Safety of withdrawing inhaled nitric oxide therapy in persistent pulmonary hypertension of the newborn

Pediatrics

Volumn 104, Issue 2 I, 1999, Pages 231-236

  Davidson, Dennis ^a,f   Barefield, Elaine S ^a,b   Kattwinkel, John ^a,c   Dudell, Golde ^a,d   Damask, Michael ^e   Straube, Richard ^e   Rhines, Jared ^e   Chang, Cheng Tao ^e  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

^d RADY CHILDREN'S HOSPITAL   (United States)

^e PPD   (United States)

^f SCHNEIDER CHILDREN'S HOSPITAL   (United States)

Author keywords

Extracorporeal membrane oxygenation; Inhaled nitric oxide; Neonatal transport; Persistent pulmonary hypertension of the newborn

Indexed keywords

NITRIC OXIDE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DOUBLE BLIND PROCEDURE; DRUG WITHDRAWAL; ECHOCARDIOGRAPHY; EXTRACORPOREAL OXYGENATION; HUMAN; INHALATIONAL DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; OXYGENATION; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RANDOMIZED CONTROLLED TRIAL; SAFETY; TREATMENT FAILURE; TREATMENT OUTCOME;

ADMINISTRATION, INHALATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EXTRACORPOREAL MEMBRANE OXYGENATION; HUMANS; HYPERTENSION, PULMONARY; NITRIC OXIDE; TREATMENT FAILURE; TREATMENT OUTCOME; VASODILATOR AGENTS;

EID: 0032780775     PISSN: 00314005     EISSN: None     Source Type: Journal    
DOI: 10.1542/peds.104.2.231     Document Type: Article

References (18)

1. Linde-Zwirble WT, Angus DC, Clermont G, et al. Diagnoses associated with the delivery of mechanical ventilation in the newborn. Pediatr Res. 1997;41:202
2. Walsh-Sukys M, Fanaroff A, Wright L, et al. Persistent pulmonary hypertension of the newborn (PPHN): prospective, multicenter study of treatments and outcome. Pediatr Res. 1995;37:244
3. Davidson D, Barefield ES, Kattwinkel J, et al. Inhaled nitric oxide for the early treatment of persistent pulmonary hypertension of the term newborn: a randomized, double-masked, placebo-controlled, dose-response multicenter study. Pediatrics. 1998;101:325-334
4. The Neonatal Inhaled Nitric Oxide Study Group. Inhaled nitric oxide in full-term and nearly full-term infants with hypoxic respiratory failure. N Engl J Med. 1997;336:597-604
5. Roberts JD, Fineman JR, Morin FC III, et al. Inhaled nitric oxide and persistent pulmonary hypertension of the newborn. N Engl J Med. 1997;336:605-610
6. Stark AR, Davidson D. Inhaled nitric oxide for persistent pulmonary hypertension of the newborn: implications and strategy for future "high-tech" neonatal clinical trials. Pediatrics. 1995;96:1147-1151
7. Boedy RF, Howell CG, Kanto WP. Hidden mortality rate associated with extracorporeal membrane oxygeration. J Pediatr. 1990;117:462-464
8. Lavore A, Hall JB, Olson DM, Wylam ME. Life-threatening effects of discontinuing inhaled nitric oxide. Am J Respir Crit Care Med. 1996;153:1985-1987
9. Ivy DD, Kinsella JP, Ziegler JW, Abman SH. Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease. J Thorac Cardiovasc Surg. 1998; 115:875-882
10. Miller OI, Tang SF, Keech A, Celermajer DS. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide. Lancet. 1995;346: 51-52
11. Kinsella JP, Truog WE, Walsh WF, et al. Randomized, multicenter trial of inhaled nitric oxide and high-frequency oscillatory ventilation in severe, persistent pulmonary hypertension of the newborn. J Pediatr. 1997;131:55-62
12. Aly H, Sahni R, Wong JT. Weaning strategy with inhaled nitric oxide treatment in persistent pulmonary hypertension of the newborn. Arch Dis Child. 1997;76:F118-F122
13. Pontoppidan H, Geffin A, Lowenstein F. Acute respiratory failure: the adult. N Engl J Med. 1972;287:743
14. Goldsmith JP, Karotkin EH. Introduction to assisted ventilation. In: Goldsmith JP, Karotkin EH, eds. Assisted Ventilation of the Neonate. 3rd ed. Philadelphia, PA: WB Saunders Inc; 1996:14
15. Kinsella JP, Abman SH. Recent developments in the pathophysiology and treatment of persistent pulmonary hypertension of the newborn. J Pediatr. 1995;126:853-864
16. Boga GM, Griscavage JM, Rogers NE, Ignarro LJ. Negative feedback regulation of endothelial cell function by nitric oxide. Arch Res. 1993; 73:808-812
17. Giaid A, Yanagisawa M, Langleben D, et al. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension. N Engl J Med. 1993;328:1732-1739
18. Kinsella JP, Schmnidt JM, Griebel J, Abman SH. Inhaled nitric oxide treatment for stabilization and emergency medical transport of critically ill newboms and infants. Pediatrics. 1995;95:773-776