Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 291, Issue 5, 2006, Pages

  Parker, Thomas A ^a,c   Roe, Gates ^a   Grover, Theresa R ^a   Abman, Steven H ^b  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^b Children's Hospital Colorado   (United States)

^c NONE   (United States)

Author keywords

Fasudil; Newborn; Nitric oxide; Persistent pulmonary hypertension of the newborn; Y 27632

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; FASUDIL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; RHO KINASE;

ANIMAL EXPERIMENT; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; FETUS; FETUS LUNG; LAMB; LUNG VASCULAR RESISTANCE; LUNG VASOCONSTRICTION; NONHUMAN; PRIORITY JOURNAL; VASODILATATION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; AMIDES; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FEMALE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LUNG; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROARGININE; PREGNANCY; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PULMONARY CIRCULATION; PYRIDINES; SHEEP; SIGNAL TRANSDUCTION; VASCULAR RESISTANCE;

EID: 33751108266     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00512.2005     Document Type: Article

References (44)

1. Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, and Takeshit A. Long-term treatment with a Tho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 20: 385-393, 2004.
2. Abman SH and Accurso FJ. Acute effects of partial compression of ductus arteriosus on fetal pulmonary circulation. Am J Physiol Heart Circ Physiol 257: H626-H634, 1989.
3. Abman SH and Accurso FJ. Sustained fetal pulmonary vasodilation with prolonged atrial natriuretic factor and GMP infusions. Am J Physiol Heart Circ Physiol 260: H183-H192, 1991.
4. Abman SH, Chatfield BA, Hall SL, and McMurtry IF. Role of endothelium-derived relaxing factor during transition of pulmonary circulation at birth. Am J Physiol Heart Circ Physiol 259: H1921-H1927, 1990.
5. Accurso FJ, Alpert B, Wilkening RB, Petersen RG, and Meschia G. Time-dependent response of fetal pulmonary blood flow to an increase in fetal oxygen tension. Resp Physiol 63: 43-52, 1986.
6. Belik J, Kerc E, and Pato MD. Rat pulmonary arterial smooth muscle myosin light chain kinase and phosphatase activities decrease with age. Am J Physiol Lung Cell Mol Physiol 290: L509-L516, 2006.
7. Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJG, and Kadowitz PJ. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism fro diabetes-associated erectile dysfunction. Proc Natl Acad Sci USA 101: 9121-9126, 2004.
8. Bolz SS, Galle J, Derwand R, deWit C, and Pohl U. Oxidized LDL increases the sensitivity of the contractile apparatus in isolated resistance arteries for Ca(2+) via a rho- and rho kinase-dependent mechanism. Circulation 102: 2402-2410, 2000.
9. Bolz SS, Vogel L, Sollinger D, Derwand R, de Wit C, Loirnd G, and Pohl U. Nitric oxide-induced decrease in calcium sensitivity of resistance arteries is attributable to activation of myosin light chain phosphatase and antagonized by the RhoA/Rho kinase pathway. Circulation 107: 3081-3087, 2003.
10. Bonnevier J and Arner A. Actions downstream of cyclic GMP/protein kinase G can reverse protein kinase C-mediated phosphorylation of CPI-17 and Ca(2+) sensitization in smooth muscle. J Biol Chem 279: 28998-29003, 2004.
11. Breitenlechner C, Gassel M, Hidaka H, Kinzel V, Huber R, Engh RA, and Bossemeyer D. Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. Structure 11: 1595-1607, 2003.
12. Cornfield DN, Chatfiled BA, McQueston JA, McMurtry IF, and Abman SH. Effects of birth-related stimuli on L-arginine-dependent pulmonary vasodilation in ovine fetus. Am J Physiol Heart Circ Physiol 262: H1474-H1481, 1992.
13. Fagan KA, Oka M, Bauer NR, Gebb SA, Ivy DD, Morris KG, and McMurtry IF. Attenuation of acute hypoxic pulmonary vasoconstriction and hypoxic pulmonary hypertension in mice by inhibition of Rho kinase. Am J Physiol Lung Cell Mol Physiol 287: L656-L664, 2004.
14. Galle J, Mameghani A, Bolz SS, Gambaryan S, Gorg M, Quaschning T, Raff U, Barth H, Siebold S, Wanner C, and Pohl U. Oxidized LDL and its compound lysophosphatidylcholine potentiate angII-induced vasoconstriction by stimulation of RhoA. J Am Soc Nephrol 14: 1471-1479, 2003.
15. Gokina NI, Park KM, McElroy-Yaggy K, and Osol G. Effects of rho kinase inhibition on cerebral artery myogenic tone and reactivity. J Appl Physiol 98: 1940-1948, 2005.
16. Gong MC, Fujihara H, Somlyo AV, and Somlyo AP. Translocation of rhoA associated with Ca2+ sensitization of smooth muscle. J Biol Chem 272: 10704-10709, 1997.
17. Hartshorne DJ, Ito M, and Erdori F. Myosin light chain phosphatase: subunit composition, interactions and regulation. J Muscle Res Cell Mot 19: 325-341, 1991.
18. Ibe BO, Hibler S, and Raj JU. Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb. J Appl Physiol 85: 1079-1085, 1998.
19. Ivy DD, Kinsella JP, and Abman SH. Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation. J Clin Invest 93: 2141-2148, 1994.
20. Kandabashi T, Shimokawa H, Miyata K, Kunihiro I, Kawano Y, Fukata Y, Higo T, Egashira K, Takahashi S, Kaibuchi K, and Takeshita A. Inhibition of myosin phosphatase by upregulated rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β. Circulation 101: 1319-1323, 2000.
21. Kawano F, Fukata Y, Onishi H, Amano M, Nakamura T, Ito M, Matsumura F, Inagaki M, and Kaibuchi K. Phosphorylation of myosin-binding subunit (MBS) of myosin phosphates by rho-kinase in vivo. J Cell Biol 147: 1023-1038, 1999.
22. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M, Yamamori B, Feng J, Nakano T, Okawa K, Iwamatsu A, and Kaibuchi K. Regulation of myosin phosphatase by rho and rho-associated kinase (rho-kinase). Science 273: 245-248, 1996.
23. Koyama M, Ito M, Feng J, Seko T, Shiraki K, Takase K, Hartshorne DJ, and Nakano T. Phosphorylation of CPI-17, an inhibitory phosphoprotein of smooth muscle myosin phosphatase, by Rho-kinase. FEBS Lett 475: 197-200, 2000.
24. Matsumoto A, Mohri Masahiro Shimokawa H, Urakami L, Usui M, and Takeshita A. Suppression of coronary artery spasm by the rho-kinase inhibitor fasudil in patients with vasospastic angina. Circulation 105: 1545-1547, 2002.
25. Matsushita T, Hislop AA, Boels PJ, Deutsch J, and Haworth SG. Changes in ANP responsiveness of normal and hypertensive porcine intrapulmonary arteries during maturation. Pediatr Res 46: 411-418, 1999.
26. McMurtry IF, Bauer NR, Fagan KA, Nagaoka T, Gebb SA, and Oka M. Hypoxia and rho/rho-kinase signaling. Lung development versus hypoxic pulmonary vasoconstriction. Adv Exp Med Biol 543: 127-137, 2003.
27. Mukai Y, Shimokawa H, Matoba T, Kandabashi T, Satoh S, Hiroki J, Kaibuchi K, and Takeshita A. Involvement of Rho-kinase in hypertensive vascular disease: a novel target in hypertension. FASEB J 15: 1062-1064, 2001.
28. Nagaoka T, Fagan KA, Gebb SA, Morris KG, Suzuki T, Shimokawa H, McMurtry IF, and Oka M. Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. Am J Respir Crit Care Med 171: 494-499, 2005.
29. Nagaoka T, Morio Y, Casanova N, Bauer N, Gebb S, McMurtry IF, and Oka M. Rho/hro-kinase signaling medciates increased basal pulmonary vascular tone in chronically hypoxic rats. Am J Physiol Lung Cell Mol Physiol 287: L665-L672, 2004.
30. Randriamboavonjy V, Busse R, and Fleming I. 20-HETE-induced contraction os small coronary arteries depends on the activation of rho-kinase. Hypertension 41: 801-806, 2003.
31. Robertson TP, Dipp M, Ward JP, Aaronson PI, and Evans AM. Inhibition of sustained hypoxic vasoconstriction by Y-27632 in isolated intrapulmonary arteries and perfused lung of the rat. Br J Pharmacol 131: 5-9, 2000.
32. Sato M, Tani E, Fujikawa H, and Kaibuchi K. Involvement of rhokinase-mediated phosphorylation of myosin light chain in enhancement of cerebral vasospasm. Circ Res 87: 195-200, 2000.
33. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 275: 21722-21729, 2000.
34. Sawada N, Itoh H, Yamashita J, Doi K, Inoue M, Masatsugu K, Fukunaga Y, Sakaguchi S, Sone M, Yamahara K, Yurugi T, and Nakao K. cGMP-dependent protein kinase phosphorylates and inactivates RhoA. Biochem Biophys Res Commun 280: 798-805, 2001.
35. Schubert R, Kalentchuk VU, and Krien U. Rho kinase inhibition partly weakens myogenic reactivity in rat small arteries by changing calcium sensitivity. Am J Physiol Heart Circ Physiol 283: H228-H2295, 2002.
36. Seko T, Ito M, Kureishi Y, Okamoto R, Moriki N, Onishi K, Isaka N, Hartshorne DJ, and Nakano T. Activiation of rhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ Res 92: 411-418, 2003.
37. rd FC. Pulmonary endothelial NO synthase gene expression is decreased in fetal lambs with pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 272: L1005-L1012, 1997.
38. Somlyo AP and Somlyo AV. Signal transduction and regulation in smooth muscle. Nature 372: 231-236, 1994.
39. Somlyo AP and Somlyo AV. Ca2+ sensitivity of smooth muscle and nonmuscle myosini II: modulated by G-proteins, kinases, and myosin phosphatase. Physiol Rev 83: 1325-1358, 2003.
40. Somlyo AP, Wu X, Walker LA, and Somlyo AV. Pharmacomechanical coupling: the role of calcium, G-proteins, kinases, and phosphatases. Rev Physiol Biochem Pharmacol 134: 201-234, 1999.
41. Takemoto M, Sun J, Hiroki J, Shimokawa H, and Liao JK. Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase. Circulation 106: 57-62, 2002.
42. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, Morishita T, Tamakawa H, Yamagami K, Inui J, Maekawa M, and Narumiya S. Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994, 1997.
43. Villamor E, Le Cras TD, Horan MP, Halbower AC, Tuder RM, and Abman SH. Chronic intrauterine pulmonary hypertension impairs endothelial nitric oxide synthase in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 272: L1013-L1020, 1997.
44. Wang Z, Lanner MC, Jin N, Swartz D, Li L, and Rhoades RA. Hypoxia inhibits myosin phosphatase in pulmonary arterial smooth muscle cells: role of Rho-kinase. Am J Respir Cell Mol Biol 29: 465-471, 2003.