Role for endothelin-1-induced superoxide and peroxynitrite production in rebound pulmonary hypertension associated with inhaled nitric oxide therapy

Circulation Research

Volumn 89, Issue 4, 2001, Pages 357-364

  Wedgwood, Stephen ^a   McMullan, D Michael ^b   Bekker, Janine M ^d   Fineman, Jeffrey R ^b,c   Black, Stephen M ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NONE

Author keywords

Nitric oxide; Peroxynitrite; Rebound pulmonary hypertension; Receptor blockade; Superoxide

Indexed keywords

3 NITROTYROSINE; 4 (4 METHOXYPHENYL) 2 (3,4 METHYLENEDIOXYPHENYL) 4 OXO 3 (3,4,5 TRIMETHOXYBENZYL) 2 BUTENOIC ACID; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PEROXYNITRITE; SUPEROXIDE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INHIBITION; NITRATION; NONHUMAN; PRIORITY JOURNAL; PULMONARY ARTERY; PULMONARY HYPERTENSION; RECEPTOR BLOCKING;

EID: 0035903240     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/hh1601.094983     Document Type: Article

References (40)

1. Inhaled nitric oxide therapy
2. Rebound pulmonary hypertension after inhalation of nitric oxide
3. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide
4. Dipyridamole attenuates rebound pulmonary hypertension after inhaled nitric oxide withdrawal in postoperative congenital heart disease
5. Inhaled nitric oxide inhibits NOS activity in lambs: A potential mechanism for rebound pulmonary hypertension
6. Nitric oxide exposure inhibits endothelial NOS activity but not gene expression: A role for superoxide
7. Nitric oxide synthase: Expression and expressional control of the three isoforms
8. Regulation of pulmonary vascular tone in the perinatal period
9. Chronic nitric oxide inhibition in utero produces persistent pulmonary hypertension in newborn lambs
10. Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension
11. Coordinated regulation of genes of the nitric oxide and endothelin pathways during the development of pulmonary hypertension in fetal lambs
12. Inhaled nitric oxide-induced rebound pulmonary hypertension: A role for endothelin-1
13. Expression of endothelin-1 in the lungs of patients with pulmonary hypertension
14. Elevated levels of plasma endothelin-1 in young patients with pulmonary hypertension caused by congenital heart disease are decreased after successful surgical repair
15. Elevated immunoreactive endothelin-1 levels in newborn infants with persistent pulmonary hypertension
16. Endothelin-1 produces pulmonary vasodilation in the intact newborn lamb
17. Developmental effects of endothelin-1 on the pulmonary circulation in sheep
18. Endothelin peptides: Biological actions and pathophysiological significance in the lung
19. Endothelin receptor antagonism
20. Endothelin receptor blockade prevents the rise in pulmonary vascular resistance after cardiopulmonary bypass in lambs with increased pulmonary blood flow
21. Characterization of rat neuronal nitric oxide synthase expressed in Saccharomyces cerevisiae
22. Nitric oxide synthase from cerebellum catalyzes the formation of equimolar quantities of nitric oxide and citrulline from L-arginine
23. Increased endothelial NOS in iambs with increased pulmonary blood flow and pulmonary hypertension
24. The endothelium of resistance arteries: Physiology and role in hypertension
25. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
26. Endothelin b receptor agonists produce pulmonary vasodilation in intact newborn lambs with pulmonary hypertension
27. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension
28. Sulfhydryl-disulfide modulation and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells
29. Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: Role of thioredoxin in regulation of catalytic activity
30. Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds
31. Feedback inhibition of nitric oxide synthase activity by nitric oxide
32. Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs
33. Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins
34. Release of endothelin from the porcine aorta: Inhibition by endothelium-derived nitric oxide
35. Evidence for free radical formation during the oxidation of 2′-7′-dichlorofluorescin to the fluorescent dye 2′-7′-dichlorofluorescein by horseradish peroxidase: Possible implications for oxidative stress measurements
36. Phenoxyl free radical formation during the oxidation of the fluorescent dye 2′,7′-dichlorofluorescein by horseradish peroxidase: Possible consequences for oxidative stress measurements
37. Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils
38. Eosinophil peroxidase nitrates protein tyrosyl residues: Implications for oxidative damage by nitrating intermediates in eosinophilic inflammatory disorders
39. Oxidative damage and tyrosine nitration from peroxynitrite
40. Biological tyrosine nitration: A pathophysiological function of nitric oxide and reactive oxygen species