, and D. Harrison. 1996. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ. Res. 79:984-991.
36. Venema, R.C., H.S. Sayegh, J.-F. Arnal, and D.G. Harrison. 1995. Role of the enzyme calmodulin-binding domain in membrane association and phospholipid inhibition of endothelial nitric oxide synthase. J. Biol. Chem. 270: 14705-14711.
37. Michel, T., and O. Feron. 1997. Nitric oxide synthases: which, where, how, and why? J. Clin. Invest. 100:2146-2152.
38. Pou, S., W.S. Pou, D.S. Bredt, S.H. Snyder, and G.M. Rosen. 1992. Generation of superoxide by purified brain nitric oxide synthase. J. Biol. Chem. 267: 24173-24176.
39. Kojima, S., S. Ona, I. Iizuka, T. Arai, H. Mori, and K. Kubota. 1995. An tioxidative activity of 5,6,7,8-tetrahydrobiopterin and its inhibitory effect on paraquat-induced cell toxicity in cultured rat hepatocytes. Free Rad. Res. 23: 419-430.
40. Pieper, G.M. 1997. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J. Cardiovasc. Pharmacol. 29:8-15.
41. Stroes, E., J. Kastelein, F. Cosentino, W. Erkelens, R. Wever, H. Koomans, T. Luscher, and T. Rabelink. 1997. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J. Clin. Invest. 99:41-46.
42. Thomson, L., M. Trujillo, R. Telleri, and R. Radi. 1995. Kinetics of cytochrome c2+ oxidation by peroxynitrite: implications for superoxide measurements in nitric oxide-producing biological systems. Arch Biochem. Biophys. 319:491-497.
43. Minor, R.L.J., P.R. Myers, R.J. Guerra, J.N. Bates, and D.G. Harrison. 1990. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J. Clin. Invest. 86:2109-2116.
44. Mügge, A., J.H. Elwell, T.E. Peterson, T.G. Hofmeyer, D.D. Heistad, and D.G. Harrison. 1991. Chronic treatment with polyethylene glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits. Circ. Res. 69:1293-1300.
45. White, C.R., T.A. Brock, L.Y. Chang, J. Crapo, P. Briscoe, D. Ku, W.A. Bradley, S.H. Gianturco, J. Gore, and B.A. Freeman. 1994. Superoxide and peroxynitrite in atherosclerosis. Proc. Natl. Acad. Sci. USA. 91:1044-1048.
46. Heitzer, T., H. Just, and T. Munzel. 1996. Antioxidant vitamin C improves endothelial dysfunction in chronic smokers. Circulation. 94:6-9.
47. Ting, H.H., F.K. Timimi, K. Boles, S. Creager, P. Ganz, and M.A. Creager. 1995. Vitamin C acutely improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. Circulation. 92(Suppl. 1):1747. (Abstr.)
48. Solzbach, U., B. Hornig, M. Jeserich, and H. Just. 1997. Vitamin C improves endothelial dysfunction of epicardial coronary arteries in hypertensive patients. Circulation. 96:1513-1519.
49. Griendling, K., J.D. Ollerenshaw, C.A. Minieri, and R.W. Alexander. 1994. Angiotensin II stimulates NADH and NADPH activity in cultured vascular smooth muscle cells. Circ. Res. 74:1141-1148.
50. Pagano, P., Y. Ito, K. Tornheim, P. Gallop, A. Tauber, and R. Cohen. 1995. An NADPH oxidase superoxide-generating system in the rabbit aorta. Am. J. Physiol. (Heart Circ. Physiol). 268:H2274-H2280.
51. Mohazzab, K.M., and M.S. Wolin. 1994. Sites of superoxide anion production detected by lucigenin in calf pulmonary artery smooth muscle. Am. J. Physiol. 267:L815-L822.
52. Mohazzab, K.M., P.M. Kaminski, and M.S. Wolin. 1994. NADH oxidoreductase is a major source of superoxide anion in bovine coronary artery endothelium. Am. J. Physiol. 266:H2568-H2572.
53. Clark, R.A., K.G. Leidal, D.W. Pearson, and W.M. Nauseef. 1987. NADPH oxidase of human neutrophils. Subcellular localization and characterization of an arachidonate-activatable superoxide-generating system. J. Biol. Chem. 262:4065-4074.
54. Amit, N., T.P. Huu, P. Sourbier, C. Marquetty, and J. Hakim. 1988. Role of cytochrome b-559 in arachidonic acid activation of resting human neutrophils. Biochim. Biophys. Acta. 944:437-443.
55. Münzel, T., S. Kurz, S. Rajagopalan, W. Bennington, A. Thompson, B. Freeman, and D. Harrison. 1996. Hydralazine prevents nitroglycerin tolerance by inhibiting activation of a membrane-bound NADH oxidase: a new action for an old drug. J. Clin. Invest. 98:1465-1470.
56. Mohazzab, K.M., and M.S. Wolin. 1994. Properties of a superoxide anion-generating microsomal NADH oxidoreductase, a potential pulmonary artery PO2 sensor. Am. J. Physiol. 267:L823-L831.
57. Rajagopalan, S., S. Kurz, T. Münzel, M. Tarpey, B. Freeman, K. Griendling, and D. Harrison. 1996. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation: contribution to alterations of vasomotor tone. J. Clin. Invest. 97:1916-1923.
58. Bech Laursen, J., S. Rajagopalan, M. Tarpey, B. Freeman, and D. Harrison. 1997. A role of superoxide in angiotensin II, but not catecholamine-induced hypertension. Circulation. 95:588-593.
59. Münzel, T., H. Sayegh, B.A. Freeman, M.M. Tarpey, and D.G. Harrison. 1995. Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance. J. Clin. Invest. 95:187-194.
60. Fukui, T., B. Lassegue, H. Kai, R.W. Alexander, and K.K. Griendling. 1995. Cytochrome b558 a-subunit cloning and expression in rat aortic smooth muscle cells. Biochim. Biophys. Acta. 1231:215-219.
61. Ushio-Fukai, M., A.M. Zafari, T. Fukui, N. Ishizaka, and K.K. Griendling. 1996. p22phox is a critical component of the superoxide-generating NADH/NADPH oxidase system and regulates angiotensin 11-induced hypertrophy in vascular smooth muscle cells. J. Biol. Chem. 271:23317-23321.
62. Fukui, T., S. Rajagopalan, N. Ishizaka, Q. Capers, W.R. Taylor, D.G. Harrison, H. de Leon, J.N. Wilcox, and K.K. Griendling. 1997. Cytochrome b558 α-subunit mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats. Circ. Res. 80:45-51.