HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI 3-kinase/Akt pathway

Journal of Clinical Investigation

Volumn 108, Issue 3, 2001, Pages 391-397

  Dimmeler, Stefanie ^a   Aicher, Alexandra ^a   Vasa, Mariuca ^a   Mildner Rihm, Christiane ^a   Adler, Klaudia ^a   Tiemann, Michaela ^b   Rütten, Hartmut ^b   Fichtlscherer, Stephan ^a   Martin, Hans ^a   Zeiher, Andreas M ^a  

^a GOETHE UNIVERSITY   (Germany)

^b SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ATORVASTATIN; CD34 ANTIGEN; COMPACTIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; RECOMBINANT VASCULOTROPIN; SIMVASTATIN; STEM CELL FACTOR; VASCULOTROPIN;

ANGIOGENESIS; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STEM CELL;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; CORONARY DISEASE; ENDOTHELIAL GROWTH FACTORS; ENDOTHELIUM, VASCULAR; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LYMPHOKINES; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; STEM CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0034908652     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200113152     Document Type: Article

References (35)

1. Angiogenesis and vasculogenesis as therapeutic strategies for postnatal neovascularization
2. Angiogenesis in cancer, vascular, rheumatoid and other disease
3. Mechanisms of angiogenesis
4. Angiogenesis in cancer and other diseases
5. Isolation of putative progenitor endothelial cells for angiogenesis
6. Evidence for circulating bone marrow-derived endothelial cells
7. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization
8. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation
9. In vitro differentiation of endothelial cells from AC 133-positive progenitor cells
10. Enhanced endothelialization and microvessel formation in polyester grafts seeded with CD34(+) bone marrow cells
11. Blood-derived angioblasts accelerate blood-flow restoration in diabetic mice
12. Transplanted cord blood-derived endothelial precursor cells augment postnatal neovascularization
13. Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization
14. Neovascularization of ischemic myocardium by human bone-marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function
15. Therapeutic potential of ex vivo expanded endothelial progenitor cells for myocardial ischemia
16. VEGF contributes to postnatal neovascularization by mobilizing bone marrow-derived endothelial progenitor cells
17. Ischemia-and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization
18. Vascular endothelial growth factor(165) gene transfer augments circulating endothelial progenitor cells in human subjects
19. Current perspectives on statins
20. HMG-CoA reductase inhibition by atorvastatin reduces neointimal inflammation in a rabbit model of atherosclerosis
21. Hyperlipidemia and coronary disease. Correction of the increased thrombogenic potential with cholesterol reduction
22. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
23. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
24. Akt takes center stage in angiogenesis signaling
25. Activation of nitric oxide synthase in endothelial cells via Akt-dependent phosphorylation
26. A role for hematopoietic stem cells in promoting angiogenesis
27. Stem cells: Units of development, units of regeneration, and units in evolution
28. Vascular endothelial growth factor regulates endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation
29. Targeting rho in cardiovascular disease
30. Improvement in coronary flow reserve determined by positron emission tomography after 6 months of cholesterol-lowering therapy in patients with early stages of coronary atherosclerosis
31. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study. A randomized controlled trial
32. Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: Involvement in suppression of apoptosis
33. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
34. Phosphorylation of the endothelial nitric oxide synthase at Ser 1177 is required for VEGF-induced endothelial cell migration
35. Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt