L-arginine increases nitric oxide production in isolated lungs of chronically hypoxic newborn pigs

Journal of Applied Physiology

Volumn 88, Issue 5, 2000, Pages 1797-1803

  Fike, Candice D ^a   Kaplowitz, Mark R ^b   Rehorst Paea, Linda A ^b   Nelin, Leif D ^b  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

L arginine uptake; Neonatal pulmonary hypertension; Nitrates; Nitrites

Indexed keywords

ARGININE; NITRATE; NITRIC OXIDE; NITRITE;

AMINO ACID TRANSPORT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CHRONICITY; CONTROLLED STUDY; ISOLATED LUNG; LUNG PERFUSION; NEWBORN; NEWBORN HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PULMONARY HYPERTENSION; SUPPLEMENTATION; SWINE;

EID: 0034094862     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.2000.88.5.1797     Document Type: Article

References (27)

1. Arnal JF, Munzel T, Venema RC, James NL, Bai CL, Mitch WE, and Harrison DG. Interactions between L-arginine and L-glutamine change endothelial NO production. An effect independent of NO synthase availability. J Clin Invest 95: 2565-2572, 1995.
2. Baudouin SV, Bath P, Martin JF, Bois RD, and Evans TW. L-Arginine infusion has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance. Br J Clin Pharmacol 36: 45-49, 1993.
3. Block ER, Herrera H, and Couch M. Hypoxia inhibits L-arginine uptake by pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 269: L574-L580, 1995.
4. Boger RH, Bode-Boger SM, Brandes RP, Phivthong-Ngam L, Bohme M, Nafe R, Mugge A, and Frolich JC. Dietary L-arginine reduces the progression of atherosclerosis in cholesterol-fed rabbits, comparison with lovastatin. Circulation 96: 1282-1290, 1997.
5. Calver A, Collier J, and Vallance P. Dilator actions of arginine in human peripheral vasculature. Clin Sci (Colch) 81: 695-700, 1991.
6. Carville C, Raffestin B, Eddahibi S, Blouquit Y, and Adnot S. Loss of endothelium-dependent relaxation in proximal pulmonary arteries from rats exposed to chronic hypoxia: effects of in vivo and in vitro supplementation with L-arginine. J Cardiovasc Pharmacol 22: 889-896, 1993.
7. Chen PY and Sanders PW. L-Arginine abrogates salt-sensitive hypertension in Dahl/Rapp rats. J Clin Invest 88: 1559-1567, 1991.
8. Dinh-Xuan AT, Pepke-Zaba J, Butt AY, Cremona G, and Higenbottam TW. Impairment of pulmonary-artery endothelium-dependent relaxation in chronic obstructive lung disease is not due to dysfunction of endothelial cell membrane receptors nor to L-arginine deficiency. Br J Pharmacol 109: 587-591, 1993.
9. Eddahibi S, Adnot S, Carville C, Blouquit Y, and Raffestin B. L-Arginine restores endothelium-dependent relaxation in pulmonary circulation of chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 263: L194-L200, 1992.
10. Fike CD and Kaplowitz MR. Effect of chronic hypoxia on pulmonary vascular pressures in isolated lungs of newborn pigs. J Appl Physiol 77: 2853-2862, 1994.
11. Fike CD, Kaplowitz MR, Thomas CJ, and Nelin LD. Chronic hypoxia decreases nitric oxide production and endothelial nitric oxide synthase in newborn pig lungs. Am J Physiol Lung Cell Mol Physiol 274: L517-L526, 1998.
12. Finemann JR, Heymann MA, and Soifer SJ. N-nitro-L-arginine attenuates endothelium-dependent pulmonary vasodilation in lambs. Am J Physiol Heart Circ Physiol 260: H1299-H1306, 1991.
13. Greenlees C, Wadsworth RM, Martorana PA, and Wainwright CL. The effects of L-arginine on neonintimal formation and vascular function following balloon injury in heritable hyperlipidaemic rabbits. Cardiovasc Res 35: 351-359, 1997.
14. Hampl V, Archer SL, Nelson DP, and Weir EK. Chronic EDRF inhibition and hypoxia: effects on pulmonary circulation and systemic blood pressure. J Appl Physiol 75: 1748-1757, 1993.
15. Hecker M, Sessa WC, Harris HJ, Anggard EE, and Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endothelium-derived relaxing factor: culture endothelial cells recycle L-citrulline to L-arginine. Proc Natl Acad Sci USA 87: 8612-8616, 1990.
16. Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, and Stamler JS. Nitric oxide synthase in human and rat lung; immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 9: 371-377, 1993.
17. McDonald KK, Zharikov S, Block ER, and Kilberg MS. A caveolar complex between the cationic amino acid transporter 1 and endothelial nitric oxide synthase may explain the "arginine paradox." J Biol Chem 272: 31213-31216, 1997.
18. Mehta S, Stewart DJ, Langleben D, and Levy RD. Short-term pulmonary vasodilation with L-arginine in pulmonary hypertension. Circulation 92: 1539-1545, 1995.
19. Minor RL Jr, Myers PR, Guerra R Jr, Bates JN, and Harrison DG. Diet-induced atherosclerosis increases the release of nitrogen oxides from rabbit aorta. J Clin Invest 86: 2109-2116, 1990.
20. Mitani Y, Maruyama K, and Minoru S. Prolonged administration of L-arginine ameliorates chronic pulmonary hypertension and pulmonary vascular remodeling in rats. Circulation 96: 689-697, 1997.
21. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 6: 3051-3064, 1992.
22. Okazaki J, Komori K, Kawasaki K, Eguchi D, Ishida M, and Sugimachi K. L-Arginine inhibits smooth muscle cell proliferation of vein graft intimal thickness in hypercholesterolemic rabbits. Cardiovasc Res 36: 429-436, 1997.
23. Panza JA, Casino PR, Badar DM, and Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normals and in patients with essential hypertension. Circulation 87: 1475-1481, 1993.
24. m for oxygen of nitric oxide synthase isoforms. J Pharmacol Exp Ther 276: 30-33, 1996.
25. Schmidt HH, Baeblich SE, Zernikow BC, Klein MM, and Bohme E. L-Arginine and arginine analogues: effects on isolated blood vessels and cultured endothelial cells. Br J Pharmacol 101: 145-151, 1990.
26. Thorne S, Mullen MJ, Clarkson P, Donald AE, and Deanfield JE. Early endothelial dysfunction in adults at risk from atheroclerosis: different responses to L-arginine. J Am Coll Cardiol 32: 110-116, 1998.
27. Wu G and Morris SM. Arginine metabolism: nitric oxide and beyond. Biochem J 336: 1-17, 1998.