20-Hydroxyeicosatetraenoic acid is a vasoconstrictor in the newborn piglet pulmonary microcirculation

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 287, Issue 2 31-2, 2004, Pages

  Fuloria, Mamta ^a   Eckman, Delrae M ^a   Leach, Daniel A ^a   Aschner, Judy L ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Calcium dependent channels; Cyclooxygenase; Cytochrome P 450; Pulmonary resistance arteries; Thromboxane PGH2 receptor

Indexed keywords

20 HYDROXYICOSATETRAENOIC ACID; ARACHIDONIC ACID; CALCIUM ACTIVATED POTASSIUM CHANNEL; INDOMETACIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE;

ANIMAL TISSUE; ARTICLE; BLOOD VESSEL REACTIVITY; BLOOD VESSEL TONE; CONTROLLED STUDY; ENZYME INHIBITION; LUNG CIRCULATION; LUNG RESISTANCE; MEDIATOR RELEASE; MICROCIRCULATION; NONHUMAN; PRIORITY JOURNAL; SWINE; VASCULAR ENDOTHELIUM; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ANIMALS, NEWBORN; ENDOTHELIUM, VASCULAR; HYDROXYEICOSATETRAENOIC ACIDS; MICROCIRCULATION; POTASSIUM CHANNELS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PULMONARY CIRCULATION; RECEPTORS, THROMBOXANE; RECEPTORS, THROMBOXANE A2, PROSTAGLANDIN H2; SIGNAL TRANSDUCTION; SWINE; VASCULAR RESISTANCE; VASOCONSTRICTOR AGENTS;

EID: 3242693445     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.00358.2003     Document Type: Article

References (27)

1. Aschner JL, Smith TK, Kovacs N, Pinheiro JM, and Fuloria M. Mechanisms of bradykinin-mediated dilation in newborn piglet pulmonary conducting and resistance vessels. Am J Physiol Lung Cell Mol Physiol 283: L373-L382, 2002.
2. Birks EK, Bousamra M, Presberg K, Marsh JA, Effros RM, and Jacobs ER. Human pulmonary arteries dilate to 20-HETE, an endogenous eicosanoid of lung tissue. Am J Physiol Lung Cell Mol Physiol 272: L823-L829, 1997.
3. Campbell WB, Gebremedhin D, Pratt PF, and Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78: 415-423, 1996.
4. Escalante B, Omata K, Sessa W, Lee SG, Falck JR, and Schwartzman ML. 20-Hydroxyeicosatetraenoic acid is an endothelium-dependent vasoconstrictor in rabbit arteries. Eur J Pharmacol 235: 1-7, 1993.
5. Escalante B, Sessa WC, Falck JR, Yadagiri P, and Schwartzman ML. Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase. J Pharmacol Exp Ther 248: 229-232, 1989.
6. Frisbee JC, Falck JR, and Lombard JH. Contribution of cytochrome P-450 ω-hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension. Am J Physiol Heart Circ Physiol 278: H1517-H1526, 2000.
7. Frisbee JC, Roman RJ, Falck JR, Krishna UM, and Lombard JH. 20-HETE contributes to myogenic activation of skeletal muscle resistance arteries in Brown Norway and Sprague-Dawley rats. Microcirculation 8: 45-55, 2001.
8. Fuloria M, Smith TK, and Aschner JL. Role of 5,6-epoxyeicosatrienoic acid in the regulation of newborn piglet pulmonary vascular tone. Am J Physiol Lung Cell Mol Physiol 283: L383-L389, 2002.
9. Gebremedhin D, Lange AR, Lowry TF, Taheri MR, Birks EK, Hudetz AG, Narayanan J, Falck JR, Okamoto H, Roman RJ, Nithipatikom K, Campbell WB, and Harder DR. Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circ Res 87: 60-65, 2000.
10. 2+ current. J Physiol 507: 771-781, 1998.
11. Harder DR, Gebremedhin D, Narayanan J, Jefcoat C, Falck JR, Campbell WB, and Roman R. Formation and action of a P-450 4A metabolite of arachidonic acid in cat cerebral microvessels. Am J Physiol Heart Circ Physiol 266: H2098-H2107, 1994.
12. Harder DR, Narayanan J, Birks EK, Liard JF, Imig JD, Lombard JH, Lange AR, and Roman RJ. Identification of a putative microvascular oxygen sensor. Circ Res 79: 54-61, 1996.
13. Imig JD, Falck JR, Gebremedhin D, Harder DR, and Roman RJ. Elevated renovascular tone in young spontaneously hypertensive rats. Role of cytochrome P-450. Hypertension 22: 357-364, 1993.
14. Imig JD, Zou AP, De Montellano PRO, Sui Z, and Roman RJ. Cytochrome P-450 inhibitors alter afferent arteriolar responses to elevations in pressure. Am J Physiol Heart Circ Physiol 266: H1879-H1885, 1994.
15. Imig JD, Zou AP, Stec DE, Harder DR, Falck JR, and Roman RJ. Formation and action of 20-hydroxyeicosatetraenoic acid in rat renal arterioles. Am J Physiol Regul Integr Comp Physiol 270: R217-R227, 1996.
16. 2 in hamster muscle, but not cheek pouch epithelium, microcirculation. Am J Physiol Heart Circ Physiol 276: H503-H508, 1999.
17. Ma YH, Gebremedhin D, Schwartzman ML, Falck JR, Clark JE, Masters BS, Harder DR, and Roman RJ. 20-Hydroxyeicosatetraenoic acid is an endogenous vasoconstrictor of canine renal arcuate arteries. Circ Res 72: 126-136, 1993.
18. 2 in rat diaphragmatic arterioles: role of the endothelium. Am J Physiol Heart Circ Physiol 272: H1419-H1425, 1997.
19. Popp R, Bauersachs J, Hecker M, Fleming I, and Busse R. A transferable β-naphthoflavone-inducible, hyperpolarizing factor is synthesized by native and cultured porcine coronary endothetial cells. J Physiol 497: 699-709, 1996.
20. Randriamboavonjy V, Busse R, and Fleming I. 20-HETE-induced contraction of small coronary arteries depends on the activation of Rho-kinase. Hypertension 41: 801-806, 2003.
21. Schwartzman ML, Falck JR, Yadagiri P, and Escalante B. Metabolism of 20-hydroxyeicosatetraenoic acid by cyclooxygenase. Formation and identification of novel endothelium-dependent vasoconstrictor metabolites. J Biol Chem 264: 11658-11662, 1989.
22. + channel activity and vascular tone in renal arterioles. Circ Res 83: 1069-1079, 1998.
23. Sun CW, Falck JR, Harder DR, and Roman RJ. Role of tyrosine kinase and PKC in the vasoconstrictor response to 20-HETE in renal arterioles. Hypertension 33: 414-418, 1999.
24. Wang MH, Zhang F, Marji J, Zand BA, Nasjletti A, and Laniado-Schwartzman M. CYP4A1 antisense oligonucleotide reduces mesenteric vascular reactivity and blood pressure in SHR. Am J Physiol Regul Integr Comp Physiol 280: R255-R261, 2001.
25. Yu M, McAndrew RP, Al Saghir R, Maier KG, Medhora M, Roman RJ, and Jacobs ER. Nitric oxide contributes to 20-HETE-induced relaxation of pulmonary arteries. J Appl Physiol 93: 1391-1399, 2002.
26. Zhu D, Birks EK, Dawson CA, Patel M, Falck JR, Presberg K, Roman RJ, and Jacobs ER. Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. Am J Physiol Heart Circ Physiol 279: H1526-H1533, 2000.
27. + channel in renal arterioles. Am J Physiol Regul Integr Comp Physiol 270: R228-R237, 1996.