Overexpression of the serine elastase inhibitor elafin protects transgenic mice from hypoxic pulmonary hypertension

Circulation

Volumn 105, Issue 4, 2002, Pages 516-521

  Zaidi, Syed H E ^a   You, Xiao Mang ^b   Ciura, Sorana ^a   Husain, Mansoor ^b   Rabinovitch, Marlene ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Hypertension, pulmonary; Hypoxia; Lung

Indexed keywords

BIOTIN; ELAFIN; ELASTASE INHIBITOR; ELASTIN; FLUOROPHOSPHATE; GELATINASE B; INTERSTITIAL COLLAGENASE; MATRIX METALLOPROTEINASE; PROTEIN; SERINE ELASTASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHRONIC DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; DOSE TIME EFFECT RELATION; ENZYME ACTIVATION; ENZYME INHIBITOR INTERACTION; GENE OVEREXPRESSION; HEART RIGHT VENTRICLE PRESSURE; HEART VENTRICLE REMODELING; HYPOXIA; MOUSE; MUSCLE GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PULMONARY HYPERTENSION; TISSUE PRESERVATION; TRANSGENIC MOUSE; VASOCONSTRICTION; ZYMOGRAPHY;

ACTINS; ANIMALS; ANOXIA; ELASTIN; ENDOTHELIN-1; HEMATOCRIT; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; KINETICS; MATRIX METALLOPROTEINASES; MICE; MICE, TRANSGENIC; PRESSURE; PROTEINASE INHIBITORY PROTEINS, SECRETORY; PROTEINS; PULMONARY ARTERY; RNA, MESSENGER; SERINE PROTEINASE INHIBITORS; UP-REGULATION; VENTRICULAR PRESSURE;

EID: 0037192329     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0402.102866     Document Type: Article

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